Month: November 2022

Weigel, William K. published the artcileSynthesis of amino-diamondoid pharmacophores via photocatalytic C-H aminoalkylation, HPLC of Formula: 343338-28-3, the main research area is amino diamondoid pharmacophore preparation; adamantane imine aminoalkylation photocatalyzed iridium; saxagliptin core rimantadine diastereoselective enantioselective preparation.

A direct C-H aminoalkylation reaction using two light-activated H-atom transfer catalyst systems that enabled the introduction of protected amines to native adamantane scaffolds with C-C bond formation was reported. The scope of adamantane and imine reaction partners was broad and deprotection provided versatile amine and amino acid building blocks. Using readily available chiral imines, the diastereo- and enantioselective synthesis of the saxagliptin core and rimantadine derivatives was also described.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aldimines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, HPLC of Formula: 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sanabria, Marialy Nieves published the artcileMicrowave Irradiation and Formamide: A Perfect Match for Ultrafast Carbamoylation via Radical Reactions, Synthetic Route of 123-39-7, the main research area is acryloyl benzamide formamide iron carbamoylation microwave irradiation green chem; dioxo isoquinolinyl acetamide preparation regioselective.

The exploitation of microwave irradiation in radical reactions, in which formamide was used as both the solvent and reagent, enabled the development of an ultrafast methodol. for amidation via carbamoyl radicals. The synthesis of functionalized isoquinoline-1,3-diones in only 10 s was described for the first time. A very efficient and environmentally benign methodol. was developed. Mild conditions, very short reaction time, low energy consumption, high atom economy, use of an inexpensive and green catalyst, nonanhydrous conditions, high selectivity, and nontoxic solvents are some advantages of this method. The low value of the E factor (6.1) reflects the low waste generation, making this method very attractive for industrial applications.

ACS Sustainable Chemistry & Engineering published new progress about Benzamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lee, Byung Joo published the artcileSynthesis of Unsymmetrical Vicinal Diamines via Directed Hydroamination, Formula: C4H11NOS, the main research area is allylamine amine rhodium regioselective chemoselective diastereoselective hydroamination; vicinal diamine preparation.

The rhodium-catalyzed hydroamination of primary and secondary allylic amines using diverse amine nucleophiles, including primary, secondary, acyclic, and cyclic aliphatic amines to access a wide range of unsym. vicinal diamines, was presented. The utility of this methodol. was further demonstrated through the rapid synthesis of several bioactive mols. and analogs.

Organic Letters published new progress about Chemoselectivity. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Formula: C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhu, Zhentong published the artcileLow-Noise Nanopore Enables In-Situ and Label-Free Tracking of a Trigger-Induced DNA Molecular Machine at the Single-Molecular Level, Synthetic Route of 123-39-7, the main research area is nanopore DNA machine.

Solid-state nanopores have shown special high potential in a label-free mol. assay, structure identification, and target-index at the single-mol. level, even though frustrating elec. baseline noise is still one of the major factors that limit the spatial resolution and signaling reliability of solid-state nanopores, especially in small target detection. Here the authors develop a significant and easy-operating noise-reduction approach via mixing organic solvents with high dielec. constants into a traditional aqueous electrolyte. The strategy is generally effective for pores made of different materials, such as the most commonly used conical glass (CGN) or SiNx. While the mechanism should be multisourced, MD simulations suggest the noise reduction may partially arise from the even ionic distribution caused by the addition of higher dielec. species. Among all solvents exptl. tested, the two with the highest dielec. constants, formamide and methylformamide, exhibit the best noise reduction effect for target detection of CGN. The power spectral d. at the low-frequency limit is reduced by nearly 3 orders with the addition of 20% formamide. The work qualifies the reliability of solid-state nanopores into much subtler scales of detection, such as dsDNAs under 100 bp. As a practical example, bare CGN is innovatively employed to perform in-situ tracking of trigger-responsive DNA machine forming oligomers.

Journal of the American Chemical Society published new progress about Glass Role: ARG (Analytical Reagent Use), BUU (Biological Use, Unclassified), TEM (Technical or Engineered Material Use), ANST (Analytical Study), USES (Uses), BIOL (Biological Study). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yi, Xuewen published the artcileCopper-Catalyzed Radical N-Demethylation of Amides Using N-Fluorobenzenesulfonimide as an Oxidant, Related Products of amides-buliding-blocks, the main research area is copper catalyzed radical demethylation amide fluorobenzenesulfonimide.

An unprecedented N-demethylation of N-Me amides has been developed by use of N-fluorobenzenesulfonimide as an oxidant with the aid of a copper catalyst. The conversion of amides to carbinolamines involves successive single-electron transfer, hydrogen-atom transfer, and hydrolysis, and is accompanied by formation of N-(phenylsulfonyl)benzenesulfonamide. Carbinolamines spontaneously decompose to N-demethylated amides and formaldehyde, because of their inherent instability.

Organic Letters published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation) (carbinol). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Delost, Michael D. published the artcileMild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF3) Aziridine and Cyclopropane Structures, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide, the main research area is trifluoromethylthiolated aziridine cyclopropane preparation diastereoselective; vinyl ketone tosyl imine trifluoromethylthiolated bromo acetophenone Darzens annulation.

Authors report mild new annulation approaches to trisubstituted trifluoromethylthiolated (SCF3) aziridines and cyclopropanes via Darzens inspired protocols. The products of these anionic annulations, rarely studied previously, possess attractive features rendering them valuable building blocks for synthesis platforms. In this study, trisubstituted acetophenone nucleophiles bearing SCF3 and bromine substituents in their α position were shown to underwent [2 + 1] annulations with vinyl ketones and tosyl-protected imines under mild reaction conditions.

Organic Letters published new progress about Aziridines Role: SPN (Synthetic Preparation), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kharaneko, A. O. published the artcileSynthesis of 3-Phenyl-1H-[1,4]oxazino[4,3-a]benzimidazol-1-one and Its Transformation into 4-Phenyl-2,5-dihydro-1H-[1,2,5]triazepino[5,4-a]benzimidazol-1-one, Safety of N-Methylformamide, the main research area is phenyl oxazinobenzimidazolone preparation; dihydrotriazepinobenzimidazolone preparation; phenylpyrazino benzimidazolone preparation; benzimidazole preparation.

A synthetic route was proposed to 3-phenyl-1H-[1,4]oxazino[4,3-a]benzimidazol-1-one I, which was the first representative of a new heterocyclic system. The transformation of the title compound I to 4-phenyl-2,5-dihydro-1H-[1,2,5]triazepino[5,4-a]benzimidazol-1-one II via reaction with hydrazine hydrate was studied.

Russian Journal of Organic Chemistry published new progress about Fused heterocyclic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hirano, Kazuki published the artcileDiastereoselective Synthesis of Enantioenriched Trifluoromethylated Ethylenediamines and Isoindolines Containing Two Stereogenic Carbon Centers by Nucleophilic Trifluoromethylation Using HFC-23, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide, the main research area is diastereoselective synthesis trifluoromethylated ethylenediamine; trifluoromethylated isoindoline diastereoselective synthesis; stereodivergent nucleophilic trifluoromethylation aza Michael sequence HFC23.

Fluoroform, HFC-23, is an industrial byproduct from the synthesis of polytetrafluoroethylene and is a vastly underused resource; however, its physicochem. properties have hindered progress toward synthetic uses. Herein, we describe the use of HFC-23 as a cheap trifluoromethylating agent in two reactions for the highly diastereoselective synthesis of medicinally attractive chiral amines with two stereogenic carbon centers: a base-dependent, stereodivergent nucleophilic addition to synthesize enantioenriched vicinal diamines and a tandem nucleophilic addition/aza-Michael sequence toward enantioenriched isoindolines.

Journal of Organic Chemistry published new progress about Aza-Michael reaction. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Du, Jinze published the artcileElectrochemical Oxidative ortho-Selective Trifluoromethylation of N-Arylamides, SDS of cas: 7465-88-5, the main research area is trifluoromethyl arylamide preparation regioselective; arylamide sodium trifluoromethanesulfinate electrochem oxidative trifluoromethylation.

A metal-catalyst-free and external-oxidant-free electrochem. oxidative radical C-H ortho-trifluoromethylation is presented. The reaction specifically occurred at the ortho-position of anilides RC(O)NHC6H4R1 (R = Ph, 2-furyl, 2-naphthyl, Me, etc., R1 = 3-Me, 4-Me, 4-Cl) without directing groups. Various anilides showed good tolerance to provide the desired products I in moderate to good yields. In addition, the gram-scale amplified product of benzanilide was obtained with a yield of 64%, which proved that it has a certain application potential.

ChemElectroChem published new progress about Electrochemical reaction (regioselective). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, SDS of cas: 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rahman, Mahbubur Md. published the artcileSynthesis of Sulfoxonium Ylides from Amides by Selective N-C(O) Activation, SDS of cas: 7465-88-5, the main research area is sulfoxonium ylide preparation; amide trimethylsulfoxonium iodide nitrogen carbon cleavage.

The direct synthesis of sulfoxonium ylides from amides by selective N-C(O) cleavage is presented. The reaction proceeds through the nucleophilic addition of dimethylsulfoxonium methylide to the amide bond in acyclic twisted amides under exceedingly mild room temperature conditions. A variety of amides can be employed, and the protocol can be applied to the late-stage derivatization of pharmaceuticals. Mechanistic studies outline the relative order of reactivity of amides.

Organic Letters published new progress about Bond cleavage (N-C(O)). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, SDS of cas: 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics