Month: November 2022

On May 29, 2012, Uttam, Surana; Krishnan, Vaidehi; Ting, Anthony; Lim, Hong Hwa published a patent.HPLC of Formula: 5455-98-1 The title of the patent was Naphthalamide derivatives having antiproliferative activity. And the patent contained the following:

The invention relates to compounds for use in medicine. The compounds are of general formula (I) as disclosed herein and the pharmaceutically acceptable salts, individual isomers and mixtures of isomers thereof, wherein X, X’ and X are independently O or S; Z is N or P; R3 is optional and is selected from the group consisting of optionally substituted C1-8 alkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C1-6 alkoxy, optionally substituted C1-6 thioalkyl, optionally substituted C5-10 aryl, optionally substituted C6-11 alkylaryl, optionally substituted C1-6 alkylamino, optionally substituted C1-6 alkylcarbonyl, optionally substituted C1-6 alkylsulfonamino, optionally substituted (C1-C6)alkylsulfinyl, optionally substituted C1-6 alkylcarbonylamino, optionally substituted hetero(C4-C10)aryl, hydroxyl, halogen, cyano, nitro, amino, formyl, and thiol; R1, R2, R4, R5, R6, R7, R8, R9, and R10 are independently selected from the group consisting of hydrogen, optionally substituted C1-8 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C1-6 alkoxy, optionally substituted C1-6 thioalkyl, optionally substituted C5-10 aryl, optionally substituted C6-11 alkylaryl, optionally substituted C1-6 alkylamino, optionally substituted C1-6 alkylcarbonyl, optionally substituted C1-6 alkylsulfonamino, optionally substituted (C1-C6)alkylsulfinyl, optionally substituted C1-6 alkylcarbonylamino, optionall. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).HPLC of Formula: 5455-98-1

The Article related to naphthalamide derivative antiproliferative agent, antitumor agent naphthalamide derivative, antifungal agent naphthalamide derivative, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.HPLC of Formula: 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yi, Yuanyuan; Wang, Luhong; Zhao, Dan; Huang, Shanshan; Wang, Changyuan; Liu, Zhihao; Sun, Huijun; Liu, Kexin; Ma, Xiaodong; Li, Yanxia published an article in 2018, the title of the article was Structural optimization of diphenylpyrimidine scaffold as potent and selective epidermal growth factor receptor inhibitors against L858R/T790M resistance mutation in non-small cell lung cancer.HPLC of Formula: 16230-24-3 And the article contains the following content:

A new class of thiodiphenylpyrimidine analogs (Thio-DPPY) were synthesized as potent and selective EGFR T790M inhibitors to overcome gefitinib resistance in non-small cell lung cancer (NSCLC). This structural optimization led to the identification of two potent EGFRT790M/L858R inhibitors, 14a (N-[3-[[5-chloro-2-[4-((1-morpholino)propylthio)phenylamino]-4-pyrimidinyl]amino]phenyl]-2-propenamide) and 14e (N-[3-[[5-chloro-2-[4-((1-morpholino)ethanethioate)phenylamino]-4-pyrimidinyl]oxygen]phenyl]-2-propenamide), which possess IC50 values of 27.5 and 9.1 nM, resp. Moreover, compounds 14a (SI > 36.4) and 14e (SI > 109.9) exhibited high selectivity and low activity against the wild-type EGFR (IC50 > 1000 nM). In particular, compound 14a also displayed strong potency against EGFRT790M-mutated H1975 cells (IC50 = 0.074 μM), but weak activity toward normal cells HBE (IC50 > 40 μM) and LO-2 (IC50 = 9.891 μM). It is important that compound 14a (SI = 52.6) significantly improved the selectivity against mutant H1975 cells over wild-type A431 cells than rociletinib (SI = 6.0), thus revealing its slight cell cytotoxicity. This study provides a promising Thio-DPPY derivative as enhanced EGFR T790M inhibitor, and also revealed valuable clues for further optimization of DPPY scaffold to overcome NSCLC resistance. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).HPLC of Formula: 16230-24-3

The Article related to diphenylpyrimidine preparation egf receptor inhibitor mutation antitumor lung nsclc, egfr t790m, nsclc, inhibitors, pyrimidine, resistance, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.HPLC of Formula: 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 21, 2021, Gruendler, Franziska; Scholz, Henrik; Herbig, Marcus; Schwarzer, Sandra; Wagler, Jorg; Kroke, Edwin published an article.Formula: C13H12N2O The title of the article was Formation of Aromatic O-Silylcarbamates from Aminosilanes and Their Subsequent Thermal Decomposition with Formation of Isocyanates. And the article contained the following:

A novel phosgene-free route to different isocyanates starts from CO2 and aminosilanes (cf. silylamines) to form so-called carbamoyloxysilanes (O-silylcarbamates), i. e., compounds with the general motif R1R2N-CO-O-SiR3R4R5 as potential precursors. The authors focused on the insertion reaction of CO2 into Si-N bonds of substrates with cyclic (mostly aromatic) amine substituents, i. e., PhNHSiMe3, (PhNH)2SiMe2, PhCH2NHSiMe3, p-(MeO)C6H4NHSiMe3, o-C6H4(NHSiMe3)2, 1,2-C6H10(NHSiMe3)2, o-C6H4(NHSiMe3)(CH2NHSiMe3) and 1,8-C10H6(NHSiMe3)2. Compared to previously studied aminosilanes these reactions are hindered due to the reduced nucleophilicity/basicity of the N-atoms. Whereas slightly increased CO2 pressure (8 bar) and prolonged reaction times (24 h) were sufficient to overcome hindrance of the insertion into, e. g., PhNHSiMe3, intermol. effects in some 2-fold NHSiMe3 functionalized substrates led to partial mono-insertion (e. g., into o-C6H4(NHSiMe3)(CH2NHSiMe3)) or intra-mol. condensation of the intermediate insertion product in case of 1,8-C10H6(NHSiMe3)2 to form 1H-perimidin-2(3H)-one and other side products. Thermal treatment of mono-silylated O-silylcarbamates RHN-CO-O-SiR’3 resulted mainly in the formation of substituted ureas (RHN)2CO, whereas desired isocyanates could not be detected in these cases. Therefore, the authors continued the authors’ studies focussing on N,O-bissilylated precursors, which were obtained by an addnl. N-silylation of the O-silylated carbamates. This allowed the successful formation of isocyanates. As a sole byproduct hexamethyldisiloxane is formed. In all cases, known as well as yet unknown substances were characterized by 1H, 13C and 29Si NMR spectroscopy, along with x-ray diffraction anal. for crystallized solids. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Formula: C13H12N2O

The Article related to aminosilane insertion reaction carbon dioxide, aromatic silylcarbamate preparation crystal structure, mol structure aromatic silylcarbamate, Organometallic and Organometalloidal Compounds: Silicon Compounds and other aspects.Formula: C13H12N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 1, 2019, Chen, Chen; Nie, Yiming; Xu, Guangsen; Yang, Xinying; Fang, Hao; Hou, Xuben published an article.Computed Properties of 97-09-6 The title of the article was Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors. And the article contained the following:

Bcl-2 family proteins, which divides into pro-apoptosis proteins and anti-apoptosis proteins, are involved in cell apoptosis progression. As numerous studies illustrated, targeting Bcl-2 family proteins is more and more attractive and practicable to cancer treatment. In this work, we designed and synthesized a series of indomethacin derivatives as new inhibitors for Bcl-2 family proteins. Our results of binding assay to Bcl-2 proteins, MTT assay and apoptotic assay indicated that some compounds had potent binding affinity to Bcl-2/Mcl-1 but not Bcl-xL. Furthermore, compound 8j showed improved anti-proliferative activity than known Bcl-2 inhibitor WL-276. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Computed Properties of 97-09-6

The Article related to apoptosis anticancer bcl2 mcl1 dual inhibitor indomethacin derivative, anticancer, apoptosis, bcl-2/mcl-1 dual inhibitor, indomethacin derivatives, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Computed Properties of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 2022, Tong, Ruoming; Fu, Rui; Yang, Zhe; Jiang, Yuanxing; Jiang, Kun; Sun, Xuhui published an article.Computed Properties of 79-07-2 The title of the article was Efficient degradation of sulfachloropyridazine by sulfite activation with CuO-Al2O3 composites under neutral pH conditions: Radical and non-radical. And the article contained the following:

In this work, CuO-Al2O3 composites were synthesized at higher temperatures to control the leaching of metal ions, which can activate sulfite (S(IV)) to degrade organic contaminants by generating reactive oxygen species (ROSs). The synthesized catalysts were characterized by X-ray diffraction, SEM, high-resolution transmission electron microscopy, Brunauer-Emmett-Teller, Raman spectroscopy, and Fourier transform IR spectrophotometry. Sulfachloropyridazine (SCP) was almost completely removed (>99%) at pH 6.8, and the leaching amount of Cu accounted for 0.027% of the total amount of Cu after the reaction. Notably, singlet oxygen (1O2) was found for the first time in the activated sulfite system, which removed organic pollutants together with sulfate (SO4·- ) and hydroxyl (·OH) radicals. And Al2O3 plays an important role in the catalyst, including anti-sintering, reducing the leaching of copper ions, and promoting the generation of oxygen vacancies. Based on the types of ROSs and XPS results, a possible ROSs generation mechanism was proposed. In addition, the stability of the catalyst and the effect of different factors on the degradation of SCP, including operating parameters and water quality, were further investigated. The intermediates were detected by using gas chromatog.-mass spectrometry and a developmental toxicity assessment of the intermediates was defined based on the Toxicity Estimation Software Tool (TEST). Overall, this paper not only provides a new strategy for sulfite activation but also promotes more attention to non-radical processes in activated sulfite systems. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Computed Properties of 79-07-2

The Article related to copper aluminum oxide sulfachloropyridazine degradation, Waste Treatment and Disposal: Physical Treatment Of Aqueous Wastes and other aspects.Computed Properties of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ali, Mohammad; Zarchi, Karimi; Tarabsaz, Ali published an article in 2015, the title of the article was Ring Opening of Epoxides by Using Cross-Linked Poly(4-Vinylpyridine)-Supported Thiocyanate in the Presence of Polymer-Supported Sulfuric Acid Under Solvent-Free Conditions.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:

Cross-linked poly(4-vinylpyridine)-supported thiocyanate ion, [P4-VP]SCN, is introduced as recyclable polymeric reagent for the efficient and regioselective conversion of epoxides to thiocyanohydrins in the presence of cross-linked poly(4-vinylpyridine)-supported sulfuric acid, [P4-VP]H2SO4, as a solid proton source and as catalyst under solvent-free conditions. The ring-opening reaction of epoxides take place very fast under solvent-free conditions and the regioselective thiocyanohydrins are prepared in high yields at 65°C. The present method offers advantages such as short reaction time, simple reaction work-up, and the polymeric reagents can be regenerated and reused several times without significant loss of their activity. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to epoxide ring opening polymer supported reagent solvent free, Plastics Manufacture and Processing: Chemical Properties Of Resins and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mohareri, Mohammad Moein; Ghaffari, Mehdi; Sattarzadeh, Elham; Kakaei, Saeed published an article in 2021, the title of the article was Preparation and application of Fe3O4@Acetamidoxanthate as a unique nanosorbent in heavy metal removing.Computed Properties of 79-07-2 And the article contains the following content:

Chelating agents are one of the most important substances in metal extraction, but separation is the main problem in the use of these agents as an adsorbent. After the adsorption of metals by an external magnet, magnetic NPs provide the possibility of easy collecting and isolating the adsorbent nanomaterial for many applications. Given the immense importance of magnetic NPs, there has been widespread interest in accessing the above adsorbent. In the present study, an attempt was made to synthesize acetamido xanthate which was coupled to NPs and has the potential to be used as a nano-adsorbent for the removal of heavy metals. This novel nano sorbent was characterized by SEM (SEM), Fourier transforms IR (FT-IR), and NMR (NMR) spectroscopy. The effect of some parameters such as temperature, time, pH, and the amount of adsorbent on the extraction reaction was investigated. The optimized condition for extraction of cerium was temperature of 30°C, pH=8, reaction time of 45 min using 7.5mg of the prepared nanosorbent, that in such condition the yield of reaction achieved up to 97%. The prepared adsorbent showed high efficiency in the adsorption of heavy metals specifically. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Computed Properties of 79-07-2

The Article related to iron oxide acetamidoxanthate nanosorbent heavy metal removing, Waste Treatment and Disposal: Physical Treatment Of Aqueous Wastes and other aspects.Computed Properties of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 3, 2014, Sugawara, Yasuhisa; Sakata, Koji; Tomioka, Yasuhiro; Demizu, Hiroyuki; Satoh, Hiroki published a patent.Formula: C11H9NO3 The title of the patent was Solid electrolytic capacitor. And the patent contained the following:

Provided is a solid electrolytic capacitor having a low initial equivalent series resistance (ESR) in which the ESR increase with time can be suppressed. It is a solid electrolytic capacitor, including an electroconductive polymer layer, a graphite layer on the electroconductive polymer layer, and a silver layer on the graphite layer, wherein the electroconductive polymer layer and the graphite layer, and/or, the graphite layer and the silver layer are bonded by a chem. bond. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Formula: C11H9NO3

The Article related to capacitor electrolytic solid low equivalent series resistance, Electric Phenomena: Capacitors, Dielectrics, Insulators, Electrets and other aspects.Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 15, 2022, Li, Xitong; Liang, Kaiming; Yang, Bo; Xiao, Ke; Duan, Huabo; Song, Guangqing; Zhao, Huazhang published an article.Formula: C8H10N2O3S The title of the article was Preparation and application of a targeted magnetically separated catalyst for sulfonamides degradation based on molecular dynamics selection and mechanism analysis. And the article contained the following:

As refractory pollutants, sulfonamides (SAs) are widely distributed in the aquatic environment. The existing methods for advanced oxidation used to remove SAs from water received wide attention. In this study, surface mol. imprinting technol. has been used to prepare targeted catalysts that can be rapidly separated The results showed that molecularly imprinted catalysts can significantly improve the removal capacity of sulfonamides. When compared to Fe3O4, the removal rates observed for 3 different SAs increased by 98, 20 and 61%, resp. over 480 min on target catalyst and a good magnetic separation effect was observed in short time. The theor. results show that the optimal imprinted conditions can be quickly determined by analyzing the energy variation in the optimized system. Combined with energy anal. and free radical detection, the effects of weak interactions such as hydrogen bonds and van der Waals forces on the selective recognition ability of the materials were determined The results also show that the selective recognition process mainly exists in the higher activity groups (-NH2 and -NH-) that connect to the benzene ring in SAs. The catalysts also maintain their targeted catalytic activity in complex water samples. The results show that computational chem. and mol. imprinting can be used to design and prepare a targeted catalyst quickly and analyze the mechanism of its targeted degradation process. This study can provide reference for the rapid design of targeted catalysts and an improvement in the degradation efficiency of refractory pollutants found in wastewater. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Formula: C8H10N2O3S

The Article related to sulfonamide surface mol imprinting degradation wastewater treatment, Waste Treatment and Disposal: Chemical Treatment Of Aqueous Wastes and other aspects.Formula: C8H10N2O3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 8, 2022, Yang, Lei; Wu, Xiaona; Chen, Xiaoyu; Chen, Fei; Zheng, Xiaona; Song, Qinan; Liu, Xiang; Li, Miao published an article.COA of Formula: C8H10N2O3S The title of the article was Synergistic Removal of Nutrient Pollutants and Pharmaceutical and Personal Care Products (PPCPs) from Contaminated Groundwater: Macro- and Microelements and Microorganisms. And the article contained the following:

The synergistic removal performance of nutrient pollutants and pharmaceutical and personal care products (PPCPs) from contaminated groundwater, and the biogeochem. interactions of macro- and microelements-contaminants-microorganisms were further studied. The electrolysis-zeolite/basalt system proved to achieve better synergistic removal performance than all other purification systems considered, reaching average removal efficiencies of 85.8% for nutrient pollutants and 74.7% for PPCPs. Electrolysis not only enhanced the abundance and distribution of MOB and DNB, but also promoted the production of microelements Fe3+ (0.1 ± 0.1 mg/L) and Zn2+ (0.3 ± 0.3 mg/L). Macroelements Ca2+ and Mg2+ increased by 27.8 ± 2.7 and 16.5 ± 9.6 mg/L, resp., which significantly stimulated the activities of function microbials. Microelements Fe3+ exchanged from zeolite, Mn2+ from basalt, and Cu2+ from groundwater itself were crucial for enzyme activity. Meanwhile, Mn2+ was co-regulated by oxidation-reduction processes and ion-exchange strength. Thus, the electrolysis-zeolite/basalt system is a promising technol. for synergistic nutrient pollutant and PPCP removal from contaminated groundwater, especially in dispersive water supplied in the countryside of China. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).COA of Formula: C8H10N2O3S

The Article related to microelement microorganism synergistic removal nutrient groundwater pollutant, Waste Treatment and Disposal: Physical Treatment Of Aqueous Wastes and other aspects.COA of Formula: C8H10N2O3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics