Month: November 2022

Saluti, Giorgio; Colagrande, Maria Novella; Castellani, Federica; Ricci, Matteo; Diletti, Gianfranco; Scortichini, Giampiero published an article in 2021, the title of the article was Survey on Antibiotic Residues in Egg Samples in Italy.Electric Literature of 144-80-9 And the article contains the following content:

The presence of antibiotic residue in eggs is a current issue due to the increasingly important phenomenon of antibiotic resistance. A multiclass, confirmatory method for the determination of seventy-three antimicrobial agents (amphenicols, cephalosporins, diaminopyrimidines, lincosamides, macrolides, penicillins, pleuromutilins, quinolones, sulfonamides, and tetracyclines) with liquid chromatog. high-resolution mass spectrometry was applied to 200 egg samples collected from 119 Italian farms during the years 2018-2021. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Electric Literature of 144-80-9

The Article related to egg sample antibiotic residue survey italy, Placeholder for records without volume info and other aspects.Electric Literature of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 12, 2020, Henschel, Henning; Andersson, Alfred T.; Jespers, Willem; Mehdi Ghahremanpour, Mohammad; van der Spoel, David published an article.Safety of N,N-Diethylacetamide The title of the article was Theoretical Infrared Spectra: Quantitative Similarity Measures and Force Fields. And the article contained the following:

IR spectroscopy can provide significant insight into the structures and dynamics of mols. of all sizes. The information that is contained in the spectrum is, however, often not easily extracted without the aid of theor. calculations or simulations. We present here the calculation of the IR spectra of a database of 703 gas phase compounds with four different force fields (CGenFF, GAFF-BCC, GAFF-ESP, and OPLS) using normal-mode anal. Modern force fields increasingly use virtual sites to describe, e.g., lone-pair electrons or the 蟽-holes on halogen atoms. This requires some adaptation of code to perform normal-mode anal. of such compounds,the implementation of which into the GROMACS software is briefly described as well. For the quant. comparison of the obtained spectra with exptl. reference data, we discuss the application of two different statistical correlation coefficients, Pearson and Spearman. The advantages and drawbacks of the different methods of comparison are discussed, and we find that both methods of comparison give the same overall picture, showing that present force field methods cannot match the performance of quantum chem. methods for the calculation of IR spectra. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Safety of N,N-Diethylacetamide

The Article related to ir spectrum similarity force field database, Placeholder for records without volume info and other aspects.Safety of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bawar, Khirsten Marie; Cruz, Leannie Praise; Ilao, Kristine Bernadette; Justiniano, Julianne Mica; Panganiban, Lara Mae; Fabito, Diane Laine; Amayun, Christine Joy; Nas, John Sylvester published an article in 2021, the title of the article was In silico identification of novel compounds as quorum-sensing inhibitors in selected waterborne pathogens.COA of Formula: C13H12N2O And the article contains the following content:

Quorum sensing (QS) is a process involved in producing, detecting, responding, and releasing signaling mols. to maintain physiol. activities of most utilized by both gram-pos. and gram-neg. bacteria in various environmental conditions. This study aims to identify novel compounds that have potential QS inhibitory mechanisms against the gram-pos. bacteria Staphylococcus aureus (S. aureus) and Streptococcus pneumoniae (S. pneumoniae), and the gram-neg. bacteria Salmonella typhi (S. typhi) and Escherichia coli (E. coli). Compounds that are structurally similar to the known QS inhibitors were identified using ligand-based screening. Candidate compounds with 40 to 80% similarity with the known QS inhibitors were further evaluated through mol. docking with the QS-associated enzymes, namely ComA, ComE, LsrF, LsrK, AgrC, AgrA, LsrB, and Hfq. The binding affinity was visualized to identify the different non-covalent binding interactions. Compounds with <-8.0 kcal/mol docking score were considered for evaluation for their distribution coefficient (LogD) at different optimal growth of the bacteria, such as pH 4, 6, 7.4, 7.8, 8, and 9. Out of the 63 compounds evaluated, only three compounds demonstrated a high binding affinity, namely 1-phenyl-3-[5-(phenylcarbamoylamino)naphthalen-1-yl]urea and 1-naphthalen1-yl-3-[5-(naphthalen-1-ylcarbamoylamino)naphthalen-1-yl]urea with ComE of S. pneumoniae and 3-[(4-Methylphenyl)sulfonyl][1,2,3]triazolo[1,5-a]quinazolin-5(4H)-one to AgrA of S. aureus. Their high binding affinity may be attributed to the numerous hydrogen bonds and hydrophobic interactions. However, only 3-[(4-Methylphenyl)sulfonyl][1,2,3]triazolo[1,5-a]quinazolin-5(4H)-one has comparable LogD value with its QS inhibitor of AgrA, savarin, at the optimal growth pH for S. aureus. These findings suggest that the use of 3-[(4-Methylphenyl)sulfonyl][1,2,3]triazolo[1,5-a] quinazolin-5(4H)-one may be effective in controlling S. aureus growth probably through inhibition of AgrA. However, further studies are needed to confirm these findings. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).COA of Formula: C13H12N2O

The Article related to waterborne pathogen quorum sensing inhibitor, Placeholder for records without volume info and other aspects.COA of Formula: C13H12N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Xiaoqin; Fang, Zhijuan; He, Xinye; Zhang, Shuqin; Ding, Hongliu; Ye, Hu published an article in 2021, the title of the article was Optimization of 204 veterinary drug residues method and establishing their mass spectrum library.Reference of N-((4-Aminophenyl)sulfonyl)acetamide And the article contains the following content:

A multi-class multi-residue anal. method was validated in this paper for simultaneously identifying 204 veterinary drugs in pork by UPLC-QTRAP MS/MS, including sulfonamides, quinolones, 尾-agonists, and nitroimidazoles. MRM-IDA-EPI mode of QTRAP was used to establish a secondary mass spectrum library of these 204 veterinary drugs, which could enhance the qual. anal. of suspect substances. The separation of substances was performed on a C18 column, with a gradient elution of 0.1% formic acid solution in water and methanol. Electrospray ionization (ESI), fast polarity switching, and scheduled MRM mode were used to collect the characterization results. Factors that affected the recovery were delicately optimized, such as solvent proportion, formic acid content, and purification method. We finally determined the extracting method with formic acid-acetonitrile-water (0.1:90:10, v:v:v) and purifying method with Cleanert LipoNo as a package for dispersive solid-phase extraction Matrix effects on the quant. results were also investigated. Some compounds had strong matrix inhibition or enhancement, and the matrix matching external standard method was used to quantify the compounds accurately. The correlation coefficient R2 was over 0.99 within the calibration linearity range for the detected 204 veterinary drugs. The limit of quantification (LOQ) was 0.5 鈭?5 渭g/kg. The recoveries ranged from 61.4% to 118.8% with RSDs of 3.1% to 19.2% (n = 6). The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Reference of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to veterinary drug residue mass spectrum library, Placeholder for records without volume info and other aspects.Reference of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Borowiecki, Pawel; Zdun, Beata; Popow, Natalia; Wiklinska, Magdalena; Reiter, Tamara; Kroutil, Wolfgang published an article in 2022, the title of the article was Development of a novel chemoenzymatic route to enantiomerically enriched 尾-adrenolytic agents. A case study toward propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:

Efficient chemoenzymic routes toward the synthesis of both enantiomers of adrenergic beta-blockers were accomplished by identifying a central chiral building block, which was first prepared using lipase-catalyzed kinetic resolution (KR, Amano PS-IM) as the asym. step at a five gram-scale (209 mM concentrate). The enantiopure (R)-chlorohydrin (>99% ee) subsequently obtained was used for the synthesis of a series of model (R)-(+)-beta-blockers (i.e., propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol), which were produced with enantiomeric excess in the range of 96-99.9%. The pharmaceutically relevant (S)-counterpart, taking propranolol as a model, was synthesized in excellent enantiomeric purity (99% ee) via acetolysis of the resp. enantiomerically pure (R)-mesylate by using cesium acetate and a catalytic amount of 18-Crown-6, followed by acidic hydrolysis of the formed (S)-acetate. Alternatively, asym. reduction of a prochiral ketone, namely 2-(3-chloro-2-oxopropyl)-1H-isoindole-1,3(2H)-dione, was performed using lyophilized E. coli cells harboring overexpressed recombinant alc. dehydrogenase from Lactobacillus kefir (E. coli/Lk-ADH-Lica) giving the corresponding chlorohydrin with >99% ee. Setting the stereocenter early in the synthesis and performing a 4-step reaction sequence in a 鈥瞣ne-pot two-step鈥?procedure allowed the design of a 鈥瞫tep-economic鈥?route with a potential dramatic improvement in process efficiency. The synthetic method can serve for the preparation of a broad scope of enantiomerically enriched beta-blockers, the chem. structures of which rely on the common 伪-hydroxy-N-isopropylamine moiety, and in this sense, might be industrially attractive. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to adrenergic betha blocker one pot two step procedure, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hussein, Ag; Sakr, Hm; Mansour, Am; Ayyad, Rr published an article in 2021, the title of the article was Ulcer index and anti-inflammatory testing of some benzimidazole derivatives.Related Products of 144-80-9 And the article contains the following content:

In this work, we carry out the testing of some Benzimidazole derivatives as anti-inflammatory using Indomethacin 10mg/Kg, diclofenac sodium 7mg/Kg, celecoxib 100mg/Kg and tested compounds of 200mg/Kg. The tested compounds showed anti-inflammatory activity in comparison with the standard reference drugs. In addnl., carrying out the testing of ulcer index for some testing compounds 600mg/Kg comparing with indomethacin 100mg/Kg, the testing revealed indomethacin causes ulcer in stomach of the testing animals, while the testing compounds no ulcerated the stomach of the testing animal. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Related Products of 144-80-9

The Article related to ulcer index inflammation benzimidazole antiinflammatory, Placeholder for records without volume info and other aspects.Related Products of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics