Month: November 2022

Ghosh, Suman Kr et al. published their research in RSC Advances in 2016 | CAS: 34489-85-5

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Application of 34489-85-5

Deep eutectic solvent mediated synthesis of quinazolinones and dihydroquinazolinones: synthesis of natural products and drugs was written by Ghosh, Suman Kr;Nagarajan, Rajagopal. And the article was included in RSC Advances in 2016.Application of 34489-85-5 The following contents are mentioned in the article:

A mild and greener protocol was developed to synthesize substituted quinazolinones and dihydroquinazolinones via deep eutectic solvent (DES) mediated cyclization with a series of aliphatic, aromatic, and heteroaromatic aldehydes in good to excellent yields. This greener strategy was further utilized to synthesize various quinazolinone natural products and drugs. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Application of 34489-85-5).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Application of 34489-85-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Barak, Dinesh S. et al. published their research in Tetrahedron Letters in 2019 | CAS: 34489-85-5

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.COA of Formula: C13H11BrN2O

NaNO2/I2 as an alternative reagent for the synthesis of 1,2,3-benzotriazin-4(3H)-ones from 2-aminobenzamides was written by Barak, Dinesh S.;Mukhopadhyay, Sushobhan;Dahatonde, Dipak J.;Batra, Sanjay. And the article was included in Tetrahedron Letters in 2019.COA of Formula: C13H11BrN2O The following contents are mentioned in the article:

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramol. cyclization. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5COA of Formula: C13H11BrN2O).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.COA of Formula: C13H11BrN2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hsu, Wayne et al. published their research in Acta Crystallographica in 2010 | CAS: 53118-43-7

N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Electric Literature of C12H10N4O2

4,4′-[Oxalylbis(azanediyl)]dipyridinium bis(perchlorate) was written by Hsu, Wayne;Hsiao, Hui Lin;Chen, Jhy Der. And the article was included in Acta Crystallographica in 2010.Electric Literature of C12H10N4O2 The following contents are mentioned in the article:

In 4,4′-[oxalylbis(azanediyl)]dipyridinium diperchlorate, C12H12N4O22+·2ClO4–, the complete cation is generated by crystallog. inversion symmetry. In the crystal, the cations and anions are linked via N-H···O and N-H···(O,O) H bonds, forming a 3-dimensional framework. Crystallog. data are given. This study involved multiple reactions and reactants, such as N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7Electric Literature of C12H10N4O2).

N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Electric Literature of C12H10N4O2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hwang, Jong Yeon et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2010 | CAS: 83909-69-7

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.SDS of cas: 83909-69-7

Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis was written by Hwang, Jong Yeon;Smithson, David;Connelly, Michele;Maier, Julie;Zhu, Fangyi;Guy, Kiplin R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.SDS of cas: 83909-69-7 The following contents are mentioned in the article:

A series of halo-nitrobenzamides were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide which exhibited low micromolar inhibitory potency against T. brucei and selectivity towards both malaria and mammalian cells. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7SDS of cas: 83909-69-7).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.SDS of cas: 83909-69-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nemazanyi, A. G. et al. published their research in Khimiya Geterotsiklicheskikh Soedinenii in 1991 | CAS: 83909-69-7

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 83909-69-7

3-Amino-4-aryl-1(2H)-isoquinolones was written by Nemazanyi, A. G.;Volovenko, Y. M.;Silaeva, T. A.;Kornilov, M. Yu.;Babichev, F. S.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1991.Recommanded Product: 83909-69-7 The following contents are mentioned in the article:

The cyclocondensation of (nitro)halobenzamides I (R = NO2, H; R1 = Cl, F; R2 = H, Me, CH2Ph, Ph, 2-pyridyl) with ArCH2CN (Ar = substituted Ph) in presence of K2CO3 gave isoquinolones II in 61-83% yields. The deflection angle of aromatic ring in the 4-position was determined to be 61°. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Recommanded Product: 83909-69-7).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 83909-69-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Majumdar, K. C. et al. published their research in Synlett in 2011 | CAS: 34489-85-5

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Electric Literature of C13H11BrN2O

CuI/L-proline-catalyzed intramolecular aryl amination: an efficient route for the synthesis of 1,4-benzodiazepinones was written by Majumdar, K. C.;Ganai, Sintu. And the article was included in Synlett in 2011.Electric Literature of C13H11BrN2O The following contents are mentioned in the article:

An effective protocol for the synthesis of potentially bioactive benzo[e]chromeno[6,5-b][1,4]diazepine-3,8(7H,13H)-dione and dibenzo[b,e][1,4]diazepin-11(10H)-one derivatives in good to excellent yields has been achieved by CuI/L-Proline catalyzed coupling reaction as the key step. The methodol. offers clean reaction conditions and easy isolation of the products in 61-92% yields. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Electric Literature of C13H11BrN2O).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Electric Literature of C13H11BrN2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Schleif, William S. et al. published their research in Journal of Pediatrics (New York, NY, United States) in 2022 | CAS: 1094-61-7

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Product Details of 1094-61-7

Defining the Healthy Infant Metabolome: Liquid Chromatography Tandem-Mass Spectrometry Analysis of Dried Blood Spot Extracts from the Prospective Research on Early Determinants of Illness and Children′s Health Trajectories Birth Cohort Study was written by Schleif, William S.;Harlan, Robert S.;Hamblin, Frances;Amankwah, Ernest K.;Goldenberg, Neil A.;Hernandez, Raquel G.;Johnson, Sara B.;Reed, Shannon;Graham, David R.. And the article was included in Journal of Pediatrics (New York, NY, United States) in 2022.Product Details of 1094-61-7 The following contents are mentioned in the article:

Newborn screening using dried plasma spots offers preanal. advantages over conventional cards for plasma-associated targets of interest. Herein we present dried plasma spot-based methods for measuring metabolites using a 250+ compound liquid chromatog. tandem mass spectrometry library. Quality assurance reduced this library to 134, and from these, 30 compounds determined the normal newborn reference ranges. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Product Details of 1094-61-7).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Product Details of 1094-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Schleif, William S. et al. published their research in Journal of Pediatrics (New York, NY, United States) in 2022 | CAS: 1094-61-7

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application In Synthesis of ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate

Defining the Healthy Infant Metabolome: Liquid Chromatography Tandem-Mass Spectrometry Analysis of Dried Blood Spot Extracts from the Prospective Research on Early Determinants of Illness and Children′s Health Trajectories Birth Cohort Study was written by Schleif, William S.;Harlan, Robert S.;Hamblin, Frances;Amankwah, Ernest K.;Goldenberg, Neil A.;Hernandez, Raquel G.;Johnson, Sara B.;Reed, Shannon;Graham, David R.. And the article was included in Journal of Pediatrics (New York, NY, United States) in 2022.Application In Synthesis of ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate The following contents are mentioned in the article:

Newborn screening using dried plasma spots offers preanal. advantages over conventional cards for plasma-associated targets of interest. Herein we present dried plasma spot-based methods for measuring metabolites using a 250+ compound liquid chromatog. tandem mass spectrometry library. Quality assurance reduced this library to 134, and from these, 30 compounds determined the normal newborn reference ranges. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Application In Synthesis of ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application In Synthesis of ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jaganmohan, Chikkanti et al. published their research in Heterocyclic Letters in 2019 | CAS: 34489-85-5

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 34489-85-5

Boron tribromide catalysed facile and efficient synthesis of 2,3-disubstituted Quinazolinone derivatives was written by Jaganmohan, Chikkanti;Rao, Vinti S. P.;Shiva Prakash, P.;Vinay Kumar, K. P.;Mohanty, Sandeep;Kumar, Jaydeep;Venkateswara Rao, B.;Raghunadh, Akula. And the article was included in Heterocyclic Letters in 2019.Recommanded Product: 34489-85-5 The following contents are mentioned in the article:

A simple, convenient synthetic protocols have been developed for the synthesis of 2,3-disubstituted quinazolinone derivatives I (R = Me, Ph, 4-methoxyphenyl, etc.) using borontribromide as efficient catalyst. This reaction proceeds under mild conditions. This method was found to be better method giving high yields. The present method shows some advantages such as short reaction times and enhanced selectivity. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Recommanded Product: 34489-85-5).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 34489-85-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tang, Gui-Hua et al. published their research in Journal of Natural Products in 2011 | CAS: 18836-52-7

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide

Cytotoxic Amide Alkaloids from Piper boehmeriaefolium was written by Tang, Gui-Hua;Chen, Dong-Mei;Qiu, Bei-Ying;Sheng, Li;Wang, Yue-Hu;Hu, Guang-Wan;Zhao, Fu-Wei;Ma, Li-Juan;Wang, Huan;Huang, Qiao-Qin;Xu, Jin-Jin;Long, Chun-Lin;Li, Jia. And the article was included in Journal of Natural Products in 2011.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

Eight new amide alkaloids (1-8) and 19 known ones were isolated from the whole plant of Piper boehmeriaefolium. Their structures were determined through spectroscopic data analyses. Cytotoxic activity of these amides against human cervical carcinoma HeLa cells was evaluated, and 1-[(9E)-10-(3,4-methylenedioxyphenyl)-9-decenoyl]pyrrolidine (9) exhibited significant inhibitory activity with an IC50 value of 2.7 μg/mL. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics