November 2022 - Page 168 of 223 - Amides-buliding-blocks

Boettcher, Stephan’s team published research in Journal of Visualized Experiments in 2015-05-31 | CAS: 125328-80-5

Journal of Visualized Experiments published new progress about. 125328-80-5 belongs to class amides-buliding-blocks, name is N-(4-Bromo-3-chloro-2-methylphenyl)acetamide, and the molecular formula is C9H9BrClNO, Safety of N-(4-Bromo-3-chloro-2-methylphenyl)acetamide.

Boettcher, Stephan published the artcileSynthesis of indoxyl-glycosides for detection of glycosidase activities, Safety of N-(4-Bromo-3-chloro-2-methylphenyl)acetamide, the main research area is glycosidase determination indoxyl glycoside substrate preparation; beta galactosidase determination indoxyl glycoside substrate preparation.

Indoxyl glycosides have proved to be valuable and versatile tools for monitoring glycosidase activities. Indoxyls are released by enzymic hydrolysis and are rapidly oxidized, e.g., by atm. O2, to indigo-type dyes. This reaction enables fast and easy screening in vivo without isolation or purification of enzymes, as well as rapid tests on agar plates or in solution (e.g., blue-white screening, microwells) and is used in biochem., histochem., bacteriol. and mol. biol. Unfortunately the synthesis of such substrates has proved to be difficult, due to various side-reactions and the low reactivity of the indoxyl OH function. Especially for glucose-type structures low yields were observed Thi authors’ novel approach employs indoxylic acid esters as key intermediates. Here, indoxylic acid esters with varied substitution patterns were prepared on scalable pathways. Phase transfer glycosylations with those acceptors and peracetylated glycosyl halides could be performed under common conditions in high yields. Ester cleavage and subsequent mild Ag-mediated glycosylation yielded the peracetylated indoxyl glycosides in high yields. Finally deprotection was performed.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hugelshofer, Cedric L.’s team published research in Journal of the American Chemical Society in 2019-05-29 | CAS: 343338-28-3

Journal of the American Chemical Society published new progress about Chiral auxiliary (Mannich reaction using sulfinyl imine chiral auxiliary). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.

Hugelshofer, Cedric L. published the artcileCalyciphylline B-Type Alkaloids: Total Syntheses of (-)-Daphlongamine H and (-)-Isodaphlongamine H, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide, the main research area is deoxyisocalyciphylline B structure revision; daphlongamine H total synthesis; isodaphlongamine H total synthesis; Mannich reaction daphlongamine H synthesis; cyclization daphlongamine H synthesis; diastereoselective hydrogenation daphlongamine H synthesis; Pauson Khand reaction daphlongamine H synthesis; calyciphylline B type alkaloid synthesis.

The first total synthesis of the complex hexacyclic Daphniphyllum alkaloid (-)-daphlongamine H (I; 5S,6R) has been accomplished. Key to the success of the strategy are a complexity-building Mannich reaction, efficient cyclizations, and a highly diastereoselective hydrogenation to assemble multigram quantities of the tricyclic core bearing four contiguous stereocenters. Following construction of the hydro-indene substructure by means of a Pauson-Khand reaction, endgame redox manipulations delivered the natural product. Importantly, the synthetic studies have also given access to (-)-isodaphlongamine H (II; 5R,6R) and led to a revision of the reported structure of deoxyisocalyciphylline B as daphlongamine H.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Charaschanya, Manwika’s team published research in ACS Medicinal Chemistry Letters in 2022-03-10 | CAS: 343338-28-3

ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Synthetic Route of 343338-28-3.

Charaschanya, Manwika published the artcileSynthesis and optimization of nitroxide-based inhibitors of ferroptotic cell death in cancer cells and macrophages, Synthetic Route of 343338-28-3, the main research area is alkene peptide isostere synthesis nitroxide inhibitor ferroptotic cell death; peptide alkene enantioselective diastereoselective synthesis antitumor structure activity ferroptosis; vinylogous Mannich reaction cross metathesis drug desigh luminescence.

JP4-039 Is an alkene peptide isostere that acts as a low-micromolar inhibitor of erastin- and RSL-3-induced ferroptotic cell death in the HT-1080 cell line. In this work, we have developed new synthetic strategies that allow access to analogs of this lead structure. Enantioselective vinylogous Mannich or cross-metathesis reactions were key to the preparation of a series of analogs that culminated in the preparation of the ca. 30-fold more potent analog (I) (BOC = tert-butoxycarbonyl). Structure-activity relationship analyses used both HT-1080 cells and a luminescence-based ferroptosis assay in RAW 264.7 macrophages. In particular, α,α-disubstituted alkene peptide isosteres (Rα ≠ H) were found to exceed the potency of the corresponding glycine (Rα = H) derivatives

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zheng, Yong’s team published research in Chemistry of Materials in 2021-05-11 | CAS: 123-39-7

Chemistry of Materials published new progress about Acrylic rubber, methoxyethyl acrylate-polyethylene glycol diacrylate Role: POF (Polymer in Formulation), PRP (Properties), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), USES (Uses), PREP (Preparation). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Zheng, Yong published the artcileNanophase Separation in Immiscible Double Network Elastomers Induces Synergetic Strengthening, Toughening, and Fatigue Resistance, Safety of N-Methylformamide, the main research area is nanophase immiscible network elastomer synergetic strengthening toughening fatigue resistance.

High modulus, toughness, and fatigue resistance are usually difficult to be obtained simultaneously in rubbery materials. Here, we report that by superimposing the nanophase separation structure in double network (DN) elastomers using immiscible polymers, the modulus, fracture energy, and energy release rate of fatigue threshold are enhanced all together by 13, 5, and 5 times, resp. We reveal that the interplay between the DN structure and the nanophase separation structure brings two effects synergistically: (1) formation of nanoclusters overstresses and homogenizes the sacrificial network, thereby remarkably increasing the modulus and yielding stress and (2) the nanoclusters act as viscoelastic nanofillers dissipating energy and pinning the crack propagation, thereby significantly enhancing toughness and fatigue resistance. This work provides a facile approach to superimpose high-order structures in DN materials for excellent mech. performance. The clarified synergetic effects should be universal for DN materials made of immiscible polymers. We believe that this work will facilitate more studies on elastomers and gels along this line.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ma, Pan et al. published their research in Chemometrics and Intelligent Laboratory Systems in 2019 |CAS: 685-91-6

The Article related to mars computational tool resolve extract gc ms dataset, Organic Analytical Chemistry: Separations and other aspects.Category: amides-buliding-blocks

On August 15, 2019, Ma, Pan; Li, Meijing; Lu, Hongmei; Zhang, Zhimin published an article.Category: amides-buliding-blocks The title of the article was MARS 2: A computational tool to resolve and extract features from large-scale GC-MS datasets. And the article contained the following:

MARS (MS-Assisted Resolution of Signal) is a computational tool for feature extraction using multivariate curve resolution approaches. However, it is time-consuming for large-scale GC-MS datasets and sensitive to the component number estimation Here we introduce MARS 2 with substantial improvements to overcome these limitations. Reverse matching (RM) and principal component optimization-iterative transformation target factor anal. (PCO-ITTFA) are developed to reduce the time for locating peak regions and determine the correct component number for resolving optimal features. The greatest strength of MARS 2 is “resolve once, extract anywhere”. It means that mass spectra of each component were needed to resolve from only one profile. Then, chromatog. features can be extracted automatically from hundreds of other profiles with the assistance from the resolved mass spectra. To evaluate its performance, plasma datasets and fatty acid standard mixtures were processed by MARS 2, AMDIS, ADAP-GC 3.0, eRah and MS-DIAL. Amino acid standard mixtures were analyzed by MARS 2 for calibration. Results show that MARS 2 can achieve better performance in both qual. and quant. anal. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Category: amides-buliding-blocks

The Article related to mars computational tool resolve extract gc ms dataset, Organic Analytical Chemistry: Separations and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Chunni et al. published their research in Crop Science in 2019 |CAS: 97-09-6

The Article related to brassica napus germination seedling temperature tolerance, Plant Biochemistry: Development and Aging and other aspects.SDS of cas: 97-09-6

On August 31, 2019, Zhang, Chunni; Luo, Tao; Liu, Jiahuan; Xian, Mengzhu; Yuan, Jinzhan; Hu, Liyong; Xu, Zhenghua published an article.SDS of cas: 97-09-6 The title of the article was Evaluation of the low-temperature tolerance of rapeseed genotypes at the germination and seedling emergence stages. And the article contained the following:

Low temperature is a main adverse factor affecting successful seedling establishment in the Yangtze River basin, and thus low-temperature stress tolerance at the germination and seedling emergence stages is an important attribute for rapeseed (Brassica napus L.) production The present study was conducted to evaluate the low-temperature stress tolerance indexes (STIs) of a large conventional rapeseed genotype population at the germination and seedling emergence stages. Twelve seed germination- and seedling emergencerelated indexes were investigated under normal and low-temperature conditions, and the broadsense heritability of these indexes ranged from 25.4 to 57.6%. Therefore, the selection of genotypes with strong low temperature tolerance is a feasible way to guarantee seedling establishment. Using principal component anal., the STIs during the seed germination and seedling emergence stages have been divided into three main categories: dry matter weight, germination speed and final germination percentage, and root length with a seedling vigor index. The top three genotypes ranked by comprehensive STI score were Huayou Number 2, SWU44, and 2012- K8053; the bottom three genotypes ranked by comprehensive STI score were Chuanyou18, wx1025, and 97096. The results of the present study could provide valuable information for breeders to utilize the rapeseed germplasm resources in the Yangtze River basin to achieve the goal of low-temperature resistance breeding. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

The Article related to brassica napus germination seedling temperature tolerance, Plant Biochemistry: Development and Aging and other aspects.SDS of cas: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Shields, Erin P. et al. published their research in Journal of Chromatography A in 2020 |CAS: 685-91-6

The Article related to ph cation exchange stationary phase thiol yne click reaction, acid stable, cation-exchange, charge-transfer, mixed-mode, thiol-yne click chemistry, Organic Analytical Chemistry: Separations and other aspects.Synthetic Route of 685-91-6

On May 10, 2020, Shields, Erin P.; Weber, Stephen G. published an article.Synthetic Route of 685-91-6 The title of the article was A crosslinked, low pH-stable, mixed-mode cation-exchange like stationary phase made using the thiol-yne click reaction. And the article contained the following:

Mixed-mode cation-exchange stationary phases are useful for the separation of mixtures containing hydrophobic, acidic, and basic mols. To ensure that weak organic bases are protonated and carboxylic acids are neutral low pH mobile phases are required. Mixed-mode stationary phases that are stable at pH < 3 are needed. We synthesized a crosslinked structure along the surface of thiol functionalized silica gel particles using the thiol-yne click reaction. The alkyne, 1,7-octadiyne, was added to the 3-mercaptopropyl silica gel, then crosslinked using 1,6-hexanedithiol. Elemental anal. showed low octadiyne ligand surface coverage, but, stoichiometrically, three sulfurs were added to each octadiyne ligand during the crosslinking step, indicating that crosslinking occurred. The effect of the crosslinking on the stability was tested with a 50:50 (volume/volume) pH 0.50 5% TFA aqueous:acetonitrile mobile phase at 70掳C for six days, over 35,000 column volumes The stationary phase showed good stability with the retention of triphenylene decreasing only 20% during that time. The Tanaka test showed that the phase has a methylene selectivity of 1.20 卤 0.04, a high shape selectivity of 2.71 卤 0.03, and a 3.98 卤 0.05 cation-exchange factor at pH 2.70. The phase has a selectivity factor for nitrobenzene and benzene of 1.41 卤 0.01, indicating the electron donating charge transfer characteristic of the phase. The mixed-mode characteristics of the phase were investigated using a mixture of the monoamine neurotransmitters norepinephrine, dopamine, and serotonin. Baseline resolution of the monoamines could be obtained using a simple 20 mM potassium phosphate (pH 2.70)/methanol mobile phase. Altering both the methanol content and the potassium ion concentration altered the retention of the monoamines indicating mixed-mode cation exchange characteristic of the crosslinked stationary phase. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Synthetic Route of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mulualem, Yared Fikadu et al. published their research in Bulletin of the Chemical Society of Ethiopia in 2021 |CAS: 456-12-2

The Article related to ligustrum vulgare phoenix reclinata olea africana metal toothbrush ethiopia, Mammalian Pathological Biochemistry: Other and other aspects.Computed Properties of 456-12-2

Mulualem, Yared Fikadu; Chandravanshi, Bhagwan Singh published an article in 2021, the title of the article was Assessment of metals content of widely used traditional toothbrushes in Addis Ababa, Ethiopia.Computed Properties of 456-12-2 And the article contains the following content:

Traditional toothbrushes are used by the vast majority of people who cannot afford to buy the com. toothbrush and toothpaste. The traditional toothbrushes are generally obtained from any slim woody part of a toothbrush tree. The main purpose of this study was to determine selected metals (Ca, Fe, Mg, Al, Cu, Cr, Ni, Zn, Mn, Pb, and Cd) in traditional toothbrushes obtained from three plants including Ligustrum vulgare L., Phoenix reclinata and Olea africana, which are extensively used in Addis Ababa, Ethiopia, by using microwave plasma-at. emission spectroscopy (MP-AES) after wet digestion. Recoveries of the metals in spiked samples varied from 90.4-107%. The overall mean concentrations determined (mg/kg, dry weight) were in the ranges of Ca (4267-36514) > Fe (131-318) > Al (81.6-224) > Mg (45.6-122) > Zn (27.2-175) > Mn (20.1-29) > Cu (6.6- 20.3) > Cr (6.7-8.9) > Ni (2.6-7.9). Anal. of variance at 95% indicated significant differences in the metals’ contents of three toothbrushes. The results indicated that the selected traditional toothbrushes are good sources of essential metals and free from Pb and Cd. Therefore, the investigated Ethiopian traditional toothbrushes are found to be safe for human use. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Computed Properties of 456-12-2

The Article related to ligustrum vulgare phoenix reclinata olea africana metal toothbrush ethiopia, Mammalian Pathological Biochemistry: Other and other aspects.Computed Properties of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zahoranszky-Kohalmi, Gergely et al. published their research in Journal of Chemical Information and Modeling in 2022 |CAS: 79-07-2

The Article related to synthesis graphs pruning algorithm, Placeholder for records without volume info and other aspects.Reference of 2-Chloroacetamide

On May 9, 2022, Zahoranszky-Kohalmi, Gergely; Lysov, Nikita; Vorontcov, Ilia; Wang, Jeffrey; Soundararajan, Jeyaraman; Metaxotos, Dimitrios; Mathew, Biju; Sarosh, Rafat; Michael, Samuel G.; Godfrey, Alexander G. published an article.Reference of 2-Chloroacetamide The title of the article was Algorithm for the Pruning of Synthesis Graphs. And the article contained the following:

Synthesis route planning is in the core of chem. intelligence that will power the autonomous chem. platforms. In this task we rely on algorithms to generate possible synthesis routes with the help of retro- and forward-synthetic approaches. Generated synthesis routes can be merged into a synthesis graph which represents theor. pathways to the target mol. However, it is often required to modify a synthesis graph due to typical constraints. These constraints might include “undesirable substances”, e.g., an intermediate that the chemist does not favor, or substances that might be toxic. Consequently, we need to prune the synthesis graph by the elimination of such undesirable substances. Synthesis graphs can be represented as directed (not necessarily acyclic) bipartite graphs, and the pruning of such graphs in the light of a set of undesirable substances has been an open question. In this study, we present the Synthesis Graph Pruning (SGP) algorithm that addresses this question. The input to the SGP algorithm is a synthesis graph, and a set of undesirable substances. Furthermore, information for substances is provided as metadata regarding their availability from inventory. The SGP algorithm operates with a simple local rule set, in order to determine which nodes and edges need to be eliminated from the synthesis graph. In this study, we present the SGP algorithm in details and provide several case studies that demonstrate the operation of the SGP algorithm. We believe that the SGP algorithm will be an essential component of computer aided synthesis planning. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Reference of 2-Chloroacetamide

The Article related to synthesis graphs pruning algorithm, Placeholder for records without volume info and other aspects.Reference of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Abd El-Hady, Faten K. et al. published their research in Current Microbiology in 2017 |CAS: 685-91-6

The Article related to cytotoxicity coral fungus aspergillus, Placeholder for records without volume info and other aspects.HPLC of Formula: 685-91-6

On November 30, 2017, Abd El-Hady, Faten K.; Shaker, Kamel H.; Souleman, Ahmed M. A.; Fayad, Walid; Abdel-Aziz, Mohamed S.; Hamed, Ahmed A.; Iodice, Carmine; Tommonaro, Giuseppina published an article.HPLC of Formula: 685-91-6 The title of the article was Comparative Correlation Between Chemical Composition and Cytotoxic Potential of the Coral-Associated Fungus Aspergillus sp. 2C1-EGY Against Human Colon Cancer Cells. And the article contained the following:

Cancer is a leading cause of death in several countries. In the search for new anticancer drugs, marine organisms have played an important role in the discovery of lead compounds and the development of new pharmaceuticals for their wide diversity of chem. structures and biol. activities. In the present study, the cytotoxicity on colorectal cancer cells HCT116 exerted by marine fungus Aspergillus sp. 2C1-EGY extracts associated with the soft coral Sinularia sp. was investigated; the sub-fractions Fr 2c and Fr 2d had significantly high cytotoxic activity (88 and 85%, resp.). Moreover, the major hexadecanoic, octadecanoic, and octadecenoic acids as well as their Me esters were isolated. GC/MS anal. revealed the identification of 46 major and minor compounds, from which 19 saturated and unsaturated fatty acids and eight fatty acid esters were identified. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).HPLC of Formula: 685-91-6

The Article related to cytotoxicity coral fungus aspergillus, Placeholder for records without volume info and other aspects.HPLC of Formula: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics