Month: November 2022

On January 31, 2020, Uslu, Azize Gizem; Maz, Tugce Gur; Nocentini, Alessio; Banoglu, Erden; Supuran, Claudiu T.; Caliskan, Burcu published an article.Formula: C6H5ClN2O4S The title of the article was Benzimidazole derivatives as potent and isoform selective tumor-associated carbonic anhydrase IX/XII inhibitors. And the article contained the following:

We describe the synthesis of a series of 2-arylbenzimidazole derivatives bearing sulfonamide functionality (4a-d, 7a-c and 10) as well as hydroxamic acid (15a-b), carboxylic acid (16a-b), carboxamide (17a-b) and boronic acid (22a-b and 26) functionalities, which act as human carbonic anhydrase (hCA, EC 4.2.1.1) inhibitors. The newly synthesized benzimidazole derivatives were evaluated against 4 physiol. relevant CA isoforms (hCA I, II, IX, and XII), and especially the sulfonamide-containing benzimidazoles demonstrated intriguing inhibitory activity against tumor associated CA IX and XII with KI values in the range of 5.2-29.3 nM and 9.9-41.7 nM, resp. Notably, compound 4c was the most potent and selective CA IX (KI = 6.6 nM) and XII (KI = 9.9 nM) inhibitor with a significant selectivity ratio over cytosolic CA I and II isoforms in the range of 3.4-25.2. In addition, compounds having hydroxamic acid (15a-b) or carboxylic acid (16a-b) functionalities resulted in greater selectivity ratios for CA IX/XII over CAI/II in the range of 4.1-121.5 although with KI values in lower micromolar potency (KIs = 0.36-0.85μM for CA IX/XII). The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Formula: C6H5ClN2O4S

The Article related to benzimidazole derivative preparation carbonic anhydrase inhibitor cancer, benzimidazole, carbonic anhydrase, carboxylic acid, hydroxamic acid, sulfonamide, Pharmacology: Structure-Activity and other aspects.Formula: C6H5ClN2O4S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2022, Igualada, Carmen; Giraldo, Jennifer; Font, Guillermina; Yusa, Vicent published an article.Computed Properties of 144-80-9 The title of the article was Validation of a multi-residue UHPLC-HRMS method for antibiotics screening in milk, fresh cheese, and whey. And the article contained the following:

The aim of this study was to develop a UHPLC-HRMS methodol. as a suitable tool for the screening of antibiotics in milk, fresh cheese, and whey. Compounds were analyzed using an Orbitrap Exactive analyzer working at a resolving power of 50,000 FWHM in full scan, both in pos. and neg. electrospray ionization mode, and a high mass accuracy (<5 ppm) and a retention time deviation of ±2.5% were set as identification criteria. The multiclass method was developed for the simultaneous determination of 36 substances from different antibiotic groups (β-lactams, lincosamides, macrolides, quinolones, sulfonamides, and tetracyclines) and the quantification was performed by using matrix-matched calibration curves corrected by the corresponding internal standards Matrix effect and recovery percentages were also calculated prior to the selection of internal standard After comparing different sample preparation procedures, a quick and easy extraction with acetate buffer at pH 5.2 and acetonitrile (20/80, volume/volume), followed by C18 dispersive Solid Phase Extraction (dSPE) bulk sorbent was selected. The detection capabilities (CCβs) were established at 25% or 50% of the Maximum Residue Limit (MRL) set in milk (no regulation for cheese and whey), and precision (repeatability and reproducibility) and trueness (recovery) were satisfactory according to Commission Decision 2002/657/EC. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Computed Properties of 144-80-9

The Article related to antibiotics milk fresh cheese whey uhplchrms, Food and Feed Chemistry: Analysis and other aspects.Computed Properties of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 25, 2013, Xiao, Run-mei; Sun, Jing-zhi; Mei, Yong; Liu, Jie; Chen, Yong published an article.COA of Formula: C10H11NO3 The title of the article was Simultaneous determination of four urinary metabolites of hippuric acid and methyl hippuric acid by HPLC. And the article contained the following:

A high performance liquid chromatog.(HPLC) method with diode array detection was established for simultaneous determination of hippuric acid (HA), Me hippuric acid(2-MHA, 3-MHA, 4-MHA) in urine. The target analytes in 0.5 mL urine sample were extracted with 0.5 mL Et acetate as extraction solvent in 3 min after the addition of 75 mg NaCL. After centrifugation, the four metabolites in sample were well separated on symmetry C18 (150 mm*4.6 mm, 5μm) column with mobile phase consisting of methanol: water: glacial acetic acid=30:70:0.1, column temperature at 35°C, the wavelength was set at 235 nm. Under the optimal conditions, the calibration curves of the four metabolites were linear in the range of 20mg/L∼500mg/L and the correlation coefficients were not less than 0.9997. The detection limits (S/N=3) were in the range of 21μg/L-200μg/L. The spiked recoveries were in the range of 97%∼104% with relative standard deviations (RSD) less than 5%. The method was sensitive, accurate and it could meet the needs of biol. monitoring on the metabolites of harmful substances in urine. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).COA of Formula: C10H11NO3

The Article related to urinary metabolite methyl hippuric acid hplc, Food and Feed Chemistry: Analysis and other aspects.COA of Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 17, 2020, Preetha, Bhadra published a patent.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the patent was Biopesticide composition based on bael extract for treating aphids in plant and preparation method thereof. And the patent contained the following:

The invention relates to a biopesticide composition having less harmful side effects for normal cells, and reducing the use of pesticides based on synthetic drugs. The composition contains the following components: 15-25% of aegeline; 15-25% of skimmianine (1); 15-25% of d-limonene; 15-25% of marmelosin and 15-25% of allocryptopine. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to plant aphid bael extract biopesticide composition, Agrochemical Bioregulators: Plant and other aspects.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2021, Yazdanfar, Najmeh; Shamsipur, Mojtaba; Ghambarian, Mahnaz published an article.HPLC of Formula: 144-80-9 The title of the article was Determination of sulfonamide residues in animal foodstuffs by magnetic dispersive solid-phase extraction using magnetic carbon nanocomposites coupled with ion pair-dispersive liquid-liquid micro-extraction combined with HPLC-DAD. And the article contained the following:

Abstract: In this study, magnetic-dispersive solid-phase extraction coupled with ion pair-dispersive liquid-liquid micro-extraction (MSPE-i-DLLME) was used to the pre-concentration and extraction of five sulfonamides residues (sulfadiazine, sulfathiazole, sulfacetamide, sulfamethazine and sulfamethoxazole) in animal foodstuffs. The sulfonamides are extracted using magnetic carbon nanocomposite and then eluted with acetonitrile. In the DLLME step, the target analytes are collected in 1-octanol containing 10% Aliquat-336 (as extraction solvent). Finally, the compounds are quantified by HPLC with DAD detection. The extraction parameters optimized using the one at the time and central composite design methods. Under the optimized conditions: sample solution volume was 100 mL; initial pH: 12, amounts of MCNs: 30 mg; desorption solvent (ACN) volume, 1 mL; desorption condition, 10 min sonication at two step; extraction solvent (1-octanol + 10% aliquat) volume, 115μL; pH of DLLME step, 3; salt effect, 24.6%, (w/v) NaCl; centrifuge, 5 min, 4000 rpm. In these extraction conditions, the proposed procedure represented good pre-concentration factors between 130 and 490; detection limits in the range from 0.01 to 5μg kg-1 (at S/N = 3), and linear response in the 0.1-400μg kg-1 concentration range. The method is successfully applied to the determination of sulfonamides residues in animal foodstuffs. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

The Article related to sulfonamide residue foodstuff mspe i dllme mcn hplc dad, Food and Feed Chemistry: Analysis and other aspects.HPLC of Formula: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2021, Price, Katilyn J.; Li, Xiao; Price, Andrew J.; Browne, Frances; Balkcom, Kris; Chen, Charles Y. published an article.Computed Properties of 79-07-2 The title of the article was Evaluation of peanut tolerance to mid-season applications of PPO-Inhibitor herbicides mixed with different surfactants. And the article contained the following:

Protoporphyrinogen oxidase (PPO) inhibitor herbicides are being increasingly used to control acetolactate synthases (ALS) inhibitor-resistant weeds in peanuts (Arachis hypogaea L.). However, PPO-inhibitor herbicides can injure the crop under certain application conditions, especially under abiotic stress and surfactants may exacerbate this injury. The objectives of this study were to (1) investigate the effect of PPO-inhibitor based treatments on dryland peanut growth and yield when applied at three timings in mid-season, (2) evaluate the interactions of surfactants, chloroacetamide herbicides, and PPO-inhibitors, and (3) assess the level of correlation of normalized difference vegetation index (NDVI) readings to traditional visible injury rating. Field studies were conducted in Henry and Escambia counties in Alabama, U.S. during 2018, and 2019. Up to 55% of visible peanut injury was observed with acifluorfen, lactofen, and carfentrazone-Et treatments. In general, the NDVI readings correlated significantly with traditional visible injury ratings. A tank mixture of chloroacetamide herbicides (pyroxasulfone, S-metolachlor, dimethenamid-P) with lactofen did not lead to more injury or yield loss than lactofen applied alone. Yield losses up 27% were observed with carfentrazone-Et plus a high surfactant oil concentrate (HSOC) at 75 and 90 days after planting (DAP) as compared to the non-treated check (NTC). Overall, treatments with HSOC and/or carfentrazone-Et were more likely to cause significant injury and yield loss than treatments with acifluorfen or lactofen plus nonionic surfactant (NIS). Peanuts are more sensitive to PPO-inhibitor herbicides at 75 DAP. NDVI did provide addnl. plant health information to subjective injury ratings, however, neither of these measurements are reliable predictors of peanut yield loss. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Computed Properties of 79-07-2

The Article related to protoporphyrinogen oxidase inhibitor herbicide arachis yield, Agrochemical Bioregulators: Plant and other aspects.Computed Properties of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2020, Matyjaszczyk, Ewa; Skrzecz, Iwona published an article.Related Products of 79-07-2 The title of the article was How European Union accession and implementation of obligatory integrated pest management influenced forest protection against diseases and weeds: A case study from Poland. And the article contained the following:

An anal. of the impact of accession to the European Union and implementation of compulsory integrated pest management on the chem. protection of forest in Poland against diseases and weeds was performed. No impact of compulsory integrated pest management has been observed on forest protection against diseases and weeds so far. However a strong influence of the legal changes and implementation of common registration rules on the availability of plant protection products was observed The paper presents data on the fungicides and herbicides use in Polish forests in the years 1997-2017. Protection against weeds and diseases in Poland is focused only on very young trees. Consequently the application of herbicides and fungicides is performed on much smaller area than application of insecticides and never from the air. In terms of volume, the use of fungicides and herbicides in Polish forests in the year 2017 was below 0,1% of fungicides and herbicides used at the same time in Polish agriculture. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Related Products of 79-07-2

The Article related to calamagrostis deschampsia powdery mildew disease fungicide herbicide poland, Agrochemical Bioregulators: Plant and other aspects.Related Products of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2021, Wang, Chun; Chen, Meng; Hu, Qi; Bai, Hua; Wang, Changhai; Ma, Qiang published an article.SDS of cas: 144-80-9 The title of the article was Non-lethal microsampling and rapid identification of multi-residue veterinary drugs in aquacultured fish by direct analysis in real time coupled with quadrupole-Orbitrap high-resolution mass spectrometry. And the article contained the following:

An anal. protocol for the identification of 52 multi-class veterinary drug residues in aquacultured fish has been developed based on direct anal. in real time (DART) coupled with quadrupole-Orbitrap high-resolution mass spectrometry (Q-Orbitrap HRMS). A “sample-and-release” strategy was adopted where live fishes are captured for non-lethal blood microsampling and then released back into the original farming water. A simple micro liquid-liquid extraction (micro-LLE) was incorporated for the extraction and clean-up of veterinary drug analytes from fish blood samples. The main parameters affecting micro-LLE, DART ionization, and Q-Orbitrap HRMS anal. were systematically studied. Data acquisition was carried out using a synchronous full-scan MS/data-dependent MS/MS (full-scan MS1/dd-MS2) workflow. Suspect screening was conducted by comparing the exptl. measured exact mass of precursor and fragment ions with the custom accurate-mass database and by matching the acquired mass spectra against the mass spectral library. The anal. performance of the developed methodol. was assessed in terms of sensitivity, linearity, repeatability, and recovery. The limits of detection (LODs) and quantitation (LOQs) of the 52 analytes were in the range of 0.5-20μg/L and 2-50μg/L, resp. The matrix effect ratios ranged from -23.5% to 25.9%. The developed approach demonstrated promising potential for rapid, real-time monitoring of veterinary drug residues to ensure food safety and consumer health. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).SDS of cas: 144-80-9

The Article related to nonlethal microsampling multiresidue veterinary drug aquacultured fish qorbitrap hrms, Food and Feed Chemistry: Analysis and other aspects.SDS of cas: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 16, 2021, Ji, Baocheng; Zhao, Wenhao; Xu, Xu; Han, Yu; Jie, Mingsha; Xu, Gaigai; Bai, Yanhong published an article.Reference of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Development of a modified quick, easy, cheap, effective, rugged, and safe method based on melamine sponge for multi-residue analysis of veterinary drugs in milks by ultra-performance liquid chromatography tandem mass spectrometry. And the article contained the following:

The purpose of this study was to develop a modified QuEChERS method based on melamine sponge for rapid determination of multi-class veterinary drugs in milks by UPLC-MS/MS. Through simple infiltration and extrusion, fast and convenient matrix purification could be achieved within several seconds, and there was no need of extra phase separation operations. Good linearity with correlation coefficient (R2) ≥0.999 was obtained for all drugs in the range of 2∼500μg·kg-1. The obtained matrix effects were within ±20% for all monitored drugs. The recoveries of all monitored drugs ranged from 60.7% to 116.0% at three spiked levels (50, 100, and 200μg·kg-1), with relative standard deviations less than 7.4%. Comparatively low LODs and LOQs were obtained in the ranges of 0.1∼3.8μg·kg-1 and 0.2∼6.3μg·kg-1, resp. Compared with conventional purification adsorbents, melamine sponge yielded an equal or higher purification performance with matrix removal rate as high as 52.5% and acceptable recoveries in range of 60%-120% for all monitored drugs. The satisfactory results have demonstrated the good potential of melamine sponge in matrix purification for rapid determination of multiclass residues in food safety. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Reference of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to milk veterinary drug melamine sponge uplc ms, matrix purification, melamine sponge, milk, quechers, veterinary drug, Food and Feed Chemistry: Analysis and other aspects.Reference of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 30, 2020, Sutcharitchan, Chayanis; Miao, Shui; Li, Wenting; Liu, Jiaming; Zhou, Heng; Ma, Yingxian; Ji, Shen; Cui, Yajun published an article.Name: 1,3-Diphenylurea The title of the article was High performance liquid chromatography-tandem mass spectrometry method for residue determination of 39 plant growth regulators in root and rhizome Chinese herbs. And the article contained the following:

A simple, rapid, and effective method based on salting-out extraction and LC-MS/MS techniques was developed for the determination of 39 plant growth regulator (PGR) residues in two of the most common root and rhizome Chinese herbs, Codonopsis Radix (Dangshen) and Notoginseng Radix et Rhizoma (Sanqi). The extraction process was performed with acetonitrile-water (5:1) and citrate buffer extraction salt. The performance of the method was validated in accordance with the anal. quality control criteria of SANTE/11813/2017 guidelines. Analyte recoveries of 79.49-109.41% (Dangshen) and 80.17-102.81% (Sanqi) were achieved. The limit of quantifications (LOQs) were determined with the consideration of accuracy and precision. LOQs were lower than the lowest residue limits in EU pesticide regulation (10μg/kg) for most PGRs. Moreover, the method was successfully applied in the anal. of 35 batches of Dangshen, and 60 batches of Sanqi products. The concentration of eleven PGRs were determined in analyzed samples. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Name: 1,3-Diphenylurea

The Article related to rhizome root hplc dangshen sanqi, chinese medicine, dangshen, determination method, hplc-ms/ms, pesticide residue, plant growth regulator, sanqi, Food and Feed Chemistry: Analysis and other aspects.Name: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics