Month: November 2022

On February 20, 2022, Wang, Yu-Qing; Hu, Li-Xin; Zhao, Jia-Hui; Han, Yu; Liu, You-Sheng; Zhao, Jian-Liang; Yang, Bin; Ying, Guang-Guo published an article.Reference of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Suspect, non-target and target screening of pharmaceuticals and personal care products (PPCPs) in a drinking water system. And the article contained the following:

Drinking water quality and safety are very important in protecting human health. Chem. contaminants in drinking water system have become an increasing concern. Our knowledge about what chems. are present in drinking water is still limited. Here we screened chems. of emerging concern in a conventional drinking water system based on suspect, non-target screening and target anal., and assessed their variations in different seasons and different treatment units. Overall, 720 chems. were identified with HRMS databases from the suspect and non-target screening and 48 chems. in five categories were further confirmed with the high confidence level, with predominance of pharmaceuticals and personal care products (PPCPs) and pesticides. Four compounds are newly found in aquatic environment with no literature or chem. occurrence data record. Temporal variations and variable removals were observed for these chems. in the system. Target anal. of 110 PPCPs showed detection of 21, 19 and 22 compounds in the drinking water treatment plant with a concentration range of 0.11-844 ng/L in the three seasons, but only 8, 9 and 15 compounds detected in tap water (0.16-32.5 ng/L). The variations of the detected chems. were less obvious in tap water, with most having concentrations below 2 ng/L. The results indicated efficient removal for most PPCPs in the drinking water system. The findings from this study demonstrated the strong capability of combined non-target screening and target anal. in identifying and assessing various organic chems. in drinking water system. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Reference of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to pharmaceutical personal care product detection drinking water system, drinking water, emerging contaminants, suspect screening, target analysis, water, Placeholder for records without volume info and other aspects.Reference of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 15, 2022, Matamoros, V.; Casas, M. Escola; Mansilla, S.; Tadic, Dj.; Canameras, N.; Carazo, N.; Portugal, J.; Pina, B.; Diez, S.; Bayona, J. M. published an article.HPLC of Formula: 144-80-9 The title of the article was Occurrence of antibiotics in Lettuce (Lactuca sativa L.) and Radish (Raphanus sativus L.) following organic soil fertilisation under plot-scale conditions: Crop and human health implications. And the article contained the following:

Recent studies have demonstrated the crop uptake of antibiotics (ABs) from soils treated with AB-carrying fertilisers. However, there is a lack of plot-scale studies linking their effects at the agronomic and metabolomic/transcriptomic level to their impact on human health. This paper assesses the plant uptake of 23 ABs following two productive cycles of lettuce and radish cropped with sewage sludge, pig slurry, the organic fraction of municipal solid waste, or chem. fertilisation under plot-scale conditions (32 plots spanning 3-10 m2 each). AB uptake by plants depended on both the vegetable and the AB class and was higher in radish than in lettuce edible parts. Levels ranged from undetectable to up to 76 ng/g (fresh weight). Repetitive organic fertilisation resulted in an increase in the concentration of ABs in lettuce leaves, but not in radish roots. Significant metabolomic and transcriptomic changes were observed following soil fertilisation. Nevertheless, a human health risk assessment indicates that the occurrence of ABs in lettuce or radish edible parts does not pose any risk. To our knowledge, this is the first holistic plot-scale study demonstrating that the use of organic fertilisers containing ABs is safe for crop security and human health. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

The Article related to lettuce radish organic soil fertilization antibiotic occurrence health implication, antibiotics, crops, human health risk, metabolomics, transcriptomics, Placeholder for records without volume info and other aspects.HPLC of Formula: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 15, 2021, Kong, Ming; Bu, Yuan-Qing; Zhang, Qin; Zhang, Sheng-Hu; Xing, Li-Qun; Gao, Zhan-Qi; Bi, Feng-Zhi; Hu, Guan-Jiu published an article.HPLC of Formula: 144-80-9 The title of the article was Distribution, abundance, and risk assessment of selected antibiotics in a shallow freshwater body used for drinking water, China. And the article contained the following:

With rapid improvements in industrialization and urbanization, antibiotics are now extensively used to prevent and treat human and animal diseases and husbandry and aquaculture. Some research has been conducted to assess the environmental distribution and risk level of antibiotics, but their distribution remains largely uncharacterized. Thus, this study investigated the distribution and abundance of 39 antibiotics belonging to five groups, and their associated risks in surface water around Luoma Lake in the north of Jiangsu province, China. Nineteen antibiotics were detected, at a detection frequency (DF) ranging from 2.27% to 100%. The total antibiotics (ΣABs) concentrations ranged from 34.91 to 825.93 ng/L, with a median concentration of 195.45 ng/L. Among these antibiotics, chlortetracycline (DF: 100%; median: 172.02 ng/L) was the dominant antibiotic, accounting for a median percentage of 91.0% of ΣABs concentrations Spearman rank correlation method found a significant correlation between clindamycin (DF: 72.7%; median: 2.01 ng/L) and lincomycin (DF: 79.5%; median: 4.58 ng/L). The ecol. risk quotient (RQ) values for two out of 44 sampling sites were higher than 1, indicating a high risk; 11.4% of the RQ values fell between 0.1 and 1, indicating a medium risk. Moreover, roxithromycin was found to be the dominant contributor to the ecol. risk, accounting for a median of 79.7% of ΣABs. However, the total non-carcinogenic (<6.54 x 10-4) and carcinogenic risks (<1.64 x 10-7) of ΣABs were negligible at the detected concentrations The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

The Article related to antibiotics drinking water shallow freshwater risk assessment china, antibiotic residues, ecological risk, health risk, luoma lake, spatial distribution, Placeholder for records without volume info and other aspects.HPLC of Formula: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2022, Ruan, Weifeng; Wang, Jiaxi; Huang, Jie; Tai, Yiping; Wang, Rui; Zhu, Weipeng; Yang, Yang published an article.HPLC of Formula: 144-80-9 The title of the article was The in vivo and vitro degradation of sulfonamides in wetland plants reducing phytotoxicity and environmental pollution. And the article contained the following:

Aquatic plants can be used for in situ remediation of water-borne pharmaceutical compounds; however, such information and that of the potential risks of metabolites released into the environment are limited. This study determined the capacity of Canna indica and Acorus calamus used in the remediation of water-borne sulfonamides (SA). The tolerance, removal, accumulation, and biotransformation of various water-borne SAs were investigated in vivo by exposing plants to SA solutions (50 μg/L and 500 μg/L). After 28 days, C. indica removed more SAs (89.3-97.8%) than A. calamus (12.8-84.6%) and non-planted systems (8.0-69.3%). The SA removal results, except from the A. calamus system with 500 μg/L SA, fit the first-order kinetics model. The estimated half-lives of all SAs were 3-40 h and 2-60 h in the C. indica and A. calamus systems, resp. In vivo biotransformation and rhizosphere degradation were the major phyto-removal mechanisms, constituting 24.9-81.1% and 0.0-37.1% of all SAs in the C. indica and A. calamus systems, resp. SA acetyl metabolites were detected only in plant tissues supporting evidence for plant metabolic processes without risk into the environment. SA metabolism including oxidation, methylation, and conjugation via acetylation was potentially beneficial to accumulation and tolerate stress of antibiotic. Canna indica was more suitable for cleaning SA. Our findings better clarify the potential and low risks of phytoremediation in antibiotic-contaminated waters. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

The Article related to sulfonamide wetland phytotoxicity biol wastewater treatment, aquatic pollution, detoxification, environmental risk, metabolism in vivo, phytoremediation, Placeholder for records without volume info and other aspects.HPLC of Formula: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ong-Artborirak, Parichat; Boonchieng, Waraporn; Juntarawijit, Yuwayong; Juntarawijit, Chudchawal published an article in 2022, the title of the article was Potential Effects on Mental Health Status Associated with Occupational Exposure to Pesticides among Thai Farmers.Application In Synthesis of 2-Chloroacetamide And the article contains the following content:

Pesticide-related mental health issues in Thailand, an upper-middle-income country, are not well known. This study aimed to investigate the association between the history of occupational exposure to pesticides and the mental health of Thai farmers. A cross-sectional study was carried out in the areas around Chiang Mai, a large city in Northern Thailand, between June 2020 and Jan. 2021. A total of 6974 farmers from six districts were interviewed to determine whether they regularly experienced symptoms related to mental health by the Self-Reporting Questionnaire (SRQ-20) as well as their lifetime history of agricultural pesticide exposure from 31 active ingredients and five functional categories: insecticides, herbicides, fungicides, rodenticides, and molluscicides. The cut-off of 6 was used to evaluate probable mental disorder. Most of the farmers under investigation were men (53.8%), with a mean age of 55.2 (11.7) years, and were involved mainly in the planting of rice, fruit, and vegetables. About 86.7% reported having used pesticides on their crops at some point in their lives-mostly glyphosate, paraquat, 2,4-D, methomyl, and carbofuran. All functional groups, as well as pesticide classes like organochlorines, organophosphates, and carbamates, were significantly associated with a higher risk of probable mental disorder based on exposure duration, frequency, personal protective equipment usage, and hygienic behavior. In a model with multiple pesticides, there was an association between mental disorder and exposure to endosulfan (AOR = 2.27, 95%CI = 1.26-4.08) and methyl parathion (AOR = 2.26, 95%CI = 1.26-4.06). Having previously reported pesticide poisoning symptoms was related to mental disorder (AOR = 7.97, 95%CI = 5.16-12.31), the findings provided evidence of pesticide exposure posing a risk to farmers′ mental health, particularly long-term and high-intensity exposure. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application In Synthesis of 2-Chloroacetamide

The Article related to glyphosate organochlorine occupational exposure mental health risk assessment population, farmer, mental health, pesticide, psychiatric disorder, symptom, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 10, 2021, Zha, Yonghong; Lu, Shiying; Hu, Pan; Ren, Honglin; Liu, Zengshan; Gao, Weihua; Zhao, Chengmin; Li, Yansong; Zhou, Yu published an article.Application of 79-07-2 The title of the article was Dual-Modal Immunosensor with Functionalized Gold Nanoparticles for Ultrasensitive Detection of Chloroacetamide Herbicides. And the article contained the following:

Convenient and ultrasensitive detection of pesticides is demanded for healthcare and environmental monitoring, which can be realized with a dual-modal strategy. In this paper, based on a biotin-labeled IgG-modified gold nanoparticle (AuNP@IgG-bio) probe, a dual-modal immunosensor was proposed for detecting chloroacetamide herbicides. This platform is relied on the dephosphorylation of ascorbic acid 2-phosphate (AA2P) by alk. phosphatase (ALP). In addition to this process, ascorbic acid (AA)-triggered deposition of silver on gold nanostars (AuNSs) and the fluorogenic reaction of dehydrogenated AA and o-phenylenediamine (OPD) occur sequentially. Thus, the dual readout of the color change of red-green-blue (RGB) and fluorescence generation in situ induced by crystal growth can be used. The limits of detection (LODs) were as low as 1.20 ng/mL of acetochlor (ATC), 0.89 ng/mL of metolachlor, 1.22 ng/mL of propisochlor, and 0.99 ng/mL of their mixture by a smartphone and 0.44 ng/mL of ATC, 1.59 ng/mL of metolachlor, 2.80 ng/mL of propisochlor, and 0.72 ng/mL of their mixture by a spectrofluorometer. The recoveries from corn were 91.4-105.1% of the colorimetric mode and 92.4-106.2% of the fluorescent mode. Due to its simple observation mode and good performance, this dual-modal immunosensor possesses considerable application prospects. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application of 79-07-2

The Article related to probe smartphone fluorescence immunosensor chloroacetamide herbicide, chloroacetamide herbicide, dual-modal, fluorescence, immunosensor, probe, smartphone, Placeholder for records without volume info and other aspects.Application of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 1, 2021, Liu, Limin; Wang, Zhengjie; Gao, Chao; Dai, Honglin; Si, Xiaojie; Zhang, Yang; Meng, Yaqi; Zheng, Jiaxin; Ke, Yu; Liu, Hongmin; Zhang, Qiurong published an article.Reference of N-(3-Aminophenyl)acrylamide The title of the article was Design, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives. And the article contained the following:

In order to find efficient new antitumor drugs, a series of novel trifluoromethyl-substituted pyrimidine derivatives were designed and synthesized and the bioactivity against four human tumor cells (PC-3, MGC-803, MCF-7 and H1975) was evaluated by MTT assay. Compound I displayed potent anti-proliferative activity on H1975 (IC50 = 2.27 渭M), which was better than the pos. control 5-FU (IC50 = 9.37 渭M). Further biol. evaluation studies showed that compound I apoptosis of H1975 cells and arrested the cell cycle at G2/M phase. Furthermore, compound I induced H1975 cells apoptosis through increasing the expression of pro-apoptotic proteins Bax and p53 and down-regulating the anti-apoptotic protein Bcl-2. In addition, compound I was able to be tightly embedded in the active pocket of EGFR. These results demonstrated that compound I has a potential as a lead compound for further investigation. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Reference of N-(3-Aminophenyl)acrylamide

The Article related to trifluoromethyl benzyl thio pyrimidin preparation sar antitumor mol docking, antitumor activity, pyrimidine derivatives, synthesis, trifluoromethyl moiety, Placeholder for records without volume info and other aspects.Reference of N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2022, Guemues, Mehmet; Babacan, Semsi N.; Demir, Yeliz; Sert, Yusuf; Koca, Irfan; Guelcin, Ilhami published an article.Product Details of 144-80-9 The title of the article was Discovery of sulfadrug-pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors. And the article contained the following:

Human carbonic anhydrase (hCA) isoenzymes are zinc ion-containing, widespread metalloenzymes and they classically play a role in pH homeostasis maintenance. CA inhibitors suppress the CA activity and their usage has been clin. established as antiglaucoma agents, antiepileptics, diuretics, and in some other disorders. Alzheimer鈥瞫 disease (AD) is a slowly progressive neurodegenerative disorder and a fatal disease of the brain. An advanced method to cure AD includes the strategy to design acetylcholinesterase (AChE) inhibitors. A novel series of pyrrole-3-one derivatives containing sulfa drugs (5a-i) were determined to be highly potent inhibitors for AChE and hCA I and hCA II (inhibitory constant [Ki] values are in the range of 6.50 卤 1.02-37.46 卤 4.12 nM, 1.20 卤 0.19-44.21 卤 1.09 nM, and 8.93 卤 1.58-46.86 卤 8.41 nM for AChE, hCA I, and hCA II, resp.). The designed compounds often show a more effective inhibition than the chems. used as the standard Among these compounds, 5f was the most effective compound against hCA I, and compound 5e was the most effective compound against hCA II. It was determined that compound 5c was the most effective inhibitor for AChE. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Product Details of 144-80-9

The Article related to alzheimer disease carbonic anhydrase acetylcholinesterase inhibitor, acetylcholinesterase, carbonic anhydrase, enzyme inhibition, pyrrole-3-one, sulfa drug, Placeholder for records without volume info and other aspects.Product Details of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2022, Dehghan Haghighi, Javid; Hormozi, Maryam; Payandeh, Abolfazl published an article.Electric Literature of 27115-50-0 The title of the article was Blood serum levels of selected biomarkers of oxidative stress among printing workers occupationally exposed to low-levels of toluene and xylene. And the article contained the following:

Printing workers (PWs) are exposed to a mixture of solvents, yet the health risks associated with such exposuer are unknown. This study aimed to compare the serum levels of selected biomarkers of oxidative stress among occupationally exposed PWs to low-level of toluene and xylenes and unexposed controls. Associations between levels of such biomarkers and occupational exposures to toluene and xylene were also investigated. Urinary levels of hippuric acid (HA) and Me hippuric acids (MHAs) as exposure biomarkers of toluene and xylenes, resp., and serum levels of oxidative stress biomarkers, including total antioxidant capacity (TAC), malondialdehyde (MDA), and the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), were measured among the 84 subjects, comprising 44 PWs and 40 unexposed subjects. Mean concentrations of urinary HA and MHAs of PWs showed a significant increase compared with the unexposed controls. Although levels of urinary biomarkers of exposure to toluene (HA) and xylenes (MHAs) were well below the biol. exposure indexes (BEIs; ACGHI), PWs presented significantly increased serum levels of MDA, and significantly decreased serum activities of SOD and GPx compared to the unexposed controls. However, for serum TAC and CAT activity, no significant difference was observed between the two groups. Correlation analyses indicated that urinary levels of HA and MHAs were pos. correlated with MDA levels and neg. correlated with GPx and SOD. Our study suggested that the alterations evidenced in serum levels of MDA, SOD, and GPx could be involved in the oxidative stress caused by co-exposure to low levels of toluene and xylene. Further investigation is needed to clarify the effect of low-level occupational exposure to solvents among PWs. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to toluene xylene blood serum printing worker biomarker oxidative stress, occupational exposure, antioxidants, oxidative stress, printing workers, toluene, xylene, Placeholder for records without volume info and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics