Month: November 2022

On October 1, 2010, Caporossi, Lidia; De Rosa, Mariangela; Papaleo, Bruno published an article.Formula: C10H11NO3 The title of the article was Complete separation of urinary metabolites of xylene in HPLC/DAD using β-cyclodextrin: Application for biological monitoring. And the article contained the following:

To determine the biomarkers of exposure to xylene, urinary 2-, 3- and 4-methyl-hippuric acids, a new HPLC/DAD anal. method has been developed, which uses β-cyclodextrin as an additive for elution; its complexing abilities are exploited to achieve complete chromatog. separation of the three isomers. The mobile phase was a 3% aqueous solution of β-cyclodextrin, pH 3, and methanol, 80:20, in isocratic conditions, with a flow rate of 1 mL/min. To optimize quant. anal. three wavelengths were employed for detection: λ = 198 nm, λ = 200 nm, and λ = 202 nm. SPE was applied for the extraction from urine samples of analytes. Validation parameters show recoveries always above 82%; LOD was set at 1 μg/mL with an LOQ of 3 μg/mL. The linear dynamic range (from 4 to 100 μg/mL) showed excellent correspondence. This method is rapid and inexpensive and can be applied to several samples simultaneously using a manifold for SPE extraction The analytes were separated completely and could be fully quantified. The method was used for the anal. of urine samples from 54 workers exposed to xylene in hospital laboratories and showed a good applicability while allowing quantification even at low doses. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Formula: C10H11NO3

The Article related to xylene occupational exposure methylhippuric acid biomarker urine analysis, methylhippuric acid urine analysis hplc cyclodextrin, Toxicology: Methods (Including Analysis) and other aspects.Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kim, Hye Jin; Seo, Young Ju; Htwe, Khin Myo; Yoon, Kee Dong published an article in 2021, the title of the article was Chemical constituents from Aegle marmelos fruits.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

Aegle marmelos (Rutaceae) is a deciduous shrub or tree and typically known as bael throughout Southeast Asia and has been used as a medicinal plant and a food ingredient. In this study eight compounds were determined to be O-(3,3-dimethylallyl) halfordinol (1), (R)-aegeline (2), (R)-marmeline (3), imperatorin (4), xanthotoxol (5), valencic acid (6), vanillic acid (7) and rutin (8). The chem. structures of the isolates were elucidated through spectroscopic evidence including 1D, 2D NMR, ESI-Q-TOF-MS and optical rotation. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle marmelos fruit chem constituent, Pharmaceuticals: Pharmacognostic Products and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 20, 2002, Li, Maojin; Hu, Junfeng; Li, Guozhen; Xie, Lin published an article.HPLC of Formula: 97-09-6 The title of the article was Antagonism of rhizoma gastrodiae to lead-induced damage of hippocampus in rats. And the article contained the following:

The antagonism of rhizoma gastrodiae (RGT) to the impairment of learning and memory ability induced by Lead was studied in rats. 36 Wistar rats were randomly divided into 3 groups, 12 rats in every group, (1) control group: treated with distilled water; lead group: treated with lead acetate(0.1 g/kg d); (3)lead-RGT group:lead acetate(0.1 g/kg d)+RGT(4.0 g/kg d). The ability of learning and memory of the rats was measured monthly by swimming test; 3 mo later, the rats were decapitated and nitric oxide(NO) and total antioxidative capacity(TAOC) in hippocampus were measured immediately and the examination for pathol. was also made. In swimming test, the number of seeking for anchorage in lead group(1, 2, 3 mo: 10.10±1.10, 7.80±1.32, 5.40±0.97 resp.) were significantly decreased, compared with the control(P < 0.01). The number of seeking for anchorage in RGT-lead group(1, 2, 3 mo: 11.90±0.95, 10.90±0.95, 9.7±0.96 resp.) were significantly increased, compared with lead group(P < 0.01). NO(0.733±0.015) μmol/g pro and TAOC(0.945±0.017) U/mg pro in hippocampus of lead group were significantly decreased compared with the control(P < 0.01) whereas NO(0.769±0.021) μmol/g pro and TAOC(0.986±0.010) U/mg pro in hippocampus of RGT-lead group were significantly increased compared with lead group(P < 0.01). Pathol. examination showed that in lead group, marked atrophy in hippocampus, cellular denaturation and necrosis, dissolution and disappearance in axon were found. In lead-RGT group, the atrophy of hippocampus was not obvious, the cell morphol. was nearly normal, no obvious abnormal changes were seen. RGT is antagnostic to the impairment of hippocampus and of learning and memory ability induced by lead. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).HPLC of Formula: 97-09-6

The Article related to lead gastrodia tianma hippocampus damage, Pharmaceuticals: Pharmacognostic Products and other aspects.HPLC of Formula: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pan, Jie; Li, Haocong; Sun, Kai; Tang, Shi; Yu, Bing published an article in 2022, the title of the article was Visible-Light-Induced Decarboxylation of Dioxazolones to Phosphinimidic Amides and Ureas.Application of 102-07-8 And the article contains the following content:

A visible-light-induced external catalyst-free decarboxylation of dioxazolones was realized for the bond formation of N = P and N-C bonds to access phosphinimidic amides and ureas. Various phosphinimidic amides and ureas (47 examples) were synthesized with high yields (up to 98%) by this practical strategy in the presence of the system′s ppm Fe. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application of 102-07-8

The Article related to dioxazolone phosphinimidic amide urea visible light decarboxylation, decarboxylation, dioxazolones, phosphinimidic amides, ureas, visible light, Placeholder for records without volume info and other aspects.Application of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 27, 2022, Duss, Michael; Soto, Miguel A.; Patrick, Brian O.; MacLachlan, Mark J. published an article.Safety of 1,3-Diphenylurea The title of the article was A Supramolecular Strategy for the Synthesis of Cyclic Oligomers and Polymers by Ring Expansion. And the article contained the following:

Ring-opening metathesis polymerization (ROMP) of strained macrocycles is a key method to prepare diverse polymers. However, lack of ring strain in most macrocycles is an impediment to polymerization In this paper, the polymerization/oligomerization of unstrained macrocycles was achieved using a supramol. approach, leading selectively to cyclic products. Di-Ph thiourea and other guest mols. were used as additives to the ROMP reaction of unstrained macrocycles. An intermediate host-guest complex leads to the stabilization of the open form of the macrocycle after treatment with Grubbs catalysts, thereby favoring polymerization by inhibiting the ring-closing reaction back to the monomer. This proof-of-concept enables ring-expansion polymerization of unstrained macrocycles leading to cyclic polymers with mol. weights up to 6700 Da. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Safety of 1,3-Diphenylurea

The Article related to supramol cyclic oligomer polymer ring expansion, cyclic polymers, host-guest chemistry, macrocycle, olefin metathesis, supramolecular chemistry, Chemistry of Synthetic High Polymers: Other and other aspects.Safety of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharma, Priyanka; Joshi, Tushar; Mathpal, Shalini; Chandra, Subhash; Tamta, Sushma published an article in , the title of the article was In silico identification of antidiabetic target for phytochemicals of A. marmelos and mechanistic insights by molecular dynamics simulations.HPLC of Formula: 456-12-2 And the article contains the following content:

The leaves and fruits of Aegle marmelos (L.) have antidiabetic activity. However, the mode of action and mols. having antidiabetic activity are not known. Hence, we conducted mol. docking of phytochems. with various mol. antidiabetic targets to find the same. Docking prioritized Dipeptidyl peptidase-4 (DPP-4) as the main target for phytochems. of Aegle marmelos. DPP-4 inactivates intestinal peptides, glucagon-like peptide-1 (GLP-1), and Gastric inhibitory polypeptide (GIP). GLP-1 and GIP stimulate a decline in blood glucose levels, but DPP-4 inhibits their functions resulting high level of glucose. Hence inhibiting the activity of DPP-4 is a well-known strategy to treat Type 2 diabetes. Therefore, to find a mechanism that may be involved to act as a natural inhibitor of DPP-4, we screened five phytochems. out of seventy-three based on Virtual Screening, ADMET Drug-likeness anal., and PAINS filtering. Further, all five phytochems., i.e. Aegeline, Citral, Marmesinin, Auraptene, β-Bisabolene, and reference compound subjected MDS for analyzing the stability of docked complexes to assess the fluctuation and conformational changes during protein-ligand interaction. The values of RMSD, RG, RMSF, SASA, and Gibbs energy revealed the good stability of these phytochems. in the active site pocket of DPP-4 in comparison to reference Addnl., we have done the pharmacophore anal., which revealed many common pharmacophore features between screened phytochems. of A. marmelos and reference mol. Our results show that these phytochems. are potential antidiabetic candidates and can be further modified and evaluated to develop more effective antidiabetic drugs against DPP-4 to treat Type 2 Diabetes. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).HPLC of Formula: 456-12-2

The Article related to aegle marmelos phytochem antidiabetic mol dynamics simulation, aegle marmelos, dpp-4, type 2 diabetes, igemdock, molecular dynamics simulations, Placeholder for records without volume info and other aspects.HPLC of Formula: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2022, Sobh, Eman A.; Khalil, Nadia A.; Faggal, Samar I.; Hassan, Marwa S. A. published an article.Application of 79-07-2 The title of the article was New benzothienopyrimidine derivatives as dual EGFR/ARO inhibitors: Design, synthesis, and their cytotoxic effect on MCF-7 breast cancer cell line. And the article contained the following:

New cytotoxic agents based on benzothienopyrimidine scaffold were designed, synthesized, and evaluated against the MCF-7 breast cancer line in comparison to erlotinib and letrozole as reference drugs. Eight compounds demonstrated up to 20-fold higher anticancer activity than erlotinib, and five of these compounds were up to 11-fold more potent than letrozole in MTT assay. The most promising compounds were evaluated for their inhibitory activity against EGFR and ARO enzymes. Compound 12, which demonstrated potent dual EGFR and ARO inhibitory activity with IC50 of 0.045 and 0.146 μM, resp., was further evaluated for caspase-9 activation, cell cycle anal., and apoptosis. The results revealed that the tested compound 12 remarkably induced caspase-9 activation (IC50 = 16.29 ng/mL) caused cell cycle arrest at the pre-G1/G1 phase and significantly increased the concentration of cells at both early and late stage of apoptosis. In addition, it showed a higher safety profile on normal MCF-10A cells, and higher antiproliferative activity on cancer cells (IC50 = 8.15 μM) in comparison to normal cells (IC50 = 41.20 μM). It also revealed a fivefold higher selectivity index than erlotinib towards MCF-7 cancer cells. Docking studies were performed to rationalize the dual inhibitory activity of compound 12. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application of 79-07-2

The Article related to benzothienopyrimidine derivative preparation aromatase egfr inhibitor antitumor activity, aro and egfr inhibitors, benzothienopyrimidine, cytotoxic, Placeholder for records without volume info and other aspects.Application of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Abdul, Shiraazkhan; Dekkers, Dick H. W.; Ariens, Robert A. S.; Leebeek, Frank W. G.; Rijken, Dingeman C.; Uitte de Willige, Shirley published an article in 2020, the title of the article was On the localization of the cleavage site in human alpha-2-antiplasmin, involved in the generation of the non-plasminogen binding form.COA of Formula: C2H4ClNO And the article contains the following content:

The C-terminus of α2AP is crucial for the initial interaction with plasmin(ogen) and the rapid inhibitory mechanism. Approx. 35% of circulating α2AP has lost its C-terminus (non-plasminogen binding α2AP/NPB-α2AP) and thereby its rapid inhibitory capacity. The C-terminal cleavage site of α2AP is still unknown. A com. available monoclonal antibody against α2AP (TC 3AP) detects intact but not NPB-α2AP, suggesting that the cleavage site is located N-terminally from the epitope of TC 3AP. For epitope mapping of TC 3AP, com. available plasma purified α2AP was enzymically digested with Asp-N, Glu-C, or Lys-N. The resulting peptides were immunoprecipitated using TC 3AP-loaded Dynabeads Protein G. Bound peptides were eluted and analyzed by liquid chromatog.-tandem mass spectometry (LC-MS/MS). To localize the C-terminal cleavage site precisely, α2AP (intact and NPB) was purified from plasma and analyzed by LC-MS/MS after enzymic digestion with Arg-C. LC-MS/MS data from plasma purified α2AP showed that NPB-α2AP results from cleavage at Gln421-Asp422 as preferred site, but also after Leu417, Glu419, Gln420, or Asp422. The C-terminal cleavage site of human α2AP is located N-terminally from the TC 3AP epitope. Because C-terminal cleavage of α2AP can occur after multiple residues, different proteases may be responsible for the generation of NPB-α2AP. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).COA of Formula: C2H4ClNO

The Article related to alpha 2 antiplasmin amino acid proteolysis protein localization, alpha-2-antiplasmin, epitope mapping, mass spectrometry, proteolysis, western blot, Placeholder for records without volume info and other aspects.COA of Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 2, 2022, Song, Xue-Chao; Dreolin, Nicola; Damiani, Tito; Canellas, Elena; Nerin, Cristina published an article.Safety of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Prediction of Collision Cross Section Values: Application to Non-Intentionally Added Substance Identification in Food Contact Materials. And the article contained the following:

The synthetic chems. in food contact materials can migrate into food and endanger human health. In this study, the traveling wave collision cross section in nitrogen values of more than 400 chems. in food contact materials were exptl. derived by traveling wave ion mobility spectrometry. A support vector machine-based collision cross section (CCS) prediction model was developed based on CCS values of food contact chems. and a series of mol. descriptors. More than 92% of protonated and 81% of sodiated adducts showed a relative deviation below 5%. Median relative errors for protonated and sodiated mols. were 1.50 and 1.82%, resp. The model was then applied to the structural annotation of oligomers migrating from polyamide adhesives. The identification confidence of 11 oligomers was improved by the direct comparison of the exptl. data with the predicted CCS values. Finally, the challenges and opportunities of current machine-learning models on CCS prediction were also discussed. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Safety of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to nonintentional substance food contact collision crossection svm, nias, collision cross section, food contact materials, ion mobility, machine learning, Placeholder for records without volume info and other aspects.Safety of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics