Month: November 2022

On May 31, 2018, Wasserman, Emily J.; Reilly, Samantha M.; Goel, Reema; Foulds, Jonathan; Richie, John P. Jr.; Muscat, Joshua E. published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Comparison of Biomarkers of Tobacco Exposure between Premium and Discount Brand Cigarette Smokers in the NHANES 2011-2012 Special Sample. And the article contained the following:

Background: Increased cigarette costs have inadvertently strengthened the appeal of discounted brands to price-sensitive smokers. Although smokers perceive discounted brands as having poorer quality, little is known about their delivery of toxic tobacco smoke constituents compared with premium-branded tobacco products. Methods: We investigated the differences between discount and premium brand smokers using the National Health and Nutrition Examination Survey 2011-2012 Special Smoker Sample. Our analyses focused on demog. differences and 27 biomarkers of harmful and potentially harmful constituents (HPHC) listed by the FDA, including volatile organic compounds, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronide [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide; reported as total NNAL (tNNAL)], metals, and polycyclic aromatic hydrocarbons (PAHs). Data were analyzed using linear regression models adjusting for potential confounders. Results: A total of 976 non-tobacco users and 578 recent cigarette smokers were eligible for anal., of which 141 (26.0% weighted) smoked discount brand cigarettes and 437 (74.0% weighted) smoked premium. Discount brand smokers were older, predominantly non-Hispanic white, and had higher serum cotinine. Discount brand smokers had significantly higher levels of 13 smoking-related biomarkers, including tNNAL, uranium, styrene, xylene, and biomarkers of exposure to PAHs (naphthalene, fluorene, and phenanthrene), compared with premium brand smokers. Conclusions: These findings suggest that discount cigarette use is associated with higher exposure to several carcinogenic and toxic HPHCs. Impact: These results may have important regulatory implications for product standards, as higher exposures could lead to a greater degree of harm. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

The Article related to premium discount brand cigarette tobacco smoke biomarker, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cengiz, Gokhan; Algin Yapar, Evren; Kara, Bilge Ahsen; Sindhu, Rakesh K. published an article in 2021, the title of the article was Comparison and evaluation of pharmacopoeial methods for the assessment of potency of antibiotics.COA of Formula: C8H10N2O3S And the article contains the following content:

The detection and assessment of potency of antibiotics are crucial for the pharmaceutics. The valid methods for microbiol. assays in pharmacopoeias are mainly based on statistical comparison of the data obtained by measuring the cidal activity resulting from the treatment of the antibiotic active ingredient in the composition of the pharmaceutics with the target microorganism. However, it was seen that there is no validated microbiol. method for some active ingredients. Due to microbiol. assays are indispensable methods for determining the potency of some active ingredient groups, the calculation of the potency is performed logarithmically. In either turbidimetric or chromatog. methods, the statistical evaluation of the sample is compared with the standard reference material. Anal. data obtained by chromatog. and chem. methods are linear peak areas and spectrophotometer readings. In microbiol. methods, the data obtained from the analyzes performed to determine the potency of antibiotics are the inhibition zone diameters or turbidimetric turbidity data. In this study, above-mentioned microbiol. assays are compared in the context of the main pharmacopoeias EP, USP, CP, IP and BP, and evaluated in terms of the chromatog. method and classical microbiol. method. It has been observed that chromatog. and chem. methods are not available to determine the potency of some pharmaceutical products containing antibiotics. The examinations made reveal the difficulty of analyzing some active ingredient groups according to chem. and chromatog. methods. For this reason, the importance of method validation studies is increasing in order to analyze active substances that do not have alternative anal. methods with microbiol. and chem. methods. In this study, all validated microbiol. methods were investigated, and it was aimed to determine alternative methods to chromatog. and chem. methods. It was concluded that the realization of new microbiol. methods to be validated by evaluating the methods in all differences would facilitate the study. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).COA of Formula: C8H10N2O3S

The Article related to antibiotics pharmacopoeial potency microbiol chem method, Placeholder for records without volume info and other aspects.COA of Formula: C8H10N2O3S

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 15, 2020, Chen, Xinfei; Ma, Xiaoqian; Zeng, Xianghao; Zheng, Chupeng; Lu, Xiaoluan published an article.Quality Control of N,N-Diethylacetamide The title of the article was Ethanol addition during aqueous phase recirculation for further improving bio-oil yield and quality. And the article contained the following:

The increase of nitrogen content caused by the re-polymerization of nitrogenous compounds remains an important challenge during aqueous phase recirculation in the water solvent. In this work, aqueous phase recirculation was conducted in the ethanol-water solvent to evaluate the feasibility of ethanol addition in inhabiting the re-polymerization of nitrogenous compounds The present study provides a comprehensive comparison of yield and quality between bio-oils derived from aqueous phase recirculation in the water solvent and ethanol-water solvent. The results showed that the addition of ethanol in aqueous phase recirculation displayed higher promotion in bio-oil yield (7%) compared with water solvent (3.55%). The energy recovery efficiency of bio-oil from ethanol-water solvent reached 87.43% after recirculation for three times, while that from the water solvent was 74.61%. The elemental anal. and gas chromatog.-mass spectrometry anal. indicated that ethanol addition could inhibit the re-polymerization of nitrogenous compounds and thus decrease the nitrogen content in bio-oil. This resulted in lower NO and HCN emission peaks during the combustion process. Besides, the addition of ethanol increased the content of light mol. weight fractions and decreased the coke formation, which contributed to complete combustion and resulted in lower CO emission peaks. Overall, this work provides a feasible way for further improving the bio-oil yield and fuel quality through ethanol addition in solvent during aqueous phase recirculation. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Quality Control of N,N-Diethylacetamide

The Article related to ethanol bio oil yield quality aqueous phase recirculation, Placeholder for records without volume info and other aspects.Quality Control of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 2020, Waghorne, W. Earle published an article.Category: amides-buliding-blocks The title of the article was A Study of Kamlet-Taft 尾 and 蟺* Scales of Solvent Basicity and Polarity/Polarizability Using Computationally Derived Molecular Properties. And the article contained the following:

The Kamlet and Taft solvent basicity parameter, 尾, and solvent polarity/polarizability parameter, 蟺*, were analyzed in terms of properties of the solvent mols. derived from computational chem. The anal. of 尾, using a larger data set, confirms earlier conclusions that, for aprotic solvents, the basicity is determined by the partial charge on the most neg. atom of the solvent mol. and by the energy of the highest energy MO associated with the donor site. For alcs. and nitrogen bases containing N-H moieties, the 尾 values deviate systematically from those for the non-hydrogen bonding solvents. Anal. of the polarity/polarizability parameter, 蟺*, shows that it depends directly on the dipole moment, and quadrupolar amplitude of the solvent and on the energy of the HOMO, but decreases linearly with increasing solvent polarizability. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Category: amides-buliding-blocks

The Article related to solvent basicity polarity polarizability molicualr property, Placeholder for records without volume info and other aspects.Category: amides-buliding-blocks

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Benkaddour, Rajae; Ben Ali, Naouar; Hamdoun, Ouafaa; Badoc, Alain; Azaroual, Latifa; Martin, Patrick; Lamarti, Ahmed published an article in 2022, the title of the article was Micropropagation and acclimatization of common Oregano (Origanum vulgare L. Subsp. vulgare) by shoot tip culture.SDS of cas: 102-07-8 And the article contains the following content:

Origanum vulgare L. is a com. valued species with remarkable biol. properties. It is subject to over-exploitation practices that seriously threaten its sustainability for future generations. Thus, micropropagation serves as a tool for the protection and domestication of this species. In this study, we established an in vitro vegetative propagation protocol for Origanum vulgare. This is done through the axillary bud technique by carrying out various tests. Six culture media (MS, MSm, N30K, SD, SH and B5) were tested. Therefore, SD was chosen for the following experiments Seven cytokinins (adenine (Ad), N6-(2-isopentenyl) (2i.p.), zeatin (Zeat), kinetin (Kin), benzyladenine (BAP), 1,3-diphenylurea (DPU) and thidiazuron (TDZ) at 5 concentrations (0.44, 1.33, 2.22, 3.11 and 4.44 渭M/L) were evaluated. Thus, Kin at 3.11 渭M allowed high regeneration of vitroplants, optimal elongation, total rooting of explants, maximum bud multiplication, and absence of hyperhydric explants. In fact, the integration of auxins (indole-3-acetic acid (IAA), indole-3-butyric acid (IBA), and 1-naphthaleneacetic acid (NAA)) into the culture medium and their combinations with 3.11 渭M Kinetin contributed to the optimization of the root part. Thus, it was improved in particular in the case of 3.11 渭M Kin and 6.27 渭M IBA. Three polyamines (Putrescine, Spermidine and Spermine) at different concentrations (1.134, 3.402, 5.67, 7.938 and 11.34 渭M/L) combined at 3.11 渭M Kin and 6.27 渭M IBA were tested. In fact, 1.304 渭M putrescine was considered to be the most suitable for in vitro culture of explants, since it allowed optimal propagation of buds and roots, also a high rate of regeneration and rhizogenesis. GA3 at 1.15 渭M combined with 3.11 渭M Kin and 6.27 渭M IBA permitted maximum bud multiplication. The acclimatization was carried out successfully using vitroplants showing good foliar and root development. Thus, three months after acclimatization, the seedlings were transferred into large pots under natural light and temperature conditions. Almost all acclimatized plants developed flowers in the first year between May and July. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).SDS of cas: 102-07-8

The Article related to origanum shoot tip culture micropropagation acclimatization, Placeholder for records without volume info and other aspects.SDS of cas: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 31, 2020, Piotrowska-Niczyporuk, Alicja; Bajguz, Andrzej; Kotowska, Urszula; Zambrzycka-Szelewa, Elzbieta; Sienkiewicz, Aneta published an article.Related Products of 102-07-8 The title of the article was Auxins and Cytokinins Regulate Phytohormone Homeostasis and Thiol-Mediated Detoxification in the Green Alga Acutodesmus obliquus Exposed to Lead Stress. And the article contained the following:

Abstract: Phytohormones, such as auxins and cytokinins, take part in the integration of growth control and stress response, but their role in algal adaptation to heavy metal remains to be elucidated. The current research indicated that lead (Pb), one of the most toxic metals in nature, causes severe depletion of endogenous cytokinins, auxins, and gibberellin and an increase in abscisic acid content in the green alga Acutodesmus obliquus. Exogenous auxins and cytokinins alleviate Pb toxicity through the regulation of the endogenous phytohormones鈥?levels. Exogenously applied auxins provoked the coordinated activation metal tolerance mechanisms leading to the increase in phytochelatin synthase activity and accumulation of phytochelatins and their precursors, which are essential for Pb sequestration. On the other hand, phytochelatin synthesis decreased in algal cells treated with cytokinins. Significant changes in the levels of low mol. weight metabolites, mainly involved in metal chelation and glutathione synthesis pathway under the influence of phytohormones in algal cells growing in the presence of Pb stress, were observed This is the first report showing that auxins and cytokinins are important regulatory factors in algal adaptation strategies to heavy metal stress based on thiol-mediated compounds and the maintenance of phytohormone homeostasis. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Related Products of 102-07-8

The Article related to acutodesmus auxin cytokinin lead stress thiol detoxifcation, Placeholder for records without volume info and other aspects.Related Products of 102-07-8

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Amide – Wikipedia,
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On December 15, 2019, Sahu, Satya Narayan; Pattanayak, Subrat Kumar published an article.Product Details of 456-12-2 The title of the article was Molecular docking and molecular dynamics simulation studies on PLCE1 encoded protein. And the article contained the following:

Phospholipase C epsilon gene (PLCE1) is encoded the 1-phosphatidylinositol 4,5- bisphosphate phosphodiesterase 蔚-1 protein. This protein is characterized by the fetal onset of enormous proteinuria following by severe steroid resistance nephrotic syndrome (SRNS). The mutation position is located on the PIPLC_X domain of PLCE1 encoded protein. Mol. docking study was carried out between aegeline, berberine, diterpenoid, roseoside phytochems. with wild type and mutant of the PIPLC_X domain of the PLCE1 gene encoded protein. From the mol. docking study, it was found that, due to mutation the binding energy was decreased for aegeline, berberine diterpenoid and roseoside with mutant PLCE1 at S1484L compared to wildtype. To achieve the depth anal., we extended our study by performing the mol. dynamic simulation of 100 ns on wild type and the mutant (S1484L) model of above said domain of the studied protein. In the MD simulation study, we analyzed the result obtained from root mean square deviation, root mean square fluctuation, radius of gyration, solvation accessible surface area, hydrogen bond number and principal component anal. These dynamical behavior results of wild type protein show similar behavior with mutant protein. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Product Details of 456-12-2

The Article related to mol docking dynamic simulation plce1 phospholipase c epsilon, Enzymes: Structure-Conformation-Active Site and other aspects.Product Details of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 1, 2022, Dou, Shuzhen; Lu, Jiaxin; Chen, Qiye; Chen, Chunning; Lu, Nan published an article.HPLC of Formula: 144-80-9 The title of the article was High-density Si nanopillars modified with Ag nanoislands: Sensitive SALDI-MS chip for sulfonamides. And the article contained the following:

In recent years, the abuse of antibiotics has brought adverse effects on water environment and food safety, to monitor the antibiotic content in water and foodstuffs is imperative for environmental protection and human health. In this work, a chip, composed of high-d. Si nanopillars and Ag nanoislands, is prepared for sensitive detection of sulfonamides with surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). In this chip, the high-d. Si nanopillars can absorb laser energy efficiently and promote electron transfer as antennas; the Ag nanoislands can enhance the thermal effect; the formation of the Schottky barrier and the conductive nanolayer between Si/Ag can extend the lifetime of electrons and promote electron tunneling effect. Therefore, the heterostructure presents high detection sensitivity (the limit of detection of sulfamethazine is as low as 3 amol); in addition, the satisfactory coefficients of determination (> 0.99) show that the chip is applicable for rapid quantification of sulfonamides. Further, the sulfacetamides spiked in milk and lake water can be sensitively identified and rapidly quantified. The prepared chip presents a considerable potential for food and environment monitoring. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

The Article related to silicon nanopillar silver nanoisland modification sulfonamide, Placeholder for records without volume info and other aspects.HPLC of Formula: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics