Month: November 2022

On December 31, 2013, Ali, Mohammad; Zarchi, Karimi; Tarabsaz, Ali published an article.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was A versatile and regioselective synthesis of vicinal azidoalcohols using cross-linked poly(4-vinylpyridine) supported azide ion under solvent-free conditions. And the article contained the following:

A new polymeric reagent, cross-linked poly(4-vinylpyridine) supported azide ion, [P4-VP]N3, was introduced as polymeric reagents for efficient and regioselective conversion of epoxides to azidohydrins in the presence of crosslinked poly(4-vinylpyridine) supported sulfuric acid, [P4-VP]H2SO4, as a solid proton source and as catalyst under solvent-free conditions. The advantages of this polymeric reagent over some of those reported in the literature are easy work-up procedure and regeneration of the reagent. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to versatile regioselective synthesis vicinal azidoalc crosslinked polyvinylpyridine, Chemistry of Synthetic High Polymers: Monomers and Reagents Used In Polymerization and other aspects.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 19, 2020, Soccio, Michelina; Mazzoni, Rita; Lucarelli, Carlo; Quattrosoldi, Silvia; Cingolani, Andrea; Fiorini, Maurizio; Lotti, Nadia; Tabanelli, Tommaso published an article.Recommanded Product: 1,3-Diphenylurea The title of the article was Urea and Polyurea Production: An Innovative Solvent- and Catalyst-Free Approach through Catechol Carbonate. And the article contained the following:

The peculiar reactivity of catechol carbonate (CC) with amines and polyamines in both solvent- and catalyst-free conditions is herein described. In all the tests performed at room temperature, CC conversion reached 100% in a few seconds leading to the selective formation of the corresponding 2-hydroxyphenylcarbamate. This compound is further rapidly converted to the disubstituted urea by the consecutive nucleophilic attack of another amine. Noteworthy, the application of this approach can be successfully extended to the one-pot bioamine-based synthesis of polyurea as herein proposed for the first time in the literature. The reaction is of general purpose for primary amines, and catechol can be easily recovered by sublimation as pure crystals ready to be recycled for the synthesis of new CC. An exception is related to the reactivity of secondary amine, which leads to the selective formation of substituted phenolic carbamates (e.g., 2-hydroxyphenyl diethylcarbamate), suitable as intermediates in medicinal chem. Superior reactivity is displayed by catechol carbonate toward aminolysis yielding urea and polyurea in mild, solvent- and catalyst-free conditions. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 1,3-Diphenylurea

The Article related to urea production solvent catalyst free catechol carbonate amine, polyurea catechol carbonate diamine polym green chem, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Recommanded Product: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2021, Spange, Stefan; Weiss, Nadine; Schmidt, Caroline H.; Schreiter, Katja published an article.Category: amides-buliding-blocks The title of the article was Reappraisal of Empirical Solvent Polarity Scales for Organic Solvents. And the article contained the following:

Correlations of Reichardt ‘s ET(30), the Catalan SdP (solvent dipolarity), SP (solvent polarizability), SA (solvent acidity), SB (solvent basicity), Kamlet-Taft π* (dipolarity/polarizability), α (hydrogen bond donating ability) and β (hydrogen bond accepting ability) polarity parameters with the molar concentration of 161 pure organic solvents are presented. Mostly, linear relationships of the polarity parameter as a function of molar concentration are obtained as long as each individual solvent class is considered sep. A phys. different interpretation of the ET(30), Kamlet-Taft π* and α as well as Catalan SA and SB parameters has been proposed. Furthermore, the Hildebrand solubility parameter in combination with the diffraction index is used for the correlation anal. with the above-mentioned solvent parameters. It can be concluded that empirical polarity parameters derived from solvatochromic UV/Vis measurements are inherently a function of the mol. structure of the probe. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Category: amides-buliding-blocks

The Article related to organic solvent empirical polarity, Phase Equilibriums, Chemical Equilibriums, and Solutions: Nonelectrolytic Solutions and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 16, 2018, Shu, Xiaohong; Chi, Fuyun; Yang, Song; Ma, Xiaodong; Li, Chuangang; Li, Hong; Wu, Moli; Zhen, Yuhong; Diao, Yunpeng; Song, Danyang; Li, Hui; Jin, Junmei published a patent.HPLC of Formula: 16230-24-3 The title of the patent was Thiopyrimidine heterocyclic antitumor compound and preparation method and its use. And the patent contained the following:

A thiopyrimidine heterocyclic antitumor compound for the treatment of small cell lung cancer, non-small cell lung cancer, EGFR-T790M mutant non-small cell lung cancer is provided. The compound is represented by the formula I, or a pharmaceutically acceptable salt thereof, which inhibits wild-type EGFR, mutant EGFR-T790M epidermal factor receptor protein tyrosine kinase, where X is O or NH; M is S(O)n; n is 0 or 1; R is alkyl-morpholine. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).HPLC of Formula: 16230-24-3

The Article related to thiopyrimidine heterocyclic antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.HPLC of Formula: 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 30, 2018, Earle Waghorne, W.; O’Farrell, Christina published an article.Product Details of 685-91-6 The title of the article was Solvent Basicity, A Study of Kamlet-Taft β and Gutmann DN Values Using Computationally Derived Molecular Properties. And the article contained the following:

Solvent basicity is recognized as playing a major role in solvation and is included, through empirical basicity parameters, in linear free energy relationships that account for the effects of changes in solvent on chem. reactions. It is reasonable to postulate that the basicity of a solvent mol. reflects some combination of its mol. properties. In the present study, d. functional calculations using the B3LYP functional, and Hartree-Fock calculations have been used to calculate the partial at. charges (using the Hirshfeld and CM5 models), orbital energies, polarizabilities, dipole moments and quadrupolar amplitudes for over one hundred mols. for which there are exptl. values for two basicity parameters, Kamlet and Taft’s hydrogen bond acceptor strength, β, and Gutmann’s donor number, DN, a measure of Lewis basicity. Regression of the exptl. β and DN values against mol. descriptors reflecting the above mol. properties yields a remarkably consistent picture. For both parameters the values for alcs. and amines lie systematically off of the regression lines through the remaining compounds, which include alkanes, aromatics, halogenated alkanes and aromatics, esters, carbonates, carboxylic acids, ketones, ethers, nitriles, phosphates, sulfides and sulfates. Independent of the calculation method or method of estimating the partial at. charges, both exptl. β and DN are essentially determined by two mol. properties: the charge on the most neg. atom of the mol. and the MO from which charge donation would occur. The regression results using any of the fours sets of descriptors (reflecting the two calculation methods and two methods of charge estimation) are remarkably similar for β and DN supporting the view that these are measures of the same “basicity”. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Product Details of 685-91-6

The Article related to kamlet taft gutmann donor number mol property, Phase Equilibriums, Chemical Equilibriums, and Solutions: Nonelectrolytic Solutions and other aspects.Product Details of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2020, Mehmood, Arshad; Janesko, Benjamin G. published an article.Name: N,N-Diethylacetamide The title of the article was Extending the Marcus μ-Scale of Solvent Softness Using Conceptual Density Functional Theory and the Orbital Overlap Distance: Method and Application to Ionic Liquids. And the article contained the following:

Abstract: The chem. hardness of a solvent can play a decisive role in solubility and reactivity in solution Several empirical scales quantifying solvent softness have been proposed. We explore whether computed properties of solvent mols. can reproduce these exptl. scales. Our “orbital overlap distance” quantifying the size of orbitals at a mol.’s surface effectively reproduces the Marcus μ-scale of solvent softness. The orbital overlap distance predicts that the surface of chem. hard solvent mols. is dominated by compact orbitals possessing a small orbital overlap distance. In contrast, the surface of chem. soft solvent mols. has a larger contribution from diffuse orbitals and a larger orbital overlap distance. Other conceptual d. functional theory descriptors, including the global hardness and electronegativity, can also reproduce the Marcus scale. We further introduce a “solvent versatility” RMSD Dsurf scale quantifying variations in the surface orbital overlap distance. “Good” solvents such as DMSO, which combine chem. “hard” and “soft” sites within a single mol., possess a large RMSD Dsurf. We conclude by applying this approach to predict the Marcus μ-parameters for widely-used ionic liquids and ionic liquid-cosolvent systems. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Name: N,N-Diethylacetamide

The Article related to ionic liquid solvent softness density functional theory, Phase Equilibriums, Chemical Equilibriums, and Solutions: Nonelectrolytic Solutions and other aspects.Name: N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Novotorzhina, Nelya N.; Ismailova, Gunay G.; Musayeva, Bella I.; Safarova, Mekhpara R.; Ismailov, Ingilab P. published an article in 2021, the title of the article was Synthesis of new derivatives of N,N-diethyldithiocarbamine acid and study of their anti-seize properties.Application In Synthesis of 2-Chloroacetamide And the article contains the following content:

By the reaction of sodium N,N-diethyldithiocarbamate and chloroacetamide, S-carbamoylmethyldiethyldithiocarbamate was obtained. The conditions of two different methods for producing S(N-2,2-dimethyl-4-methyloxymethyl-1,3 dioxolane) carbamoylmethyldiethyldithiocarbamate were proposed. One of which was based on the homocondensation of hydroxylmethylcarbamoyldiethyldithiocarbamate and 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane, the other on the interaction of 2,2-dimethyl-4- chloromethylcarbamoylmethyloxymethyl-1,3-dioxolane and sodium N,N-diethyldithiocarbamate. At the first stage of the study, 4 starting reagents were synthesized, 2 of which were not previously described in the literature: 2,2-dimethyl-4-chloromethylcarbamoylmethoxymethyi-1,3-dioxolane and S-hydroxymethylcarbamoylethyldithiocarbamate. The structure of the synthesized compounds was proved by determining their elemental compositions, calculating mol. refractions based on refractive indexes and specific gravities, as well as recording IR absorption spectra on a spectrophotometer. The presence of comparatively high extreme pressure properties of the synthesized compounds in the mineral oil SN-1200 and synthetic oil consisting of penta erythritol of fatty acids was revealed and it was shown that they are superior to the known additives in the literature of tricresyl phosphate and N-allyl-5-hexyloxycarbocarbonylmethyl-1,3-thiazolidin-4-one-2-thione. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application In Synthesis of 2-Chloroacetamide

The Article related to diethyl carbamothioyl sulfanyl acetamide preparation antiwear, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Application In Synthesis of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2022, Zhao, Zhongqian; Chen, Xiumin; Wu, Jian; Wang, Wenjing; He, Bingyang; Yin, Qi; Xu, Peilin; Liu, Li published an article.Safety of N,N-Diethylacetamide The title of the article was A Study of the Mechanism of Particle Size Control of Ferrous Oxalate Dihydrate by N,N-Diethylacetamide. And the article contained the following:

D. functional theory was used to study the effect of N,N-diethylacetamide (DEAc) in the preparation of ferrous oxalate dihydrate. The calculation results indicated that DEAc mols. can affect the growth of ferrous oxalate dihydrate crystals by hydrogen bonding and van der Waals forces with C2O2-4 or H2O in ferrous oxalate dihydrate crystals. DEAc encases ferrous oxalate dihydrate crystals to inhibit crystal growth, and preferentially binds to both sides of C2O2-4 to control the axial growth of ferrous oxalate dihydrate crystals. The exptl. program was conducted based on these theor. calculation results. Rod-shaped particles with a particle size of 100 nm were obtained by adding DEAc during the preparation of ferrous oxalate dehydrate. Therefore, DEAc had a significant effect on the particle size of the ferrous oxalate dihydrate. The theor. calculations were thus confirmed by the exptl. results. And this work explains the growth mechanism of the ferrous oxalate dihydrate. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Safety of N,N-Diethylacetamide

The Article related to ferrous oxalate dihydrate diethylacetamide particle size control, Phase Equilibriums, Chemical Equilibriums, and Solutions: Nonelectrolytic Solutions and other aspects.Safety of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 1, 2021, Rahimpour, Elaheh; Acree, William E. Jr.; Jouyban, Abolghasem published an article.Synthetic Route of 144-80-9 The title of the article was Prediction of sulfonamides’ solubilities in the mixed solvents using solvation parameters. And the article contained the following:

The exptl. solubility data of various sulfonamides in the binary solvent systems at various temperatures are collected from the literature and fitted to Jouyban-Acree model as an accurate cosolvency model for providing solubility prediction tools. In order to obtain predictive cosolvency models, the Jouyban-Acree model is combined with physicochem. parameters of the Abraham solvation parameters and the Hansen solubility parameters. Based on these computations, the generally trained versions of the combined models are proposed which enable one to predict the solubility of sulfonamides in the binary solvent mixtures at various temperatures with reasonable error levels. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Synthetic Route of 144-80-9

The Article related to sulfonamide solubility binary solvent system solvation parameter, Phase Equilibriums, Chemical Equilibriums, and Solutions: Nonelectrolytic Solutions and other aspects.Synthetic Route of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2012, Reddy, Pingili Krishna; Mukkanti, K.; Rao, Dodda Mohan published an article.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Synthesis of antibiotic linezolid analogues. And the article contained the following:

New oxazolidinones were synthesized and were evaluated for antibacterial activity against S. aureus, S. citreus, P. vulgaris, S. typhimurium, and K. pneumoniae. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to oxazolidinone antibiotic linezolid analog preparation antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics