Month: November 2022

On October 1, 2022, Lamaoui, Abderrahman; Karrat, Abdelhafid; Amine, Aziz published an article.Related Products of 144-80-9 The title of the article was Molecularly imprinted polymer integrated into paper-based analytical device for smartphone-based detection: Application for sulfamethoxazole. And the article contained the following:

In this work, we developed a paper-based anal. device (PAD) that utilizes molecularly imprinted polymer (MIP) as the biomimetic receptor and a very simple colorimetric assay combined with a smartphone readout. Sulfamethoxazole was used as a model analyte to evaluate the feasibility of the developed MIP-PAD. After the synthesis of MIP, its adsorption properties (isotherm, kinetic and thermodn.) were scrutinized. Thereafter, The MIP- PAD was fabricated through the vacuum-assisted deposition of MIP suspension onto porous paper forming a 7 mm diameter of MIP layer. The MIP-PAD was characterized by Fourier-transform IR spectroscopy and SEM. The sulfamethoxazole transforms into azo dye through a colorimetric reaction. The smartphone was utilized for the read-out of results. The LOD was 0.21 ppm. The proposed MIP-PAD showed high long-term stability. The determination of SMX was carried out in spiked tap and river water samples to evaluate the applicability of the proposed anal. strategy in real-world applications. The developed MIP-PAD would provide a new platform for real-time, selective, rapid, user-friendly, low-cost, portable, and straightforward colorimetric assays in environmental monitoring, public health, and food control. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Related Products of 144-80-9

The Article related to molecularly imprinted polymer smartphone sulfamethoxazole, Biochemical Methods: Apparatus and other aspects.Related Products of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Martinho, Nuno; Pires, Rita F.; Zloh, Mire; Bonifacio, Vasco D. B. published an article in 2021, the title of the article was Intrinsic acetamide brush-off by polyurea biodendrimers.Electric Literature of 685-91-6 And the article contains the following content:

The presence of genotoxic impurities in active pharmaceutical ingredients (APIs) is a major concern for the pharmaceutical industry. Acetamide is a common genotoxic byproduct found in synthetic routes of many APIs, mainly due to acetonitrile hydrolysis, and selective scavenging is a still a challenging task. Herein, as a proof-of-concept, we evaluate polyurea (PURE) biodendrimers as strategic nanopolymers to prepare safe drug nanoformulations from mixtures containing acetamide, using (S)-ibuprofen (IBF) as a model drug. Furthermore, computational mol. dynamics (MD) simulations were conducted to rationalize in vitro results and to identify the key intermol. interactions within mixtures Exptl. data were corroborated by MD simulations which showed that acetamide, IBF and carboxyfluorescein interactions with PURE biodendrimers are mostly at the surface. Also, PURE nanoformulations appear to be driven by hydrogen bonding, electrostatic and hydrophobic interactions. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Electric Literature of 685-91-6

The Article related to intrinsic acetamide nanoformulation polyurea biodendrimer, Pharmaceuticals: Pharmaceutics and other aspects.Electric Literature of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 2011, Mugabe, Clement; Matsui, Yoshiyuki; So, Alan I.; Gleave, Martin E.; Heller, Markus; Zeisser-Labouebe, Magali; Heller, Lindsay; Chafeeva, Irina; Brooks, Donald E.; Burt, Helen M. published an article.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was In vitro and in vivo evaluation of intravesical docetaxel loaded hydrophobically derivatized hyperbranched polyglycerols in an orthotopic model of bladder cancer. And the article contained the following:

The objective of this study was to evaluate the tolerability, to establish a dosing regimen, and to evaluate the efficacy of intravesical docetaxel (DTX) formulations in a mouse model of bladder cancer. DTX in com. formulation (Taxotere, DTX in Tween 80) or loaded in hyperbranched polyglycerols (HPGs) was evaluated. The synthesis and characterization of HPGs with hydrophobic cores and derivatized with methoxy poly(ethylene glycol) in the shell and further functionalized with amine groups (HPG-C8/10-MePEG and HPG-C8/10-MePEG-NH2) is described. Intravesical DTX in either com. or HPGs formulations (up to 1.0 mg/mL) was instilled in mice with orthotopic bladder cancer xenografts and was well tolerated with no apparent signs of local or systemic toxicities. Furthermore, a single dose of intravesical DTX (0.5 mg/mL) loaded in HPGs was significantly more effective in reducing the tumor growth in an orthotopic model of bladder cancer than the com. formulation of Taxotere. In addition, DTX-loaded HPG-C8/10-MePEG-NH2 was found to be more effective at lower instillation dose than DTX (0.2 mg/mL)-loaded HPG-C8/10-MePEG. Overall, our data show promising antitumor efficacy and safety in a recently validated orthotopic model of bladder cancer. Further research is warranted to evaluate its safety and efficacy in early phase clin. trials in patients refractory to standard intravesical therapy. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to hyperbranched polyglycerol amino peg nanoparticle docetaxel bladder cancer, Pharmaceuticals: Pharmaceutics and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 15, 2014, Geissler, Jacobo Edward; Zhou, Jiang; Jiang, Yang; Zhou, Li published a patent.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the patent was Compositions and methods for affecting mental state and body composition. And the patent contained the following:

Nutritional products and dietary supplements comprise aegeline, consumption of which may result in increased mental stamina, focus, and energy level, improved mood, increased thermogenesis, increased libido, and anabolic effects and increased strength output and(or) muscle mass. The effects may include improved cognition and body composition, with promotion of weight loss, and(or) fitness and well-being. Aegeline may be synthesized by: (a) preparing 2-amino-1-(4-methoxyphenyl)ethanone hydrochloride from 1-(4-methoxyphenyl)ethanone; (b) reacting 2-amino-1-(4-methoxyphenyl)ethanone hydrochloride with cinnamoyl chloride to form N-(2-(4-methoxyphenyl)-2-oxoethyl)cinnamamide intermediate; and (c) reacting the N-(2-(4-methoxyphenyl)-2-oxoethyl)cinnamamide with a reducing agent to form aegeline. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegeline preparation diet supplement mental activity libido muscle strength, Food and Feed Chemistry: Other and other aspects.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 31, 2021, Mahmoudabadi, Samane zarei; Pazuki, Gholamreza published an article.Recommanded Product: N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was A predictive PC-SAFT EOS based on COSMO for pharmaceutical compounds. And the article contained the following:

The present study was conducted to develop a predictive type of PC-SAFT EOS by incorporating the COSMO computations. With the proposed model, the phys. adjustable inputs to PC-SAFT EOS were determined from the suggested correlations with dependency to COSMO computation results. Afterwards, we tested the reliability of the proposed predictive PC-SAFT EOS by modeling the solubility data of certain pharmaceutical compounds in pure and mixed solvents and their octanol/water partition coefficients The obtained RMSE based on logarithmic scale for the predictive PC-SAFT EOS was 1.435 for all of the solubility calculations The reported values (1.435) had a lower value than RMSE for COSMO-SAC model (4.385), which is the same as that for RMSE for COSMO-RS model (1.412). The standard RMSE for octanol/water partition coefficient of the investigated pharmaceutical compounds was estimated to be 1.515. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Recommanded Product: N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to pharmaceutical compound cosmo perturbed chain statistical associating fluid theory, Pharmaceuticals: Pharmaceutics and other aspects.Recommanded Product: N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 12, 2021, Ma, Yiming; Sun, Mengmeng; Liu, Yanbo; Chen, Mingyang; Wu, Songgu; Wang, Mengwei; Wang, Lingyu; Gao, Zhenguo; Han, Dandan; Liu, Lande; Wang, Jingkang; Gong, Junbo published an article.SDS of cas: 144-80-9 The title of the article was Design of Spherical Crystallization of Active Pharmaceutical Ingredients via a Highly Efficient Strategy: From Screening to Preparation. And the article contained the following:

This work aims to develop a highly efficient spherical crystallization from screening to preparation stage based on liquid-liquid phase separation (LLPS). Mixtures than can undergo an LLPS split into two liquid phases with different phys. properties, and the oil droplets formed during that process make LLPS a promising approach to prepare spherical particles of an active pharmaceutical ingredient (API). In the screening stage, three machine learning (ML) models (artificial neural network, support vector machine, and logistic regression) were established for predicting LLPS for an API. Two linear models, a simple linear model and a machine learning-based linear model, were also constructed to produce further optimization. The ML-based prediction of LLPS was first established in this work and showed high accuracy and reliability. Also, when compared to a method where the screening depended on the results of experiments, the prediction model highly reduced the use of chem. substances and saved labor and time. In the preparation stage, water and ethanol, which have low toxicity to mammals and have environmental advantages over other organic solvents, were applied as the solvents of LLPS-based spherical crystallization The LLPS-based preparation process of spherical particles possesses advantages in terms of reduction of the number of unit operations as well as energy consumption and processing cost. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).SDS of cas: 144-80-9

The Article related to aprepitant design spherical crystallization screening active pharmaceutical ingredient, Pharmaceuticals: Pharmaceutics and other aspects.SDS of cas: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2021, Kuljanin, Miljan; Mitchell, Dylan C.; Schweppe, Devin K.; Gikandi, Ajami S.; Nusinow, David P.; Bulloch, Nathan J.; Vinogradova, Ekaterina V.; Wilson, David L.; Kool, Eric T.; Mancias, Joseph D.; Cravatt, Benjamin F.; Gygi, Steven P. published an article.Related Products of 79-07-2 The title of the article was Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. And the article contained the following:

Current methods used for measuring amino acid side-chain reactivity lack the throughput needed to screen large chem. libraries for interactions across the proteome. Here we redesigned the work flow for activity-based protein profiling of reactive cysteine residues by using a smaller desthiobiotin-based probe, sample multiplexing, reduced protein starting amounts and software to boost data acquisition in real time on the mass spectrometer. Our method, streamlined cysteine activity-based protein profiling (SLC-ABPP), achieved a 42-fold improvement in sample throughput, corresponding to profiling library members at a depth of >8,000 reactive cysteine sites at 18 min per compound We applied it to identify proteome-wide targets of covalent inhibitors to mutant Kirsten rat sarcoma (KRAS)G12C and Bruton’s tyrosine kinase (BTK). In addition, we created a resource of cysteine reactivity to 285 electrophiles in three human cell lines, which includes >20,000 cysteines from >6,000 proteins per line. The goal of proteome-wide profiling of cysteine reactivity across thousand-member libraries under several cellular contexts is now within reach. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Related Products of 79-07-2

The Article related to reactive cysteine screening large electrophile library, Biochemical Methods: Biological and other aspects.Related Products of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yousefinejad, Saeed; Honarasa, Fatemeh; Fararouei, Mohammad; Moosavi-Movahedi, Ali A. published an article in 2019, the title of the article was Structure-electrochemistry relationship for monovalent alkaline metals in non-aqueous solutions.Product Details of 685-91-6 And the article contains the following content:

Electrochem. methods, which deal with the interrelation of chem. and elec. properties, are interesting because of numerous advantages. Here, the electrochem. behavior of three important single-at. metallic monovalent ions (Li+, Na+, K+) were modelled in some organic solvents based on quant. structure electrochem. relationships. Because the inorganic ions have not mol. structure, only structural information of organic solvents was involved in the model. Q2 of cross validation were 0.95, 0.88 and 0.82 in lithium, sodium and potassium models, resp., and the R2test were 0.97, 0.89 and 0.93 in lithium, sodium and potassium models, resp. Various validation approaches were used to evaluate the proposed linear models. The results not only are useful for the prediction and estimation of the voltammetric behavior of the studied cations but also give a way to descript the important features of the utilized organic solvents on the half wave potential of lithium, sodium and potassium. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Product Details of 685-91-6

The Article related to structure electrochem relationship monovalent alkanic metal non aqeous solution, Biochemical Methods: Electrical and other aspects.Product Details of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 30, 2016, Guillon, Jean; Moreau, Stephane; Ronga, Luisa; Basmacyian, Louise; Cohen, Anita; Rubio, Sandra; Bentzinger, Guillaume; Savrimoutou, Solene; Azas, Nadine; Mullie, Catherine; Sonnet, Pascal published an article.HPLC of Formula: 5455-98-1 The title of the article was Design, Synthesis and Antimalarial Activity of Some New Aminoalcoholpyrrolo[1,2-a]quinoxaline Derivatives. And the article contained the following:

Following our search for antimalarial compounds, novel series of piperazinylalc. pyrrolo[ 1,2-a]quinoxaline derivatives 1-2 were synthesized from 2-nitroaniline or 2-amino-3- nitrophenol and tested for in vitro activity upon the intraerythrocytic stage of W2 and 3D7 Plasmodium falciparum strains. Biol. results showed good antimalarial activity with IC50 ranging from 0.3 to 21.1 μM. In attempting to investigate the large broad-spectrum antiprotozoal activities of these pyrrolo[1,2-a]quinoxaline derivatives, their properties toward the promastigote form of Leishmania donovani were also investigated and revealed their selective antiplasmodial profile. In parallel, the in vitro cytotoxicity of these mols. was assessed on the human HepG2 cell line. Structure-activity relationships of these new synthetic compounds are here discussed. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).HPLC of Formula: 5455-98-1

The Article related to antimalarial msbar, Pharmacology: Structure-Activity and other aspects.HPLC of Formula: 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2016, Beloglazkina, Anastasia A.; Wobith, Birgit; Barskaia, Elena S.; Zefirov, Nikolay A.; Majouga, Alexander G.; Beloglazkina, Elena K.; Zyk, Nikolay V.; Kuznetsov, Sergei A.; Zefirova, Olga N. published an article.Application of 27115-50-0 The title of the article was Synthesis and biological testing of (5Z)-2-aryl-5-arylmethylidene-3,5-dihydro-4H-imidazol-4-ones as antimitotic agents. And the article contained the following:

Compounds interacting with cell protein tubulin and microtubules represent an important type of antimitotic agents. A series of tubulin-targeted 2-aryl-4-benzoyl-imidazoles were reported to possess high cytotoxicity, and so, the authors prepared a series of structural isomers of these to be evaluated as antimitotic agents. The synthesis of the novel (Z)-2-aryl-5-arylmethylidene-3,5-dihydro-4H-imidazol-4-ones involved coupling of substituted hippuric acids with aromatic aldehydes. Subsequent conversion of the resulting oxazolones to the corresponding imidazolones was carried out under microwave irradiation in the presence of urea and ammonium acetate. The cytotoxicity of the majority of the compounds to human epithelial carcinoma cancer cell line A549 was in the sub-micromolar range and was found to be more sensitive to the substituents on the 5-arylmethylidene fragment than on the 2-aryl ring in general. The cytotoxicities of the synthesized compounds were lower than those of the previously reported isomeric 2-aryl-4-benzoyl-imidazoles, and the basic structure-activity relationships in the isomeric pairs were different. Synthesized (5Z)-5-[(4-bromophenyl)methylidene]-2-(4-methylphenyl)-3,5-dihydro-4H-imidazol-4-one, which had the highest cytotoxicity (IC50 ∼ 440 nM) in the series of novel compounds, had a definite cytostatic effect on the A549 cells, but its antiproliferative properties were not linked to action on the microtubules. This would be an interesting lead compound for addnl. investigation into the mechanism of cytostatic action, and further structural optimization. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application of 27115-50-0

The Article related to antimitotic antitumor neoplasm, Pharmacology: Structure-Activity and other aspects.Application of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics