Month: November 2022

On May 21, 2010, Liu, Chen; Lu, Yixin published an article.HPLC of Formula: 167316-28-1 The title of the article was Primary amine/(+)-CSA salt-promoted organocatalytic conjugate addition of nitro esters to enones. And the article contained the following:

The combination of 9-amino-9-deoxy-epi-cinchonine and (+)-CSA resulted in a novel primary amine-based organocatalyst for effective iminium activation of 伪,尾-unsaturated ketones. Such a catalytic system could catalyze the conjugate addition of nitroacetate to enones in a highly enantioselective manner, affording the desired adducts in high yields and with up to 99% ee. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).HPLC of Formula: 167316-28-1

The Article related to substituted nitroester asym preparation, nitroacetate unsaturated ketone asym michael addition chiral amine csa, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 167316-28-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bonciolini, Stefano; Di Filippo, Mara; Baumann, Marcus published an article in 2020, the title of the article was A scalable continuous photochemical process for the generation of aminopropylsulfones.Category: amides-buliding-blocks And the article contains the following content:

An efficient continuous photochem. process that delivers a series of novel 纬-aminopropylsulfones RSO2CH2CH2CH(R1)N(R2)C(O)R3 (R = Ph, Et; R1 = H, Me; R2 = Me, Et; R3 = H, Ph, cyclohexyl, etc.) and RSO2CH2CH2CH(O)NHMe via a tetrabutylammonium decatungstate (TBADT) catalyzed HAT-process is presented. Crucial to this success is the exploitation of a new high-power LED emitting at 365 nm that was found to be superior to an alternative medium-pressure Hg lamp. The resulting flow process enabled the scale-up of this transformation reaching throughputs of 20 mmol h-1 at substrate concentrations up to 500 mM. Addnl., the substrate scope of this transformation was evaluated demonstrating the straightforward incorporation of different amine substituents as well as alkyl appendages next to the sulfone moiety. It is anticipated that this methodol. will allow for further exploitations of these underrepresented 纬-aminopropylsulfone scaffolds in the future. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Category: amides-buliding-blocks

The Article related to aminopropylsulfone preparation, amide vinyl sulfone coupling reaction tetrabutylammonium decatungstate photocatalyst, General Organic Chemistry: Synthetic Methods and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2010, Ali, Muhammad Shaiq; Shahnaz; Tabassum, Sobia; Ogunwande, Isiaka Ajani; Pervez, Muhammad Kashif; Ibrahim, Oladosu Adebayo published an article.Safety of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Naturally occurring antifungal aromatic esters and amides. And the article contained the following:

During the search of antifungal natural products from terrestrial plants, a new long chained aromatic ester named grandiflorate (1) along with spatazoate (2) from Portulaca grandiflora and N-[2-methoxy-2-(4-methoxyphenyl) ethyl]-trans-cinnamide (3) and aegeline (4) from Solanum erianthum of Nigeria were isolated and tested against six fungal species. The known constituents 2-4 have not been reported so far from mentioned investigated plants. Structures of the isolated compounds were elucidated with the aid of spectroscopic techniques including two dimensional NMR experiments Among the compounds 1-4, the esters (1-2) found more potent than amides (3-4) against Candida albicans and Aspergillus flavus. The new compound grandiflorate (1) gave response against all tested fungal species while aegeline (4) was found to give lowest inhibition during this study. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Safety of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to grandiflorate structure spatazoate fungicide portulaca, methoxymethoxyphenylethylcinnamide aegeline solanum fungicide, Plant Biochemistry: Composition and Products and other aspects.Safety of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chhatwal, A. Rosie; Lomax, Helen V.; Blacker, A. John; Williams, Jonathan M. J.; Marce, Patricia published an article in 2020, the title of the article was Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO3)2 or imidazole as catalysts.Recommanded Product: 1,3-Diphenylurea And the article contains the following content:

A new method for the direct synthesis of primary and secondary amides from carboxylic acids was described using Mg(NO3)2路6H2O or imidazole as a low-cost and readily available catalyst, and urea as a stable, and easy to manipulate nitrogen source. This methodol. was particularly useful for the direct synthesis of primary and Me amides avoiding the use of ammonia and methylamine gas which can be tedious to manipulate. Furthermore, the transformation does not require the employment of coupling or activating agents which are commonly required. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 1,3-Diphenylurea

The Article related to urea carboxylic acid magnesium nitrate imidazole catalyst coupling, primary amide preparation, secondary amide preparation, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 5, 2021, Das, Saikat; Murugesan, Kathiravan; Villegas Rodriguez, Gonzalo J.; Kaur, Jaspreet; Barham, Joshua P.; Savateev, Aleksandr; Antonietti, Markus; Koenig, Burkhard published an article.HPLC of Formula: 685-91-6 The title of the article was Photocatalytic (Het)arylation of C(sp3)-H Bonds with Carbon Nitride. And the article contained the following:

Mesoporous graphitic carbon nitride(mpg-CN)as a heterogeneous organic semiconductor photocatalyst for direct arylation of sp3 C-H bonds in combination with nickel catalysis are reported. This protocol has a broad synthetic scope (>70 examples including late-stage functionalization of drugs and agrochems.), was operationally simple, and shows high chemo- and regioselectivities. Facile separation and recycling of the mpg-CN catalyst in combination with its low preparation cost, innate photochem. stability, and low toxicity are beneficial features overcoming typical shortcomings of homogeneous photocatalysis. Detailed mechanistic investigations and kinetic studies indicate that an unprecedented energy-transfer process (EnT) from the organic semiconductor to the nickel complex was operated. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).HPLC of Formula: 685-91-6

The Article related to alkylamide aryl halide carbon nitride regioselective chemoselective arylation photochem, aryl methylalkylamide preparation, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ellis, J.; Gellert, E.; Summons, R. E. published an article in 1972, the title of the article was Alkaloids of Mitrella kentii (Annonaceae).Formula: C18H19NO3 And the article contains the following content:

Bark extracts of Mitrella kentii yielded 4 alkaloids: liriodenine, anonine, asimilobine, and egeline. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Formula: C18H19NO3

The Article related to mitrella bark alkaloid, liriodenine mitrella bark, anonaine mitrella bark, asimilobine mitrella bark, egeline mitrella bark, Plant Biochemistry: Composition and Products and other aspects.Formula: C18H19NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 20, 2015, Wang, Zhen; Kuninobu, Yoichiro; Kanai, Motomu published an article.Computed Properties of 5455-98-1 The title of the article was Palladium-Catalyzed Oxirane-Opening Reaction with Arenes via C-H Bond Activation. And the article contained the following:

We achieved a palladium-catalyzed C-H activation/C-C coupling reaction between arenes with a pyridyl, aminoquinolinyl, imino, or amide directing group, and oxiranes. The reaction proceeded at room temperature without any additives and tolerated a wide variety of functional groups, and the products were obtained in good to excellent yields, even on gram scale. This is the first example of a transition-metal-catalyzed intermol. direct coupling reaction between a C-H bond of aromatic compounds and a carbon atom of oxiranes via C-H bond activation. By using N-methoxybenzamide as a substrate, we obtained 3-substituted isochroman-1-ones in one pot. The coupling reaction proceeded with stereoretention. Kinetic isotope effect experiments suggested that C-H bond activation is the rate-determining step. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Computed Properties of 5455-98-1

The Article related to arene oxirane ring opening palladium catalyst, carbon hydrogen bond activation intermol direct coupling, hydroxyalkyl arene preparation, General Organic Chemistry: Synthetic Methods and other aspects.Computed Properties of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Xin; Werner, Thomas published an article in 2021, the title of the article was Indirect reduction of CO2 and recycling of polymers by manganese-catalyzed transfer hydrogenation of amides, carbamates, urea derivatives and polyurethanes.Name: 1,3-Diphenylurea And the article contains the following content:

A manganese pincer complex as a versatile catalyst for the transfer hydrogenation of amides, carbamates, urea derivatives and even polyurethanes leading to the corresponding alcs., amines and methanol as products were reported. Since these compound classes can be prepared using CO2 as a C1 building block the reported reaction represents an approach to the indirect reduction of CO2. Notably, these are the first examples on the reduction of carbamates and urea derivatives as well as on the C-N bond cleavage in amides by transfer hydrogenation. The general applicability of this methodol. is highlighted by the successful reduction of 12 urea derivatives, 26 carbamates and 11 amides. The corresponding amines, alcs. and methanol were obtained in good to excellent yields up to 97%. Furthermore, polyurethanes were successfully converted which represents a viable strategy towards a circular economy. Based on control experiments and the observed intermediates a feasible mechanism was proposed. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Name: 1,3-Diphenylurea

The Article related to carbonyl compound manganese catalyst transfer hydrogenation, polyurethane manganese catalyst transfer hydrogenation, alc amine preparation, General Organic Chemistry: Synthetic Methods and other aspects.Name: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 5, 2020, Wang, Jiajia; Wen, Yinhang; Zheng, Lu; Dou, Biao; Li, Linrong; Zhao, Kangkang; Wang, Na; Ma, Jing published an article.SDS of cas: 102-07-8 The title of the article was Characterization of chemical profiles of pH-sensitive cleavable D-gluconhydroximo-1, 5-lactam hydrolysates by LC-MS: A potential agent for promoting tumor-targeted drug delivery. And the article contained the following:

Currently, controllable linker cleavage at the target site will facilitate the clin. treatment of cancer. Dual-functional prodrugs in combination of carbohydrate as targeting group and pH-sensitive cleavable linker are desired in clin. development. Here, a qualified structure of N-phenylcarbamate-D-gluconhydroximo-1,5-lactam was employed and proved to be a potential candidate prodrug in the drug design. To proof this concept, the possible mechanism of Beckmann rearrangement and the degraded products were confirmed by HPLC and LC-MS under the acid condition mimic lysosome. Hence, the strategy of D-gluconhydroximo-1,5-lactam as a prodrug carrier fabricated with interested drugs will provide a great potential approach for chemotherapy. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).SDS of cas: 102-07-8

The Article related to gluconhydroximolactam tumor targeting prodrug, beckmann rearrangement, n-phenylcarbamate-d-gluconhydroximo-1,5-lactam, prodrug, ph sensitive, Pharmaceuticals: Formulation and Compounding and other aspects.SDS of cas: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 19, 2020, Chen, Hui-Ting; Huang, Yangen; Qing, Feng-Ling; Xu, Xiu-Hua published an article.Computed Properties of 5455-98-1 The title of the article was Trifluoromethylthiolation of epoxides with AgSCF3: a new access to vinyl trifluoromethyl thioethers. And the article contained the following:

An unexpected synthesis of vinyl trifluoromethyl thioethers RCH=CHSCF3 [R = Ph, PhCO2CH2, indol-1-ylmethyl, etc.] from epoxides is described. Treatment of epoxides with AgSCF3 in the presence of n-Bu4NI and KI in toluene afforded various vinyl trifluoromethyl thioethers in moderate to good yields. The use of easily available substrates and tolerance of wide functional groups are the notable advantages of this protocol. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Computed Properties of 5455-98-1

The Article related to vinyl trifluoromethyl thioether preparation diastereoselective, epoxide silver trifluoromethanethiolate trifluoromethylthiolation ring opening, General Organic Chemistry: Synthetic Methods and other aspects.Computed Properties of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics