Month: November 2022

On February 28, 2007, Galenko, A. V.; Lobanov, P. S.; Potekhin, A. A. published an article.Name: 2-Amino-6-methylnicotinamide The title of the article was Reactions of α-tosyl- and α-cyanoacetamidoximes with 1,3-dicarbonyl compounds. And the article contained the following:

Cyclocondensation of α-tosylacetamidoxime and α-cyanoacetamidoxime with 1,3-dicarbonyl compounds affords the corresponding pyrimidine N-oxides. The 2-(cyanomethyl)pyrimidine-3-oxides isolated readily undergo cyclization to isoxazolopyrimidinium salts via intramol. addition of N-oxide to the nitrile group under acidic conditions. The experimental process involved the reaction of 2-Amino-6-methylnicotinamide(cas: 100524-09-2).Name: 2-Amino-6-methylnicotinamide

The Article related to isoxazolopyrimidinium preparation ring opening, pyrimidine oxide cyano preparation intramol cycloaddition, acetamidoxime cyclocondensation dicarbonyl compound, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: 2-Amino-6-methylnicotinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 1, 2016, Gampe, Christian M.; Kahne, Daniel Evan; Kahne, Suzanne Walker; Qiao, Yuan; East, Stephen; Parkes, Alastair L.; Southey, Michelle; Hunter, James; Whittaker, Mark; Arthuis, Martin published a patent.Application of 5455-98-1 The title of the patent was Preparation of 6H,7H-pyrazolo[1,5-a][1,3,5]triazin-7-one derivatives as inhibitors of bacterial glycosyl transferases. And the patent contained the following:

The title compounds of formula I [A = independently each (un)substituted C2-6 alkyl, aryl, carbocyclyl, 5-membered heteroaryl, or 6-membered heteroaryl; B = independently H or each (un)substituted alkyl, alkenyl, alkynyl, aryl, carbocyclyl, heterocyclyl, or heteroaryl; Y = a bond or each (un)substituted C1-6-alkylene, C3-6 carbocyclylene, or heterocyclylene; X = a bond, O, CH2, NRNX, NRNX-C(O)-NRNX, or (un)substituted heterocyclylene; L = a bond, O, C(O), NRLBC(O), C(O)NRLB, NRLB, or SO2; each RLB = independently H or each (un)substituted alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl, or RLB and B are taken together with their intervening atoms to form an (un)substituted heterocyclic ring; R1 = H, halogen, or (un)substituted substituted C1-6 alkyl; RN1 = H, (un)substituted C1-6 alkyl, or a nitrogen protecting group; RNX = H, (un)substituted C1-6 alkyl, or a nitrogen protecting group], pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof are prepared The invention also provides pharmaceutical compositions of the compounds I for human and veterinary use. The compounds I are useful for inhibiting bacterial growth and therefore are useful in treating and/or preventing bacterial infections. Thus, 100 mg 2-(4-tert-butylphenyl)-4-(methylsulfanyl)-6H,7H-pyrazolo[1,5-a][1,3,5]triazin-7-one and 190 mg N-(3-aminopropyl)-4-chloro-3-methylaniline were dissolved in 4 mL 1,4-dioxane, heated to 130° in a microwave for 11 h, then concentrated, and purified using HPLC to give 7.9 mg 2-(4-tert-butylphenyl)-4-[[3-[(4-chloro-3-methylphenyl)amino]propyl]amino]-6H,7H-pyrazolo[1,5-a][1,3,5]triazin-7-one (II) (5% yield). II showed min. inhibitory concentration of 3.1, 2, and 4 μg/mL against methicillin-susceptible Staphylococcus aureus Newman, S. aureus 29213, and S. aureus 43300 at 24 h, resp. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application of 5455-98-1

The Article related to bacterial infection prevention treatment pyrazolotriazinone preparation, pyrazolotriazinone preparation inhibitor bacterial glycosyl transferase antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Feng-Hua; Wang, Chen; Xie, Jian-Hua; Zhou, Qi-Lin published an article in 2019, the title of the article was Synthesis of Tridentate Chiral Spiro Aminophosphine-Oxazoline Ligands and Application to Asymmetric Hydrogenation of α-Keto Amides.Category: amides-buliding-blocks And the article contains the following content:

A new type of tridentate chiral spiro aminophosphine-oxazoline ligands (SpiroOAP) were synthesized through four steps. The SpiroOAP ligands are highly efficient for the asym. hydrogenation of α-keto amides, providing a variety of synthetically useful α-hydroxy amides with excellent enantioselectivity (up to 98% ee) and turnover numbers (up to 10,000). The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Category: amides-buliding-blocks

The Article related to chiral spiro aminophosphine oxazoline ligand preparation, keto amide aminophosphine oxazoline iridium catalyst enantioselective hydrogenation, hydroxy amide preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Alcohols and Thiols and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 23, 2009, Leito, Ivo; Raamat, Elin; Kutt, Agnes; Saame, Jaan; Kipper, Karin; Koppel, Ilmar A.; Koppel, Ivar; Zhang, Min; Mishima, Masaaki; Yagupolskii, Lev M.; Garlyauskayte, Romute Yu.; Filatov, Andrey A. published an article.Reference of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Revision of the Gas-Phase Acidity Scale below 300 kcal/mol-1. And the article contained the following:

The gas-phase acidity (GA) scale from (CF3CO)2NH to (C2F5SO2)2NH-about a 24 kcal/mol-1 range of gas-phase acidities-was reexamined using the Fourier transform ion cyclotron resonance equilibrium measurement approach. Some additions and modifications to the standard methodol. of GA measurements were introduced (estimation of partial pressures from mass spectra of the compounds, instead of the pressure gauge readings and use of long reaction times) to achieve higher reliability. Gas-phase acidities of 18 compounds were determined for the first time. The results reveal a contraction of the previously published values in this part of the scale. In particular, the GA values of (CF3SO2)2NH and (C2F5SO2)2NH (important components of lithium ion battery electrolytes and ionic liquids) were revised toward stronger acidities from 291.8 kcal/mol-1 to 286.5 kcal/mol-1 and from 289.4 kcal/mol-1 to 283.7 kcal/mol-1 (i.e., by 5.3 and 5.7 kcal/mol-1), resp. Exptl. and computational evidence is presented in support of the current results. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Reference of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to gas phase acidity ga scale revision, Physical Organic Chemistry: Acid-Base, Tautomerism, and Other Equilibrium Studies and other aspects.Reference of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 1, 2020, Pacheco, Kelvin A.; Bresciani, Antonio E.; Nascimento, Claudio A. O.; Alves, Rita M. B. published an article.COA of Formula: C13H12N2O The title of the article was Assessment of property estimation methods for the thermodynamics of carbon dioxide-based products. And the article contained the following:

Carbon dioxide can be used as feedstock to produce chems. It represents a stimulating defiance to manufacture novel cost competitive materials with less environmental impact, besides to investigate new opportunities for catalysts and industrial chem. The contribution of carbon dioxide conversion goes beyond lowering global warming, by reducing fossil resource depletion or even yielding more benign production pathways. Albeit promising, the literature data regarding the quantity of energy needed to convert carbon dioxide into chems. is limited and narrowed to the most studied processes and products. In order to understand and model the formation of species using carbon dioxide as raw material, some basic thermodn. data are needed. The development of detailed reaction schemes in the field is also scarce. To enhance and further complete the database of the products obtained from carbon dioxide, this study investigates different procedures to estimate the basic thermodn. properties of the reactants and products of these reactions. To date various methods have been developed and introduced to determine the gas-phase standard enthalpies of formation and Gibbs energy. Among them, group additivity and semi-empirical methods are widely employed due to their accuracy and effort time for implementation compared to more rigorous methods. Semi empirical quantum-chem. methods were compared with group additivity methods. Available literature data were used to select the best method for property estimation of the whole set of species, whereby produced from carbon dioxide. The products from carbon dioxide were categorized in sixteen chem. classes, the reaction enthalpy for the direct route to manufacture the products were assessed and indicate a large difference among the classes. The results of this investigation show that semi empirical quantum-chem. methods revealed to be more accurate for the studied species; addnl., the method demonstrates robustness in estimating the properties. Together, these results provide important insights into the thermodn. of carbon dioxide related products. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).COA of Formula: C13H12N2O

The Article related to carbon dioxide product thermodn property, Thermodynamics, Thermochemistry, and Thermal Properties: Thermochemical Properties and other aspects.COA of Formula: C13H12N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 1, 2019, Zaitseva, Ksenia V.; Varfolomeev, Mikhail A.; Verevkin, Sergey P. published an article.HPLC of Formula: 685-91-6 The title of the article was Vapour pressures and enthalpies of vaporisation of N,N-di-alkyl-acetamides. And the article contained the following:

Molar enthalpies of vaporisation of N,N-di-alkyl-acetamides (alkyl = Me, Et, Bu, and n-hexyl) were obtained from the temperature dependence of the vapor pressure measured using the transpiration method. A large number of primary exptl. results on temperature dependencies of vapor pressures have been collected from the literature and have been treated uniformly in order to derive vaporisation enthalpies at the reference temperature 298.15 K. The evaluated data were checked for internal consistency successfully. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).HPLC of Formula: 685-91-6

The Article related to dialkyl acetamide vapor pressure enthalpy vaporization, Thermodynamics, Thermochemistry, and Thermal Properties: Thermochemical Properties and other aspects.HPLC of Formula: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 18, 2016, Mueller, Thomas Ernst; Guertler, Christoph; Basu, Susmit; Rangheard, Claudine; Rivillo, David; Leitner, Walter; Koehler, Burkhard published a patent.Synthetic Route of 5455-98-1 The title of the patent was Manufacturing of polyoxazolidinone compounds with high stability by reacting a biscarbamate compounds with a bisepoxide compounds. And the patent contained the following:

The present invention relates to polyoxazolidinone compounds, a method for the production of polyoxazolidinone compounds, comprises the step of reacting a biscarbamate compound with a bisepoxide compound in the presence of a mono-carbamate, a mono-isocyanate and/or a mono-epoxide compound as chain regulator and a suitable base having a pKb value of ≤ 9 as catalyst. The invention further relates to the use of polyoxazolidinone compounds with high thermal stability. Thus, a mixture of O,O’-Dimethyl-4,4′-methylendiphenyl-1,1′-dicarbamate 6.33 g, 4,4′-isopropylidenediphenol diglycidyl ether 3.45 g, 4-tert-butylphenyl glycidyl ether 5.20 g and DBU 16.5 mg was admixed and heated 180° to get polyoxazolidinone with Tg 127 and thermal stability until 389°. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Synthetic Route of 5455-98-1

The Article related to polyoxazolidinone bisepoxide isocyanate thermal stability, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Synthetic Route of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jain, Preeti; Kumar, Anil published an article in 2018, the title of the article was Structural Elucidation of the Binary Mixtures of [EMIM][BF4] and [BMIM][BF4] in Ethyl-Substituted Solvents by Isothermal Titration Calorimeter.Category: amides-buliding-blocks And the article contains the following content:

In order to address the issue whether both ionic liquids and solvents influence the enthalpy of their solutions, highly accurate excess partial molar enthalpy, HILE values have been measured using Isothermal Titration Calorimeter (ITC). Therefore, thermodn. behavior has been observed in the mixtures containing ionic liquids It essentially depends on the mol. structure of the constituents of the mixture The hydrogen bonding between ionic liquids and ethyl-substituted solvents (2-ethoxyethanol, ethylene glycol, diethylamine, Et acetate and N,N- diethylacetamide) may lead to strong ion-solvent interactions. In the present study, an effort has been made to quantify various interactions between ionic liquid and solvent, based on the HILE values. Linear solvation free relation shows dependence of limiting excess partial molar enthalpies, HILE,∞ upon the solvent properties. Structural orientation of solvent mols. and ionic liquids also described by the HILE,∞ values. The ion-ion, ion-solvent interactions have also been investigated in terms of the enthalpic interaction parameters, HIL-ILE and relative apparent molar enthalpy, φL of ionic liquid-ethyl-substituted solvent systems. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Category: amides-buliding-blocks

The Article related to solvent ionic liquid binary mixture structural elucidation, Thermodynamics, Thermochemistry, and Thermal Properties: Thermochemical Properties and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 8, 2018, there was a patent about biscarbamate bisepoxide polymerization polyoxazolidinone synthesis fiber.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Method for production of polyoxazolidinone, and spun fiber comprising polyoxazolidinone. And the patent contained the following:

A method for production of polyoxazolidinone compounds comprises reaction of at least one biscarbamate compound (A) with at least one bisepoxide compound (B) in the presence of at least one base (D), at least one Lewis acid catalyst (E), and optionally at least one compound (C), wherein the compound (C) comprising a mono-carbamate group, a mono-isocyanate group and/or a mono-epoxide group, and wherein the base (D) has a pKb value of ≤ 9. The invention also relates to a polyoxazolidinone compound produced according to the method, and a spun fiber comprising the polyoxazolidinone compound Thus, di-Me diphenylmethane-4,4′-dicarbamate (5.62 g, 17.9 mmol) and resorcinol diglycidyl ether (in resin form, Denacol EX 201, 3.65 g, 16.4 mmol) in o-dichlorobenzene (20 mL) were heated to 180° while stirring at 400 rpm, followed by addition of tert-butyliminotri(pyrrolidino)phosphorane (55 μL, 1% mol relative to biscarbamate) and tetraphenylstibonium bromide (0.18 g, 2% mol relative to biscarbamate), stirring for 480 min, adding 4-tert-butylphenyl glycidyl ether (1.5 mL, 6 mmol), o-dichlorobenzene (10 mL) and N-methyl-2-pyrrolidinone (5 mL), and stirring for another 60 min to obtain a polyoxazolidinone (chemoselectivity to oxazolidinone > 98%, 5-oxazolidinone regioisomer content of 50%, and 4-oxazolidinone content of 50%.). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to biscarbamate bisepoxide polymerization polyoxazolidinone synthesis fiber, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 9, 2018, Mueller, Thomas Ernst; Guertler, Christoph; Koopmans, Carsten; Marker, Volker; Rangheard, Claudine; Leitner, Walter published a patent.Recommanded Product: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Method for production of polyoxazolidinone, and spun fiber comprising polyoxazolidinone. And the patent contained the following:

A method for production of polyoxazolidinone compounds comprises reaction of at least one biscarbamate compound (A) with at least one bisepoxide compound (B) in the presence of at least one base (D), at least one Lewis acid catalyst (E), and optionally at least one compound (C), wherein the compound (C) comprising a mono-carbamate group, a mono-isocyanate group and/or a mono-epoxide group, and wherein the base (D) has a pKb value of ≤ 9. The invention also relates to a polyoxazolidinone compound produced according to the method, and a spun fiber comprising the polyoxazolidinone compound Thus, di-Me diphenylmethane-4,4′-dicarbamate (5.62 g, 17.9 mmol) and resorcinol diglycidyl ether (in resin form, Denacol EX 201, 3.65 g, 16.4 mmol) in o-dichlorobenzene (20 mL) were heated to 180° while stirring at 400 rpm, followed by addition of tert-butyliminotri(pyrrolidino)phosphorane (55 μL, 1% mol relative to biscarbamate) and tetraphenylstibonium bromide (0.18 g, 2% mol relative to biscarbamate), stirring for 480 min, adding 4-tert-butylphenyl glycidyl ether (1.5 mL, 6 mmol), o-dichlorobenzene (10 mL) and N-methyl-2-pyrrolidinone (5 mL), and stirring for another 60 min to obtain a polyoxazolidinone (chemoselectivity to oxazolidinone > 98%, 5-oxazolidinone regioisomer content of 50%, and 4-oxazolidinone content of 50%.). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Recommanded Product: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to biscarbamate bisepoxide polymerization polyoxazolidinone synthesis fiber, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Recommanded Product: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics