Month: November 2022

On February 21, 2020, McKay, Alasdair I.; Altalhi, Weam A. O.; McInnes, Lachlan E.; Czyz, Milena L.; Canty, Allan J.; Donnelly, Paul S.; O’Hair, Richard A. J. published an article.Application of 102-07-8 The title of the article was Identification of the Side Products That Diminish the Yields of the Monoamidated Product in Metal-Catalyzed C-H Amidation of 2-Phenylpyridine with Arylisocyanates. And the article contained the following:

The Ru(II)-catalyzed amidation of 2-arylpyridines with aryl isocyanates via C-H bond activation is less efficient than described previously, due to the formation of a series of side products, which were readily identified using direct infusion electrospray mass spectrometry and high-performance liquid chromatog.-mass spectrometry. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application of 102-07-8

The Article related to aryl pyridylbenzamide preparation, phenylpyridine arylisocyanate amidation ruthenium catalyst, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 18, 2021, Peng, Guibin; Zhu, Chengzhen; Liao, Junbin; Gao, Xing; Hao, Liang; Sotto, Arcadio; Shen, Jiangnan published an article.Application In Synthesis of 2-Chloroacetamide The title of the article was A two-step strategy for the preparation of anion-exchange membranes based on poly(vinylidenefluoride-co-hexafluoropropylene) for electrodialysis desalination. And the article contained the following:

The development of a facile approach to fabricate anion exchange membranes (AEMs) with efficient ionic transport and desirable stabilities (mech. and dimensional) for various applications is meaningful. In this work, a two-step strategy for the preparation of AEMs with 3D network structure, via crosslinking reaction between 2-chloroacetamide (CAA) modified poly (vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) and N,N,N’,N’-tetramethyl-1,4-diaminobutane (TMDAB) has been reported. The as-prepared AEMs with ion-exchange capacity (IEC) in the range of 1.38-1.84 mmol g-1, exhibit the much lower water uptake (13.14-22.45%, 80°C) relative to the un-crosslinked AEM (35.89%, 80°C). In addition, due to the presence of fluorine-based 3D network structure, the as-prepared AEMs show much enhanced mech. and thermal stability in comparison with the un-crosslinked AEM. In the electrodialysis (ED) application, the optimized AEM shows the higher current efficiency (78.6%) and lower energy consumption (2.01 kWh kg-1 NaCl) than those of com. AEM AEM-Type II (76.4%; 2.26 kWh kg-1), resp., within 150 min of operation interval. The proposed facile fabrication protocol and the better-performance of optimized PVDF-HFP -based AEM demonstrate the potential ED application. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application In Synthesis of 2-Chloroacetamide

The Article related to strategy anion exchange membrane polyvinylidene hexafluoropropylene electrodialysis desalination, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Application In Synthesis of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 15, 2022, Xu, Liang; Liu, Yan; Meng, Faming; Lu, Hanbin; Li, Youzhi published a patent.Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Preparation of 3,5-diamide-1,4-dihydropyridine hydrogenation reagent and its application. And the patent contained the following:

The invention discloses a preparation of 3,5-diamide-1,4-dihydropyridine hydrogenation reagent and its application, which has the advantages of simple synthesis method, mild reaction conditions, and can effectively reduce the production cost and improve the production safety. The hydrogenation reagent is shown in formula I, wherein R is selected from hydrogen atom, linear alkyl with 1-20 carbon atoms, branched alkyl with 3-10 carbon atoms and branched alkyl with 3-10 carbon atoms-cycloalkyl group with 10 carbon atoms, or substituted or unsubstituted Ph group. The hydrogenation reagent was prepared via ring opening reaction and heterocyclization. The step of asym. hydrogenation includes the following steps: mixing the substrate, the hydrogenation reagent, proton acid and organic solvent, separating and purifying after the reaction is complete. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to preparation diamide dihydropyridine hydrogenation reagent ring opening reaction heterocyclization, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xue, Weifeng; Zhang, Haiqin; Wang, Mei; Liu, Ying; Liu, Mengyao; Shen, Baozhen published an article in 2022, the title of the article was Metabolomics-based non-targeted screening analysis of 34 PPCPs in bovine and piscine muscles.Application of 144-80-9 And the article contains the following content:

The metabolomics-based anal. strategy has showed superiority on the non-targeted screening of contaminants, especially for unknown and unexpected (U&U) contaminants in the field of food safety, but data anal. is often the bottleneck of the strategy. In this study, a novel metabolomics-based anal. method via searching for marker compounds was developed on the basis of ultrahigh-performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) results to accurately, rapidly and comprehensively achieve the non-targeted screening of 34 pharmaceutical and personal care products (PPCPs) as U&U contaminants spiked in bovine and piscine muscle matrixes. Three concentration groups (20, 50 and 100 ng mL-1) were intentionally designed to simulate the control and exptl. groups for the discovery of marker compounds, for which multivariate and univariate analyses were adopted. In multivariate anal., each concentration group was fully separated from the other two groups in PCA and OPLS-DA plots, laying a foundation to distinguish marker compounds among groups. The S-plot, permutation and variable importance in projection (VIP) in OPLS-DA were employed to screen and identify marker compounds, which were further verified by pairwise t-test and fold change judgement in univariate anal. The results indicate that 34 PPCPs spiked in two muscle matrixes were all identified as marker compounds, proving the validity and practicability of this novel metabolomics-based non-targeted screening method, which will exhibit great superiority and broad application prospects, especially in the face of massive PPCPs and various animal matrixes in the field of food safety control. In addition, the limits of detection (LODs) for 34 PPCPs were calculated to be 0.2-2.6μg kg-1 and 0.3-2.1μg kg-1 in bovine and piscine muscle matrixes, resp. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Application of 144-80-9

The Article related to muscle pharmaceutical personal care product metabolomics screening, Biochemical Methods: Spectral and Related Methods and other aspects.Application of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 15, 2022, Dou, Shuzhen; Wang, Zhongshun; Chen, Qiye; Lu, Nan published an article.Electric Literature of 144-80-9 The title of the article was One-step fabrication of high-density Si nanotips as SALDI-MS substrate for highly sensitive detection. And the article contained the following:

The high sensitivity of surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) anal. depends on the enhancement of the signal intensity and the reduction of the background. Here, high-d. Si nanotips were prepared as SALDI-MS substrate by taking template-free reactive ion etching for sensitive detection. The high-d. Si nanotips act as tiny antennas to concentrate the laser energy and generate photo-induced electrons on a small area, which promotes desorption and ionization of mol., enhancing the signal intensity. Addnl., the high stability of Si nanotips under laser irradiation ensures low background interference. The applicability of the substrate was demonstrated by the detection of various small mols., e.g., fatty acids, amino acids, environmental pollutants and drugs. In addition, this substrate can be successfully applied for detecting trace small mols. in complex sample, such as 10-9 M verapamil in serum and 10-12 M crystal violet in lake water. Moreover, the banned fungicides left on the fish skin was also detected. The substrate is compatible with imaging, and the endogenous and exogenous substances in fingerprint were visualized by MS imaging. These results demonstrate the easily prepared high-d. Si nanotips SALDI-MS substrate is of high detection sensitivity and great value toward large-scale practical applications. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Electric Literature of 144-80-9

The Article related to silicon nanotip verapamil stearic acid sarcosine saldi ms fabrication, Biochemical Methods: Spectral and Related Methods and other aspects.Electric Literature of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 13, 2021, Kawamata, Yu; Hayashi, Kyohei; Carlson, Ethan; Shaji, Shobin; Waldmann, Dirk; Simmons, Bryan J.; Edwards, Jacob T.; Zapf, Christoph W.; Saito, Masato; Baran, Phil S. published an article.Synthetic Route of 5455-98-1 The title of the article was Chemoselective Electrosynthesis Using Rapid Alternating Polarity. And the article contained the following:

Challenges in the selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically been overcome either by using reagents/catalysts that tunably interact with a substrate or through modification to shield undesired sites of reactivity (protecting groups). Although electrochem. offers precise redox control to achieve unique chemoselectivity, this approach often becomes challenging in the presence of multiple redox-active functionalities. Historically, electrosynthesis has been performed almost solely by using d.c. (DC). In contrast, applying a.c. (AC) has been known to change reaction outcomes considerably on an anal. scale but has rarely been strategically exploited for use in complex preparative organic synthesis. Here we show how a square waveform employed to deliver elec. current-rapid alternating polarity (rAP)-enables control over reaction outcomes in the chemoselective reduction of carbonyl compounds, one of the most widely used reaction manifolds. The reactivity observed cannot be recapitulated using DC electrolysis or chem. reagents. The synthetic value brought by this new method for controlling chemoselectivity is vividly demonstrated in the context of classical reactivity problems such as chiral auxiliary removal and cutting-edge medicinal chem. topics such as the synthesis of PROTACs. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Synthetic Route of 5455-98-1

The Article related to electrochem chemoselective reduction ketone rapid alternating polarity, Heterocyclic Compounds (One Hetero Atom): General and other aspects.Synthetic Route of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2020, Kim, Da-Hye; Park, Chang Gyun; Kim, Young Jun published an article.Formula: C2H4ClNO The title of the article was Characterizing the potential estrogenic and androgenic activities of two disinfection byproducts, mono-haloacetic acids and haloacetamides, using in vitro bioassays. And the article contained the following:

Exposure to disinfection byproducts (DBPs) is potentially related to cytotoxic, genotoxic, mutagenic, and tumorigenic effects in humans, in addition to their adverse effects on the environment. However, their impacts on endocrine disruption, especially reproductive toxicity, remain largely unknown. In this study, the estrogenic and androgenic activities of DBPs and corresponding antagonistic activities were investigated using a yeast-based reporter assay, focusing on haloacetic acids and haloacetamides. We also examined the cytotoxicity of DBPs and mechanisms of antagonistic activities. Of the DBPs assayed, iodoacetamide (IAM) and bromoacetamide (BAM) were the most cytotoxic, with LC50 values of 0.0462 and 0.0537 mM, resp., followed by chloroacetic acid (CAA; LC50 = 4.87 mM) and chloroacetamide (CAM; LC50 = 5.28 mM). Iodoacetic acid (IAA) and bromoacetic acid (BAA) were the least cytotoxic, with LC50 values of 5.52 and 6.35 mM, resp. IAA (EC10 = 0.00573 mM; EC50 = 0.0215 mM) exhibited most potent estrogenic activity, and CAA (EC10 = 0.0434 mM) and BAM (EC10 = 0.0150 mM) showed weak estrogenic and androgenic activities, resp. By contrast, IAM exhibited anti-estrogenic effects. These results suggest that DBPs interact with hormone receptors. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to pituitary cell iodoacetamide bromoacetamide cytotoxicity estrogenic androgenic, cytotoxicity, disinfection byproducts, endocrine disrupting potency, yes/yas assay, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 3, 2014, Spear, Kerry L.; Campbell, Una published a patent.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Preparation of piperidinylindoline derivatives for use as nervous system agents. And the patent contained the following:

Title compounds I [R1 = halo, OH, CN, (un)substituted alkyl, aryl, etc.; R2 = H, halo, OH, alkyl, etc.; or R1 and R2 are taken together with the C atom to which they are attached to form an (un)substituted alkenyl, cycloalkyl or heterocyclyl; R3 = H, OH, halo, CN, alkyl, etc.; R5 = (un)substituted alkyl, cycloalkyl, aryl, heteroaryl, etc.; each X independently = CH or N; Y = absent, O, NH, N-alkyl, or (un)substituted alkylene], and their pharmaceutically acceptable salts, are prepared and disclosed as nervous system agents. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in CAMP assays on CHO cells expressing the human NOP/MOP receptors (data given). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to piperidinylindoline preparation nervous system agent, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2013, Sano, Satoshi; Ishino, Tomonori; Nagata, Ichiro; Shiratsuchi, Kentaro; Itou, Shigehide; Ishizuka, Kenichi; Umehara, Takeshi published a patent.Safety of N-(3-Aminophenyl)acrylamide The title of the patent was Composite membranes for separating gases, gas separation module using same, gas separation devices and gas separation method. And the patent contained the following:

Provided is a composite membrane for separating gases having a gas separation layer, which contains a crosslinked polyimide resin, on a gas permeable support layer side, wherein the crosslinked polyimide resin has a structure in which a polyimide compound is crosslinked via a specific crosslinking chain, and the specific crosslinking chain has at least one type of linking group selected from a group comprising -NRaC(:O)-, -NRbC(:O)O-, -CH2OCH2-, -CH2SCH2-, -OC(:O)O-, -C(:O)O-N+(Rc)3-, -SO3-N+(Rd)3-, and -PO3-N+(Re)3-, wherein Ra, Rb, Rc, Rd and Re = hydrogen atom or a substituent. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Safety of N-(3-Aminophenyl)acrylamide

The Article related to composite membrane gas separator crosslinked polyimide, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Safety of N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics