Month: November 2022

Yuguda, Yakubu Magaji; Pandey, Rishikesh; Chavhan, Mayur Meghashyam; Mitra, Disha; Vijay, Aswathy; Ahmad, Sajjad; Daya, Minerva L.; Kumar, Shivam published an article in 2022, the title of the article was In-silico analysis for the confirmation of insulin receptor as a target for reported GLUT4 anti-diabetic natural compounds.HPLC of Formula: 456-12-2 And the article contains the following content:

There are 425 million people with diabetes in the World. There will be 629 million people with diabetes in the World in 2045. The insulin receptor controls glucose homeostasis, a physiol. mechanism that can lead to diabetes and cancer if disrupted. This study aimed to confirm the Insulin Receptor target for reported GLUT4 anti-diabetic natural compounds based on their pharmacokinetic properties, toxicity prediction, mol. docking, target anal., similar FDA approved drugs prediction, and mol. dynamic simulation. We selected 24 compounds on the basis of their mode of action from the anti-diabetic natural compounds database (ADNCD). Initially, we performed ADME anal. for the selected 24 compounds Among these 24 compounds, it has been found that 18 compounds followed the Lipinski Rule of Five. Further, we did a toxicity anal. of those 18 compounds, and it was found that 15 compounds were toxic in nature. We performed mol. docking against the Insulin Receptor (PDB ID: 1IR3) of the rest of the 3 compounds after ADME and toxicity anal. To understand the dynamic motions of the ligand-protein complex, we perform a root mean square fluctuation anal. We also checked the similarity of Apigenin from the FDA-approved drugs, but no similar mol. was found. It has been found that Apigenin was selected as the best compound as it showed the lowest binding energy and satisfied all our study parameters. Our promising findings based on preliminary and in-silico anal. need to be validated further by in-vitro and in-vivo studies. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).HPLC of Formula: 456-12-2

The Article related to insulin receptor glut antidiabetic natural compound silico analysis, Placeholder for records without volume info and other aspects.HPLC of Formula: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 30, 2015, Wang, Feng; Fan, Di; Qian, Jun; Zhang, Zhe; Zhu, Jianhua; Chen, Jian published an article.Synthetic Route of 5455-98-1 The title of the article was Preparation and Biodistribution of Technetium-99m-Labeled Bis- Misonidazole (MISO) as an Imaging Agent for Tumour Hypoxia. And the article contained the following:

Diagnosis of tumor hypoxia is an important aspect in determining the course of tumor therapy. In this study, we developed a novel imaging agent, 99mTcethylenedicysteine- bis-misonidazole (99mTc-EC-MISO), for diagnosing tumor hypoxia. We used 2-nitroimidazole as a reactant to synthesize the amino derivative of misonidazole (MISO) in the first step and then conjugated the di-amino derivative of MISO to the chelating agent ethylenedicysteine (EC) for labeling 99mTc in the second step. 99mTc-pertechnetate (99mTcO4 -) was reduced by tin chloride (SnCl2) for radiolabeling. The radiochem. purity was up to 94%. Tissue biodistribution and SPECT/CT imaging studies were conducted on s.c. gliomal tumor-bearing mice. The tumor-to-muscle ratio in the 99mTc-EC-MISO group increased with time, up to 4.6 at 4 h after injection. SPECT/CT imaging confirmed that the tumors could be visualized clearly with 99mTc-EC-MISO at 2 h. By introducing a second 2-nitroimidazole redox center, an apparent hypoxic accumulation of this novel 99mTc-labeled imaging agent in the tumor was observed The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Synthetic Route of 5455-98-1

The Article related to technetium 99m ecmiso spect ct biodistribution tumor hypoxia imaging, Placeholder for records without volume info and other aspects.Synthetic Route of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ko, Ik Jang; Park, Jin Hwan; Kim, Gyeong Woo; Lampande, Raju; Kwon, Jang Hyuk published an article in 2019, the title of the article was High-Performance Reflective Electrochromic Device by Integrating White Reflector and High Optical Density Electrochromic System.Quality Control of N,N-Diethylacetamide And the article contains the following content:

This paper reports an efficient reflective electrochromic device (ECD) by integrating a highly reflective micro-porous titanium dioxide-based white reflector film and an optimized transparent to black convertible electrochromic (EC) system. This reflective ECD can reflect almost 58.5% of light in the white state and 4.7% in the dark black state at 550 nm. Similarly, it also exhibits a very high ambient contrast ratio of 38:1 under office ambient light condition and good driving stability of about 83% in the white state (0 V) and 98% in the black state (1.7 V) after 10 000 driving cycles. In addition, the EC system is optimized by selecting good proton generator and suitable solvent for better coloration property as well as a low driving voltage via lactone ring opening reaction of leuco dye and supporting polymer for high optical d. through suppressing the movement of oxidized leuco dye to the electrode. An ECD with the optimized EC system shows significant improvement in average optical d. from 0.62 to 1.9 (at 400 to 700 nm) and faster switching speeds of about 1.6 s. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Quality Control of N,N-Diethylacetamide

The Article related to titanium dioxide white reflector electrochromic device optical density, Placeholder for records without volume info and other aspects.Quality Control of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bozkus, Tugba Nigar; Deger, Orhan; Yasar, Ahmet published an article in 2021, the title of the article was Chemical characterization of water and ethanolic extracts of Turkish propolis by HPLC-DAD and GC-MS.Name: N,N-Diethylacetamide And the article contains the following content:

This study aims to determine the qual. and quant. contents of Turkish propolis collected from various regions of Turkey using high-performance liquid chromatog. with the diode-array detector (HPLC-DAD) and gas chromatog.-mass spectrometry (GC-MS) in water and ethanolic extracts In HPLC-DAD analyses, it was determined that water extract of Turkish propolis contains phenolic acids such as caffeic acid (204.00 渭g/mL), trans-cinnamic, chlorogenic, and caffeoylquinic acids, responsible for its antioxidant activity; whereas, the ethanolic extract of Turkish propolis contains chrysin (641.33 渭g/mL), caffeic acid phenethyl ester (630.67 渭g/mL), pinocembrin (572.67 渭g/mL), galangin (534.11 渭g/mL), naringenin (372.39 渭g/mL), and also kaempferol, trans-cinnamic acid, caffeic acid, myricetin, and quercetin. GC-MS analyses showed that ethanolic extract of propolis contains caffeic acid by Rtx-1 column and the water extract of propolis contains quinic acid and ferulic acid by Rtx-5ms column. Various sugar derivatives were detected by both columns in water and ethanolic extracts of Turkish propolis. HPLC-DAD can be considered as a more effective method than GC-MS for the chem. characterization of propolis. Water extract of Turkish propolis can be a good source of raw materials for various sectors, as it is both cheap and has less health risk than ethanolic extract, and is suitable for human use. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Name: N,N-Diethylacetamide

The Article related to water ethanolic extract propolis liquid gas chromatog mass spectrometry, Placeholder for records without volume info and other aspects.Name: N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wu, Huizhen; Zhou, Min; Xu, Jie; Wang, Jianmei; Tong, Jianying; Sun, Nabo; Qian, Mingrong published an article in 2022, the title of the article was Determining a wide range of antibiotics and pesticides in poultry feathers using selective accelerated solvent extraction-liquid chromatography-mass spectrometry.SDS of cas: 144-80-9 And the article contains the following content:

This study established a detection method based on accelerated solvent extraction-liquid chromatog.-mass spectrometry for determining residues of 3 chloramphenicols, 8 macrolides, 18 sulfonamides, 4 nitroimidazoles, 15 insecticides, and 22 fungicides in poultry feathers. The extraction solvent, methanol, was used for a static extraction time of 5 min, and repeated three times. Fifty milligrams of adsorbents C18/PSA (1 : 1, W/W) were added to the extraction cell to achieve simultaneous extraction and purification The extraction efficiency of three solvents, methanol, acetonitrile and Et acetate, was investigated. An orthogonal exptl. design was used to explore the optimal combination of extraction temperature, static extraction time, number of extraction cycles, and adsorbent ratio for accelerated solvent extraction After the optimal ratio was determined, the dosage of adsorbents was optimized. The extracted sample solution was concentrated by blowing nitrogen, redissolved, passed through a 0.22 渭m PTFE membrane filter, then injected for instrumental anal. The validation results showed that the recovery of the proposed method was 60.4-107.6%, the limit of detection 0.2-3.0 渭g kg-1, and the limit of quantification 0.5-8.3 渭g kg-1. This quant. multi-residue detection method was able to determine the residues of 70 target compounds in poultry feathers. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).SDS of cas: 144-80-9

The Article related to liquid chromatog mass spectrometry antibiotic pesticide poultry feather, Placeholder for records without volume info and other aspects.SDS of cas: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 16, 2021, Shi, Wei; Tiwari, Surya P.; Thompson, Robert L.; Culp, Jeffrey T.; Hong, Lei; Hopkinson, David P.; Smith, Kathryn; Resnik, Kevin; Steckel, Janice A.; Siefert, Nicholas S. published an article.Recommanded Product: 1,3-Diphenylurea The title of the article was Computational Screening of Physical Solvents for CO2 Pre-combustion Capture. And the article contained the following:

A computational scheme was used to screen phys. solvents for CO2 pre-combustion capture by integrating the com. NIST database, an inhouse computational database, chem-informatics, and mol. modeling. A com. available screened hydrophobic solvent, di-Et sebacate, was identified from the screening with favorable phys. properties and promising absorption performance. The promising performance to use di-Et sebacate in CO2 pre-combustion capture has also been confirmed from experiments Water loading in di-Et sebacate is very low, and therefore, water is kept with H2 in the gas stream. The favorable CO2 interaction with di-Et sebacate and the intermediate solvent free volume fraction leads to both high CO2 solubility and high CO2/H2 solubility selectivity in di-Et sebacate. An inhouse NETL computational database was built to characterize CO2, H2, N2, and H2O interactions with 202 different chem. functional groups. It was found that 13% of the functional groups belong to the strong interaction category with the CO2 interaction energy between -15 and -21 kJ/mol; 62% of the functional groups interact intermediately with CO2 (-8 to -15 kJ/mol). The remaining 25% of functional groups interact weakly with CO2 (below -8 kJ/mol). In addition, calculations show that CO2 interactions with the functional groups are stronger than N2 and H2 interactions but are weaker than H2O interactions. The CO2 and H2O interactions with the same functional groups exhibit a very strong linear pos. correlation coefficient of 0.92. The relationship between CO2 and H2 gas solubilities and solvent fractional free volume (FFV) has been systematically studied for seven solvents at 298.2 K. A skewed bell-shaped relation was obtained between CO2 solubility and solvent FFV. When an organic compound has a d. approx. 10% lower than its d. at 298.2 K and 1 bar, it exhibits the highest CO2 loading at that specific solvent d. and FFV. Note that the solvent densities were varied using simulations, which are difficult to be obtained from the experiment In contrast, H2 solubility results exhibit an almost perfect pos. linear correlation with the solvent FFV. The theor. maximum and min. phys. CO2 solubilities in any organic compound at 298.2 K were estimated to be 11 and 0.4 mol/MPa L, resp. An examination of 182 exptl. CO2 phys. solubility data and 29 simulated CO2 phys. solubilities shows that all the CO2 phys. solubility data are within the maximum and min. with only a few exceptions. Finally, simulations suggest that in order to develop phys. solvents with both high CO2 solubility and high CO2/H2 solubility selectivity, the solvents should contain functional groups which are available to interact strongly with CO2 while minimizing FFV. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 1,3-Diphenylurea

The Article related to computational screening solvent carbon dioxide absorption precombustion, Placeholder for records without volume info and other aspects.Recommanded Product: 1,3-Diphenylurea

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zheng, Guihua; Yang, Yiyi; Deng, Linghui; Zhang, Ting; Zhu, Feiyun; Sun, Jing; Li, Shuangjiang; Feng, Xiaonan published an article in 2022, the title of the article was Pollution status and health impact assessment of antibiotics in environmental – and drinking water.Electric Literature of 144-80-9 And the article contains the following content:

The problem of antibiotics pollution in environmental water and drinking water has attracted the attention of environmental protection departments and all walks of life. At present, antibiotics have been widely detected in many water systems, and the concentration range is from ng/L to pg/L. In this paper, a method for the anal. of antibiotics in water by high performance liquid chromatog. tandem mass spectrometry (HPLC-MS/MS) was established. Then, the risk quotient (HQ) of antibiotics in wastewater treatment plant effluent and river water was calculated and studied. The results showed that some antibiotics did not cause direct ecol. risk. Finally, the health risk assessment of environmental water and drinking water was carried out. The results showed that the non carcinogenic risk caused by antibiotic pollution in the reservoir was far lower than the acceptable risk level, even far lower than the negligible risk level, indicating that the residues of these antibiotics in the drinking water would not pose significant non carcinogenic harm to human body. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Electric Literature of 144-80-9

The Article related to antibiotic wastewater treatment plant drinking water health risk assessment, Placeholder for records without volume info and other aspects.Electric Literature of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2019, Gupta, Ena; Shakyawar, Snehlata; Sundaram, Shanthy published an article.Related Products of 456-12-2 The title of the article was Therapeutic and Nutraceutical Potential of Bioactive Compounds in Aegle marmelos (L.): An Overview. And the article contained the following:

A review. Aegle Marmelos (L.) Correa (A. marmelos), is a medicinal plant of Rutaceae family having a long history of curative property in traditional medicine. This plant is a rich source of bioactive compounds and natural antioxidants which can be isolated from its various parts such as fruit (carotenoids, tannins, flavonoids, ascorbic acid, marmelosin, marmelide, psoralen, aurapten, luvangetin); leaf (phenols, lupeol, skimmianine, citral, aegeline, eugenol, citronella, marmesinine) and bark (marmin, skimmianine, fagarine), etc. Many clin. and pre-clin. researches suggest the therapeutic applications of A. marmelos, such as anti-bacterial, anti-fungal, anti-viral, anti-ulcer, anti-diabetic, anticancer, anti-inflammatory and antioxidant properties which play a potential role in the prevention and treatment of various diseases. This review article focuses on exploring novel bioactive compounds of the above plant possessing potential therapeutic and health promoting applications. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Related Products of 456-12-2

The Article related to review aegle marmelos therapeutic nutraceutical potential bioactive compound, Placeholder for records without volume info and other aspects.Related Products of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics