Month: November 2022

Liebscher, Juergen published the artcileNitrile-formamide chloride adducts; VII. A simple route to 6-N-formamidino-1,3-thiazinium salts, SDS of cas: 14294-10-1, the publication is Zeitschrift fuer Chemie (1976), 16(7), 268-70, database is CAplus.

R3R4N+:CHCR:CClN:CHNR1R2 ClO4-(I; R = Ph, CN, CO2Et, 4-ClC6H4, etc; R1, R2, R3, R4 = Me; R1R2N, R3R4N = morpholino) reacted with R5CSNH2 (R5 = Ph, Me2N, morpholino, PhNH, etc.) to give the thiazinium salts II. I were prepared by the reaction of RCH2CN with dialkylformamide chlorides in the presence of HCl.

Zeitschrift fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, SDS of cas: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liebscher, Juergen published the artcileNitrile-formamide adducts. 4. Reaction of nitrile-formamide adducts. Synthesis of N-thioacylamide derivatives and aza analogs of thiopyrylium salts, Safety of Morpholine-4-carbothioamide, the publication is Zeitschrift fuer Chemie (1975), 15(11), 438-40, database is CAplus.

4-RC6H4CSN:CHNR1R2 (R = H, Me, OMe; NR1R2 = pyrrolidino, morpholino, NMe2) were obtained by treating 4-RC6H4CONHCH:N+R1R2 ClO4- with P2S5 or by treating 4-RC6H4CCl:NCH:N+R1R2 ClO4- (I) with Na2S or Na2S2O3. 4-RC6H4CSN:CHNR1R2 were hydrolyzed to 4-RC6H4CSNHCHO or condensed with I (R = H, Cl) to the thiazines II. The thiadiazines III were similarly obtained from I and R4NHCSNR1R2 (R4 = Bz, 4-O2NC6H4CO, 3-O2NC6H4CO, H).

Zeitschrift fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Safety of Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liebscher, Juergen published the artcileReaction of 3-chloroprop-2-eniminium salts with alkali rhodanides, SDS of cas: 14294-10-1, the publication is Zeitschrift fuer Chemie (1978), 18(9), 334-5, database is CAplus.

The pyrimidinethiones I (R = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 4-ClC₆H₄, 2-naphthyl; R¹ = 4-MeOC₆H₄, 2-MeOC₆H₄, 4-MeC₆H₄, 2-naphthyl, 3-MeOC₆H₄) were obtained by treating RCCl:CHCH:N⁺Me₂ ClO₄^– was alkali metal isothiocyanate and treating SCNCR:CHCH:N⁺Me₂ ClO₄^– (II) with R¹NH₂. Treatment of II with R₂²NH (NR₂² = morpholino, pyrrolidino, NMe₂) gave the thiazinium salts III (R³ = H). Reaction of III (R = 4-MeC₆H₄, NR₂² = NMe₂, R³ = H) with PhNMe₂ gave III (R = 4-MeC₆H₄, NR₂² = NMe₂, R³ = 4-Me₂NC₆H₄).

Zeitschrift fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, SDS of cas: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Keil, Dietmar published the artcileA simple route to N,N-disubstituted selenoureas from N,N-disubstituted cyanamides, Application In Synthesis of 2451-91-4, the publication is Synthesis (2004), 15-16, database is CAplus.

N,N-Disubstituted selenoureas I [R¹ = R² = Me, Et, Bn; R¹R² = O(CH₂CH₂)₂, (CH₂)₅, (CH₂)₄] can be obtained in good yields by addition of an acid to a mixture of freshly prepared sodium selenide and N,N-disubstituted cyanamides II.

Synthesis published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Application In Synthesis of 2451-91-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Keil, Dietmar published the artcilePreparation and characterization of N,N-disubstituted 2-amino-selenazoles, Recommanded Product: N,N-Dibenzylcyanamide, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (1999), 169-184, database is CAplus.

As a result of checking suited methods for preparing N,N-disubstituted 2-amino-selenazoles, e.g. I, as a nearly unknown class of highly reactive selenazoles a simple route starting from N,N-disubstituted selenoureas has been elaborated and used for the synthesis of a series of these compounds The necessary selenium-containing starting compounds N,N-disubstituted selenoureas are available from N,N-disubstituted cyanamides and hydrogen selenide.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Recommanded Product: N,N-Dibenzylcyanamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Flaig, Ronald published the artcileSynthesis of N-substituted 2,4-diaminothiazoles and their salts, Product Details of C5H10N2OS, the publication is Heterocycles (1997), 45(5), 875-888, database is CAplus.

A series of N(2),N(4)-substituted 2,4-diaminothiazoles I (R¹R²N = morpholino, pyrrolidino, piperidino, diethylamino, n-butylamino, phenylamino, di-n-propylamino, R³R⁴N = morpholino, pyrrolidino, piperidino, diphenylamino, diethylamino, n-butylamio) and their corresponding mineral acid salts have been prepared by the reaction of POCl₃ with N-substituted S-(dialkylaminocarbonylmethylene)isothiouronium salts R¹R²NC(:NH₂)SCH₂CONR³R⁴ available from corresponding substituted thioureas R¹R²NC(S)NH₂ (II) and N,N-disubstituted chloroacetamides ClCH₂CONR³R⁴ or by the reaction of primary or secondary amines R³R⁴NH in excess with N(2)-unsubstituted or N(2)-disubstituted 2-amino-4-thiazolinimine hydrochlorides III available by the reaction of corresponding N-substituted thioureas II with chloroacetonitrile.

Heterocycles published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Czerney, Peter published the artcileHeterocyclic substituted coumarins from β-chloropropeniminium salts, Application of Morpholine-4-carbothioamide, the publication is Journal fuer Praktische Chemie (Leipzig) (1982), 324(2), 255-66, database is CAplus.

The chloropropeniminium salts I (X = N⁺Me₂ ClO₄^–; R = H, 6-Br, 7-OH, 7-OMe, 7-NMe₂, 7-pyrrolidino, 8-OMe, 7-NEt₂, R¹ = H; RR¹ = 5,6-CH:CHCH:CH, 7,8-CH:CHCH:CH) and the aldehydes I (X = O) were prepared by treating 3-acetylcoumarins with DMF-POCl₃ in the presence of HClO₄ or H₂O, resp. I are versatile synthetic intermediates giving I (X = CR²CN, R² = cyano, CO₂Et, 2-benzimidazolyl, 4-O₂NC₆H₄) which were converted to the aminobutadienes. I were also cyclized to pyrylium, thiopyrylium, pyrazolyl, and thiazinyl derivatives

Journal fuer Praktische Chemie (Leipzig) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Application of Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Keil, D. published the artcileSynthesis and characterization of 1,3-bis-(2-dialkylamino-5-thiazolyl)-substituted squaraines and their 2-(dialkylamino)thiazole precursors, Product Details of C5H10N2OS, the publication is Liebigs Annalen (1995), 979-84, database is CAplus.

By condensing of squaric acid with 2-(dialkylamino)-substituted thiazoles, a novel type of heterocyclic-substituted squaraines was prepared in moderate yield mostly. The squaraines are sparingly soluble in most organic solvents and exhibit narrow absorption bands in the visible range at ∼ 620-700 nm in solution. In dispersed form, the absorption bands of the squaraines are, however, broadened and shifted into the near IR region at ∼ 900 nm. These unique properties of the new squaraines suggest the use of these dyes as spectral sensitizers for laser-driven data recording or data storage media.

Liebigs Annalen published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Albrecht, Brian K. published the artcileDiscovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase, Product Details of C8H9BFNO3, the publication is Journal of Medicinal Chemistry (2008), 51(10), 2879-2882, database is CAplus and MEDLINE.

Tumorigenesis is a multistep process in which oncogenes play a key role in tumor formation, growth, and maintenance. MET was discovered as an oncogene that is activated by its ligand, hepatocyte growth factor. Deregulated signaling in the c-Met pathway has been observed in multiple tumor types. Herein we report the discovery of potent and selective triazolopyridazine small mols. that inhibit c-Met activity.

Journal of Medicinal Chemistry published new progress about 849833-86-9. 849833-86-9 belongs to amides-buliding-blocks, auxiliary class Fluoride,Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid, and the molecular formula is C8H9BFNO3, Product Details of C8H9BFNO3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Morita, Mikio published the artcileFacile synthesis of 2-azaazulenes from thiobenzoyl isocyanates using trimethylsilyldiazomethane, Related Products of amides-buliding-blocks, the publication is Tetrahedron (2008), 64(8), 1753-1758, database is CAplus.

The reaction of trimethylsilyldiazomethane with thiobenzoyl isocyanates, in situ generated from thiazole-4,5-diones, yielded diazo ketones, which were converted into 2-azaazulenes by the intramol. Buchner reaction.

Tetrahedron published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics