Month: November 2022

Donor-Flexible Bis(pyridylidene amide) Ligands for Highly Efficient Ruthenium-Catalyzed Olefin Oxidation was written by Salzmann, Kevin;Segarra, Candela;Albrecht, Martin. And the article was included in Angewandte Chemie, International Edition in 2020.Formula: C12H10N4O2 The following contents are mentioned in the article:

An exceptionally efficient ruthenium-based catalyst for olefin oxidation was designed by exploiting N,N’-bis(pyridylidene)oxalamide (bisPYA) as a donor-flexible ligand. The dynamic donor ability of the bisPYA ligand, imparted by variable zwitterionic and neutral resonance structure contributions, paired with the redox activity of ruthenium provided catalytic activity for Lemieux-Johnson-type oxidative cleavage of olefins to efficiently prepare ketones and aldehydes. The ruthenium bisPYA complex significantly outperforms state-of-the-art systems and displays extraordinary catalytic activity in this oxidation, reaching turnover frequencies of 650,000 h^-1 and turnover numbers of several millions. This study involved multiple reactions and reactants, such as N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7Formula: C12H10N4O2).

N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Formula: C12H10N4O2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

New constituents from the dried fruit of Piper nigrum Linn., and their larvicidal potential against the Dengue vector mosquito Aedes aegypti was written by Gulzar, Tahsin;Uddin, Nizam;Siddiqui, Bina Shaheen;Naqvi, Syed N. H.;Begum, Sabira;Tariq, Rajput Muhammed. And the article was included in Phytochemistry Letters in 2013.COA of Formula: C14H25NO The following contents are mentioned in the article:

Six bioactive compounds were isolated from the seeds extract of Piper nigrum Linn. following a larvicidal activity guided isolation against 4th instar larvae of Aedes aegypti L., a Dengue vector mosquito and a carrier of yellow fever. Their structures were elucidated using spectroscopic methods including HR-EI-MS, FAB-MS, ¹H and ¹³C NMR (Broad Bond Decoupled, & DEPT), and 2D-NMR techniques (¹H-¹H COSY, NOESY, HMQC, HMBC, & 2D-J-resolved). These include three new constituents namely pipilyasine (1), pipzubedine (2) and pipyaqubine (3), and three known constituents pellitorine (4), pipericine (5) and piperine (6). The larvicidal activity was determined by WHO method. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7COA of Formula: C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.COA of Formula: C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The novel mitochondria activator, 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (TND1128), promotes the development of hippocampal neuronal morphology was written by Katsurabayashi, Shutaro;Oyabu, Kohei;Kubota, Kaori;Watanabe, Takuya;Nagamatsu, Tomohisa;Akaike, Norio;Iwasaki, Katsunori. And the article was included in Biochemical and Biophysical Research Communications in 2021.Reference of 1094-61-7 The following contents are mentioned in the article:

ATP (ATP) is the most vital energy source produced mainly in the mitochondria. Age-related mitochondrial dysfunction is associated with brain diseases. NAD (NAD+) is an essential cofactor for energy production in mitochondria. Here, we examined how the novel NAD+-assisting substance, 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (TND1128), modulates the morphol. growth of cultured mouse hippocampal neurons. The morphol. growth effect of TND1128 was also compared with that of beta-NMN (beta-NMN). TND1128 induced the branching of axons and dendrites, and increased the number of excitatory synapses. This study provides new insight into TND1128 as a mitochondria-stimulating drug for improving brain function. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Reference of 1094-61-7).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 1094-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Biological activities of extract from Coleonema album in vitro was written by Rarova, L.;Jager, A. K.;Xuehong, G.;Bauer, R.;Gruz, J.;Van Staden, J.;Strnad, M.. And the article was included in South African Journal of Botany in 2019.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

Coleonema album is a South African shrub which is used as an anti-inflammatory. A methanolic leaf extract of C. album was here tested in vitro in various anti-inflammatory assays to establish a possible mode of action, as well as for cytotoxicity. The C. album extract did not change the signaling of anti-inflammatory activity in vitro. The extract inhibited COX-1, COX-2 and IL-6, but not ELAM or ICAM-1. Pellitorine, an alkamide isolated and identified from C. album, did not show any activity in the anti-inflammatory assays. The extract showed no cytotoxicity in normal and cancer cell lines. Finally, pellitorine was identified in C. album by UHPLC-QTOF-MS and its concentration was determined by an external standard method. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Comparative analysis of major alkaloids in Piper species traded as ‘Pippali’ in South Indian markets: absence of the chief known constituent – piperine in selected samples was written by Babu, Vijayalakshmi;Singh, Sandhya Kumari;Venkatasubramanian, Padma;Gajurel, Padma Raj. And the article was included in Current Science in 2016.Application of 18836-52-7 The following contents are mentioned in the article:

The major alkaloids in piper species traded in South Indian markets as the Ayurvedic drug, Pippali, have been studied using a rapid HPLC-based method. Piper longum is the accepted botanical source of Pippali. Bengaluru and Chennai markets contained mixtures of closely related species, Piper peepuloides and Piper sylvaticum. Chem. anal. showed that these samples do not contain the alkaloid piperine present in Piper longum fruits. Market samples from Trissur were identified as Piper longum and piperine was detected as one of the major alkaloids. All the samples contained pellitorine, another alkaloid reported in most peppers of the genus Piper. The two types of Pippali can therefore be easily differentiated on the basis of their HPLC profiles. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A review on traditional usage, phytochemistry, anticancer molecules of Piper nigrum L. (Indian pepper) was written by Chowdhury, U.;Baruah, P. K.. And the article was included in Annals of Plant Sciences in 2021.Product Details of 18836-52-7 The following contents are mentioned in the article:

A review. Piper nigrum L. is a historic spice yielding plant and its fruit forms an integral part of human diet. It comprises of versatile mols. with prime pharmacol. actions and therapeutic use including those that are very promising for the combat of dreaded disease such as cancer. Piperine, pellitorine and piperidine are important antitumor mols. present in the plant that are ideal for inclusion in the battery of approaches in cancer therapy. This plant may still be explored considering the medicinally important biomols. inherent in it. This study was aimed at making a systematic with regard to data on traditional uses and pharmacol. attributes of the biomols. that are present in the plant, particularly those having antitumor potentiality. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Product Details of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Product Details of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Palladium-catalysed regioselective N-arylation of anthranilamides: a tandem route for dibenzodiazepinone synthesis was written by Laha, Joydev K.;Manral, Neelam;Hunjan, Mandeep Kaur. And the article was included in New Journal of Chemistry in 2019.Product Details of 34489-85-5 The following contents are mentioned in the article:

A palladium-catalyzed domino approach to the synthesis of 10,11-dihydro-5H-dibenzo[b,e][1,4]diazepinones from 2-aminobenzamides and 1,2-dihaloarenes was developed. Our strategy integrating double N-arylations (inter- and intra-mol.) of 2-aminobenzamides with 1,2-dihaloarenes under palladium-catalyzed conditions is clearly distinct from the current literature available for the synthesis of dibenzodiazepinones. Unlike a previous report described for regioselective N-arylation of 2-aminobenzamide at the amine group, our mechanistic studies support the regioselective N-arylation of 2-aminobenzamide occurring first primarily at the amide group. The translational application of our protocol may be demonstrated in the synthesis of a marketed drug, clozapine. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Product Details of 34489-85-5).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Product Details of 34489-85-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Piperamides and their derivatives as potential anti-trypanosomal agents was written by Cotinguiba, Fernando;Regasini, Luis Octavio;Bolzani, Vanderlan da Silva;Debonsi, Hosana Maria;Duo Passerini, Gabriela;Cicarelli, Regina Maria Barretto;Kato, Massuo Jorge;Furlan, Maysa. And the article was included in Medicinal Chemistry Research in 2009.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

We describe herein an evaluation of the trypanocidal effect of eight piperamides (1-8) isolated from Pipertuberculatum bearing dihydropyridone, piperidine, and iso-Bu moieties against epimastigote forms of Trypanosoma cruzi, the causative agent of Chagas’ disease. Based on such results, three hydrogenated and two hydrolyzed derivatives (10-14) were prepared and evaluated as well. The dihydropyridone amides (1-3) displayed higher anti-trypanosomal activity. The (Z)-piplartine (1) showed higher activity with a 50% inhibition concentration (IC₅₀) value of 10.5 μM, almost four times more potent than the pos. control, benznidazole (IC₅₀ = 42.7 μM), and should be further evaluated as a suitable hit for the design of new antiprotozoal agents. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chemical constituents and antibacterial activity from the stems and leaves of Piper wallichii was written by Nongmai, Chalini;Kanokmedhakul, Kwanjai;Promgool, Trinop;Paluka, Jakkapat;Suwanphakdee, Chalermpol;Kanokmedhakul, Somdej. And the article was included in Journal of Asian Natural Products Research in 2022.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

A phytochem. investigation of the stems and leaves of Piper wallichii led to the isolation of two new compounds, an aryl alkanone, piwalkanone () and a dioxoaporphine alkaloid, piwallidione (), together with nine known compounds, a dioxoaporphine alkaloid, cepharadione A (); two aristolactams, piperolactam A () and stigmalactam (); a piperidine, piperine (); four isobutylamides, piperlonguminine (), pellitorine (), N-isobutyl-2E,4E-octadecadienamide (), and guineensine (); and a tyramine, N-trans-feruloyltyramine (). Their structures were elucidated on the basis of spectroscopic evidence (IR, 1H NMR, 13C NMR and 2 D NMR) and MS. Compounds and showed inhibitory activities against pathogenic bacteria, Bacillus cereus, Bacillus subtilis and Staphylococcus aureus. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A highly efficient copper-catalyzed method for the synthesis of 2-hydroxybenzamides in water was written by Balkrishna, Shah Jaimin;Kumar, Sangit. And the article was included in Synthesis in 2012.Reference of 83909-69-7 The following contents are mentioned in the article:

An efficient copper-catalyzed synthetic method for the preparation of 2-hydroxybenzamides was described from 2-chlorobenzamide substrates using CuI/1,10-phenanthroline and a base, KOH, in neat water. By using this reaction, a series of 2-hydroxybenzamides with functional groups, such as F, Cl, I, MeO, amide, and alc., were obtained in 33-96% yield. Other aromatic 2-chloroarylamides, such as naphthalene, pyridine, and thiophene, are equally compatible to the reaction. It is proposed that the reaction proceeds via formation of a copper-amide complex, which may facilitate the hydroxylation in water. Simple purification procedure and convenience of employing low-cost reagents in neat water make this method practical and economical for the synthesis of 2-hydroxybenzamides. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Reference of 83909-69-7).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Reference of 83909-69-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics