Month: November 2022

On August 15, 2022, Tan, Haiguang; Sun, Feifei; Abdallah, Mohamed F.; Li, Jianxun; Zhou, Jinhui; Li, Yi; Yang, Shupeng published an article.Category: amides-buliding-blocks The title of the article was Background ions into exclusion list: A new strategy to enhance the efficiency of DDA data collection for high-throughput screening of chemical contaminations in food. And the article contained the following:

Foods contaminated with hazardous compounds, could pose potential risks for human health. To date, there is still a big challenge in accurate identification. In this study, a novel data-dependent acquisition (DDA) approach, based on a combination of inclusion list and exclusion list, was proposed to acquire more effective MS/MS spectra. This strategy was successfully applied in a large-scale screening survey to detect 50 mycotoxins in oats, 155 veterinary drugs in dairy milk, and 200 pesticides in tomatoes. Compared with traditional acquisition modes, this new strategy has higher detection rate, particularly at ultra-low concentration by eliminating background influence, thereby generating the MS/MS spectra for more potential hazardous materials instead of matrix interference. Addnl., the obtained MS/MS spectra are simpler and more likely to be traced back than DIA. Moreover, this new strategy would be more comprehensively applied in food safety monitoring with the improvement of HRMS and post-acquisition techniques. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Category: amides-buliding-blocks

The Article related to throughput screening chem contamination food, data acquisition, food safety, high-resolution mass spectrometer, non-targeted screening, Placeholder for records without volume info and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 15, 2022, Zhang, Keqiang; Ruan, Rong; Zhang, Zulin; Zhi, Suli published an article.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was An exhaustive investigation on antibiotics contamination from livestock farms within sensitive reservoir water area: Spatial density, source apportionment and risk assessment. And the article contained the following:

Although the studies on antibiotic contamination are common at present, large-scale sampling studies drawing highly representative conclusions are still scarce. This study conducted a comprehensive investigation on a total of 1183 samples from 70 livestock farms within a sensitive area around reservoir waters. 45 types of antibiotics belonging to 5 different classes were monitored. This is the first anal. to comprehensively investigate the d. distribution, source apportionment, ecol. and health risk of antibiotics in an entire area of sensitive waters. The results showed that the layer manure samples had highest detection rate of antibiotics (0.0 %-96.1 %, average value = 30.7 %) followed by pig manure samples. Oxytetracycline had the highest concentration of 712.16 mg/kg in a pig manure sample. Different from using antibiotic concentration as a proxy for pollution level, the spatial d. was calculated by averaging antibiotic concentration to area and converting different livestock to pig equivalent The spatial d. of pig equivalent can more realistically reflect the pollution caused by different breeds of livestocks. It was shown that the pig farms contributed higher to total antibiotic d. than the layer and cattle farms did. After assessed, a few antibiotics (oxytetracycline, chlorotetracycline and tetracycline) have posed high ecol. risks to soil around the farms. However, none of them caused hazard quotient (HQ) risk and carcinogenic risk (CR) to human health in the water of reservoir. Children were more likely to be at hazard risk than adults. Antibiotic mass fluctuation rules were analyzed along the chain (feed 鈫?livestock waste 鈫?soil 鈫?surface water). Feed, livestock waste and soil had similar diversity, but the antibiotic concentrations continued to decline, implying the possible sources of antibiotic residues were similar. Thus, it is important to reduce unnecessary antibiotic use to prevent the potential long-term risk of antibiotics. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to antibiotic livestock farm risk assessment surface water, antibiotic, livestock farm, risk assessment, source apportionment, spatial density, Placeholder for records without volume info and other aspects.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Handa, Takeshi; Araki, Akira; Yamamoto, Ken-ichi published an article in 2020, the title of the article was Hemolymph acid-base balance of akoya pearl oyster Pinctada fucata martensii with cannulated adductor muscle in normoxic conditions.COA of Formula: C6H5ClN2O4S And the article contains the following content:

We collected the hemolymph anaerobically through a cannula inserted into the adductor muscle of Akoya pearl oyster Pinctada fucata martensii submerged in exptl. seawater, and examined hemolymph pH, total CO2 concentration (Tco2), CO2 partial pressure (Pco2), and bicarbonate concentration ([HCO3-]) in order to evaluate the ability of the acid-base balance of P. fucata martensii in normoxic conditions. The mean values of hemolymph pH and Tco2 were 7.544 and 2.21 mM/L, resp. The apparent dissociation constant of carbonic acid (pKapp) was estimated using the following equation: pKapp = 225.712 – 97.096 • pH + 14.313 • pH2 – 0.7035 • pH3. Using mean values of pKapp (5.99585) and CO2 solubility coefficient (αco2, 37.02 μM/L/torr) determined in this study, the hemolymph Pco2 and [HCO3-] were calculated as 1.69 torr and 2.14 mM/L, resp. The non-bicarbonate buffer value (βNB) was 0.967 slykes. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).COA of Formula: C6H5ClN2O4S

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. COA of Formula: C6H5ClN2O4S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Eliel, Ernest L.; Nelson, Kenneth W. published an article in 1955, the title of the article was Reactions of p-chlorobenzenesulfonic acid and derivatives. The σp* constant of the N,N-dimethylsulfonamido group.Synthetic Route of 97-09-6 And the article contains the following content:

In order to find other uses for p-ClC6H4SO3H (I), a by-product in the manufacture of DDT, some experiments are carried out with I. Adding (10 min.) 200 g. ClSO3H to 100 g. dry I at 10°, heating until the evolution of HCl ceases, and pouring the mixture slowly onto ice gives 70-85% p-ClC6H4SO2Cl, m. 51°, which (75 g.) is treated with 28% NH4OH (or 40% NH2Me or 40% NHMe2) at such a rate that the temperature does not exceed 40°, giving 70-80% p-ClC6H4SO2NH2 (II), m. 143-4° [or p-ClC6H4SO2NHMe (III), m. 62-4°, or p-ClC6H4SO2NMe2 (IV), m. 78-9°]. Heating 5 g. IV and 100 cc. 10% NaOH 4 hrs. at 200° in a stainless-steel bomb with shaking gives 91% p-HOC6H4SO2NMe2, m. 94°. p-MeOC6H4SO2NMe2, prepared with CH2N2, m. 71-2°, is also obtained from PhOMe and SO2Cl2 and treatment of the MeOC6H4SO2Cl with NHMe2. Treating 5 g. III with 100 cc. 10% aqueous NaOH 4 hrs. at 200° leaves III unchanged but at 250° PhOH is formed. Heating 7 g. IV with 130 cc. 36% aqueous NH4OH at 250° (about 2700 lb. pressure) 4 hrs. gives 63% p-H2NC6H4SO2NMe2, m. 170.5-1°. Heating 20 g. IV and 10 g. CuCN in 12 cc. C5H5N 4 hrs. at 240-50°, pouring the cooled (100°) mixture into 100 cc. concentrated HCl, stirring the mixture at 20° with 200 cc. C6H6, and evaporating the washed (NH4OH, H2O) C6H6 layer gives 62% p-NCC6H4SO2NMe2 (V), m. 124-7°. Refluxing 2 g. V in 20 cc. 10% NaOH until a homogeneous solution is formed gives 97% p-HO2CC6H4SO2NMe2, m. 251-3°. Refluxing 20 g. V in 100 cc. tetrahydrofuran (THF) 1 hr. with 8 g. LiAlH4 in 50 cc. THF and acidifying the mixture with dilute H2SO4 gives (p-H2NCH2C6H4SO2NMe2)2.H2SO4 not m. below 250°. Adding 20 g. I to 15 cc. 18% fuming H2SO4, 35 cc. concentrated H2SO4, and 30 cc. fuming HNO3, keeping the mixture 1 hr. at 20°, adding 100 cc. H2O, and distilling it off until the temperature reaches 220° gives 11 g. 4,3-Cl(O2N)C6H3SO3H (VI). Heating 10 g. VI with 20 g. ClSO3H 1 hr. at 100° and pouring the cooled mixture onto crushed ice gives 18% sulfonyl chloride (VII) which (3 g.), treated with 50 cc. 28% aq NH4OH, heated to boiling and cooled, yields 79% sulfonamide (VIII), m. 175-7°. Adding 5 g. VII to 25 cc. 40% NHMe2 at such a rate that the temperature does not exceed 40°, filtering the precipitate, and triturating it with 25 cc. concentrated HCl gives 56% N,N-dimethylsulfonamide (IX), m. 100-2°. Heating 3 g. VII with 25 cc. 40% aqueous NHMe2 at 90° gives 84% 4,3-Me2N(O2N)C6H3SO2NMe2, m. 182-3°; 4-methylamino analog, 88%, m. 183°. The reaction rates of 2,4-Cl2C6H3NO2, VIII, IX, and o-ClC6H4NO2 with NaOMe are found to be 1.54, 0.0911, 0.0106, and 0.00306, resp. From the value for VIII σp* for SO2NMe2 is calculated to be 0.99. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Synthetic Route of 97-09-6

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Synthetic Route of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Arthur, H. R.; Ng, Y. L. published an article in 1959, the title of the article was Examination of the rutaceae of Hong Kong. IV. Synthesis of dihydronitidine.Category: amides-buliding-blocks And the article contains the following content:

Dihydronitidine (I) was synthesized and the structures for nitidine (II) and oxynitidine (III) proposed in the earlier work confirmed. Acetopiperone (25 g.) and 30 g. veratraldehyde treated with 150 ml. alc. with 30 ml. 10% aqueous NaOH gave 30 g. 3,4-dimethoxy-3′,4′-methylenedioxychalcone (IV), m. 135° (alc.). IV (30 g.) in 110 ml. EtOCH2CH2OH containing 6.5 ml. AcOH treated 3 min. at 100° with 12.5 g. KCN in 45 ml. H2O, heating continued 10 min., 150 ml. H2O added, and the mixture cooled gave 30 g. α-(3,4-dimethoxyphenyl)-γ-(3,4-methylenedioxyphenyl)-α-oxobutyronitrile (V), yellow needles, m. 146° (alc.). V (30 g.) in 200 ml. AcOH treated gradually with 30 ml. concentrated H2SO4 gave 25 g. α-(3,4-dimethoxyphenyl)-γ-(3,4-methylenedioxyphenyl)-γ-oxobutyramide (VI), m. 177° (alc.). VI (25 g.) in 350 ml. 7% aqueous NaOH and 200 ml. alc. refluxed 10 hrs. and then acidified gave 22 g. α-(3,4-dimethoxyphenyl)-γ-(3,4-methylenedioxyphenyl)-γ-oxobutyric acid (VII), needles, m. 172° (alc.). VII (11 g.) in 110 ml. AcOH containing 2 ml. 70% HClO4 hydrogenated during 2 hrs. at 60°/1 atm. over 2 g. 5% Pd-C, most of the solvent removed, H2O added, the oily product extracted with C6H6, the 8 g. brown oil [α-(3,4-dimethoxyphenyl)-γ-(3,4-methylenedioxyphenyl)-butyric acid] refluxed 4 min. with 20 ml. POCl3, the mixture poured on ice, the solid dissolved in CHCl3, washed with aqueous NaOH, H2O, dried, and evaporated gave 6.5 g. 2-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-methylenedioxy-1-oxonaphthalene (VIII), m. 165° (alc.). VIII(6 g.) in 15 ml. HCONH2 and 0.8 ml. HCO2H heated 3 hrs. at 180° with 0.8 g. (NH4)2SO4, 0.8 ml. HCO2H added hourly, the mixture cooled, diluted with H2O, extracted with CHCl3, washed, and evaporated gave 3.5 g. 2-(3,4-dimethoxyphenyl)-1-formamido-1,2,3,4-tetrahydro-6,7-methylenedioxynaphthalene (IX), m. 178° (dioxane-alc.). IX (1.5 g.) refluxed 15 min. with 3 ml. POCl3 in 10 ml. PhMe gave a solid which suspended in MeOH and basified gave 1 g. 3,4,11,12-tetrahydro-6,7-di-methoxy-2′,3′-methylenedioxy-1,2-benzophenanthridine (X), m. 188-9° (MeOH). X (0.9 g.) heated 0.5 hr. at 240° with 0.2 g. 30% Pd-C and extracted with CHCl3 gave 0.6 g. 6,7-dimethoxy-2′,3′-methylenedioxy-1,2-benzophenanthridine (XI), m. 273° (C5H5N). XI (0.5 g.) in 5 ml. xylene and 10 ml. PhNO2 refluxed a few min. with 1 ml. Me2SO4 gave the methosulfate of XI, m. 306-7° (decomposition) (aqueous alc.). XI methosulfate (0.4 g.) in 60 ml. H2O and 4 ml. concentrated HCl refluxed 5 hrs. with 8 g. Zn powder under argon, 3 ml. more HCl added after each hr., the solution cooled to 0-5°, sealed 12 hrs. under argon, the solid washed, shaken with CHCl3 and NH3, the extract washed, dried, and evaporated gave 0.2 g. I, prisms, m. 208-11° (alc.). Simple transformations used for I led to syntheses of II and III. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Banerjee, Sunil Kumar; Chakravarti, R. N. published an article in 1965, the title of the article was Action of Raney nickel on egeline, egelone, and dihydro egeline.Recommanded Product: 456-12-2 And the article contains the following content:

cf. CA 52, 13672h. Egeline, p-MeOC6H4CH(OH)CH2NHCOCH:CHPh, was refluxed about 10 hrs. with Raney Ni in a p-cymene solution, filtered hot, and cooled to give needle crystals (I). I was dissolved in EtOH and chromatographed on Brockmann alumina to yield dihydroegelone, m. 126-7° (EtOH), identified by its semicarbazone, m. 139-40°. Following the same procedure, egelone and dihydroegeline were both converted into dihydroegelone. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: 456-12-2

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Recommanded Product: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chaudhury, N. Aditya; Chatterjee, A. published an article in 1959, the title of the article was β-Phenylethanolamines. I. New synthesis of aegeline and papaverine.Electric Literature of 456-12-2 And the article contains the following content:

cf. C.A. 52, 14630i. Substituted benzaldehyde cyanohydrins are reduced to the corresponding amines, condensed with piperonal (I), and converted to the N-Me derivatives Thus, 6 g. p-MeOC6H4CH(OH)CN in 50 cc. Et2O is added dropwise to 4 g. LiAlH4 in 200 cc. Et2O at 0°, the mixture stirred at room temperature 5-6 hrs., refluxed 4-5 hrs., the complex decomposed by addition of 5 cc. H2O, 10 cc. 20% aqueous NaOH, and 15 cc. H2O and refluxed 30 min. The solution is filtered hot, extracted with 150 cc. Et2O and β-hydroxy-β-(p-methoxyphenyl)ethylamine (II) (80%), m. 70° (C6H6-petr. ether), isolated by evaporation of the Et2O. II.HCl m. 173°. Equal moles of I and II are refluxed in 95% EtOH 1 hr. and the solvent evaporated in vacuo to give N-piperonylidene-β-hydroxy-β-(p-methoxyphenyl)ethylamine (III) (90-5%), needles, m. 115-16° (C6H6-petr. ether). III (3 g.) in 100 cc. C6H6 is refluxed with 5 cc. MeI 5-6 hrs., the sticky solid product dissolved in 20-5 cc. hot water and 2-3 cc. concentrated HCl, warmed 1 hr., extracted with Et2O, made alk. with 30% NaOH, and extracted with Et2O and then CHCl3. From the combined extracts on distillation in vacuo is obtained N-methyl-β-hydroxy-β-(p-methoxyphenyl)ethylamine (50 %); HCl salt, needles, m. 101° (Me2CO-EtOAc). From the corresponding cyanohydrins are prepared: β-hydroxy-β-(3,4-dimethoxyphenyl)ethylamine (72%), b4 180-2°; HCl salt (IV), m. 163°; its I derivative m. 129-30°; and N-methyl-β-hydroxy-β(3,4-dimethoxyphenyl)ethylamine (46%), HCl salt m. 143-5° (decomposition); also β-hydroxy-β-(3,4-methylenedioxyphenyl)ethylamine (80%), HCl salt m. 181-2°; its I derivative m. 155-6°; and N-methyl-β-hydroxy-β-(3,4-methylene-dioxyphenyl)ethylamine (50%), HCl salt m. 163-5° (decomposition). Homoveratroyl chloride (3 g.) is added to 2 g. IV in the min. amount of H2O, 1.5 g. KOH added, the mixture stirred vigorously 2 hrs., the yellow mass which separates washed with a little H2O, dissolved in the min. amount EtOH containing a few drops dilute NaOH, and allowed to stand 1 day to give 2 g. homoveratroyloxyhomoveratrylamine (V), m. 127-8° (C6H6). V (2 g.) refluxed in PhMe 5 min. with 10 g. P2O5, the PhMe decanted, the residue dissolved in ice H2O, the solution extracted with Et2O, the aqueous portion made alk. with concentrated NaOH, and the resulting emulsion kept 1 day gives 0.51 g. papaverine, m. 147° (CHCl3-petr. ether). Trans-cinnamoyl chloride (3 g.) in 15 cc. Et2O is added dropwise to 2 g. II in 50 cc. Et2O with vigorous stirring, the solution made alk. with dilute NaOH after a solid forms, and dl-trans-N-[β-hydroxy-β-(p-methoxyphenyl)]ethylcinnamide (VI) (1.2 g.), m. 177-8°, filtered, washed (H2O), and recrystallized from EtOAc. VI is identical with natural aegeline. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Electric Literature of 456-12-2

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Electric Literature of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chakravarti, R. N.; Dasgupta, B. published an article in 1958, the title of the article was Structure of aegelin.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

cf. C.A. 50, 11281h. Air-dried powd. young leaves (14 kg.) of Aegle marmelos (May-Aug. crop) repeatedly extracted with cold 90% alc. and the extract mixed with filter paper pulp, dried at 80° and extracted 80 hrs. with Et2O, the extract evaporated to 1.5 l. and kept at 0° 1 week, filtered and the product washed with Et2O, crystallized from EtOAc and EtOH-Me2CO and the crystalline product filtered in alc. through Al2O3, the filtrate evaporated and the residue crystallized (alc.) gave 0.15-0.20% aegelin (I), C18H19NO3, m. 178-9°, evolving little H2Se on heating with Se (cf. Chatterjee and Bose, C.A. 47, 10544g), λ 212, 219, 275 mμ (log ε 4.36, 4.36, 4.42) similar to that of trans-PhCH:CHCONHMe, λ 218, 270 mμ (log ε 4.18, 4.39); acetate, m. 123-5°; benzoate, m. 147-8°. I (0.5 g.) in 25 ml. AcOH shaken 4 hrs. at 30° with portionwise addition of 0.2 g. CrO3 and excess AcOH evaporated in vacuo, the residue diluted with H2O and the mixture filtered, gave 0.35 g. aegelone (II), C18H17 159-60° (alc.), λ 280 mμ (log ε 4.67), reducing hot AgNO3NH4OH solution in 1 min., no reaction with Angeli-Rimini or Schiff reagents; semicarbazone, m. 234-5°. I (0.5 g.) hydrogenated 15 min. in 25 ml. AcOH with 50 mg. prereduced PtO2 at 30°/760 mm. and the filtered solution evaporated in vacuo, the residue taken up in H2O and filtered gave 0.33 g. dihydroaegelin (III), m. 140-1° (alc.), similar to I in not reducing AgNO3-NH4OH on heating several min. at 100°, oxidized by CrO3 to the corresponding dihydroaegelone (IV), m. 126-7° (alc.), reducing AgNO3-NH4OH solution; semicarbazone, m. 138-40°. IV was also obtained by partial hydrogenation of 0.5 g. II in 20 ml. AcOH with 50 mg. prereduced PtO2. IV (0.5 g.) in 25 ml. AcOH hydrogenated 30 min. by shaking with 50 mg. prereduced PtO2 and the filtered solution evaporated in vacuo gave III. I (1 g.) in 10 ml. boiling H2O treated portionwise with 4 g. KMnO4 and 0.5 g. KOH in 100 ml. H2O and excess KMnO4 decomposed with MeOH, the solution filtered and concentrated to 20 ml., the cooled concentrate acidified with HCl, and the precipitate (0.4 g.) repeatedly crystallized (hot H2O) gave p-anisic acid, m. 183-4°, and BzOH. Oxidation of I under similar conditions and distillation gave BzH, converted to 60 mg. 2,4-(O2N)2C6H3NHN:CHPh. I (2 g.) refluxed 8 hrs. with 72 ml. 90% alc. and 12 ml. concentrated HCl and the solution steam distilled, the 2nd fraction of the distillate extracted with Et2O and the extract washed with aqueous NaHCO3 and H2O, the dried extract evaporated and the oil (0.427 g.) warmed 0.5 hr. with aqueous H2NNHCONH2.HCl and NaOAc in a min. of alc., kept overnight and decanted, the product washed with H2O and Et2O and the crystalline residue (45 mg.) crystallized (alc.) gave p-MeOC6H4CH:NNHCONH2, m. 203-4°. The oil from the Et2O washings hydrolyzed with 10% alc. KOH and the alc. evaporated, the aqueous solution acidified with HCl and the product crystallized (hot H2O) gave trans-PhCH:CHCO2H (V). The distillation residue steam distilled and extracted with Et2O (extract A) and the aqueous layer (solution B) basified with evolution of NH3, extracted with Et2O and the product (basic crystals) acidified and treated with Meyer reagent gave a creamy precipitate The presence of NH3 in the hydrolysis products of I was confirmed by evaporating solution B to dryness and heating the residue with alkali, adsorbing the evolved gas in alc. and treating the solution with 1,2,4-ClC6H3(NO2)2. Extract A extracted with aqueous NaHCO3 and the extract acidified with HCl gave 0.32 g. V. Hydrogenation of 1.3 g. p-MeC6H4COCN in 15 ml. AcOH 20 min. with 0.1 g. prereduced PtO2 at 30°/760 mm., the dark brown filtered solution treated with 0.46 ml. concentrated H2SO4 and diluted with Et2O gave 1.3 g. p-MeOC6H4COCH2NH2.H2SO4 (VI), m. 167-8° (AcOH) (cf. Kindler and Peschke, C.A. 26, 3785). VI (0.3 g.) and 0.3 ml. trans-PhCH:CHCOCl stirred with gradual addition of 10% NaOH to appearance of pink coloration, the solution stirred with 0.2 ml. trans-PhCH:CHCOCl and the colorless solution made alk. gave 0.2 g. p-MeOC6H4COCH2NHCOCH:CHPh, m. 156-60° (cf. Lister and Robinson, C.A. 7, 326), identical with II, and dehydrated with concentrated H2SO4 to 5-p-methoxyphenyl-2-styryloxazole, showing intense blue fluorescence in solution VI (0.3 g.) and 0.3 ml. PhCH2CH2COCl stirred with cooling with 10% NaOH and the brick-red product crystallized (alc.) gave 0.2 g. p-MeOC6H4COCH2NHCOCH2CH2Ph, m. 126-7°, identical with IV. VI (0.7 g.) in 15 ml. AcOH and 2 ml. H2O hydrogenated 45 min. at 30°/760 mm. with 50 mg. prereduced Pt2O and again hydrogenated 20 min. with 50 mg. catalyst, the filtered solution evaporated in vacuo and the residue in H2O divided, a portion condensed with 0.3 ml. PhCH:CHCOCl to give 0.15 g. I and the other portion condensed with 0.3 ml. PhCH2CH2COCl gave III. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nerdel, Friedrich; John, Ute published an article in 1956, the title of the article was Hydratropic acids. V. Optically active m- and p-substituted homohydratropic acids.Product Details of 456-12-2 And the article contains the following content:

cf. C.A. 49, 13938c. Methylation of p-O2NC6H4CH2CHMeCO2H (I) with CH2N2 in EtOH yields 93% Me ester, b0.002 90°, m. 57° (amide, needles, m. 116°). I (60 g.) in 100 cc. (Me2CH)2O with 50 g. (+)-bornylamine (II) in 50 cc. (Me2CH)2O yields almost 100% II salt, m. 161-3°, [α]D20 11°, which, on fractional crystallization from C6H6 gives 38 g. (-)-salt, m. 168-9°, [α]D20 -3.5°; decomposition of the latter yields (-)-I, needles, m. 107°, [α]D20 -32.4° (EtOH) [Me ester, sirup, [α]D20 -49.1° (EtOH); amide, m. 112-13°, [α]D20 -60.5° (EtOH)]. m-O2NC6H4CH2CHMeCO2Me b0.05 100° (amide, small needles, m. 113°). m-O2NC6H4CH2CHMeCO2H (III) (95 g.) with 65 g. II gives the II salt, m. 144-6° [α]D20 13.4°, which, fractionally crystallized from C6H6, yields 50 g. II salt of (-)-III, m. 159-60°, [α]D20 0°; free (-)-III, m. 69-70°, [α]D20 -24°; quinine salt, m. 83-5°, does not change the rotation; Me ester, b0.001 85°, [α]D20 -40.1°; amide, needles, m. 135°, [α]D20 -61.6°. Reduction of 6.3 g. I in 75 cc. EtOH 20 min. with 0.2 g. PtO2 yields the p-NH2 acid (IV).HCl, pale yellow needles, m. 191° (decomposition); free IV, needles, m. 126°. Reduction of (-)-I in the same way yields (-)-IV, m. 191° (decomposition), [α]D20 -46° (H2O); N-Ac derivative of (-)-IV, prisms, m. 129°, [α]D20 -22.4° (EtOH). Reduction of III with PtO2 in EtOH gives m-H2NC6H4CH2CHMeCO2H (V), m. 99°. Hydrogenation of m-O2NC6H4CH:CMeCO2H gives, after 3 moles H are absorbed, m-H2NC6H4CH:CMeCO2H, m. 137°; further hydrogenation yields V. (-)-V, m. 94°, [α]D20 -14.3°; HCl salt, m. 136°, [α]D20 -42.8°. N-Ac derivative of V, prisms, m. 137°; N-Ac derivative of (-)-V, prisms, m. 123°, [α]D20 -21° (EtOH). Diazotizing IV.HCl at 0° and heating the diazonium solution at 50° give p-HOC6H4CH2CHMeCO2H (VI), needles, m. 102° (-)-VI, m. 99°, [α]D20 -18.5° (EtOH). m-HOC6H4CH2CHMeCO2H (VII) is an oil; (-)-VII, needles, m. 98°, [α]D20 -15.2° (EtOH). Diazotizing a 54% optically pure (-)-IV and heating the diazonium solution with CuH2 yield (-)-PhCH2CHMeCO2H, [α]D20 -14°, corresponding to an [α]D20 of -26° for the optically pure acid. Hydrogenating PhCH:CMeCO2H with NaHg and resolving the acid with quinine yield a quinine salt, m. 122°, [α]D20 116.2°; free (+)-acid, [α]D20 22.9°, d20 1.062; Me ester, b22 230°, d22 1.017, [α]D20 30.1°; (+)-amide, needles, m. 115°. The rotation dispersion of the substituted homohydratropic acids, their esters, and amides are listed in tables and show that the rotation direction is not changed by the entrance of m- and p-substituents. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Product Details of 456-12-2

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Product Details of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chakravarti, R. N.; Dasgupta, B. published an article in 1956, the title of the article was Synthesis of aegelin.Application of 456-12-2 And the article contains the following content:

Anisaldehyde was converted to the corresponding cyanohydrin which was oxidized and with catalytic hydrogenation yielded β-hydroxy-β-p-methoxyphenylethylamine, which with cinnamoylation yielded aegelin. Dihydroaegelin, aegelone, and dihydroaegelone were synthesized in a similar manner. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Application of 456-12-2

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Application of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics