Month: November 2022

On December 30, 2015, Aizawa, Ryo; Araki, Koichi published a patent.SDS of cas: 100524-09-2 The title of the patent was Method for producing 2-amino-6-methylnicotinic acid. And the patent contained the following:

Disclosed is a preparation method of 2-amino-6-methylnicotinic acid, characterized by (1) reaction of 2-chloro-3-cyano-6-methylpyridine with ammonia aqueous solution to obtain reaction mixture containing 2-amino-6-methylnicotinamide (2) removal of ammonia from the resulting reaction mixture followed by treatment with a base. Thus, to 2-chloro-3-cyano-6-methylpyridine (6.10 g) was added 28% aqueous ammonia (70 mL), the resulting mixture was reacted at 170° for 7 h and cooled to room temperature After removal of ammonia under reduced pressure, the residue was treated with KOH (9.00 g) [100°, 3 h], precipitated using 4 N HCl at room temperature (pH 4-5), filtered, washed with water, and dried to give 2-amino-6-methylnicotinic acid (82.9% yield, 97.06% purity). The experimental process involved the reaction of 2-Amino-6-methylnicotinamide(cas: 100524-09-2).SDS of cas: 100524-09-2

The Article related to aminomethylnicotinic acid preparation, amination amidation hydrolysis, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.SDS of cas: 100524-09-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 25, 2020, Li, Yanxiong; Meng, Faming; Xu, Liang; Guo, Jun published a patent.Application In Synthesis of (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Environmentally-friendly preparation method of Avibactam intermediate. And the patent contained the following:

A process for preparation of Avibactam intermediate is disclosed. The process comprises mixing compound I, chiral catalyst, protic acid and solvent, stirring, filtering, and concentrating to obtain (2S,5R)-5-[(phenylmethoxy)amino]-2-piperidinecarboxamide, wherein the chiral catalyst is represented by the structure II (R = H, C1-20 alkyl, C3-10 cycloalkyl, (un)substituted phenyl). The process is simple and cost-effective, has high yield and purity, and suitability for large-scale industrial production The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Application In Synthesis of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to avibactam intermediate preparation stereoselective catalytic hydrogenation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2022, Bardakova, Kseniia N.; Kholkhoev, Bato Ch.; Farion, Ivan A.; Epifanov, Evgenii O.; Korkunova, Olga S.; Efremov, Yuri M.; Minaev, Nikita V.; Solovieva, Anna B.; Timashev, Peter S.; Burdukovskii, Vitaliy F. published an article.Name: 1,3-Diphenylurea The title of the article was 4D Printing of Shape-Memory Semi-Interpenetrating Polymer Networks Based On Aromatic Heterochain Polymers. And the article contained the following:

Most of the presently known thermosensitive shape-memory polymers suitable for 4D printing have insufficient mech. strength and thermal stability that restricts their potential areas of application. Here, new photosensitive compositions (PSCs) based on aromatic heterochain polymers – poly-N,N’-(m-phenylene)isophthalamide (MPA) or poly-2,2′-(p-oxydiphenylene)-5,5′-dibenzimidazole (OPBI) – for DLP printing are proposed. Thermal post-curing and supercritical carbon dioxide (scCO2) are used for post-processing of the structures. During the scCO2 treatment the removal of unreacted monomeric component (N,N-dimethylacrylamide) and its uncrosslinked oligomers is accompanied by the preservation of the initial degree of crosslinking. The more stable shrinkage is observed for the combined post-processing method (T°+scCO2) in the case of OPBI-PSC and after the heat treatment for MPA-PSC specimens. The method of post-processing and the nature of the heterochain polymer strongly affect the mech. properties and thermal resistance of the structures. The tensile strength has the maximum value after the thermal post-treatment (101.1 ± 7.1 and 78.4 ± 5.1 MPa of OPBI-PSC and MPA-PSC, resp.). The intense destruction of the materials is observed at 393 and 408°C for MPA-PSC and OPBI-PSC, resp. Moreover, the 4D-printed structures exhibit excellent shape memory performance at transition temperatures >100°C, thus have a great potential for the use in aerospace, robotics, sensorics. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Name: 1,3-Diphenylurea

The Article related to polybenzimidazole semi interpenetrating polymer network shape memory property, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Name: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 28, 2019, Hansel, Christian; Kundu, Dipan published an article.Recommanded Product: 685-91-6 The title of the article was Development of Hierarchically Porous Ionomer Membranes for Versatile and Fast Metal Ion Conduction. And the article contained the following:

Innovative design concept can play a key role in the realization of high-performance ionomer membranes that are capable of exclusive metal ion conduction and potentially applicable in electrochem. devices including sensors, fuel cells, and high energy batteries. Herein, we report on the development of new ionomers, based on sulfonated poly(ether ether ketone) (SPEEK), engineered to conduct a variety of ions, namely Li+, Na+, K+, Zn2+, and Mg2+, when soaked with nonaqueous solvents. Application of a facile phase inversion method results in M-SPEEK (M = Li/Na/K/Zn/Mg) membranes with hierarchical porous network, facilitating organic solvent infusion that is necessary to promote dissociation and rapid transport of cations between anionic sulfonate groups on the polymer chains. This strategy leads to membranes with alkali ion conductivities approaching 10-4 S cm-1 at room temperature, and near unity cation transference numbers (tΜ+ ≥ 0.9). Furthermore, an exceptionally high Zn-ion conductivity of 10-2 S cm-1 is obtained for the water infused Zn-SPEEK membrane. In comparison, the dense membranes demonstrate 2-3 orders of magnitude lower conductivities due to insufficient solvent infusion. Preliminary electrochem. studies with solvent infused ionomer membranes as the electrolyte look assuring. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Recommanded Product: 685-91-6

The Article related to sulfonated polyether polyketone porous ionomer membrane metal ion conductivity, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Recommanded Product: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 21, 2020, McKay, Alasdair I.; Altalhi, Weam A. O.; McInnes, Lachlan E.; Czyz, Milena L.; Canty, Allan J.; Donnelly, Paul S.; O’Hair, Richard A. J. published an article.Application of 102-07-8 The title of the article was Identification of the Side Products That Diminish the Yields of the Monoamidated Product in Metal-Catalyzed C-H Amidation of 2-Phenylpyridine with Arylisocyanates. And the article contained the following:

The Ru(II)-catalyzed amidation of 2-arylpyridines with aryl isocyanates via C-H bond activation is less efficient than described previously, due to the formation of a series of side products, which were readily identified using direct infusion electrospray mass spectrometry and high-performance liquid chromatog.-mass spectrometry. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application of 102-07-8

The Article related to aryl pyridylbenzamide preparation, phenylpyridine arylisocyanate amidation ruthenium catalyst, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 18, 2021, Peng, Guibin; Zhu, Chengzhen; Liao, Junbin; Gao, Xing; Hao, Liang; Sotto, Arcadio; Shen, Jiangnan published an article.Application In Synthesis of 2-Chloroacetamide The title of the article was A two-step strategy for the preparation of anion-exchange membranes based on poly(vinylidenefluoride-co-hexafluoropropylene) for electrodialysis desalination. And the article contained the following:

The development of a facile approach to fabricate anion exchange membranes (AEMs) with efficient ionic transport and desirable stabilities (mech. and dimensional) for various applications is meaningful. In this work, a two-step strategy for the preparation of AEMs with 3D network structure, via crosslinking reaction between 2-chloroacetamide (CAA) modified poly (vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) and N,N,N’,N’-tetramethyl-1,4-diaminobutane (TMDAB) has been reported. The as-prepared AEMs with ion-exchange capacity (IEC) in the range of 1.38-1.84 mmol g-1, exhibit the much lower water uptake (13.14-22.45%, 80°C) relative to the un-crosslinked AEM (35.89%, 80°C). In addition, due to the presence of fluorine-based 3D network structure, the as-prepared AEMs show much enhanced mech. and thermal stability in comparison with the un-crosslinked AEM. In the electrodialysis (ED) application, the optimized AEM shows the higher current efficiency (78.6%) and lower energy consumption (2.01 kWh kg-1 NaCl) than those of com. AEM AEM-Type II (76.4%; 2.26 kWh kg-1), resp., within 150 min of operation interval. The proposed facile fabrication protocol and the better-performance of optimized PVDF-HFP -based AEM demonstrate the potential ED application. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application In Synthesis of 2-Chloroacetamide

The Article related to strategy anion exchange membrane polyvinylidene hexafluoropropylene electrodialysis desalination, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Application In Synthesis of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 15, 2022, Xu, Liang; Liu, Yan; Meng, Faming; Lu, Hanbin; Li, Youzhi published a patent.Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Preparation of 3,5-diamide-1,4-dihydropyridine hydrogenation reagent and its application. And the patent contained the following:

The invention discloses a preparation of 3,5-diamide-1,4-dihydropyridine hydrogenation reagent and its application, which has the advantages of simple synthesis method, mild reaction conditions, and can effectively reduce the production cost and improve the production safety. The hydrogenation reagent is shown in formula I, wherein R is selected from hydrogen atom, linear alkyl with 1-20 carbon atoms, branched alkyl with 3-10 carbon atoms and branched alkyl with 3-10 carbon atoms-cycloalkyl group with 10 carbon atoms, or substituted or unsubstituted Ph group. The hydrogenation reagent was prepared via ring opening reaction and heterocyclization. The step of asym. hydrogenation includes the following steps: mixing the substrate, the hydrogenation reagent, proton acid and organic solvent, separating and purifying after the reaction is complete. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to preparation diamide dihydropyridine hydrogenation reagent ring opening reaction heterocyclization, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chau, Nguyen Dang Giang; Van Hop, Nguyen; Long, Hoang Thai; Duyen, Ngo Thi My; Raber, Georg published an article in 2020, the title of the article was Multi-residue analytical method for trace detection of new-generation pesticides in vegetables using gas chromatography-tandem mass spectrometry.Formula: C2H4ClNO And the article contains the following content:

A GC-MS/MS method with low solvent consumption and easy operation was developed to simultaneously determine ten new-generation pesticides, namely fenobucarb, acetochlor, pretilachlor, fipronil, trifloxystrobin, fluazifop-p-Bu, isoprothiolane, tebuconazole, cypermethrin and difenoconazole in leafy vegetables. Influences from ultrasonic sample extraction and the clean-up steps to reduce matrix effects were investigated. Under suitable conditions, good linearity (deviation of back calculated concentration from true concentration lower than 20%) was achieved for all studied pesticides; the method detection limits (MDLs) ranged from 1.4 to 3.6 ng g-1 wet weight For mustard green and green onion the method yielded good recoveries at two spiking levels (201 and 100 ng g-1) ranging from 80% to 111% (n = 5). The repeatability, expressed as relative standard deviation (RSD), was lower than 11% (n = 5). The method was successfully used to quantify pesticide residues in 207 vegetable samples (green onions, mustard greens, and lettuce) collected in Thua Thien Hue and Quang Binh Provinces, Central Vietnam. The insecticide cypermethrin was found at critical levels in 98% of the vegetable samples. Green onions had high pesticide residues with a significant number of samples containing pesticides at concentrations exceeding the maximum residue levels (MRLs). The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to onion mustard green lettuce pesticide gas chromatog mass spectrometry, gc-ms/ms, method development, pesticides residues, solid phase extraction, ultrasonic extraction, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2011, Nugroho, Agung Endro; Riyanto, Sugeng; Sukari, Mohamad Aspollah; Maeyama, Kazutaka published an article.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Effects of aegeline, a main alkaloid of Aegle marmelos correa leaves, on the histamine release from mast cells. And the article contained the following:

Aegeline or N-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide is a main alkaloid isolated from Aegle marmelos Correa collected in Yogyakarta Indonesia. In our study, we investigated the effects of aegeline on the histamine release from mast cell. The study was performed by using (1) rat basophilic leukemia (RBL-2H3) cell line, and (2) rat peritoneal mast cells (RPMCs). DNP24-BSA, thapsigargin, ionomycin, compound 48/80 and PMA were used as inducers for histamine release from mast cell. In our study, aegeline inhibited the histamine release from RBL-2H3 cells induced by DNP24-BSA. Indeed, aegeline showed strong inhibition when RBL-2H3 cells induced by Ca2+ stimulants such as thapsigargin and ionomycin. Aegeline is suggested to influence the intracellular Ca2+ pool only since could not inhibit the 45Ca2+ influx into RBL-2H3 cells. Aegeline showed weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin. These findings indicate that aegeline altered the signaling pathway related to the intracellular Ca2+ pool in which thapsigargin acts. Based on the results, the inhibitory effects of aegeline on the histamine release from mast cells depended on the type of mast cell and also involved some mechanisms related to intracellular Ca2+ signaling events via the same target of the action of thapsigargin or downstream process of intracellular Ca2+ signaling in mast cells. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to antihistamine aegeline alkaloid aegle leaf histamine release mast cell, Pharmacology: Effects Of Gastrointestinal and Respiratory Drugs and other aspects.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2018, Zhang, Yinsheng; Gao, Yong; Ren, Jing; Wang, Qinglin; Zhao, Damin; Zhou, Yu; Wu, Zheyang published a patent.Synthetic Route of 16230-24-3 The title of the patent was Preparation of boron-containing compounds as tyrosine kinase inhibitors. And the patent contained the following:

The title compounds I [wherein R1 is H, F, Cl, Br, alkyl, etc.; X is NH or O; R4 and R6 are independently H, alkyl, alkoxy, etc.; R3 and R7 are independently H and alkoxy; R5 is H, alkylamino, alkyl, cycloalkyl, etc.; Cy is (un)substituted Ph] were claimed and prepared The inventive compound has good inhibitory action on tyrosine kinase, and can be applied in treating the proliferative diseases caused by tyrosine kinase. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Synthetic Route of 16230-24-3

The Article related to preparation boron tyrosine kinase inhibitor treatment proliferative disease, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Synthetic Route of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics