Month: November 2022

Ionescu, Maria; Panea, Ioan published an article in 1967, the title of the article was Infrared spectra of some sulfamides.Synthetic Route of 97-09-6 And the article contains the following content:

A series of sulfamides were pelletized with KBr (1:300 mg./mg.), and the ir spectra were determined The data were tabulated for the bands corresponding to νs–…C, νs–…N, νs–…O, and The first 3 bands at 1090, 1050, and 1030 cm.-1, resp., are present in the spectra of the arylsulfamides in the 1100-1000-cm.-1 range, in addition to the bands corresponding to the νβ-CH of the substituted benzene nucleus. In many cases, these bands coupled with each other or with addnl. bands. The band at 913 cm.-1 in I was used for quant. anal. The ir spectrum of the equimol. mixture of I and its isomer showed that it was additive, each vibration (even of the same bond but in different connection) manifesting its presence by a corresponding maximum Determinations, by using various amounts of I and II and measuring the extinction by the base line method, verified the rectilinear correlation between extinction and concentration of I, when the latter is >90%, but if it is <60% the error is >>2.8%. 16 references. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Synthetic Route of 97-09-6

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Synthetic Route of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dykhanov, N. N.; Ryzhkova, T. S.; Khaletskii, A. M. published an article in 1967, the title of the article was Ammonolysis of isomeric chlorobenzensulfonamides.Application of 97-09-6 And the article contains the following content:

Heating o-ClC6H4SO2NH2 (I) with 15 moles NH3 (as 30% solution in water) to 200° in the absence of catalysts failed to give any reaction. However, in the presence of Cu2O, ammonolysis took place at 145-50° to give 5-6% o-H2NC6H4SO2NH2 (II) and a polymeric mass (III). Hydrolysis of III with 40% H2SO4 gave o-H2NC6H4SO3H and II. Presence of an alkyl substituent on the amino group of I prevents the formation of a polymer. Thus, ammonolysis of o-ClC6H4SO2NHMe in the presence of Cu+ at 155-60° gave ∼80% o-H2NC6H4SO2NHMe. Also ammonolysis of m-ClC6H4SO2NH2 gave ∼80% m-H2NC6H4SO2NH2 and no polymer. Formation of II was explained by postulating the existence of an intermediate Cu+ complex of the average composition [ClC6H4SO2NH2.CuCl.2H2O],which at 200° nearly instantaneously decompose to III. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Application of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 9, 2022, Itelman, Edward; Vatury, Ori; Kuperstein, Rafael; Ben-Zekry, Sagit; Hay, Ilan; Fefer, Paul; Barbash, Israel; Klempfner, Robert; Segev, Amit; Feinberg, Micha; Guetta, Victor; Maor, Elad published an article.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was The Association of Severe Tricuspid Regurgitation with Poor Survival Is Modified by Right Ventricular Pressure and Function: Insights from SHEBAHEART Big Data.. And the article contained the following:

BACKGROUND: Contemporary data on the independent association of severe tricuspid regurgitation (TR) with excess mortality are needed. The aims of this study were to describe contemporary outcomes of patients with severe TR and to identify outcome modifiers. METHODS: Consecutive echocardiographic reports linked to clinical data from the largest medical center in Israel (2007-2019) were reviewed. The primary outcome was all-cause mortality. Cox regression and propensity score matching models were applied. RESULTS: The final cohort included 97,096 patients. Mild, moderate, and severe TR was documented in 27,147 (28%), 2,844 (3%) and 1,805 (2%) patients, respectively. During a median follow-up period of 5 years (interquartile range, 2-8 years), 22,170 patients (23%) died. Kaplan-Meier survival analysis demonstrated an increased risk for death with an increasing degree of TR (log-rank P < .001). Propensity score matching of 1,265 patients with severe TR and matched control subjects showed that compared with those with nonsevere TR, patients with severe TR were 17% more likely to die (95% CI, 1.05-1.29; P = .003). The association of severe TR with survival was dependent on estimated right ventricular (RV) pressure, with a more pronounced effect among patients with estimated systolic pressure ≤ 40 mm Hg (hazard ratio, 2.12 vs 1.04; P for interaction < .001). A landmark subanalysis of 17,967 patients demonstrated that RV function deterioration on follow-up echocardiography modified the association of severe TR with survival. It was more significant among patients with preserved and stable RV function (P for interaction = .035). CONCLUSIONS: The outcome of severe TR is modified by RV pressure and function. Once RV function deteriorates, differences in the outcomes of patients with and without severe TR are less pronounced. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 15, 2021, Murphy, EmmaRae L.; Joy, Andrew P.; Ouellette, Rodney J.; Barnett, David A. published an article.Formula: C2H4ClNO The title of the article was Optimization of cysteine residue alkylation using an on-line LC-MS strategy: Benefits of using a cocktail of haloacetamide reagents. And the article contained the following:

Several common reagents for the alkylation of cysteine residues of model intact proteins were evaluated for reaction speed, yield of alkylated product and degree of over-alkylation using an online LC-MS platform. The efficiency of the alkylation reaction is found to be dependent on the (1) reagent, (2) peptide/protein, (3) reagent concentration and (4) reaction time. At high reagent concentrations, iodoacetic acid was found to produce significant levels of over-alkylation products wherein methionine residues become modified. For optimal performance of the alkylation reaction, we found the use of a cocktail of chloroacetamide, bromoacetamide and iodoacetamide worked best. The alkylating efficiency of each haloacetamide is a balance between the characteristics of the halogen leaving group and the steric hindrance of the alkylation site on the peptide or protein. A key aspect of using a cocktail of haloacetamides is that they all produce the same modification (+57.0209 Da) to the cysteine residues of the protein while the alkylation efficiency of each site may differ for each of the three reagents. Over-alkylation effects appear to be lower with the cocktail due to a lower concentration of each reagent. The haloacetamide cocktail could be useful when considering complex mixtures of proteins. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to alkylation, kinetics, liquid chromatography and quadrupole-orbitrap mass spectrometer, protein, acetamides: chemistry, alkylation, chromatography, liquid, cysteine: chemistry, iodoacetamide: chemistry, proteins: chemistry, tandem mass spectrometry and other aspects.Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 24, 2019, Wyss, Thomas; Roos, Lilian; Studer, Fabian; Mäder, Urs; Beuchat, Christiane; Staub, Kaspar published an article.Computed Properties of 456-12-2 The title of the article was Development of physical fitness performance in young Swiss men from 2006 to 2015.. And the article contained the following:

From 1980 to 2000, physical fitness decreased and body mass index (BMI) increased in the population of many industrialized countries. Little is known about these trends after the year 2000. This study aimed to investigate physical fitness performance, physical activity (PA) behavior, and BMI of young, male Swiss adults between 2006 and 2015. For this purpose, results from the Swiss Armed Forces mandatory recruitment were used. A total of 306 746 male conscripts provided complete fitness test data, mean ± SD (range from 5th to 95th percentile): 20 ± 1 (18-21) years, 178 ± 7 (168-189) cm; 74 ± 13 (58-97) kg, predicted maximal oxygen consumption of 49.9 ± 4.6 (41.8-56.9) mL/kg/min (Conconi test), 125 ± 58 (43-232) seconds in trunk muscle strength test (prone bridge), 2.31 ± 0.24 (1.90-2.66) m in standing long jump, 6.46 ± 0.73 (5.30-7.70) m in seated shot put (2 kg medical-ball shot) and 45.6 ± 12.2 (29.9-66.7) seconds in one-leg standing test (sum of both legs; eyes closed after 10 seconds and head tilted back after 20 seconds). In the investigated population, 73.8% fulfilled basic PA recommendations, 46.2% were classified as regularly vigorously active. Performances in aerobic endurance and muscle power did not show secular changes over time. However, core stability performance and PA behavior increased, while balance ability decreased over this 10-year period. Average BMI increased by 2.0% between 2006 and 2010 and did not change thereafter. Male Swiss adults are at least as physically fit as they were a decade ago. The secular trends of decreasing physical performances and increasing BMI have stopped, and self-reported sport participation and leisure time PA have been increased in the observed population over the last 10 years. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Computed Properties of 456-12-2

The Article related to adolescent, body mass index, exercise test, humans, linear models, male, military personnel, muscle strength, oxygen consumption, physical endurance, physical fitness, switzerland: geographic, young adult and other aspects.Computed Properties of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Prothiwa, Michaela; Bottcher, Thomas published an article in 2020, the title of the article was Competitive profiling for enzyme inhibitors using chemical probes.Name: 2-Chloroacetamide And the article contains the following content:

Enzyme inhibitors are central tools for chem. biol. In this chapter we will discuss the application of chem. probes for competitive profiling of inhibitors of the quinolone biosynthesis enzyme PqsD of Pseudomonas aeruginosa. The human pathogen P. aeruginosa produces a large diversity of 2-alkyl-4(JH)-quinolones and their derivatives as metabolites with major roles in quorum sensing, virulence, and interspecies competition. PqsD is a central enzyme in the biosynthesis of all ofthese quinolones and hence an interesting target for inhibitor discovery. Aaivity-based probes with an elearophilic warhead bind covalently to aaive site nucleophiles like cysteine or serine. An α-chloroacetamide probe with terminal alkyne tag allowed to selectively label the aaive site cysteine of PqsD and was demonstrated to be a useful tool for inhibitor discovery using competition experiments Potent inhibitors bind to the aaive site and thereby prevent labeling ofthe enzyme by the probe. Labeling intensity is quantified. on polyacrylamide gels by the fluorescence of a reporter tag appended by bioorthogonal click chem. The competitive inhibitor profiling strategy has many advantages over traditional screening approaches and is applicable in vitro as well as in live cells. Here we describe the synthesis of an activity-based probe and provide our detailed protocols for target enzyme labeling as well as its application for the screening for potent enzyme inhibitors of PqsD by a competitive profiling strategy. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Name: 2-Chloroacetamide

The Article related to acetamides: chemistry, bacterial proteins: antagonists & inhibitors, bacterial proteins: biosynthesis, bacterial proteins: genetics, binding, competitive, catalytic domain, click chemistry: methods, electrophoresis, polyacrylamide gel: methods, enzyme inhibitors: chemistry, enzyme inhibitors: pharmacology and other aspects.Name: 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Klontz, Karl C; DeBeck, Heidi J; LeBlanc, Pamela; Mogen, Kathryn M; Wolpert, Beverly J; Sabo, Jonathan L; Salter, Monique; Seelman, Sharon L; Lance, Susan E; Monahan, Caitlin; Steigman, David S; Gensheimer, Kathleen published an article in 2015, the title of the article was The Role of Adverse Event Reporting in the FDA Response to a Multistate Outbreak of Liver Disease Associated with a Dietary Supplement..Formula: C18H19NO3 And the article contains the following content:

OBJECTIVE: Liver disease is a potential complication from using dietary supplements. This study investigated an outbreak of non-viral liver disease associated with the use of OxyELITE Pro(TM), a dietary supplement used for weight loss and/or muscle building. METHODS: Illness details were ascertained from MedWatch reports submitted to the U.S. Food and Drug Administration (FDA) describing consumers who ingested OxyELITE Pro alone or in combination with other dietary supplements. FDA’s Forensic Chemistry Center analyzed samples of OxyELITE Pro. RESULTS: From February 2012 to February 2014, FDA received 114 reports of adverse events of all kinds involving consumers who ingested OxyELITE Pro. The onset of illness for the first report was December 2010 and for the last report was January 2014. Thirty-three states, two foreign nations, and Puerto Rico submitted reports. Fifty-five of the reports (48%) described liver disease in the absence of viral infection, gallbladder disease, autoimmune disease, or other known causes of liver damage. A total of 33 (60%) of these patients were hospitalized, and three underwent liver transplantation. In early 2013, OxyELITE Pro products entered the market with a formulation distinct from products sold previously. The new formulation replaced 1,3-dimethylamylamine with aegeline. However, the manufacturer failed to submit to FDA a required “new dietary ingredient” notice for the use of aegeline in OxyELITE Pro products. Laboratory analysis identified no drugs, poisons, pharmaceuticals, toxic metals, usnic acid, N-Nitroso-fenfluramine, pyrrolizidine alkaloids, aristocholic acid, or phenethylamines in the products. CONCLUSIONS: Vigilant surveillance is required for adverse events linked to the use of dietary supplements. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Formula: C18H19NO3

The Article related to adult, adverse drug reaction reporting systems: legislation & jurisprudence, amides: poisoning, amines: poisoning, anti-obesity agents: poisoning, chemical and drug induced liver injury: epidemiology, chemical and drug induced liver injury: etiology, chemical and drug induced liver injury: surgery, chemistry and other aspects.Formula: C18H19NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 15, 2013, Karmase, Aniket; Jagtap, Sneha; Bhutani, Kamlesh K published an article.Category: amides-buliding-blocks The title of the article was Anti adipogenic activity of Aegle marmelos Correa.. And the article contained the following:

In continuation of evaluating the anti-obesity effect of Aegle marmelos, we have screened the n-hexane, dichloro methane (DCM), ethyl acetate (EtOAc) and methanol (MeOH) extracts of the leaves at the concentration of 25, 50, 75 and 100 μg/ml for adipogenesis inhibition in the adipocytes. Nile red staining with the help of fluorometry was used as indicator of the antiobesity activity. The most active DCM extract showed the 33.98±3.55% lipid content at 100μg/ml and was selected for the further isolation. 14 compounds were isolated from DCM extract of A. marmelos leaves. The compounds were screened for the adipogenesis inhibition at 50 and 100 μM concentrations. Out of the 14 compounds, halfordinol, ethyl ether aegeline and esculetin were showing 10.04±0.52, 16.29±0.85 and 25.09±1.31% lipid content respectively at 100 μM. We hereby report the adipogenesis inhibition by A. marmelos as one of the pathway for its antiobesity effect. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to 3t3-l1 cells, adipogenesis: drug effects, adipose tissue: cytology, adipose tissue: drug effects, adipose tissue: metabolism, aegle: chemistry, amides: isolation & purification, amides: pharmacology, animals, anti-obesity agents: pharmacology, lipid metabolism: drug effects, mice, obesity: prevention & control and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Singh, Abhilasha; Srinivasan, Ashok Kumar; Chakrapani, Lakshmi Narasimhan; Kalaiselvi, Periandavan published an article in 2019, the title of the article was LOX-1, the common therapeutic target in hypercholesterolemia: a new perspective of antiatherosclerotic action of aegeline.Related Products of 456-12-2 And the article contains the following content:

Background. Lectin-like oxidized low-d. lipoprotein receptor-1 (LOX-1) is the major receptor for oxidized low-d. lipoprotein (Ox-LDL) in the aorta of aged rats. Ox-LDL initiates LOX-1 activation in the endothelium of lipid-accumulating sites of both animal and human subjects of hypercholesterolemia. Targeting LOX-1 may provide a novel diagnostic strategy towards hypercholesterolemia and vascular diseases. Hypothesis. This study was planned to address whether aegeline (AG) could bind to LOX-1 with a higher affinity and modulate the uptake of Ox-LDL in hypercholesterolemia. Study Design. Thirty-six Wistar rats were divided into six groups. The pathol. group rats were fed with high-cholesterol diet (HCD) for 45 days, and the treatment group rats were fed with HCD and aegeline/atorvastatin (AV) for the last 30 days. In vivo and in vitro experiments were carried out to assay the markers of atherosclerosis like Ox-LDL and LOX-1 levels. Histopathol. examination was performed. Oil Red O staining was carried out in the IC-21 cell line. Docking studies were performed. Results. AG administration effectively brought down the lipid levels induced by HCD. The lowered levels of Ox-LDL and LOX-1 in AG-administered rats deem it to be a potent antihypercholesterolemic agent. Compared to AV, AG had a pronounced effect in downregulating the expression of lipids evidenced by Oil Red O staining. AG binds with LOX-1 at a higher affinity validated by docking. Conclusion. This study validates AG to be an effective stratagem in bringing down the lipid stress induced by HCD and can be deemed as an antihypercholesterolemic agent. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Related Products of 456-12-2

The Article related to amides: metabolism, amides: therapeutic use, animals, anticholesteremic agents: therapeutic use, atherosclerosis: drug therapy, atorvastatin: therapeutic use, cell line, diet, high-fat, disease models, animal, humans, hypercholesterolemia: drug therapy, hypercholesterolemia: metabolism, lipoproteins, ldl: metabolism and other aspects.Related Products of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2021, Bogdanovic, Aleksandra; Lazic, Anita; Grujic, Slavica; Dimkic, Ivica; Stankovic, Slavisa; Petrovic, Slobodan published an article.Safety of 2-Chloroacetamide The title of the article was Characterisation of twelve newly synthesised N-(substituted phenyl)-2-chloroacetamides with QSAR analysis and antimicrobial activity tests. And the article contained the following:

In this study we screened twelve newly synthesized N-(substituted phenyl)-2-chloroacetamides for antimicrobial potential relying on quant. structure-activity relationship (QSAR) anal. based on the available cheminformatics prediction models (Molinspiration, SwissADME, PreADMET, and PkcSM) and verified it through standard antimicrobial testing against Escherichia coli, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), and Candida albicans. Our compounds met all the screening criteria of Lipinski’s rule of five (Ro5) as well as Veber’s and Egan’s methods for predicting biol. activity. In antimicrobial activity tests, all chloroacetamides were effective against Gram-pos. S. aureus and MRSA, less effective against the Gram-neg. E. coli, and moderately effective against the yeast C. albicans. Our study confirmed that the biol. activity of chloroacetamides varied with the position of substituents bound to the Ph ring, which explains why some mols. were more effective against Gram-neg. than Gram-pos. bacteria or C. albicans. Bearing the halogenated p-substituted Ph ring, N-(4-chlorophenyl), N-(4-fluorophenyl), and N-(3-bromophenyl) chloroacetamides were among the most active thanks to high lipophilicity, which allows them to pass rapidly through the phospholipid bilayer of the cell membrane. They are the most promising compounds for further investigation, particularly against Gram-pos. bacteria and pathogenic yeasts. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Safety of 2-Chloroacetamide

The Article related to n-substituted amides, antimicrobial potential, quantitative analysis of chemical structure and activity relationship, and other aspects.Safety of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics