Month: November 2022

Gopalan, D. H.; Vani, M.; Manikandan, S.; Vijayakumar, V. published an article in 2021, the title of the article was An immunohistochemical and biochemical evidences of pancreatic β-cell regeneration in type 2 diabetic rats after treated with Aegle marmelos leaf extract and Aegeline.Category: amides-buliding-blocks And the article contains the following content:

The study aims to investigate the Immunohistochem. changes in pancreatic beta cells in fructose fed, streptozocin (STZ) induced Type 2 Diabetes (T2DM) rats treated with various doses of leaf extract of Aegle marmelos (AAM) and Aegeline (AG). 42 adult male wistar albino rats were separated into 7 groups, including Vehicle Control (VC); T2DM; T2DM + AAM 250 mg/kg; T2DM + AAM 500 mg/kg; T2DM + AG 20mg/kg; T2DM + AG 50 mg/kg and T2DM + AG 100 mg/kg. Exptl. T2DM was created by a single dose of 40 mg/kg STZ injection intra-peritoneally along with 10% of fructose solution given orally for 30 days. Calculated dosages of AAM and AG were given with oral gavage for 30 days. Pancreas was harvested and processed. Slides were stained using hematoxylin and eosin (H & E) stains. Insulin expressing beta-cells was analyzed using immunohistochem. Fructose fed, STZ induced rats showed degenerative expressions in beta-cells. In STZ treated rats, AG reduced the blood glucose concentration and serum insulin levels at the maximum functional dose compared to AAM. The immunohistochem. information suggests that the AG at 100 mg/kg dose has the capability of making the dormant cells to reproduce to restore the lost cells of islets of Langerhans. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to diabetics aegle marmelos leaf extract aegeline pancreatic beta cell, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Category: amides-buliding-blocks

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 15, 2013, Karmase, Aniket; Birari, Rahul; Bhutani, Kamlesh K. published an article.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Evaluation of anti-obesity effect of Aegle marmelos leaves. And the article contained the following:

The study was carried out to investigate the anti-obesity effects of Aegle marmelos leaves extracts and its phytochem. constituents in vitro and in vivo. The dichloromethane (DCM), Et acetate (EtOAc) and n-butanol extracts of A. marmelos leaves were studied for their lipolytic effect. Lipolysis was measured by determining the amount of glycerol released at 12 h and 24 h at 50 μg/mL and 100 μg/mL concentrations Phytochem. investigation of the most active DCM extract yielded 14 compounds The isolated compounds were evaluated for their lipolytic effects at 50 μM and 100 μM. The most active compounds, umbelliferone and esculetin were further screened for their antiobesity effects in vivo in the high fat diet (HFD) induced obese rat model. Umbelliferone and esculetin reduced body weight, total triglyceride (TG), total cholesterol (TC) and glucose level in their resp. HFD groups. A. marmelos DCM extract and compounds isolated from it have the potential of counteracting the obesity by lipolysis in adipocytes. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle umbelliferone esculetin antiobesity agents lipolysis obesity, adipocytes, aegle marmelos, anti-obesity, high fat diet, lipolysis, rat model, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 5, 2015, Gautam, Sudeep; Ishrat, Nayab; Singh, Rohit; Narender, Tadigoppula; Srivastava, Arvind K. published an article.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling, and contributes to a cytoskeletal rearrangement through PI3K/Rac1. And the article contained the following:

Aegeline is an alkaloidal-amide, isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus. Here we delineate, aegeline enhanced GLUT4 translocation mediated 2-deoxy-glucose uptake in both time and concentration-dependent manner. 2-deoxy-glucose uptake was completely stymied by the transport inhibitors (wortmannin and genistein) in C2C12 myotubes. Pharmacol. inhibition of Akt (also known as protein kinase B) and Ras-related C3 botulinum toxin substrate 1 (Rac1) suggest that both Akt and Rac1 operate aegeline-stimulated glucose transport via distinct parallel pathways. Moreover, aegeline activates p21 protein-activated kinase 1 (PAK1) and cofilin (an actin polymerization regulator). Rac1 inhibitor (Rac1 inhib II) and PAK1 inhibitor (IPA-3) completely blocked aegeline-induced phosphorylation of cofilin and p21 protein-activated kinase 1 (PAK1). In summary, these findings suggest that aegeline stimulates the glucose transport through Akt and Rac1 dependent distinct parallel pathways and have cytoskeletal roles via stimulation of the PI3-kinase-Rac1-PAK1-cofilin pathway in the skeletal muscle cells. Therefore, multiple targets of aegeline in the improvement of insulin sensitivity of the skeletal muscle cells may be suggested. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegeline antidiabetic aegle leaf extract akt rac1 signaling diabetes, aegeline, aegle marmelos, c2c12 myotubes, cofilin, glucose uptake, insulin resistance, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2020, Canner, Adam J.; Harwood, Laurence M.; Cowell, Joseph; Babra, Jasraj S.; Brown, Solomon F.; Ogden, Mark D. published an article.SDS of cas: 685-91-6 The title of the article was Spectrophotometric Analysis of Ternary Uranyl Systems to Replace Tri-N-butyl Phosphate (TBP) in Used Fuel Reprocessing. And the article contained the following:

In this report, the interaction of monoamide/diamide and monoamide/diglycolamide mixtures with UO2+2 are investigated in pH = 1 methanolic nitric acid media. These monoamides include N,N-dimethylacetamide (DMAA), N,N-diethylacetamide (DEAA), N,N-dibutylacetamide (DBAA) and N,N-dibutylbutanamide (DBBA). N,N,N’N’-tetraethylmalonamide (TEMA) and N,N,N’,N’-tetraethyldiglycolamide (TEDGA), which were chosen as model diamides and diglycolamides, resp. Complex stability constants for each ligand were modeled using the Stability Quotients Using Absorbance Data program using UV-visible data. Complex stoichiometry of ligand mixtures was determined using Job plots and UV-Vis spectrometry. Monoamides were confirmed to produce only disolvate complexes with UO2+2 in solution The log10(K) values for monoamides were found to be independent of amine-side chain length, but were slightly dependent on the carbonyl-side chain length. TEDGA was found to produce multiple uranyl complexes in solution Job plot data indicated that the uranyl cation strongly prefers to bond either only with the monoamide or diamide in ternary monoamide-diamide-UO2 systems. Monoamide-diglycolamide-UO2 systems were more complicated, with Job plot data indicating the potential for multiple ternary species being present is dependent on the monoamide structure. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).SDS of cas: 685-91-6

The Article related to trinbutyl phosphate ternary uranyl system fuel reprocessing, Phase Equilibriums, Chemical Equilibriums, and Solutions: Partition, Extraction and other aspects.SDS of cas: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 15, 2021, Brown, Trevor N. published an article.Recommanded Product: 685-91-6 The title of the article was Empirical regressions between system parameters and solute descriptors of polyparameter linear free energy relationships (PPLFERs) for predicting solvent-air partitioning. And the article contained the following:

Polyparameter Linear Free Energy Relationships (PPLFERs) are an empirical tool used to predict the equilibrium partitioning of solutes between two phases, referred to as a system. There are exptl. determined solute descriptors for thousands of chems., but there are only on the order of 100 systems with calibrated system parameters, the majority of which are solvents and environmental matrixes in equilibrium with air or water. The goal of this work is to create empirical regressions which use the much more numerous solute descriptors to predict the system parameters of systems which have not yet been calibrated due to a lack of partitioning data. The special case of liquid solvents in equilibrium with air is the focus of this work because this is the case in which the relationship between solute and solvent properties is most clear. First a consistent dataset of PPLFER equations was compiled using partition coefficient data from the literature to recalibrate equations for solvent-air partitioning into the Goss form (Goss, K.-U. 2005) for 89 solvents including water. All 89 solvents have also solute descriptors available in a database curated for this work which describe their behavior as solutes. The pool of descriptors drawn from to create the empirical regressions were the solute descriptors of the solvents normalized to McGowan volume (V), along with interaction parameters between the normalized descriptors. An applicability domain (AD) for the empirical regressions was defined using leverage to measure similarity to the training dataset of solvents, and solvents in the AD typically had lower RMSE for predictions. Some of the empirical regressions for the six system parameters have good predictive power (s, a, b, c) while others are only adequate (v, l). However, when these equations are combined to predict partition coefficients there is a significant cancellation of error and when predicting partition coefficients in an external validation dataset the RMSE is in the range 0.30-0.35. The empirical regressions combined with the PPLFER equations and solvent d. can also be used to predict vapor pressures as an addnl. external validation. Predictions for a dataset of vapor pressures from the literature had an RMSE of 0.26-0.75. Analyzing and comparing the results from these two external validation datasets the RMSE for predicting datasets of partition coefficients for arbitrary solutes in arbitrary systems of solvents in equilibrium with air is estimated to be 0.66 on average The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Recommanded Product: 685-91-6

The Article related to solvent air partitioning regression system parameter solute descriptor pplfer, Phase Equilibriums, Chemical Equilibriums, and Solutions: Partition, Extraction and other aspects.Recommanded Product: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 17, 2021, Arisawa, Mieko; Mizuno, Taro; Nozawa-Kumada, Kanako; Itto-Nakama, Kaori; Furuta, Miyu; Tanii, Saori published an article.Application of 102-07-8 The title of the article was Rhodium-Catalyzed Synthesis of Unsymmetric Di(heteroaryl)ureas Involving an Equilibrium Shift. And the article contained the following:

Unsym. di(heteroaryl)ureas such as Ar1NHC(O)NHAr2 [Ar1 = pyrimidin-2-yl, 4-methoxyphenyl, 4,6-dimethylpyrimidin-2-yl, etc.; Ar2 = Ph, 4-pyridyl, 4-methoxy-2-pyridyl, etc.] were efficiently synthesized from two sym. ureas, Ar1NHC(O)NHAr1 and Ar2NHC(O)NHAr2, by rhodium-catalyzed exchange reactions. The equilibrium in some of the reactions could be shifted to the formation of unsym. ureas by the aggregation of the dimers formed by inter- and intramol. hydrogen bonding. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application of 102-07-8

The Article related to di heteroaryl urea preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 14, 2014, Haq, Nadia; Niu, Deqiang; Petter, Russell C.; Qiao, Lixin; Singh, Juswinder; Zhu, Zhendong published a patent.Quality Control of N-(3-Aminophenyl)acrylamide The title of the patent was Pyrimidine derivatives as ERK inhibitors and their preparation. And the patent contained the following:

The invention provides compounds of formula I, compositions thereof, and methods of using the same. Compounds of formula I wherein A is (un)substituted Ph, 3- to 8-membered (un)saturated monocyclic ring, 4- to 7-membered monocyclic heterocyclic ring, etc.; B is (un)substituted Ph, (un)substituted (un)saturated 3- to 7-membered carbocyclic ring, 5- to 6-membered monocyclic heteroaryl, absent, etc.; m and p are independently 0 – 4; R1 is a warhead group, wherein R1 is attached to an atom adjacent to where W is attached; each R2 is H, (un)substituted C1-6 aliphatic, halo and OH and derivatives; each R3 is H, halo, OH and derivatives, SH and derivatives, CN, etc.; R4 is H, (un)substituted C1-6 aliphatic, halo, haloalkyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their ERK inhibitor activity (some data given). The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Quality Control of N-(3-Aminophenyl)acrylamide

The Article related to pyrimidine preparation erk inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nishida, K.; Ohtsu, T.; Tanaka, S.; Miyatake, M.; Hotsuta, T.; Iwamoto, H. published an article in 1973, the title of the article was Preparation of 2-nitro-N,N-dimethylaniline-4-sulfon-N-alkylamides and their dyeing properties on synthetic polymer fibers.Recommanded Product: 97-09-6 And the article contains the following content:

Disperse dyes (I, R = H, Me, Et, Pr, Bu, pentyl) were prepared and the substantivity of I on polyamide, cellulose acetate, acrylic, and polyester fibers increased with increasing chain length of R. In general, bright yellow dyeings were obtained, the brightest on cellulose acetate, with good fastness properties except for poor light-fastness. The amount of dye transferred in heat-transfer printing decreased as the chain length of R increased. Thus, 4,3-Cl(O2N)C6H3SO2Cl was treated with RNH2, the intermediate 4,3-Cl(O2N)C6H3SO2NHR treated with NMe2 to give I. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 97-09-6

The Article related to nitro disperse dye, substantivity nitro dye, Dyes, Fluorescent Whitening Agents, and Photosensitizers: Nitroso and Nitro Dyes and other aspects.Recommanded Product: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 17, 2018, Na, Yun Soo; Bang, Keuk Chan; Park, Joon Seok published a patent.Product Details of 16230-24-3 The title of the patent was Preparation of novel pyrrolopyrimidine derivatives as BTK inhibitors and pharmaceutical composition comprising the same. And the patent contained the following:

The invention relates to a compound of formula I or a pharmaceutically acceptable salt thereof, and the compound according to the invention can be usefully used for the prevention or treatment of diseases in which the BTK inhibitory action is beneficial. Compounds of formula I wherein X is NH and O; L is a bod and CO; R is H, (un)substituted C6-10 aryl and (un)substituted C3-10 heteroaryl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their BTK inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of 20.9 n< and 100 % inhibition at 1 μM. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Product Details of 16230-24-3

The Article related to pyrrolopyrimidine preparation btk inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 16, 2018, Na, Yun Su; Bang, Geuk Chan; Park, Jun Seok published a patent.Related Products of 16230-24-3 The title of the patent was Preparation of novel pyrrolopyrimidine derivatives as BTK inhibitors and pharmaceutical composition comprising the same. And the patent contained the following:

The invention relates to a compound of formula I or a pharmaceutically acceptable salt thereof, and the compound according to the invention can be usefully used for the prevention or treatment of diseases in which the BTK inhibitory action is beneficial. Compounds of formula I wherein X is NH and O; L is a bod and CO; R is H, (un)substituted C6-10 aryl and (un)substituted C3-10 heteroaryl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their BTK inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of 20.9 n< and 100 % inhibition at 1 μM. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Related Products of 16230-24-3

The Article related to pyrrolopyrimidine preparation btk inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Related Products of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics