Month: November 2022

On December 29, 2020, Li, Yanxiong; Xu, Liang; Meng, Faming; Yu, Yonghai published a patent.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Method for synthesizing (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline using 1-phenyl-3,4-dihydroisoquinoline. And the patent contained the following:

The present invention relates to a (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline synthesizing method comprising: mixing 1-phenyl-3,4-dihydroisoquinoline, chiral catalyst, acid and solvent, and reacting them. The (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline with high chiral purity can be generated during the hydrogenation reduction process. The product is easy to sep. and purify, and the yield is high. In addition, the reaction conditions are mild, the process is stable, the reaction operation is simple, convenient and safe, the production cost is low, the three-waste treatment is simple and feasible, the environment is friendly, the equipment used in the reaction process is simple, the raw materials are easy to obtain, and the method is suitable for industrial production The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to phenyltetrahydroisoquinoline preparation stereoselective hydrogenation phenyldihydroisoquinoline, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 5, 2021, Wang, Huihong; Cao, Fei; Gao, Weiwei; Wang, Xiaodong; Yang, Yuhang; Shi, Tao; Wang, Zhen published an article.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Pd(II)-Catalyzed Annulation Reactions of Epoxides with Benzamides to Synthesize Isoquinolones. And the article contained the following:

Epoxides as alkylating reagents were unprecedentedly applied in Pd(II)-catalyzed C-H alkylation and oxidative annulation of substituted benzamides to synthesize isoquinolones I [R = 7-Me, 6-t-Bu, 6,8-di-OMe, etc.; R1 = Me, n-pentyl, Bn, etc.; R2 = OMe, OEt, OBn, etc.] rather than isochromans, which was accomplished through alerting the previously reported reaction mechanism by the addition of oxidant and TEA. Under these conditions, various isoquinolones were prepared with yields up to 92%. In addition, this methodol. was successfully employed in the total syntheses of rupreschstyril, siamine, and cassiarin A in an expedient fashion. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to isoquinolone preparation, epoxide benzamide ch alkylation oxidative annulation palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Coote, Steven J.; Davies, Stephen G.; Middlemiss, David; Naylor, Alan published an article in 1989, the title of the article was Enantiospecific synthesis of (+)-(R)-6,7-dimethoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline from (+)-(S)-2-methylamino-1-phenylethanol.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide And the article contains the following content:

Acid-promoted cyclization of (+)-(R)-N-(3,4-dimethoxybenzyl)halostachine tricarbonylchomium at -20° is highly stereoselective proceeding with retention of configuration to yield, after removal of the tricarbonylchromium unit, homochiral (+)-(R)-6,7-dimethoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline. In contrast, cyclization of (-)-(R)-N-(3,4-dimethoxybenzyl)halostachine under acidic conditions at -20° showed poor stereoselectivity giving predominantly the tetrahydroisoquinoine product corresponding to inversion of configuration, (+)-(R)-6,7-dimethoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, with an enantiomeric excess of 54%. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to methylaminophenylethanol conversion isoquinoline derivative, isoquinoline derivative stereoselective synthesis, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 10, 2016, Bergman, Ylva Elisabet; Lessene, Romina; Ganame, Danny; Foitzik, Richard Charles; Morrow, Benjamin Joseph; Camerino, Michelle Ang; Walker, Scott Raymond; Lagiakos, H. Rachel; Feutrill, John; Stupple, Paul Anthony published a patent.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Preparation of aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5 inhibitors. And the patent contained the following:

The invention relates to compounds of formula I, II and III as PRMT5-inhibitors; their preparation and use in the treatment of cancer and hemoglobinopathy. Compounds of formula I, II and III wherein n = 1 and 2; R is H and Me; R1 is halo and Me; R2a and R2b are independently F, H, Me and CH2OH; R2c and R2n are independently F, H, Me and CH2OH; R3a and R3b are independently H and Me; R4a is OH, NH2, CONH2 and CH2OH; R4b is H and Me; R5 is H and Me; A is (un)substituted Ph, (un)substituted naphthyl; and (un)substituted C5-12 heteroaryl, are claimed. Example compound IV was prepared by acylation of 1-amino-3-((2,3-dihydro-1H-inden-2-yl)amino)propan-2-ol with 4-chlorobenzoic acid. The invention compounds were evaluated for their PRMT5 inhibitory activity. From the assay, it was determined that example IV exhibited IC50 value of 0.792 μM. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to aminoindane aminotetrahydronaphthalene aminobenzocyclobutane preparation prmt5 inhibitor treatment cancer hemoglobinopathy, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kwon, Jae-Woo; Park, Hee-Won; Kim, Woo Jin; Kim, Man-Goo; Lee, Seung-Joon published an article in 2018, the title of the article was Exposure to volatile organic compounds and airway inflammation.Safety of 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

Exposure to low levels of volatile organic compounds (VOCs) in ordinary life is suspected to be related to oxidative stress and decreased lung function. This study evaluated whether exposure to ambient VOCs in indoor air affects airway inflammation. Thirty-four subjects from the hospital that had moved to a new building were enrolled. Symptoms of sick building syndrome, pulmonary function tests, and fractional exhaled nitric oxide (FeNO) were evaluated, and random urine samples were collected 1 wk before and after the move. Urine samples were analyzed for VOC metabolites, oxidative stress biomarkers, and urinary leukotriene E4 (uLTE4) levels. The level of indoor VOCs in the new building was higher than that in the old building. Symptoms of eye dryness and eye irritation, as well as the level of a xylene metabolite (o-methylhippuric acid) increased after moving into the new building (p = 0.012, p = 0.008, and p < 0.0001, resp.). For the inflammatory markers, FeNO decreased (p = 0.012 and p = 0.04, resp.) and the uLTE4 level increased (p = 0.005) after the move. Exposure to a higher level of VOCs in everyday life could affect airway inflammation. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Safety of 2-(4-Methylbenzamido)acetic acid

The Article related to volatile organic compound airway inflammation, inflammation, oxidative stress, sick building syndrome, spirometry, volatile organic compounds, Air Pollution and Industrial Hygiene: Air Pollutants and Air Pollution and other aspects.Safety of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 7, 2021, Giroux, Simon; Nuhant, Philippe Marcel; Bandarage, Upul Keerthi; Garcia Barrantes, Pedro Manuel; Liao, Yusheng; Gale-Day, Zachary; Gu, Wenxin; Karns, Alexander S.; Zhang, Hu; Allen, Emily Elizabeth; Xu, Jinwang; Deninno, Michael Paul; Tang, Qing; Boucher, Diane Marie; Fanning, Lev T.D.; Hall, Amy B.; Hurley, Dennis James; Johnson, Mac Arthur, Jr.; Maxwell, John Patrick; Swett, Rebecca Jane; Tapley, Timothy Lewis; Thomson, Stephen A.; Damagnez, Veronique; Cottrell, Kevin Michael published a patent.Quality Control of 2-Fluoro-4-hydroxybenzamide The title of the patent was Preparation of 1H-pyrazolo[4,3-g]isoquinoline and 1H-pyrazolo[4,3-g]quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency. And the patent contained the following:

1H-pyrazolo[4,3-g]isoquinoline and 1H-pyrazolo[4,3-g]quinoline derivatives(I) as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD). Compounds I wherein Z1-Z3 each independently -N, -NH, or -CH; V1 and V2 are each selected from C and N; W1 and W2 are each selected from -C=O, -CR2, N, etc.; etc., are claimed. The example compound II was prepared via 4-steps synthesis using (4-chlorophenyl)boronic acid as starting material reacting with intermediate (also prepared)(procedure given). Compounds I were evaluated for alpha-1-antitrypsin modulating activity (data given). Compounds I can be used for the treatment of α1-antitrypsin deficiency. The experimental process involved the reaction of 2-Fluoro-4-hydroxybenzamide(cas: 1133122-96-9).Quality Control of 2-Fluoro-4-hydroxybenzamide

The Article related to pyrazoloquinoline preparation alpha1 antitrypsin deficiency treatment, pyrazoloisoquinoline preparation alpha1 antitrypsin modulator deficiency treatment, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Quality Control of 2-Fluoro-4-hydroxybenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 31, 2021, Vala, Anand; Parmar, Nirali; Soni, Jigar Y.; Kotturi, Sharadsrikar; Guduru, Ramakrishna published an article.HPLC of Formula: 102-07-8 The title of the article was 1,4,2-Dioxazol-5-ones as Isocyanate Equivalents: An Efficient Synthesis of 2-Quinolinones via β-Keto Amides. And the article contained the following:

Under thermal conditions, 1,4,2-dioxazol-5-ones were known to undergo decarboxylation followed by Lossen’s rearrangement to yield isocyanates. A safe and efficient method for the generation and capture of isocyanates to gave β-keto amides I [R1 = H, 3-Cl, 4-OMe; R2 = H, 4-Br, 4-F, etc.] was established. The β-keto amides I were efficiently converted into quinolin-2-ones II [R1 = H, 3-Cl, 4-OMe; R2 = H, 4-Br, 4-F, etc.] in good to excellent yields. Importantly, the method was transition metal-free and involved a simple two-step procedure that could be of interest to the pharmaceutical industry. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).HPLC of Formula: 102-07-8

The Article related to quinolinone preparation, beta keto amide preparation polyphosphoric acid cyclization, dioxazolone acetophenone thermal degradation isocyanate in situ trapping, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.HPLC of Formula: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 20, 2012, Bappert, Erhard; De Vries, Andreas Hendrikus Maria; Domin, Doris; Helms, Matthias; Imboden, Christoph; Nazir, Zarghun; Skranc, Wolfgang; Spindler, Felix; Stanek, Michael; Tschebull, Wilhelm; Verzijl, Gerardus Karel Maria published a patent.Related Products of 65645-88-7 The title of the patent was Process for the preparation of an enantiomeric trisubstituted 3,4-dihydro-isoquinoline derivative. And the patent contained the following:

The present invention relates to a process for the preparation of the compound of formula (7) which process comprises the hydrogenation of the compound of formula (4) using bis[chloro-1,5-cyclooctadiene-iridium], (S)-i-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]-ferrocene as a catalyst. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Related Products of 65645-88-7

The Article related to dihydroisoquinoline derivative hydrogenation iridium chiral ligand, tetrahydroisoquinoline derivative asym preparation, iridium chiral ligand asym hydrogenation catalyst, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Related Products of 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 9, 2009, Bappert, Erhard; De Vries, Andreas Hendrikus Maria; Domin, Doris; Helms, Matthias; Imboden, Christoph; Nazir, Zarghun; Skranc, Wolfgang; Spindler, Felix; Stanek, Michael; Tschebull, Wilhelm; Verzijl, Gerardus Karel Maria published a patent.Computed Properties of 65645-88-7 The title of the patent was Process for the preparation of an enantiomeric trisubstituted 3,4-dihydroisoquinoline derivative. And the patent contained the following:

The invention relates to a process for the preparation of the compound of formula I by enantioselective hydrogenation of the corresponding imine intermediate catalyzed by bis[chloro-1,5-cyclooctadiene-iridium] and (S)-1-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]ferrocene. Reaction conditions, such as additives, ratios of substrate/catalyst and solvent systems, play roles respect to enantioselectivity and yields therefore were examined Other metal/chiral ligand catalyst systems were evaluated for the enantioselective hydrogenation of the substrate. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Computed Properties of 65645-88-7

The Article related to dihydroisoquinoline derivative hydrogenation iridium chiral ligand, tetrahydroisoquinoline derivative asym preparation, iridium chiral ligand asym hydrogenation catalyst, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Computed Properties of 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 8, 2021, Chen, Yan-Ru; Chung, Hsiao-Wei; Tung, Shih-Huang published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was On the Formation Mechanism of Nonsolvent-Induced Porous Polylactide Electrospun Fibers. And the article contained the following:

Polylactide (PLA) fibers were electrospun from the solutions of PLA dissolved in the mixtures of its good and poor solvents, and the formation mechanism of the poor solvent-induced porous structure on the fibers was investigated. From a systematic study using the pairs of a variety of good/poor solvents for electrospinning, the conditions, specifically the solvent properties, for producing uniform fibers with controllable pores that appear not only on the surface but also throughout the fibers were proposed. The water miscibility of the good/poor solvents is crucial, which is because the ambient moisture that condenses during electrospinning plays an important role in the formation of the pores. Furthermore, the evaporation rate of the good/poor solvents is another key factor that affects the pore size and pore distribution on fibers because the solvent evaporation rate regulates the moisture condensation and the phase-separated scale that are closely related to fiber morphol. The principles generalized in this work can be applied to other low-polar polymers for controlling the porosity of fibers. In addition, this work demonstrates that the porous PLA fibers can be electrospun from low-toxic solvents and that with a large surface area and storage space provided by the pores, the PLA porous fibers are highly capable of adsorbing oils, with a capacity double that of the smooth counterpart. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to porous polylactide electrospun fiber, Textiles and Fibers: Fiber and Yarn Processing and Processing Materials and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics