Month: November 2022

Kumar, Vishal; Dhawan, Sanjeev; Bala, Renu; Mohite, Sachin Balaso; Singh, Parvesh; Karpoormath, Rajshekhar published an article in 2022, the title of the article was Cu-catalysed transamidation of unactivated aliphatic amides.Quality Control of N,N-Diethylacetamide And the article contains the following content:

Direct transamidation was gaining prominence as a ground-breaking technique that generates a wide variety of amides without the requirement of acid-amine coupling or other intermediate steps. However, transamidation of unactivated aliphatic amides, on the other hand, was a long-standing issue in comparison to transamidation of activated amides. Herein, a transamidation approach of an unactivated aliphatic amide using a copper catalyst and chlorotrimethylsilane as an additive was reprted. In addition, used transamidation as a tool for selective N-C(O) cleavage and O-C(O) formation to synthesize 2-substituted benzoxazoles and benzothiazoles. The reactions were carried out without using any solvents and offered wide substitution scope. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Quality Control of N,N-Diethylacetamide

The Article related to amino phenyl alkylamide copper catalyst tranamidation, phenyl amide preparation, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Changpeng; Ling, Liang; Luo, Meiming; Zeng, Xiaoming published an article in 2021, the title of the article was Chromium-Catalyzed Ligand-Free Amidation of Esters with Anilines.Reference of 1,3-Diphenylurea And the article contains the following content:

Amides are important structural motifs in pharmaceutical and agrochem. chem. because of the intriguing biol. active properties. Author’s report here the amidation of com. available esters with anilines that was promoted by low-cost and air-stable chromium(III) pre-catalyst combined with magnesium, providing access to amides. This reaction occurs without the use of external ligands in a simple operation. Mechanistic studies indicate that a reactive aminated Cr species responsible for the amidation can be considered, which may be formed by reaction of low-valent Cr with aniline followed by reduction with hydrogen evolution. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Reference of 1,3-Diphenylurea

The Article related to secondary amide tertiary preparation chromium catalyst, ester aniline amidation, General Organic Chemistry: Synthetic Methods and other aspects.Reference of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2013, Barati, Behjat; Moghadam, Majid; Rahmati, Abbas; Mirkhani, Valiollah; Tangestaninejad, Shahram; Mohammadpoor-Baltork, Iraj published an article.Recommanded Product: 27115-50-0 The title of the article was Direct oxidation of alcohols to carboxylic acids over ruthenium hydride catalyst with diphenyl sulfoxide oxidant. And the article contained the following:

Direct oxidation of alcs. to their corresponding carboxylic acids with di-Ph sulfoxide oxidant over RuHCl(CO)(PPh3)3 catalyst was investigated. Mild reaction conditions, short reaction times and excellent yields make this method as an appealing way for preparation of carboxylic acids. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Recommanded Product: 27115-50-0

The Article related to alc diphenyl sulfoxide oxidation ruthenium catalyst, carboxylic acid preparation, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 17, 2020, Borchardt, Allen; Brady, Thomas P.; Chen, Zhi-Yong; Do, Quyen-Quyen Thuy; Jiang, Wanlong; Tari, Leslie W. published a patent.Computed Properties of 5455-98-1 The title of the patent was Compositions and methods for the treatment of human immunodeficiency virus. And the patent contained the following:

Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral gp120 receptor (e.g., temsavir, BMS-818251, DMJ-ll-121, BNM-IV-147, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin- binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., HIV infections). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Computed Properties of 5455-98-1

The Article related to composition treatment human hiv antiviral immunosuppression conjugate drug antibody, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Della Casa de Marcano, D.; Hasegawa, M.; Castaldi, A. published an article in 1972, the title of the article was Neutral compounds and alkaloids of Zanthoxylum ocumarense.Computed Properties of 456-12-2 And the article contains the following content:

Bark of Z. ocumarense was extracted with benzene and chromatographed on Al2O3. A mixture of n-alkanes (C21H44-C33H68) lupeol, 尾-amyrin and 2 amides (I, m. 149-51掳, and II, m. 175-6掳) were detected. The bark was again extracted with hot MeOH to yield 3 quaternary bases, N-methyl-伪-(-)-canadine, (+)-laurifoline, and cheleritrine, 2 alkaloids, C20H16NO5Cl (III), m. 245掳, and C15H11NO3 (IV), m. 216掳; and hesperidin. III was obtained in low yield, and IV proved unstable. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Computed Properties of 456-12-2

The Article related to zanthoxylum composition, alkaloid zanthoxylum, alkane zanthoxylum, amide zanthoxylum, Plant Biochemistry: Composition and Products and other aspects.Computed Properties of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chatterjee, Puranjan; Wang, Hsin; Manzano, J. Sebastian; Kanbur, Uddhav; Sadow, Aaron D.; Slowing, Igor I. published an article in 2022, the title of the article was Surface ligands enhance the catalytic activity of supported Au nanoparticles for the aerobic 伪-oxidation of amines to amides.Name: N,N-Diethylacetamide And the article contains the following content:

The catalytic aerobic 伪-oxidation of amines in water is an atom economic and green alternative to current methods of amide synthesis. The reaction uses O2 as terminal oxidant, avoids hazardous reactants and gives water as the only byproduct. Here we report that the catalytic activity of silica-supported Au nanoparticles for the aerobic 伪-oxidation of amines can be improved by tethering pyridyl ligands to the support. In contrast, immobilization of thiol groups on the material gives activities comparable to Au supported on bare silica. Our studies indicate that the ligands affect the electronic properties of the Au nanoparticles and thereby determine their ability to activate O2 and mediate C-H cleavage in the amine substrate. The reaction likely proceeds via an Au catalyzed 尾-hydride elimination enabled by back donation from electron-rich metal to the orbital. O2, which is also activated on electron-rich Au, acts as a scavenger to remove H from the metal surface and regenerate the active sites. The mechanistic understanding of the catalytic conversion led to a new approach for forming C-C bonds 伪 to the N atoms of amines. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Name: N,N-Diethylacetamide

The Article related to amide preparation amine aerobic alpha oxidation, supported au nanoparticle catalysis, General Organic Chemistry: Synthetic Methods and other aspects.Name: N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 20, 2015, Pant, Kritee; Groeger, Dominic; Bergmann, Ralf; Pietzsch, Jens; Steinbach, Joerg; Graham, Bim; Spiccia, Leone; Berthon, Fannely; Czarny, Bertrand; Devel, Laurent; Dive, Vincent; Stephan, Holger; Haag, Rainer published an article.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Synthesis and Biodistribution Studies of 3H- and 64Cu-Labeled Dendritic Polyglycerol and Dendritic Polyglycerol Sulfate. And the article contained the following:

Dendritic polyglycerol sulfate (dPGS) is a biocompatible, bioactive polymer which exhibits anti-inflammatory activity in vivo and thus represents a promising candidate for therapeutic and diagnostic applications. To investigate the in vivo pharmacokinetics in detail, dPGS with a mol. weight of approx. 10 kDa was radiolabeled with 3H and 64Cu, and evaluated by performing biodistribution studies and small animal positron emission tomog. (PET). 3H-labeling was accomplished by an oxidation-reduction process with sodium periodate and [3H]-borohydride. 64Cu-labeling was achieved by conjugation of isothiocyanate- or maleimide-functionalized copper(II)-chelating ligands based on 1,4-bis(2-pyridinylmethyl)-1,4,7-triazacyclononane (DMPTACN) to an amino functionalized dPGS scaffold, followed by reaction with an aqueous solution containing 64CuCl2. Independent biodistribution by radioimaging and PET imaging studies with healthy mice and rats showed that the neutral dPG was quant. renally eliminated, whereas the polysulfated analogs accumulated mainly in the liver and spleen. Small amounts of the dPGS derivatives were slowly excreted via the kidneys. The degree of uptake by the reticuloendothelial system (RES) was similar for dPGS with 40% or 85% sulfation, and surface modification of the scaffold with the DMPTACN chelator did not appear to significantly affect the biodistribution profile. On the basis of our data, the applicability of bioactive dPGS as a therapeutic agent might be limited due to organ accumulation even after 3 wk. The inert characteristics and clearance of the neutral polymer, however, emphasizes the potential of dPG as a multifunctional scaffold for various nanomedical applications. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to tritium copper 64 dendrimer polyglycerol sulfate chelator biodistribution preparation, Pharmaceuticals: Formulation and Compounding and other aspects.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 31, 2017, Gui, Yong-Yuan; Chen, Xiao-Wang; Zhou, Wen-Jun; Yu, Da-Gang published an article.Recommanded Product: N,N-Diethylacetamide The title of the article was Arylation of Amide and Urea C(sp3)-H Bonds with Aryl Tosylates Generated In Situ from Phenols. And the article contained the following:

The arylation of amide and urea C(sp3)-H bonds with aryl tosylates generated in situ from phenols has been realized at room temperature by combining visible-light-photoredox catalysis, hydrogen-atom-transfer catalysis, and nickel catalysis. This streamlined protocol permits rapid functionalization of phenols and direct transformation of 伪-amino C(sp3)-H bonds. The C(sp3)-H arylation products are obtained in high yields with good functional-group tolerance at low catalyst loadings. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Recommanded Product: N,N-Diethylacetamide

The Article related to amide urea arylation aryl tosylate, photoredox hydrogen atom transfer nickel catalysis, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gu, Zheng-Yang; Chen, Jie; Xia, Ji-Bao published an article in 2020, the title of the article was Pd-catalyzed amidation of 1,3-diketones with CO and azides via a nitrene intermediate.HPLC of Formula: 102-07-8 And the article contains the following content:

An efficient Pd-catalyzed amidation of 1,3-diketones has been developed using carbon monoxide and organic azides. This reaction provides a step-economic approach to produce 尾-ketoamides from readily available compounds under mild ligand-, oxidant-, and base-free conditions. The mechanistic studies showed that the reaction occurred through an in situ generated isocyanate intermediate. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).HPLC of Formula: 102-07-8

The Article related to beta ketoamide preparation, diketone azide carbon monoxide amidation palladium catalyst, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics