Month: November 2022

Dornow, Alfred; Siebrecht, Manfred published an article in 1960, the title of the article was Syntheses of nitrogen-containing heterocycles. XXII. The synthesis of some pyrazolo[3,4-b]pyridines.Product Details of 100524-09-2 And the article contains the following content:

5-Amino-3-pyrazolone (I) with β-dicarbonyl compounds gave good yields of pyrazolopyridines. AcMeCHCHO (II) condensed with I gave as the main product the corresponding pyrazolopyrimidine. NCCH2CONHNH2 (99 g.) and 89 g. NaOEt in 400 cc. EtOH heated 1 hr. at 100°-cooled, and filtered gave 116 g. Na salt (III) of I; the concentrated aqueous solution of III acidified with glacial AcOH gave I, m. 204°. III (12.1 g.) in 45 cc. H2O treated with stirring and warming with 13.0 g. AcCH2CO2Et to solution, cooled, filtered, and the residue dissolved in H2O and acidified with AcOH gave 16.2 g. 3,6-dihydroxy-4-methyl-1-pyrazolo [3,4-b]pyridine (IV), m. 335° (decomposition) (MeOH). CH2(CO2Et)2 (8 g.) and 4.95 g. I added to 10.5 g. NaOEt in 100 cc. EtOH, heated 4 hrs. on the water bath and filtered, and the residue dissolved in H2O and acidified with AcOH gave 7.1 g. 4-OH analog of IV, m. 370° (decomposition) (glacial AcOH). III (12.1 g.) in 30 cc. H2O, 11.1 g. AcCH: CHONa in 15 cc. H2O, and 2.5 g. piperidine acetate refluxed 2 hrs., cooled, neutralized with AcOH, and filtered gave 9.9 g. 3-hydroxy-6-methyl-1-pyrazolo[3,4-b]pyridine (V), m. 282° (EtOH). III (6 g.) in 30 cc. H2O treated with 8.5 g. BzCH:CHONa in 20 cc. H2O, heated 2 hrs. with 2 g. piperidine acetate on the water bath, cooled, and acidified with glacial AcOH yielded 6.7 g. 6-Ph analog of V, m. 288° (MeOH). III (6 g.) in 20 cc. H2O treated with 6 g. Na salt of II in 10 cc. H2O, refluxed 2 hrs. with 2 g. piperidine acetate, and worked up gave 5.1 g. orange precipitate; the precipitate extracted with hot EtOH and the extract cooled gave 3.4 g. 2-hydroxy-6,7-dimethylpyrazolo[2,3-a]pyrimidine (VI), m. 239° with sintering from 226° (EtOH); the residue from the extraction gave 1.7 g. 5-Me derivative (VII) of V, m. 343°. I (3 g.) and 3.7 g. Na salt of 1-formyl-2-cyclohexanone in 40 cc. absolute EtOH refluxed 2 hrs., filtered after 2 hrs., and the residue dissolved in H2O and neutralized with glacial AcOH yielded 3.4 g. 3-hydroxy-5,6,7,8-tetrahydro-1-pyrazolo[3,4-b]quinoline (VIII), yellow, m. 297° (EtOH). IV (1 g.) and 10 g. Raney Ni in 230 cc. EtOH refluxed 2 hrs., filtered hot, evaporated, and the residue washed with Et2O gave 0.65 g. 6-hydroxy-2-amino-4-methylnicotinic acid amide (IX), m. 250° (PhMe). V (0.5 g.) and 8 g. Raney Ni in 200 cc. EtOH gave similarly 0.45 g. 2-amino-6-methylnicotinic acid amide (X), m. 219° (PhMe). VII (0.5 g.) and 8 g. Raney Ni refluxed 3 hrs. in 200 cc. EtOH yielded 0.5 g. 5-Me derivative of X, m. 230° (PhMe). VIII (2 g.) and 12 g. Raney Ni in 300 cc. EtOH heated 3 hrs. gave 1.2 g. amide (XI) of 2-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acid (XII), m. 223° (PhMe). XI (0.7 g.) in 5 cc. concentrated HCl refluxed 3 hrs. and neutralized with aqueous NaOH-NaOAc gave 0.6 g. XII. XII (3 g.) distilled at 250° gave with CO2 evolution 2.1 g. 2,4,5-trimethylpyrimidine, b12 107°; picrate m. 198° (EtOH). The experimental process involved the reaction of 2-Amino-6-methylnicotinamide(cas: 100524-09-2).Product Details of 100524-09-2

2-Amino-6-methylnicotinamide(cas:100524-09-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Product Details of 100524-09-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dahlbom, Richard; Misiorny, Alfons published an article in 1957, the title of the article was Amines related to adrenaline containing nuclear chlorine.Formula: C18H19NO3 And the article contains the following content:

Nuclear substituted amino ketones were prepared from appropriate ω-chloroacetophenones and the desired amines. E.g., the appropriate ω-chloroacetophenone (0.025 mole) and the amine (0.065 mole) were dissolved in toluene (usually 25 ml.) and the mixture kept overnight at room temperature The amine hydrochloride was removed by filtration and the toluene solution washed with water and extracted with 2N HCl. The extract was made alkaline with aqueous Na2CO3 and the precipitated base extracted with Et2O. The extract was dried over Na2SO4 and the amino ketone was then isolated as the hydrochloride by the addition of ethereal HCl and recrystallized These compounds were of the general formula 3,4-R’RC6H3COCH2R”.HCl with R, R’, R”, and m.p. given: Cl, H, piperidino (I), 222-3° (free amine, m. 52-3°); OH, Cl, I, 268-270°; Cl, Cl, I, 249-51°; Cl, H, NHEt, 246-8°; Cl, H, 4-methyl-1-piperazinyl (II), 248-9°; Cl, Cl, II, 252-4°; Cl, H, 4-ethyl-1-piperazinyl, 266-8°; Cl, H, 4-carbethoxy-1-piperazinyl (III), 196-7°; Cl, Cl, III, 212-14° (free amine, m. 108-9°). Most of these amine hydrochlorides m. with decomposition and the yields were 41-87%. The hydrochlorides were converted to the free amino ketones which were dissolved in Et2O and reduced with LiAlH4 to give the following corresponding amino alcohols with R, R’, R”, and m.p. given in that order; Cl, H, I, 68.5-70°; Cl, Cl, I, 89-90°; Cl, H, NHEt, b0.8 190°, m. 87-8°; Cl, H, II, 85-85.5° (hydrochloride, m. 236-7°); Cl, Cl, II, 121-2°. A weak antagonism toward adrenaline and noradrenaline was shown by several of the piperidino compounds in experiments on the blood pressure of cats. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Formula: C18H19NO3

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Formula: C18H19NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chakravarti, R. N.; Dasgupta, B. published an article in 1955, the title of the article was Structure of aegelin.Computed Properties of 456-12-2 And the article contains the following content:

cf. C.A. 47, 10544g. Analysis showed the formula of aegelin (I) to be C18H19ON3; it is neutral with one OMe and one OH but no NMe or CMe. Oxidation (C.A. 43, 1386i) gave aegelone (II), C18H17O3N, m. 159-60° and hydrogenation (PtO2 in HOAc) gave dihydroaegelin (III). Similarly, hydrogenation of II afforded dihydroaegelone (IV), m. 126-7°. Hydrolysis (H2O-EtOH-HCl) of I gave NH3, PhCH:CHCO2H (and its Et ester) and a little p-MeOC6H4CHO. The following structures are proposed: p-MeOC6H4CH(OH)CH2NHCOCH:CHPh for I, p-MeOC6H4COCH2NHCOCH:CHPh for II, p-MeOC6H4CH(OH)CH2NHCO(CH2)2Ph for III, and p-MeOC6H4COCH2NHCO(CH2)2Ph for IV. These structures have been confirmed by the alk. condensation of p-MeOC6H4CH(OH)CH2NH2 or p-MeOC6H4COCH2NH2 with PhCH:CHCOCl or Ph(CH2)2COCl. The products were identified by mixed m.p. The ultraviolet absorption curves of natural and synthetic I are identical. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Computed Properties of 456-12-2

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Computed Properties of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chatterjee, Asima; Bose, Sukumar published an article in 1952, the title of the article was The active principles of the leaves of Aegle marmelos.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

cf. C.A. 43, 2993g. From the leaves of Aegle marmelos have been isolated skimmianine (I) and a sterol, aegelin (II), C18H18O4. I is characterized by the preparation of 7 salts and by its ultraviolet absorption spectrum. II from EtOAc, then Me2CO or EtOH, m. 174-5°. It gives a yellow Liebermann-Burchard test, a yellow-to-pink Salkowsky test, and a red Lifschütz test. II with Ac2O-pyridine gives a mono-Ac derivative m. 159-60°. Se dehydrogenation of II gives no identifiable product. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lavrishchev, V. A.; Kretov, A. E. published an article in 1962, the title of the article was Reaction of unsymmetric substituted ureas on melting with 4-chloro-3-nitrophenyl alkyl(aryl) sulfones and sulfonamides.Name: 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

cf. CA 55, 18646h. Fusion of a sulfone or sulfonamide of general type 4,3-Cl(O2N)C6H3SO2R or 4,3-Cl(R2NSO2)C6H3NO2, resp., with unsym. substituted ureas in 1:4 molar ratio at 200° gave after treatment with EtOH some cyanuric acid and the following amines (urea derivative and the product shown, resp.): methylurea, 4-methylsulfonyl-2-nitrophenylmethylamine m. 190-1°, dimethylurea, 4-methylsulfonyl-2-nitrophenyldimethylamine m. 135-6°; phenylurea, 4-methylsulfonyl-2-nitrodiphenylamine m. 133-4°; p-anisylurea, 4-methylsulfonyl-2-nitro-4′-methoxydiphenylamine m. 168-9°; p-ethoxyphenylurea, 4-methylsulfonyl-2-nitro-4′-ethoxydiphenylamine m. 130-1°; methylurea, 4-N-methylsulfonamido-2-nitrophenylmethylamine m. 180-1°; dimethylurea, 4-N-methylsulfonamido-2-nitrophenyldimethylamine m. 158-9°; p-anisylurea, 4-N-methylsulfonamido-2-nitro-4′-methoxydiphenylamine m. 170-1°; p-ethoxyphenylurea, 4-N-methylsulfonamido-2-nitro-4′-ethoxydiphenylamine m. 179-80°; methylurea, 4-N-dimethylsulfonamido-2-nitrophenylmethylamine m. 149-50°; dimethylurea, 4-N-dimethylsulfonamido-2-nitrophenyldimethylamine m. 103-4°; p-anisylurea, 4-N-dimethylsulfonamido-2-nitro-4′-methoxydiphenylamine m. 124-5°; p-ethoxyphenylurea, 4-N-dimethylsulfonamido-2-nitro-4′-ethoxydiphenylamine m. 126-7°; methylurea, 4-sulfonamido-2-nitrophenylmethylamine m. 212-13°; dimethylurea, 4-sulfonamido-2-nitrophenyldimethylamine m. 147-8°; methylurea, 4-phenylsulfonyl-2-nitrophenylmethylamine m. 154-5°; dimethylurea, 4-phenylsulfonyl-2-nitrophenyldimethylamine m. 104-5°; phenylurea, 4-phenylsulfonyl-2-nitrodiphenylamine m. 147-8°; p-anisylurea, 4-phenylsulfonyl-2-nitro-4′-methoxydiphenylamine m. 153-4°; p-ethoxyphenylurea, 4-phenylsulfonyl-2-nitro-4′-ethoxydiphenylamine m. 139-40°; methylurea, 4-benzylsulfonyl-2-nitrophenylmethylamine m. 182-3°; dimethylurea, 4-benzylsulfonyl-2-nitrophenyldimethylamine m. 121.5-2.5°; phenylurea, 4-benzylsulfonyl-2-nitrodiphenylamine m. 182.5-3°; p-anisylurea, 4-benzylsulfonyl-2-nitro-4′-methoxydiphenylamine m. 185-6°; p-ethoxyphenylurea, 4-benzylsulfonyl-2-nitro-4′-ethoxydiphenylamine m. 162.5-3.5°; dimethylurea, 2-N-methylsulfonamido-4-nitrophenyldimethylamine m. 127-8°. p-Phenetidine and 4-chloro-3-nitrophenyl methyl sulfone fused as above gave product, m. 130-1°, identical with 4-methylsulfonyl-2-nitro-4′-ethoxydiphenylamine shown above. 4-N-Dimethylsulfonamido-2-nitrophenyldimethylamine, m. 103-4°, was also prepared according to Eliel and Nelson (CA 50, 11965c); E. and N. reported 182-3°. Yields of the above amines are best with 1:4 reactant ratio; equimolar mixtures gave lower yields. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Name: 3-Nitro-4-chlorobenzenesulfonamide

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Name: 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bourdais, Jacques; Meyer, Francois published an article in 1961, the title of the article was 1,3-Benzenedisulfonamides as carbonic anhydrase inhibitors.SDS of cas: 97-09-6 And the article contains the following content:

4,5,6-XYZC6H(SO2Cl)2 (I) were prepared from the appropriate benzene derivatives and ClSO3H, and converted to the corresponding diamides (II) by boiling with concentrated aqueous NH3. The following I were prepared (X, Y, Z, % yield, and m.p. given): Me, H, H, 85, 52°; H, COCl, H, 51, 90; OH, Me, H, 47, 85-6°; Cl, Me, H, 45, 78°; Me, H, Cl, 64, 122-5°; Cl, H, Cl, 75, 122-3°; Cl, H, F, 36, 105°; Cl, Me, Cl, 41, 163-4°; Cl, Cl, Cl, 31, 178°. II prepared were (X, Y, Z, % yield, m.p., pK1 and pK2 determined in H2O + 15% MeOH at 20°, and carbonic anhydrase inhibitory activity relative to 1.0 for 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide given): Me, H, H, 57, 189°, 9.3, 10.3, 0.33; CO2H (by KMnO4 oxidation of the corresponding Me compound), H, H, 22, 283°, 9.51, 10.66, 0.025; H, CONH2, H, 85, -, 8.93, 10.02, 0.33; Cl, Me, H, 36, 235°, 8.97, 10.14, 0.25; Me, H, Cl, 31, 247°, 8.98, 10.1, 0.63; Cl, H, Cl, 53, 265°, 8.52, 9.78, 1.67; Cl, H, F, 38, 229°, 8.55, 9.76, 1.0; NH2, H, Cl, 64, 254-5°, 9.34, 10.36, 0.025; Cl, Me, Cl, 39, 296-7°, 8.80, 9.98, 0.125; Cl, Cl, Cl, 30, 295°, 8.73, 9.51, 2.0; NH2, Me, Cl, 64, 282-3°, -, -, -. Also prepared were (compound, % yield, m.p., pK1, pK2, and inhibitory activity as above): 4,3,1-Cl(O2N)C6H3SO2Cl, 92, 56, -, -, -; 4,3,1-Cl(O2N)C6H3SO2NH2, 64, 176°, 9.18, -, 0.33; 1,3,4,6-Cl2C6H2(SO2NHMe)2, 51, 186°, 9.83, 10.63, 0.025. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. SDS of cas: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Somasekhara, S.; Trivedi, B. S.; Mukherjee, S. L. published an article in 1965, the title of the article was Sulfonation of 2-hydroxybenzimidazoles.Recommanded Product: 97-09-6 And the article contains the following content:

2-Hydroxybenzimidazole (1.5 g.), 2 g. NaCl, and 9 ml. ClSO3H was heated 4 hrs. at 130-40° to yield crude 5-chlorosulfonyl-2-hydroxybenzimidazole, which was treated with 20 ml. NH3 to yield 5-sulfamoyl-2-hydroxybenzimidazole (I), m. 325-8° (decomposition) (EtOH). Similarly, 4 g. 6-chloro-2-hydroxybenzimidazole, 4 g. NaCl, and 16 ml. ClSO2OH was heated 4 hrs. at 140-50°. Treatment of the crude 6-chloro-5-chlorosulfonyl-2-hydroxybenzimidazole thus obtained with 20 ml. NH3 yielded 6-chloro-5-sulfamoyl-2-hydroxybenzimidazole, m. 301-3° (EtOH). I was also prepared as follows: 2-Nitrochlorobenzene (31.5 g.), 5.83 g. NaCl, and 93 g. ClSO3H was heated 5 hrs. at 140-50° to yield 4-chlorosulfamoyl-2-nitrochlorobenzene as a gray powder, which was treated with 50 ml. NH3. The resulting solution was clarified (C) and acidified with HOAc (pH 5.5) to obtain 15 g. 4-sulfamoyl-2-nitrochlorobenzene (II), m. 172-3° (EtOH). II (2 g.) and 4 ml. NH3 was heated 4 hrs. at 110-20° in a sealed tube to yield 4-sulfamoyl-2-nitroaniline (III), m. 204-5° (EtOH). III (1 g.) was refluxed 4 hrs. in 100 ml. 5% aqueous HOAc containing 4 g. Zn dust to yield 4-sulfamoyl-2-aminoaniline (IV), m. 165-7° (EtOH). IV (1 g.) and 2 g. urea sulfate was heated 4 hrs. at 150° in a sealed Pyrex glass tube to yield I, m. 318-21° (EtOH). The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 97-09-6

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Recommanded Product: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kulka, Marshall published an article in 1950, the title of the article was Derivatives of p-chlorobenzenesulfonic acid.Name: 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

In the manufacture of DDT from PhCl and Cl3CCHO (H2SO4 as condensing agent), p-ClC6H4SO3H is a byproduct; derivatives have been prepared to be tested as possible insecticides and fungicides. p-ClC6H4SO3Na (I) (335 g.) in 700 cc. CHCl3, treated (15 min.) with 370 g. ClSO3H at a rate to maintain a temperature of 60° and then heated 6 h. at 55-60°, gives 89% p-ClC6H4SO2Cl (II), b12 140°, m. 52-3°. FSO3H (200 g.) in an Al beaker, treated dropwise (3 h.) with 57 g. PhCl at 48-50° and stirred and heated an addnl. 4 h., gives 74% ClC6H4SO2F (III), m. 48-9°, and 2.5 g. (p-ClC6H4)2SO2, m. 146-7°. I (100 g.), 200 g. FSO3H, and 150 cc. CCl4, heated 24 h. at 70-5° and the acid layer heated and stirred another 24 h. with fresh CCl4, gives 85% III. III (50 g.), added (10 min.) to 125 cc. HNO3 (d. 1.5) and 50 cc. concentrated H2SO4 at 60° and heated and stirred 1.25 h. at 65°, gives 10 g. III and 67% 3-nitro-4-chlorobenzenesulfonyl fluoride, b17 165-6°, m. 51-2°; with liquid NH3 it gives 85% of the amide, m. 175-6°. III (100 g.), added to 300 g. Na2SO3 in 1000 cc. H2O at 70° and heated 5 h. at 70-80° and a few min. at 100°, gives 81% p-ClC6H4SO2H (IV), m. 98-9°; 1 mol. II, reduced at 55-60° with 2 1. 28.5% aqueous Na2SO3, gives 60% IV; 2 1. of a 31.5% solution gives 80% IV. The Na salt from 27 g. IV in 150 cc. hot EtOH and 35 g. 3,4-Cl2C6H3CH2Cl, refluxed 8 h., gives 68% p-chlorophenyl 3,4-dichlorobenzyl sulfone, m. 135-6°; p-xylylene bis(p-chlorophenyl) disulfone, m. 335-7°, 78%. IV (72 g.) and 45 g. Na2CO3 in 900 cc. H2O, added to 61 g. Cl2CHCO2H and heated 44 h. on the steam bath, give 65% p-chlorophenyl chloromethyl sulfone, m. 120-1°. III (25 g.) and 35 cc. ClCH2CH2OH, treated with 7 g. NaOH and heated 3 h. at 20-5°, give 93% 2-chloroethyl p-chlorobenzenesulfonate, b13 197°, nD20 1.5465 (II gives 47%). III (13 g.), 10 g. Cl3CCH2OH, 3 g. NaOH, and 40 cc. ether, kept 3 h. at 22-5°, give 87% 2,2,2-trichloroethyl p-chlorobenzenesulfonate, m. 73-4° (63% from II and Cl3CCH2OH on refluxing 8 h.). III and HOCH(CH2Cl)2 give 25% 1,3-dichloro-2-Pr p-chlorobenzenesulfonate (V), b14 190-200°, m. 53-4°. II (106 g.) in 50 cc. C5H5N, treated with 28 g. HOCH2CH(OH)CH2Cl (VI) (temperature below 100°) and heated 1 h. on the steam bath, give 38 g. V and 9 g. ClCH(CH2Cl)2. II (106 g.) in 50 cc. C5H5N, treated (15 min.) with 28 g. VI at 25-35°, stirred 0.5 h. at 30-5° and kept 4 h. at room temperature, give 84% 3-chloropropylene bis(p-chlorobenzenesulfonate) (VII), m. 66-7°; VII and II in C5H5N at 100° give a mixture of VI and ClCH(CH2Cl)2. 2,4-Cl2C6H3OH (16.3 g.) and 4 g. NaOH in 40 cc. H2O, treated with 19.5 g. III and heated 2 h. at 50-60°, give 85% 2,4-dichlorophenyl p-chlorobenzenesulfonate, m. 119-20°. ClCH2CH2OH (20 cc.) and 50 g. 3,4-Cl2C6H3SO2Cl (VIII), treated dropwise (0.5 h.) with 17 g. C5H5N at 10-15°, stirred an addnl. hr. at 10-15°, and kept 2 h. at 5°, give 81% 2-chloroethyl 3,4-dichlorobenzenesulfonate (IX), m. 69-70°. VIII and excess ClCH2CH2OH on refluxing give a poor yield of IX. p-ClC6H4SO2NHCH2CH2OH (X) (5 g.) and 10 g. SOCl2, refluxed 2 h., give 2 g. N-(2-chloroethyl)-p-chlorobenzenesulfonamide, m. 152-3°. II (1 mol.) in CHCl3, treated dropwise with 1 mol. amine at a temperature below 40° and then with 1 mol. aqueous NaOH, and stirred an addnl. 0.5 h., gives a nearly quant. yield of the following p-chlorobenzenesulfonamides: N,N-di-Me, m. 79-80°; N,N-di-Et, m. 37-8°; N-iso-Pr, m. 85-6°; N-Bu, m. 50-1°; X, m. 104-5°. 4-(p-Chlorophenylsulfonyl) morpholine, m. 148-9°; N,N’-bis (p-chlorophenyl-sulfonyl)-1,2-diaminopropane, m. 141-2°. II (50 g.) and a trace of Fe2(SO4)3, treated 1 h. with Cl at 175-80°, gives 63% p-C6H4Cl2 and 4 g. 1,2,3,5-C6H2Cl4. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Name: 3-Nitro-4-chlorobenzenesulfonamide

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Name: 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chakravarti, R. N.; Dasgupta, B. published an article in 1958, the title of the article was Ultraviolet absorption spectra of aegelin and its derivatives.Category: amides-buliding-blocks And the article contains the following content:

A study of the spectra of aegelin (I), aegelone (II), dihydroaegelin (III), dihydroaegelone (IV) and of related simpler compounds is presented. Absolute alc. was used as a solvent in all cases except with ω-amino-p-methoxyacetophenone-HSO4 (V) with which H2O was used. Concentrations of 2-5 mg./1000 cc. were used. I shows absorption maximum at 212 (log ε 4.36), 219 (log ε 4.36), and 275 mμ (log ε 4.42). I gives trans-cinnamic acid (VI) on hydrolysis and comparison of the spectra of I, VI, trans-cinnamide, and trans-N-methylcinnamide confirmed the trans configuration of the cinnamoyl grouping in I. Other maximum and log ε values obtained were: II, 280, 4.67; V, 216-19, 4.05; 282, 4.27; III, 220, 4.22; 274, 3.78; IV, 271, 4.30. Values obtained for min. and log ε were: I, 216, 4.32; 236, 3.78; 237, 3.78; II, 2.33, 3.95; V, 217, 4.20; III, 217, 4.20; 239, 3.49; 240, 3.49; IV, 233, 3.46; 235, 3.46. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dasgupta, B.; Chakravarti, R. N. published an article in 1958, the title of the article was Isolation of Aegelin.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

cf. C.A. 51, 7328a. A modified method is described for the isolation of aegelin, N-[2-hydroxy-2-(p-methoxyphenyl)ethyl]cinnamamide (I), by extraction of Aegle marmelus Correa leaves. The leaves, 7 kg., were extracted by cold percolation with fresh 90% alc. on 6 alternate days. After distilling off the alc., the residues from 2 extractions were combined, absorbed on filter paper, dried at 80°, and extracted with Et2O in a 5-l. Soxhlet. Overconcn. in the initial extractions was prevented by funnelling Et2O between the thimble and Soxhlet wall. The extract was concentrated to 1.5 l. and refrigerated for 1 week. The precipitate was filtered off, washed with ether, recrystallized from EtOAc, dissolved in absolute alc., and refluxed 1 hr. with activated C. The solution was filtered hot and concentrated to yield I, thin colorless plates, m. 174-5°. A gel occasionally formed in the final alc. solution which could be removed by addition of excess cold alc. and filtration. Passage of alc. solution of I through Al2O3 removed the green color of some batches not decolorized by C and gave purest I, m. 178-9°. Yield of I from dried leaves is negligible during the winter and is maximum (0.2%) during June to Aug. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics