Month: November 2022

Adegboyega, Abdullahi K. published the artcileReaction of Dioxazolones with Boronic Acids: Copper-Mediated Synthesis of N-Aryl Amides via N-Acyl Nitrenes, HPLC of Formula: 7465-88-5, the main research area is aryl amide preparation; dioxazolone boronic acid copper mediated reaction.

Dioxazolones, as direct amide sources, have been used with boronic acids in the presence of copper(I) chloride to access N-aryl amides at room temperature The versatility of the developed reaction is proven by ample scope having a wide range of functional group tolerance. The reaction optimization conditions revealed that a fluorine additive demonstrated improved reactivity toward the intended transformation. The addition of triphenylphosphine resulted in N-acyl iminophosphorane, suggesting the involvement of an N-acyl nitrene intermediate.

Organic Letters published new progress about Aromatic amides Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, HPLC of Formula: 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bai, Jin published the artcileVisible-Light Carbon Nitride-Catalyzed Aerobic Cyclization of Thiobenzanilides under Ambient Air Conditions, Safety of 4-Methoxy-N-phenylbenzamide, the main research area is thiobenzanilide cyclization carbon nitride catalyst photochem; benzothiazole preparation.

A metal-free heterogeneous photocatalysis has been developed for the synthesis of benzothiazoles via intramol. C-H functionalization/C-S bond formation of thiobenzanilides by inexpensive graphitic carbon nitride (g-C3N4) under visible-light irradiation This reaction provides access to a broad range of 2-substituted benzothiazoles in high yields under an air atm. at room temperature without addition of a strong base or organic oxidizing reagents. In addition, the catalyst was found to be stable and reusable after five reaction cycles.

Organic Letters published new progress about Anilides Role: SPN (Synthetic Preparation), PREP (Preparation) (thio). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Safety of 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Huanan published the artcilePd-Catalyzed Enantioselective Syntheses of Trisubstituted Allenes via Coupling of Propargylic Benzoates with Organoboronic Acids, Computed Properties of 343338-28-3, the main research area is allene preparation enantioselective; racemic propargylic benzoate organoboronic acid coupling palladium catalyst.

Enabled by the newly developed ligand, Ming-Phos, the first example of palladium-catalyzed highly enantioselective coupling of racemic propargylic benzoates with organoboronic acids for chiral allenes synthesis has been developed. Excellent asym. induction has been achieved with a decent substrate scope. Synthetic potentials for the construction of polycyclic compounds with multiple chiral centers have been demonstrated.

Journal of the American Chemical Society published new progress about Allenes Role: SPN (Synthetic Preparation), PREP (Preparation) (chiral). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Computed Properties of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tyrol, Chet C. published the artcileIron-catalysed enantioconvergent Suzuki-Miyaura cross-coupling to afford enantioenriched 1,1-diarylalkanes, Product Details of C4H11NOS, the main research area is diarylalkane enantioselective preparation; benzylic chloride aryl boronic ester iron catalyst Suzuki Miyaura.

The first stereoconvergent Suzuki-Miyaura cross-coupling reaction was developed to afford enantioenriched 1,1-diarylalkanes I [R = Me, Et, i-Pr, etc.; R1 = Ph, 4-FC6H4, 1-naphthyl, etc.; R2 = Ph, 4-MeC6H4, 2-naphthyl, etc.]. An iron-based complex containing a chiral cyanobis(oxazoline) ligand framework was best to obtain enantioenriched 1,1-diarylalkanes from cross-coupling reactions between unactivated aryl boronic esters and benzylic chlorides. Enhanced yields were obtained when 1,3,5-trimethoxybenzene was used as an additive, which was hypothesized to extend the lifetime of the iron-based catalyst. Exceptional enantioselectivities were obtained with challenging ortho-substituted benzylic chlorides.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkanes Role: SPN (Synthetic Preparation), PREP (Preparation) (diaryl). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Product Details of C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ramaiah, Manjunatha M. published the artcile1,8-Diazabicyclo[5.4.0]undec-7-ene-mediated formation of N-sulfinyl imines, Application of (S)-2-Methylpropane-2-sulfinamide, the main research area is sulfinyl imine preparation; tert butanesulfinamide aldehyde para toluenesulfinamide condensation DBU mediated; para toluenesulfinamide alc tert butanesulfinamide condensation DBU mediated.

A facile and efficient method was developed for the preparation of a variety of aryl, heteroaryl, and alkyl N-sulfinyl imines RCH=NS(O)R1 [R = cyclopropyl, 2-FC6H4, 8-quinolinyl, etc.; R1 = tBu, 4-MeC6H4; stereo = (S)] using 1,8-diazabicyclo[5.4.0]undec-7-ene. In addition to tert-butanesulfinamide, the condensation was also effective with p-toluenesulfinamide. The reaction was performed at room temperature and produced corresponding N-sulfinyl imines RCH=NS(O)R1 in excellent yields in absence of acids, metals, and additives. This methodol. was also useful for the preparation of N-sulfinyl imines on gram scale. A one-pot synthesis was developed using aryl and heteroaryl alcs. with both tert-butanesulfinamide and p-toluenesulfinamide at room temperature, resulting in corresponding N-sulfinyl imines with good yields.

Journal of Chemical Research published new progress about Alcohols, unsaturated Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Application of (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jin, Ming Yu published the artcileSimultaneous Kinetic Resolution and Asymmetric Induction within a Borrowing Hydrogen Cascade Mediated by a Single Catalyst, Category: amides-buliding-blocks, the main research area is unsaturated ketone preparation; alkoxy ketone preparation; ketone amino preparation; alc alkoxy preparation enantioselective; amino alc preparation enantioselective; racemic allylic alc borrowing hydrogen cascade ruthenium catalyst; asymmetric induction; borrowing hydrogen cascade; density functional theory; kinetic resolution; π-π interactions.

In a borrowing hydrogen cascade starting from racemic allylic alcs., one of the enantiomers could be kinetically resolved, while the other enantiomer could be purposely converted to various targeted products, including α,β-unsaturated ketones RC(O)C=CCH2R1 [R = Ph, 4-FC6H4, 2-naphthyl, etc.; R1 = (CH2)6, (CH2)7, OTBS], β-functionalized ketones R2C(O)CH2CH2R3 [R2 = 4-MeSC6H4, 4-t-BuC6H4, 4-MeOC6H4, etc.; R3 = OMe, OEt, morpholino, etc.] and γ-functionalized alcs. R4CH(OH)CH2CH2R5 [R4 = 4-ClC6H4, 4-FC6H4, 2-naphthyl, etc.; R5 = OMe, OBn, morpholino, etc.] was reported. By employing a robust Ru-catalyst, both kinetic resolution and asym. induction were achieved with remarkable levels of efficiency and enantioselectivity. D. functional theory (DFT) calculations suggested that corresponding catalyst-substrate π-π interactions were pivotal to realize the observed stereochem. diversity.

Angewandte Chemie, International Edition published new progress about Alcohols, alkoxy Role: SPN (Synthetic Preparation), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jat, Jawahar L. published the artcileMetal-free synthesis of secondary amides using N-Boc-O-tosylhydroxylamine as nitrogen source via Beckmann rearrangement, Computed Properties of 7465-88-5, the main research area is ketone tertbutyloxycarbonyl tosylhydroxylamine Beckmann rearrangement; secondary amide preparation.

Herein, the first direct method for the synthesis of secondary amides from ketones via the Beckmann rearrangement using N-Boc-O-tosylhydroxylamine (TsONHBoc) as the aminating agent was reported. This reagent was expected to play a dual role, first in the formation of the activated oxime intermediate, and then via facilitation of the amide formation as a Bronsted acid by the tosylic acid byproduct. The metal and additive-free one-step method progresses in TFE solvent through the in situ generation of the primary amine reagent (TsONH2), and produces a water-soluble byproduct.

New Journal of Chemistry published new progress about Amides, secondary Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Computed Properties of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chandra, Dinesh published the artcileDirect synthesis of secondary amides from ketones through Beckmann rearrangement using O-(mesitylsulfonyl)hydroxylamine, Category: amides-buliding-blocks, the main research area is mesitylsulfonyl hydroxylamine preparation ketone Beckmann rearrangement; secondary amide preparation.

A highly efficient direct method for the preparation of secondary amides and lactams from ketones using O-(mesitylsulfonyl)hydroxylamine (MSH) was developed. The reactions proceeded rapidly at room temperature under mild condition without requiring any additive and tolerate multiple functional groups. A simple aqueous work-up often furnished the products in excellent yield with high purity.

Tetrahedron Letters published new progress about Amides, secondary Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Swetha, Sathyendran published the artcileAn Umpolung Route to Amides from α-Aminonitriles under Metal-Free Conditions, Related Products of amides-buliding-blocks, the main research area is secondary tertiary amide preparation umpolung; aminonitrile decyanation.

A metal-free, base-mediated decyanation of α-aminonitriles has been developed to synthesize secondary and tertiary amides using O2 or air as an amide oxygen source. Radical scavenging studies disclosed that the cleavage of C-CN bond may proceed via an anionic pathway. The practicality of the work was also demonstrated through an in situ generated α-aminonitriles from corresponding aldehydes and amines to afford amides. The important features of this work include broad functional group compatibility, 41% to 89% product yields, gram-scale synthesis of 2° and 3° amides, broad substrate scope, and an umpolung strategy.

Advanced Synthesis & Catalysis published new progress about Amides, secondary Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xu, Xu-Dong published the artcileMetal-Free Regioselective Radical Cyclization of 1,6-Enynes with Carbonyl Compounds, Product Details of C2H5NO, the main research area is enyne carbonyl regioselective radical cyclization.

A regioselective cyclization of 1,6-enynes is reported by a tert-Bu hydroperoxide (TBHP)-mediated, one-pot, cascade reaction with com. available carbonyl compounds under metal- and additive-free conditions. The reaction scope includes both 1,6-enynes and carbonyl compounds A possible cascade reaction mechanism, consisting of acyl radical addition, intramol. cyclization, and hydrogen abstraction, is proposed.

ACS Sustainable Chemistry & Engineering published new progress about Alkenynes Role: RCT (Reactant), RACT (Reactant or Reagent) (1,6-Enynes). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics