Month: November 2022

Lutskii, A. E.; Volchenok, S. A.; Kanevskaya, Z. M.; Sheina, G. G. published an article in 1970, the title of the article was Electron-vibrational spectra of trisubstituted benzenes.Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

The energies Emax.(eV), the frequencies νmax.-(cm-1), logεmax.and oscillator strength f of the absorption bands of πR → πR*, πR → πA-*, and nD →A-* transitions (where R = benzene ring, A = electron acceptor substituent, D = electron-donor substituent) of 30 trisubstituted benzene derivatives in hexane and EtOH solutions were calculated from uv spectral curves. The data are discussed. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide

The Article related to benzenes trisubstituted spectra, electronic spectra benzenes trisubstituted, vibrational spectra benzenes trisubstituted, and other aspects.Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

King, Rodney William; Burgen, Arnold S. V. published an article in 1970, the title of the article was Sulfonamide complexes of human carbonic anhydrases ultraviolet difference spectroscopy.Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

Uv difference spectra are generated when human carbonic anhydrases B or C form complexes with aromatic sulfonamides. Difference spectra obtained using a variety of ring-substituted benzene sulfonamides show certain constant features; a broad peak, λmax 294-299 nm, a trough at 290-291 nm, a peak at 285-287 nm, and a peak at 232-234 nm. All the spectra obtained had other features, varying from sulfonamide to sulfonamide, not normally associated with protein perturbation difference spectra. A pH study using p-nitrobenzene sulfonamide has shown that these addnl. features may be accounted for by the dissociation of a proton from the amido group of the sulfonamide, causing changes in the uv absorption of the sulfonamide on formation of the complex. These results indicate that a conformational change takes place in the enzyme on binding the sulfonamide, exposing aromatic residues to the solvent, and that in the complex the sulfonamide is in the anionic state. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide

The Article related to carbonic anhydrases sulfonamides, anhydrases carbonic sulfonamides, sulfonamides carbonic anhydrases, uv spectra carbonic anhydrases, and other aspects.Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2018, Rajan, Sujith; Satish, Sabbu; Shankar, Kripa; Pandeti, Sukanya; Varshney, Salil; Srivastava, Ankita; Kumar, Durgesh; Gupta, Abhishek; Gupta, Sanchita; Choudhary, Rakhi; Balaramnavar, Vishal M.; Narender, Tadigoppula; Gaikwad, Anil N. published an article.Safety of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Aegeline inspired synthesis of novel β3-AR agonist improves insulin sensitivity in vitro and in vivo models of insulin resistance. And the article contained the following:

In our drug discovery program of natural product, earlier we have reported Aegeline that is N-acylated-1-amino-2- alc., which was isolated from the leaves of Aeglemarmelos showed anti-hyperlipidemic activity for which the QSAR studies predicted the compound to be the β3-AR agonist, but the mechanism of its action was not elucidated. In our present study, we have evaluated the β3-AR activity of novel N-acyl-1-amino-3-arylopropanol synthetic mimics of aegeline and its beneficial effect in insulin resistance. In this study, we have proposed the novel pharmacophore model using reported mols. for antihyperlipidemic activity. The reported pharmacophore features were also compared with the newly developed pharmacophore model for the observed biol. activity. Based on 3D pharmacophore modeling of known β3AR agonist, we screened 20 synthetic derivatives of Aegeline from the literature. From these, the top scoring compound 10C was used for further studies. The in-slico result was further validated in HEK293T cells co-trransfected with human β3-AR and CRE-Luciferase reporter plasmid for β3-AR activity. The most active compound was selected and β3-AR activity was further validated in white and brown adipocytes differentiated from human mesenchymal stem cells (hMSCs). Insulin resistance model developed in hMSC derived adipocytes was used to study the insulin sensitizing property. 8week HFD fed C57BL6 mice was given 50mg/Kg of the selected compound and metabolic phenotyping was done to evaluate its anti-diabetic effect. As predicted by in-silico 3D pharmacophore modeling, the compound 10C was found to be the most active and specific β3-AR agonist with EC50 value of 447nM. The compound 10C activated β3AR pathway, induced lipolysis, fatty acid oxidation and increased oxygen consumption rate (OCR) in human adipocytes. Compound 10C induced expression of brown adipocytes specific markers and reverted chronic insulin induced insulin resistance in white adipocytes. The compound 10C also improved insulin sensitivity and glucose tolerance in 8week HFD fed C57BL6 mice. This study enlightens the use of in vitro insulin resistance model close to human physiol. to elucidates the insulin sensitizing activity of the compound 10C and edifies the use of β3AR agonist as therapeutic interventions for insulin resistance and type 2 diabetes. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Safety of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegeline beta3 adrenergic receptor agonist insulin sensitivity resistance, browning, insulin resistance, hmsc derived adipocytes, β3-ar agonist, and other aspects.Safety of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lutskii, A. E.; Obukhova, E. M.; Kochergina, L. A. published an article in 1969, the title of the article was Dipole moments of some trisubstituted benzenes.Category: amides-buliding-blocks And the article contains the following content:

Dipole moments were calculated by a simplified formula from the dipole moments of the corresponding mono- and di-substituted benzenes. The data are tabulated for 16 1,2,4-trisubstituted compounds The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Category: amides-buliding-blocks

The Article related to dipole moment calculated, benzenes dipole moment, dipole moment and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kaiser, Emil Thomas; Lo, Kwok-Wing published an article in 1969, the title of the article was Carbonic anhydrase catalyzed hydrolysis of 2-hydroxy-5-nitro-α-toluenesulfonic acid sultone.Application of 97-09-6 And the article contains the following content:

An ionizable group in bovine carbonic anhydrase (BCA) with a pK of 7.3 appears to be involved in the enzyme-catalyzed hydrolysis of 2-hydroxy-5-nitro-α-toluenesulfonic acid sultone (I). Similar observations have been reported previously for the pH-rate behavior of the BCA-catalyzed hydration of CO2, hydration of carbonyl compounds, and hydrolysis of nitrophenyl esters of carboxylic acids. The BCA-catalyzed hydrolysis of I is subject to sulfonamide inhibition as are the other reactions mentioned above. Also, human carbonic anhydrases B and C have been demonstrated to be effective catalysts for the hydrolysis of I. On the basis of observations taken in conjunction with those of other investigations, it is proposed that a Zn-bound hydroxide ion is the active catalytic species in carbonic anhydrase action, and a cyclic mechanism for the carbonic anhydrase catalyzed solvolysis of I, involving no net proton transfer to the solvent is suggested. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

The Article related to carbonic anhydrase, bovine carbonic anhydrase, catalytic species carbonic anhydrase, reaction kinetics and other aspects.Application of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kakeya, Nobuharu; Aoki, Masaru; Kamada, Akira; Yata, Noboru published an article in 1969, the title of the article was Biological activities of drugs. VI. Structure-activity relation of sulfonamide carbonic anhydrase inhibitors. 1.Application of 97-09-6 And the article contains the following content:

A study was made of the correlation of carbonic anhydrase inhibitory activity with the chem. structures of 19 derivatives of benzenesulfonamide and 3 heterocyclic sulfonamides, with reference to the physicochem. properties of the compounds A linear correlation was observed for Hammett’s σ factor against pKa, chem. shift of the sulfamoyl protons, and valence-force constant of the S:O bond. Inhibitory activity increased with a decrease of pKa, and with an increase of Hammett’s σ factor, chem. shift of the sulfamoyl protons, and the S:O valence-force constant of the sulfamoyl group. A close correlation was also found between the inhibitory activity and water solubility of the unionized mols. of benzenesulfonamides except for p-CH3NH and o-NO2 derivatives The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

The Article related to structure activity drug, sulfonamides biol activity, carbonic anhydrase inhibitor, enzyme inhibitor structure, benzenesulfonamides enzyme, sulfonamides role: biol (biological study) and other aspects.Application of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kakeya, Nobuharu; Yata, Noboru; Kamada, Akira; Aoki, Masaru published an article in 1969, the title of the article was Biological activities of drugs. VIII. Structure-activity relation of sulfonamide carbonic anhydrase inhibitors.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

Hansch-Fujita’s method was applied to a structure-activity anal. of 22 sulfonamide derivatives with an inhibitory activity against carbonic anhydrase. Electronic parameters such as Hammett’s σ factor, ΔpKa, Dppm and Δfr , and hydrophobic parameters such as π, πc and β were employed. ΔpKa, Δppm, Δfr, π, πc and β were derived from dissociation constant, NM R chem. shift of sulfamoyl protons, S:O valence-force constant, n-oc tyl alc.-H2O partition coefficient, CHCl3-H2O partition coefficient and association constant to albumin, resp. This anal. proved to be useful in predicting not only the activity of substituted benzenesulfonamides except o-substituted derivatives but also that of 1,3,4-thiadiazole-5-sulfonamide derivatives The activity of o-substituted derivatives was satisfactorily predicted with the use of polar parameter σ* and steric constant ES. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to sulfonamides carbonic anhydrase, carbonic anhydrase sulfonamides, structure activity antienzymes, activity structure antienzymes, antienzymes structure activity, sulfonamides role: biol (biological study) and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Xi; Zhang, Zhi; Zhang, Lu; Fan, Weiying; Yang, Chao; Li, Enhua; Du, Yun; Wang, Xuelei published an article in 2021, the title of the article was Inconsistent seasonal variation of antibiotics between surface water and groundwater in the Jianghan Plain: Risks and linkage to land uses.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide And the article contains the following content:

Antibiotics are widely used in humans and animals, but their transformation from surface water to groundwater and the impact of land uses on them remain unclear. In this study, 14 antibiotics were systematically surveyed in a complex agricultural area in Central China. Results indicated that the selected antibiotic concentrations in surface waters were higher in winter (average: 32.7 ng/L) than in summer (average: 17.9 ng/L), while the seasonal variation in groundwaters showed an opposite trend (2.2 ng/L in dry winter vs.8.0 ng/L in summer). Macrolides were the predominant antibiotics in this area, with a detected frequency of over 90%. A significant correlation between surface water and groundwater antibiotics was only observed in winter (R2=0.58). This study further confirmed the impact of land uses on these contaminants, with optimal buffer radii of 2500 m in winter and 500 m in summer. Risk assessment indicated that clarithromycin posed high risks in this area. Overall, this study identified the spatiotemporal variability of antibiotics in a typical agricultural area in Central China and revealed the impact of land uses on antibiotic pollution in aquatic environments. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to antibiotic surface water groundwater, antibiotic pollution, honghu lake, land use, optimal buffer, risk assessment, antibiotics, environmental risk assessment, groundwaters, nitrates role: pol (pollutant), occu (occurrence), ph, redox potential, surface waters, temperature, turbidity and other aspects.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Guo, Yaoguang; Liu, Zhiyuan; Lou, Xiaoyi; Fang, Changling; Wang, Pu; Wu, Genying; Guan, Jie published an article in 2021, the title of the article was Insights into antimicrobial agent sulfacetamide transformation during chlorination disinfection process in aquaculture water.Name: N-((4-Aminophenyl)sulfonyl)acetamide And the article contains the following content:

Antibiotic addition and chlorination are two common processes in fishery culture. Antibiotic residues not only pollute aquaculture water, but are also one of the potential precursors of disinfection byproducts (DBPs) during chlorination. The degradation kinetics, products identification and reaction mechanism of sulfacetamide (SFA), a new sulfonamides antibiotics, and potential formation of haloacetic acids (HAAs) in chlorination were explored. The results showed that the degradation of SFA followed pseudo first-order kinetic model, and chlorinating agent dose, pH of water, water temperature, NH4+, HCO3- and humic acid (HA) had various effects on the degradation of SFA and the yields of HAAs. The presence of Br- accelerated both the degradation rate of SFA and more formation of Br-DBPs. Through the identification of intermediate products, we proposed the transformation pathway of SFA during the chlorination disinfection process. Namely, in this NaClO disinfection system, the C-S bond between the sulfonyl group and benzene ring, and S-N bond between sulfonyl and acylamino of SFA were broken, and then the primary formed groups were further oxidized to produce intermediates, such as chloroanilines and chlorophenols. And then chlorophenols were subsequently chlorinated to form toxic HAAs. The present study might be of significance for the evaluation of effective degradation of SFA and potential production of halogenate-DBPs (H-DBPs) during the chlorination disinfection process in aquaculture water. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Name: N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to sulfacetamide chlorination disinfection degradation, Water: Analysis and other aspects.Name: N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2021, Low, Kyleyoung; Chai, Layching; Lee, Choonweng; Zhang, Gan; Zhang, Ruijie; Vahab, Vaezzadeh; Bong, Chuiwei published an article.Formula: C8H10N2O3S The title of the article was Prevalence and risk assessment of antibiotics in riverine estuarine waters of Larut and Sangga Besar River, Perak. And the article contained the following:

Abstract: Antibiotics released into the environment through anthropogenic activities exert selective pressure, driving bacteria towards increasing antimicrobial resistance. The prevalence of antibiotics and the ecol. risks posed in the riverine estuarine of Larut River and Sangga Besar River, which included wastewater effluents from hospital, zoo, and poultry slaughterhouse sources were investigated. Solid phase extraction (SPE) followed by high-performance liquid chromatog. tandem mass chromatog. (HPLC-MS/MS) were used to extract and quantify the antibiotic residues from 22 antibiotics belonging to six major antibiotic classes (sulfonamide, macrolide, fluoroquinolone, phenicol, trimethoprim, and tetracycline). Sixteen antibiotic residues were detected with concentrations ranging from limit of detection (LOD) to 1 262.3 ng/L. Fluoroquinolones and macrolides were the most frequently detected compounds Erythromycin, clarithromycin, and ofloxacin detected in hospital and zoo effluents posed a high risk to algae while tetracycline had low to medium ecol. risks toward all the relevant organisms from aquatic environments (algae, invertebrate Daphnia magna, and fish). The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Formula: C8H10N2O3S

The Article related to antibiotic risk assessment riverine estuarine water perak, Water: Analysis and other aspects.Formula: C8H10N2O3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics