Month: November 2022

On April 30, 2022, Hu, Jingrun; Qi, Dianqing; Chen, Qian; Sun, Weiling published an article.Product Details of 144-80-9 The title of the article was Comparison and prioritization of antibiotics in a reservoir and its inflow rivers of Beijing, China. And the article contained the following:

The occurrence of antibiotics in drinking water resources, like reservoirs, is of considerable concern due to their potential risks to ecosystem, human health, and antimicrobial resistance development. Here, we quantified 83 antibiotics in water and sediments of wet and dry seasons from the Miyun reservoir and its inflow rivers in Beijing, China. Twenty-four antibiotics were detected in water with concentrations of ND-11.6 ng/L and 19 antibiotics were observed in sediments with concentrations of ND-6.50 ng/g. Sulfonamides (SAs) were the dominated antibiotics in water in two seasons. SAs and quinolones (QNs) in wet season and macrolides (MLs) and QNs in dry season predominated in sediments. The reservoir and inflow rivers showed significant differences in antibiotic concentrations and compositions in water and sediments. As an important input source of reservoir, the river water showed significantly higher total antibiotic concentrations than those in the reservoir. In contrast, the reservoir sediments are the sink of antibiotics, and had higher total antibiotic concentrations compared with rivers. A prioritization approach based on the overall risk scores and detection frequencies of antibiotics was developed, and 3 (sulfaguanidine, anhydroerythromycin, and sulfamethoxazole) and 5 (doxycycline, sulfadiazine, clarithromycin, roxithromycin, and flumequine) antibiotics with high and moderate priority, resp., were screened. The study provides a comprehensive insight of antibiotics in the Miyun Reservoir and its inflow rivers, and is significant for future monitoring and pollution mitigation of antibiotics. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Product Details of 144-80-9

The Article related to antibiotic inflow river pollution beijing china, antibiotics, comparison, prioritization, reservoir, inflow rivers, Placeholder for records without volume info and other aspects.Product Details of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 2022, Kohn, Elkana; Barchel, Dana; Golik, Ahuva; Lougassi, Marc; Wainstock, Tamar; Berkovitch, Matitiahu; Schwartsburd, Frieda published an article.Related Products of 27115-50-0 The title of the article was Analysis of 10 urinary BTEX metabolites using LC-MS/MS. And the article contained the following:

Benzene, toluene, ethylbenzene, and xylene (BTEX) are a group of volatile organic compounds that are ubiquitous in the environment due to numerous anthropogenic sources. Exposure to BTEX poses a health hazard by increasing the risk for damage to multiple organs, neurocognitive impairment and birth defects. Urinary BTEX metabolites are useful biomarkers for the evaluation of BTEX exposure, because of the ease of sampling and their longer physiol. half-lives compared with parent compounds A method that utilizes LC-MS/MS was developed and validated for simultaneously monitoring of 10 urinary BTEX metabolites. During the sample preparation an aliquot of urine was diluted with an equal volume of 1% formic acid; internal standard solution was added, and then the sample was centrifuged and analyzed. The analytes were separated on the Kinetex-F5 column by applying a linear gradient, consisting of 0.1% formic acid and methanol. The method was validated according to the FDA Bioanal. Method Validation Guidance for Industry. The mean method鈥瞫 accuracies of the spiked matrix were 81-122%; the inter-day precision ranged from 4 to 20%; the limits of quantitation were 0.5-2 渭g/L. The method was used for the evaluation of baseline levels of urinary BTEX metabolites in 87 firefighters. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Related Products of 27115-50-0

The Article related to benzene toluene ethylbenzene xylene urine metabolite lcmsms analysis, btex, lc-ms/ms, metabolites, urine, validation, Placeholder for records without volume info and other aspects.Related Products of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2022, Balic, Ivan; Olmedo, Patricio; Zepeda, Baltasar; Rojas, Barbara; Ejsmentewicz, Troy; Barros, Miriam; Aguayo, Daniel; Moreno, Adrian A.; Pedreschi, Romina; Meneses, Claudio; Campos-Vargas, Reinaldo published an article.Computed Properties of 685-91-6 The title of the article was Metabolomic and biochemical analysis of mesocarp tissues from table grape berries with contrasting firmness reveals cell wall modifications associated to harvest and cold storage. And the article contained the following:

Tissue texture influences the grape berry consumers acceptance. We studied the biol. differences between the inner and outer mesocarp tissues in hard and soft berries of table grapes cv NN107. Texture anal. revealed lower levels of firmness in the inner mesocarp as compared with the outer tissue. HPAEC-PAD anal. showed an increased abundance of cell wall monosaccharides in the inner mesocarp of harder berries at harvest. Immunohistochem. anal. displayed differences in homogalacturonan methylesterification and cell wall calcium between soft and hard berries. This last finding correlated with a differential abundance of calcium measured in the alc.-insoluble residues (AIR) of the inner tissue of the hard berries. Anal. of abundance of polar metabolites suggested changes in cell wall carbon supply precursors, providing new clues in the identification of the biochem. factors that define the texture of the mesocarp of grape berries. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Computed Properties of 685-91-6

The Article related to table grape mesocarp cell wall metabolomic harvest cold storage, calcium, pectin, polar metabolites, texture, vitis vinifera, Placeholder for records without volume info and other aspects.Computed Properties of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2022, Fent, Kenneth W.; Mayer, Alexander C.; Toennis, Christine; Sammons, Deborah; Robertson, Shirley; Chen, I-Chen; Bhandari, Deepak; Blount, Benjamin C.; Kerber, Steve; Smith, Denise L.; Horn, Gavin P. published an article.Product Details of 27115-50-0 The title of the article was Firefighters鈥?urinary concentrations of VOC metabolites after controlled-residential and training fire responses. And the article contained the following:

Firefighters are exposed to volatile organic compounds (VOCs) during structural fire responses and training fires, several of which (e.g., benzene, acrolein, styrene) are known or probable carcinogens. Exposure studies have found that firefighters can absorb chems. like benzene even when self-contained breathing apparatus (SCBA) are worn, suggesting that dermal absorption contributes to potentially harmful exposures. However, few studies have characterized VOC metabolites in urine from firefighters. We quantified VOC metabolites in firefighters urine following live firefighting activity across two field studies. In two sep. controlled field studies, spot urine was collected before and 3 h after firefighters and firefighter students responded to simulated residential and training fires. Urine was also collected from instructors from the training fire study before the first and 3 h after the last training scenario for each day (instructors led three training scenarios per day). Samples were analyzed for metabolites of VOCs to which firefighters may be exposed. In the residential fire study, urinary metabolites of xylenes (2MHA), toluene (BzMA), and styrene (MADA) increased significantly (at 0.05 level) from pre- to post-fire. In the training fire study, MADA concentrations increased significantly from pre- to post-fire for both firefighter students and instructors. Urinary concentrations of benzene metabolites (MUCA and PhMA) increased significantly from pre- to post-fire for instructors, while metabolites of xylenes (3MHA+4MHA) and acrolein (3HPMA) increased significantly for firefighter students. The two highest MUCA concentrations measured post-shift from instructors exceeded the BEI of 500 渭g/g creatinine. Some of the metabolites that were significantly elevated post-fire are known or probable human carcinogens (benzene, styrene, acrolein); thus, exposure to these compounds should be eliminated or reduced as much as possible through the hierarchy of controls. Given stringent use of SCBA, it appears that dermal exposure contributes in part to the levels measured here. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Product Details of 27115-50-0

The Article related to volatile organic compound firefighter urinary concentration fire response, acrolein, benzene, biomarker, fire, styrene, urine, Placeholder for records without volume info and other aspects.Product Details of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yang, Fan; Dong, Xin; Ma, Feixiang; Xu, Feng; Liu, Jie; Lu, Jingkun; Li, Chunyan; Bu, Ren; Xue, Peifeng published an article in 2020, the title of the article was The interventional effects of Tubson-2 decoction on ovariectomized rats as determined by a combination of network pharmacology and metabolomics.Reference of 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

Post-menopausal osteoporosis (PMOP) is associated with estrogen deficiency and worldwide, is becoming increasingly more prevalent in aging women. Various anti-PMOP drugs have been developed to reduce the burden of PMOP; generally, these drugs are efficacious, but with some adverse side effects. Tubson-2 decoction (TBD), a popular traditional Mongolian medicine, has been used to treat PMOP for centuries. However, the precise mechanisms underlying the action of TBD on PMOP have yet to be fully elucidated. Herein, we combined network pharmacol. with untargeted metabolomics to identify the key targets and metabolic pathways associated with the interventional effects of TBD on ovariectomized (OVX) rats. Furthermore, we investigated the bone histomorphometry of eight different groups of rats to evaluate the therapeutic effect of TBD. First, we established a TBD-target/PMOP network via network pharmacol.; this network identified three key protein targets-vitamin D receptor (VDR), cytochrome P 450 19A1 (CYP19A1), and 11尾-hydroxysteroid dehydrogenase type 1 (HSD11B1). Morphol. anal. showed that severe impairment of the bone micro-architecture in OVX rats could be improved by TBD administration. The TBD-treated rats had a significantly lower bone surface-to-tissue volume (BS/TV) and a significantly smaller trabecular separation (Tb路Sp.) (P<0.05) than the OVX rats; in contrast, bone volume fraction (BVF), trabecular thickness (Tb路Th.), trabecular number (Tb路N.), and bone mineral d. (BMD) were significantly higher in the TBD-treated rats (P<0.05). Multivariate and univariate anal. showed that OVX resulted in significant alterations in the concentrations of 105 metabolites and 11 metabolic pathways (P<0.05); in addition, 26 potential biomarkers were identified to investigate the progression of PMOP. Network pharmacol. showed that major alterations in vitamin B6 metabolism were associated with the VDR target. Next, we validated the three crucial targets (VDR [P<0.01], HSD11B1 [P<0.01], and CYP19A1 [P<0.05]) by enzyme-linked immunosorbent assays (ELISAs) and demonstrated that the levels of these targets were elevated in the OVX group but reduced in the TBD-treatment group. Collectively, our results suggest that the interventional effects of TBD on OVX rats are likely to be associated with the down regulation of VDR. Our findings enhance our mol. understanding of the interventional effects of TBD on PMOP and will allow us to develop further TBD studies. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid

The Article related to tubson network pharmacol metabolomic, tubson-2, metabolomics, network pharmacology, ovariectomized, post-menopausalosteoporosis, Placeholder for records without volume info and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tian, Min; Zhou, Shenzhi; Li, Wei; Li, Jiaru; Yang, Lan; Peng, Ying; Zheng, Jiang published an article in 2021, the title of the article was Metabolic activation of aegeline mediated by CYP2C19.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

Aegeline (AGL) is a natural alkaloidal amide mainly isolated from the leaves and fruits of tropical plant Aegle marmelos, with multiple pharmacol. activities. As one component of several dietary supplements, AGL caused a series of acute and chronic liver injuries. Nevertheless, the mechanisms of AGL-induced hepatotoxicity remain unclear. This study was conducted to identify reactive metabolite(s), to determine related metabolic pathways, and define the possible association of the bioactivation with AGL cytotoxicity. A demethylation metabolite (M1) and a GSH conjugate (M2) were detected in rat liver microsomal incubations containing AGL and GSH. The two metabolites were both found in bile of rats and rat primary hepatocytes after AGL administration. Recombinant P 450 enzyme incubations showed that CYP2C19 was the principal enzyme catalyzing this metabolic activation. Ticlopidine, a selective inhibitor of CYP2C19, decreased the formation of M1 and M2 in hepatocytes and attenuated the susceptibility of hepatocytes to the cytotoxicity of AGL. The results suggest that AGL was metabolized to a p-quinone methide intermediate which could in part participate in AGL-induced cytotoxicity. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegeline cytochrome p metabolic activation, aegeline, cyp2c19, cytotoxicity, metabolic activation, quinone methide intermediate, Placeholder for records without volume info and other aspects.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2022, Chibwe, Leah; Parrott, Joanne L.; Shires, Kallie; Khan, Hufsa; Clarence, Stacey; Lavalle, Christine; Sullivan, Cheryl; O鈥睟rien, Anna M.; De Silva, Amila O.; Muir, Derek C. G.; Rochman, Chelsea M. published an article.Synthetic Route of 102-07-8 The title of the article was A Deep Dive into the Complex Chemical Mixture and Toxicity of Tire Wear Particle Leachate in Fathead Minnow. And the article contained the following:

The ecol. impact of tire wear particles in aquatic ecosystems is a growing environmental concern. We combined toxicity testing, using fathead minnow (Pimephales promelas) embryos, with nontarget high-resolution liquid chromatog. Orbitrap mass spectrometry to characterize the toxicity and chem. mixture of organic chems. associated with tire particle leachates. We assessed: 1) exposure to tire particle leachates after leaching for 1-, 3-, and 10-d; and 2) the effect of the presence and absence of small tire particulates in the leachates. We observed a decrease in embryonic heart rates, hatching success, and lengths, as well as an increase in the number of embryos with severe deformities and diminished eye and body pigmentation, after exposure to the leachates. Overall, there was a pattern whereby we observed more toxicity in the 10-d leachates, and greater toxicity in unfiltered leachates. Redundancy anal. showed that several benzothiazoles and aryl-amines were correlated with the toxic effects observed in the embryos. These included benzothiazole, 2-aminobenzothiazole, 2-mercaptobenzothiazole, N,N鈥?diphenylguanidine, and N,N鈥?diphenylurea. However, many other chems. characterized as unknowns are likely to also play a key role in the adverse effects observed Our study provides insight into the types of chems. likely to be important toxicol. drivers in tire leachates, and improves our understanding of the ecotoxicol. impacts of tire wear particles. Environ Toxicol Chem 2021;00:1-10. 2021 The Authors. Environmental Toxicol. and Chem. published by Wiley Periodicals LLC on behalf of SETAC. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Synthetic Route of 102-07-8

The Article related to pimephales chem mixture tire wear particle toxicol, complex chemical mixtures, fathead minnow, tire toxicity, tire wear particles, Placeholder for records without volume info and other aspects.Synthetic Route of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 10, 2021, Yao, Shuyang; Fang, Wei-Hui; Sun, Yayong; Wang, San-Tai; Zhang, Jian published an article.Reference of 2-(4-Methylbenzamido)acetic acid The title of the article was Mesoporous assembly of aluminum molecular rings for iodine capture. And the article contained the following:

The effective capture and storage of radioiodine are of worldwide interest for sustainable nuclear energy. However, the direct observation of ambiguous binding sites that accommodate iodine is extremely rare. Here, the authors present a crystallog. visualization of the binding of iodine within mesoporous cages assembled from aluminum mol. rings. These nanocages are formed through 蟺-蟺 interactions between adjacent aluminum mol. rings. Compared with the general nanotubes arrangement, the supramol. nanocage isomer exhibits better iodine adsorption behavior. The robust mol. nanocages demonstrate a high iodine vapor saturation uptake capacity of 50.3 weight% at 80掳C. Furthermore, the resulting adsorbent can be recycled. Single-crystal x-ray diffraction reveals binding sites of mol. I2 within the pores of the phenyl-based linkers stabilized by the strong I路路路蟺 interactions. These compounds represent an excellent model to deduce the trapping mechanism of guest mols. interacting with the host. In addition, this work develops a promising cluster-based aluminum material as iodine adsorbents. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid

The Article related to mesoporous assembly aluminum mol ring radioiodine capture, pyrazole thermal synthesis aluminum oxy cluster radioiodine adsorption, Placeholder for records without volume info and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 5, 2021, Song, Mengke; Song, Dandan; Jiang, Longfei; Zhang, Dayi; Sun, Yingtao; Chen, Guoen; Xu, Huijuan; Mei, Weiping; Li, Yongtao; Luo, Chunling; Zhang, Gan published an article.Synthetic Route of 144-80-9 The title of the article was Large-scale biogeographical patterns of antibiotic resistome in the forest soils across China. And the article contained the following:

Soil is a reservoir of environmental resistomes. Information about their distribution, profiles, and driving forces in undisturbed environments is essential for understanding and managing modern antibiotic resistance genes (ARGs) in human disturbed environments. However, knowledge about the resistomes in pristine soils is limited, particularly at national scale. Here, we conducted a national-scale investigation of soil resistomes in pristine forests across China. Although the antibiotics content was low and ranged from below limit of detection (LOD) to 0.290 渭g/kg, numerous detected ARGs conferring resistance to major classes of modern antibiotics were identified and indicated forest soils as a potential source of resistance traits. ARGs ranged from 6.20 x 10-7 to 2.52 x 10-3 copies/16S-rRNA and were predominated by those resisting aminoglycoside and encoding deactivation mechanisms. Low abundance of mobile genetic elements (MGEs) and its scarcely pos. connections with ARGs suggest the low potential of horizontal gene transfer. The geog. patterns of ARGs and ARG-hosts in pristine forest soils were mainly driven by soil physiochem. variables and followed a distance-decay relationship. This work focusing on pristine soils can provide valuably new information for our understanding of the ARGs in human disturbed environments. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Synthetic Route of 144-80-9

The Article related to gene expression antibiotic resistance forest soil, antibiotic resistome, distribution, driving force, forest soils, national scale, Placeholder for records without volume info and other aspects.Synthetic Route of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2022, Shinde, Jivan; Bhimrao Patil, Prakash; Kavala, Veerababurao; Yao, Ching-Fa published an article.Related Products of 102-07-8 The title of the article was Synthesis of Unsymmetrical Urea Derivatives via Cu-Catalyzed Reaction of Acylazide and Secondary Amine. And the article contained the following:

The synthesis of unsym. urea generally requires toxic reagent, solvent and harsh reaction condition. Herein, we introduce Cu-catalyzed greener and safer unsym. urea derivatives synthesis in Et acetate. This method minimized utilization of toxic reagent. A variety of indole, amines, and azides with bis-indole successfully employed leading to high yields and gram scale synthesis of isolated urea. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Related Products of 102-07-8

The Article related to urea derivative copper acylazide secondary amine catalysis, curtius rearrangement, copper catalyst, green solvent, unsymmetrical urea, Placeholder for records without volume info and other aspects.Related Products of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics