Month: November 2022

On February 1, 2022, Xu, Xu; Zhao, Wenhao; Ji, Baocheng; Han, Yu; Xu, Gaigai; Jie, Mingsha; Wu, Nan; Wu, Yongmei; Li, Junguang; Li, Ke; Zhao, Dianbo; Bai, Yanhong published an article.COA of Formula: C8H10N2O3S The title of the article was Application of silanized melamine sponges in matrix purification for rapid multi-residue analysis of veterinary drugs in eggs by UPLC-MS/MS. And the article contained the following:

Fast and convenient matrix purification is an important prerequisite for high-throughput anal. of drug multiresidues in food. In this study, a silanized melamine sponge was prepared and first applied in the rapid determination of multiclass veterinary drugs in eggs by ultrahigh-performance liquid chromatog.-tandem mass spectrometry. Within five seconds, fast, convenient and efficient matrix separation could be achieved through simple soaking and squeezing. Compared to other matrix adsorbents, the developed material demonstrated equivalent or better purification performance. Good validation results were obtained in terms of drug recoveries (61.5%∼97.0%, relative standard deviation (RSD) ≤ 10.8%), and linearities (R2 ≥ 0.999), as well as low limits of quantitation (0.3 ∼ 10.9μg·kg-1) and detection (0.1 ∼ 3.8μg·kg-1). By analyzing 52 egg samples, high concentrations of ofloxacin, trimethoprim, metronidazole, and dimetridazole were found at 542.9, 121.2, 66.1 and 58.0μg·kg-1, resp. The silanized melamine sponge has shown its great potential for rapid anal. of multiclass residues in food safety. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).COA of Formula: C8H10N2O3S

The Article related to silanized melamine sponges matrix purification drug residue uplc ms, egg, mass spectrometry, matrix purification, melamine sponge, veterinary drug, Food and Feed Chemistry: Analysis and other aspects.COA of Formula: C8H10N2O3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 16, 2021, Jia, Wei; Zhang, Min; Du, An; Zhang, Rong; Xu, Mudan; Shi, Lin published an article.Formula: C8H10N2O3S The title of the article was Accurate Quantification of Sulfonamide Metabolites in Goat Meat: A New Strategy for Minimizing Interaction between Sheep Serum Albumin and Sulfonamide Metabolites. And the article contained the following:

To date, the determination of sulfonamide metabolites in animal-derived food has universal disadvantages of low throughput and no integrated metabolites involved. In this study, a powerful and reliable strategy for high-throughput screening of sulfonamide metabolites in goat meat was proposed based on an aqueous two-phase separation procedure (ATPS) combined with ultrahigh-performance liquid chromatog. quadrupole-Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap). Noncovalent interactions including van der Waals force, hydrogen bonding, and hydrophobic effect were determined to be staple interactions between the sulfonamide metabolites and sheep serum albumin by fluorescence spectroscopy and mol. docking technol., and an 80% acetonitrile-water solution/(NH4)2SO4 was used as ATPS in order to release combined sulfonamide metabolites and minimize the influence of sheep serum albumin. Sulfonamide metabolites in the matrix were screened based on a mechanism of mass natural loss and core structure followed by identification combined with the pharmacokinetic. The developed strategy was validated according to EU standard 2002/657/EC with CCα ranging from 0.07 to 0.98μg kg-1, accuracy recovery with 84-107%, and RSDs lower than 8.9%. Eighty seven goat meat samples were used for determination of 26 sulfonamides and 8 potential metabolites. On the basis of the established innovative process, this study has successfully implemented the comprehensive detection of sulfonamide metabolites, including N4-acetylated substitution, N4-hydroxylation, 4-nitroso, azo dimers, oxidized nitro, N4 monoglucose conjugation, β-D-glucuronide, and N-4-aminobenzenesulfonyl metabolites, which were shown to undergo oxidation, hydrogenation, sulfation, glucuronidation, glucosylation, and O-aminomethylation. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Formula: C8H10N2O3S

The Article related to sulfonamide metabolite goat meat albumin uhplc, uhplc-q-orbitrap, goat meat, interaction, noncovalent bonds, quantification, sulfonamide metabolites, Food and Feed Chemistry: Analysis and other aspects.Formula: C8H10N2O3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 1, 2022, Semail, Nadhiratul-Farihin; Abdul Keyon, Aemi Syazwani; Saad, Bahruddin; Kamaruzaman, Sazlinda; Mohamad Zain, Nur Nadhirah; Lim, Vuanghao; Miskam, Mazidatulakmam; Wan Abdullah, Wan Nazwanie; Yahaya, Noorfatimah; Chen, David D. Y. published an article.SDS of cas: 144-80-9 The title of the article was Simultaneous preconcentration and determination of sulfonamide antibiotics in milk and yoghurt by dynamic pH junction focusing coupled with capillary electrophoresis. And the article contained the following:

A dynamic pH junction was used in capillary electrophoresis (CE-DAD) to online preconc., sep., and determine trace amounts of sulfonamide antibiotics (SAs) in milk and yoghurt samples in this study. A sample matrix with 0.15% acetic acid and 10% methanol (MeOH) at a pH of 4.0, and a background electrolyte (BGE) that contained 35 mM sodium citrate with 10% MeOH at a pH of 8.5, and an acidic barrage of 0.4% acetic acid with 10% MeOH at a pH of 2.5 were utilized to achieve a stacking effect for SAs through a dynamic pH junction. Under optimized conditions, the proposed preconcentration method showed good linearity (30-500 ng/mL, r2 ≥ 0.9940), low limits of detection (LODs) of 4.1-6.3 ng/mL, and acceptable analytes recovery (81.2-106.9%) with relative standard deviations (RSDs) within 5.3-13.7 (n = 9). The limits of quantification (LOQs) were below the maximum residue limit approved by the European Union (EU) in this type of matrixes. Sensitivity enhancement factors of up to 129 were reached with the optimized dynamic pH junction using CE with a diode array detector (DAD). The method was used to determine SAs in fresh milk, low-fat milk, full-cream milk, and yoghurt samples. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).SDS of cas: 144-80-9

The Article related to capillary electrophoresis sulfonamide milk yoghurt, capillary electrophoresis, dynamic ph junction, milk, online preconcentration, sulfonamide antibiotics, yoghurt, Food and Feed Chemistry: Analysis and other aspects.SDS of cas: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gika, Helen G.; Ji, Cheng; Theodoridis, Georgios A.; Michopoulos, Filippos; Kaplowitz, Neil; Wilson, Ian D. published an article in 2012, the title of the article was Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass spectrometry based metabolite profiling.SDS of cas: 27115-50-0 And the article contains the following content:

Alc. consumption in man, when seen in its extreme form of alcoholism, is a complex and socially disruptive disorder that can result in significant levels of liver injury. Here the rodent “intragastric feeding model” was used together with UHPLC-TOFMS anal. to determine changes in global metabolite profiles for plasma and urine from alc. treated rats and mice compared to control animals. Multivariate statistical anal. (using principal components anal., PCA) revealed robust differences between profiles from control and alc.-treated animals from both species. A large number of metabolites were seen to differ between control and alc.-treated animals, for both biofluids. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).SDS of cas: 27115-50-0

The Article related to investigation chronic alc consumption rodents ultra high performance liquid, Toxicology: Ethanol and Alcoholism and other aspects.SDS of cas: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nelson, G. L.; Webb, J. L. published an article in 1973, the title of the article was Oxygen index of liquids. Halogen compounds.Application of 97-09-6 And the article contains the following content:

The oxygen indices of 150 halogenated compounds are reported and the effectiveness of F, Cl, Br, and I substituents on fire retardancy compared. All halogens were more effective in aromatic compounds than in aliphatic materials. On average, the introduction of a single halogen atom into aromatic compounds increased the oxygen index 1.5 unit/F atom. 4.3 units/Cl atom, 7.4 units/Br atom, and 6.5 units/I atom. The introduction of greater numbers of halogen atoms in aromatic compounds led to a nonlinear increase in oxygen index. Particularly in the case of F and Cl, highly specific structural effects were seen. Halogen can be particularly effective for aromatic systems containing other electron-withdrawing groups. Perhaps this is due to the increased difficulty in oxidation imposed on an already electron-poor organic system. Polyacromaticity had a strong enhancement of fire retardancy. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

The Article related to oxygen index halogen compound, fire retardancy halogen compound, safety fire halogen compound, Propellants and Explosives: General and other aspects.Application of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 2021, Hermann, Markus R.; Pautsch, Alexander; Grundl, Marc A.; Weber, Alexander; Tautermann, Christofer S. published an article.Related Products of 79-07-2 The title of the article was Covalent inhibitor reactivity prediction by the electrophilicity index-in and out of scope. And the article contained the following:

Drug discovery is an expensive and time-consuming process. To make this process more efficient quantum chem. methods can be employed. The electrophilicity index is one property that can be calculated by quantum chem. methods, and if calculated correctly gives insight into the reactivity of covalent inhibitors. Herein we present the usage of the electrophilicity index on three common warheads, i.e., acrylamides, 2-chloroacetamides, and propargylamides. We thoroughly examine the properties of the electrophilicity index, show which pitfalls should be avoided, and what the requirements to successfully apply the electrophilicity index are. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Related Products of 79-07-2

The Article related to acrylamide chloroacetamide propargylamide covalent inhibitor reactivity electrophilicity, compound reactivity, covalent drug discovery, dft, Physical Organic Chemistry: General and other aspects.Related Products of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 15, 2022, Sun, Feifei; Tan, Haiguang; Abdallah, Mohamed F.; Li, Yanshen; Zhou, Jinhui; Li, Yi; Yang, Shupeng published an article.Name: N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was A novel calibration strategy based on isotopic distribution for high-throughput quantitative analysis of pesticides and veterinary drugs using LC-HRMS. And the article contained the following:

Preparation of calibration curves is a critical step for large-scale quantification. However, this procedure is time-consuming, labor intensive. Herein, a novel isotopologue multipoint calibration (IMC) strategy, was proposed and demonstrated for the simultaneous quantitation of 120 pesticides and 83 veterinary drugs in surface water samples using Liquid Chromatog.-High Resolution Mass Spectrometry (LC-HRMS). In this strategy, the natural isotopic distribution was used to generate external calibration curves, eliminating the need of analyst’s adjustment and many sets of chem. standard solutions required in external calibration curves. Addnl., this strategy was comprehensively validated, and the results indicated this strategy had better performance in both accuracy and precision, fully meeting the requirements for the quant. anal. Interestingly, for the samples with high concentration beyond the upper limit of quantitation, the IMC strategy could avoid samples dilution by monitoring the less abundant isotopic channels. Furthermore, the IMC method was successfully applied in the surface water samples collected from Anhui province, China. Among which, sulfamethoxazole and imidacoprid were the main contributors. In conclusion, we present a promising LC-HRMS strategy for the accurate quantitation of small mols., which has a potential application in food and environmental anal. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Name: N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to pesticide veterinary drug isotopic distribution calibration, high resolution mass spectrometry, isotope distribution, quantitative analysis, water environment pollution, Waste Treatment and Disposal: Other and other aspects.Name: N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 20, 2013, Liu, Jie; Mei, Yong; Wang, Ya-nan; Gu, Ying-ying; Wang, Qian; Jiang, Jin-feng published an article.Category: amides-buliding-blocks The title of the article was Standardized study on determination of methylhippuric acids in urine by HPLC. And the article contained the following:

The aim of this paper is to get a better separation of methylhippuric acid isomers and establish a standardized method for the determination of methylhippuric acids in urine by HPLC. C18 column was used to determine the methylhippuric acid. The mobile phase was methanol-0.1% acetic acid (33:67). The detector was performed at λ=230 nm, at 0.7 mVmin. Calibration curves of three methylhippuric acids were linear in the range of 25μg/mL∼1000μg/mL, with a correlation coefficient more than 0.999. The average recovery was in the range of 91.36%∼101.36% and the average RSD was in the range of 2.0%∼9.6%. The min. detection concentrations of 2-MHA, 3-MHA, 4-MHA were resp. 0.47μg/mL, 0.46μg/mL, 0.41μg/mL. The separation of 4-methylhippuric acid and 3-methylhippuric acid was up to 1.44. The method is able to make 3-methylhippuric acid and 4-methylhippuric acid baseline separated, and the methodol. indicators are in line with the relevant requirements of the method for determination of chems. in the occupational health standard-setting Guide Part V. So it can be used to determine methylhippuric acids in urine of xylene exposure workers. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Category: amides-buliding-blocks

The Article related to hplc methylhippuric acid determination, Biochemical Methods: Chromatographic and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ghamari, Farhad; Bahrami, Abdulrahman; Yamini, Yadollah; Shahna, Farshid Ghorbani; Moghimbeigi, Abbas published an article in 2017, the title of the article was Hollow-fiber liquid-phase microextraction based on carrier-mediated transport for determination of urinary methyl hippuric acids.Reference of 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

Hollow-fiber liquid-phase microextraction based on carrier-mediated transport for anal. of Me hippuric acids in aqueous samples is described. Under optimized conditions, relative recoveries of 83%-98% and limits of detection of 2-3μg L-1 were obtained, with linear calibration curves for the three isomers in the range of 10-50,000μg L-1. The method was applied for the determination of urine samples of volunteers at various working environments. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid

The Article related to urinary methyl hippuric acid microextraction, Biochemical Methods: Chromatographic and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tinland, Bernard published an article in 1973, the title of the article was Theoretical EHT [extended Hueckel theory] study of structure-activity relations in a series of sulfonamides.Electric Literature of 97-09-6 And the article contains the following content:

The carbonic anhydrase inhibitory activities of 17 sulfonamides were compared with their structures, based on quantum chem. calculations performed within the framework of the extended Hueckel theory. Correlations were found between the activity of mols. and the reduced Mulliken overlap populations relative to the SO2 group. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Electric Literature of 97-09-6

The Article related to sulfonamide structure activity, quantum chem drug activity, carbonic anhydrase sulfonamide, Pharmacodynamics: Structure-Activity and other aspects.Electric Literature of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics