Month: November 2022

A new phenylpropanoid glucoside from Remusatia vivipara (Araceae) was written by Tang, Guihua;Wang, Yuehu;Long, Chunlin. And the article was included in Yunnan Zhiwu Yanjiu in 2010.Application of 18836-52-7 The following contents are mentioned in the article:

A new phenylpropanoid glucoside, caffeyl alc.-3-O-β-D-glucopyranoside, together with nine known compounds, was isolated from the dry corms of Remusatia vivipara Schott. The structure of the new compound was determined by the spectroscopic method and acidic hydrolysis. The known compounds included three phenylpropanoids (coniferin, caffeyl alc. and coniferyl alc.), three neolignans [4,7,9,9′-tetrahydroxy-3,3′-dimethoxy-8-O-4′-neolign-7′-ene, (7 R, 8 S)-Δ⁷-3,3′-dimethoxy-4,7,9,9′-tetrahydroxy-8-O-4′-neolignan-7-O-β-D-glucopyranoside and dehydrodiconiferyl alc.-4-β-D-glucoside], an amide [(2E,4E)-N-isobutyl-2,4-decadienamide], a steroid saponin (Me proto-taccaoside) and a triterpenoid saponin (saxifragifolin B). All compounds were isolated from the genus Remusatia for the first time. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Antileishmanial amides and lignans from Piper cubeba and Piper retrofractum was written by Bodiwala, Hardik S.;Singh, Gaganmeet;Singh, Ranvir;Dey, Chinmoy Sankar;Sharma, Shyam Sundar;Bhutani, Kamlesh Kumar;Singh, Inder Pal. And the article was included in Journal of Natural Medicines in 2007.Electric Literature of C14H25NO The following contents are mentioned in the article:

The n-hexane, Et acetate, methanol, and acetone extracts of Piper cubeba Linn. and P. retrofractum Vahl. (Piperaceae) were evaluated in vitro against promastigotes of Leishmania donovani, and all exhibited significant in vitro activity at 100 μg/mL. Two lignans, cubebin and hinokinin, were isolated from the hexane extract of P. cubeba; and one bis-epoxy lignan, (-)-sesamin, and two amides, pellitorine and piplartine, were isolated from the hexane and methanol extracts of P. retrofractum. Cubebin and piplartine showed significant antileishmanial activity in vitro at 100 μM and were further tested in vivo in a hamster model of visceral leishmaniasis. Piplartine showed activity at 30 mg/kg dose. This is the first report of antileishmanial activity of these two plants and their isolated constituents. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Electric Literature of C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Electric Literature of C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Insecticidal activity of isobutylamides derived from Piper nigrum against adult of two mosquito species, Culex pipiens pallens and Aedes aegypti was written by Park, Il-Kwon. And the article was included in Natural Product Research in 2012.Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

The insecticidal activity of Piper nigrum fruit-derived piperidine alkaloid (piperine) and N-isobutylamide alkaloids (pellitorine, guineensine, pipercide and retrofractamide A) against female adults of Culex pipiens pallens and Aedes aegypti was examined On the basis of 24-h LD₅₀ values, the compound most toxic to female C. pipiens pallens was pellitorine (0.4 μg/female) followed by guineensine (1.9 μgfemale/), retrofractamide A (2.4 μg/female) and pipercide (3.2 μg/female). LD₅₀ value of chlorpyrifos was 0.03 μg/female. Against female A. aegypti, the insecticidal activity was more pronounced in pellitorine (0.17 μg/) than in retrofractamide A (1.5 μg/female), guineensine (1.7 μg/female), and pipercide (2.0 μg/female). LD₅₀ value of chlorpyrifos was 0.0014 μg/female. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fatty acid amides and anilides. Syntheses and antimicrobial properties was written by Bistline, R. G. Jr.;Maurer, E. W.;Smith, F. D.;Linfield, W. M.. And the article was included in Journal of the American Oil Chemists’ Society in 1980.HPLC of Formula: 730-25-6 The following contents are mentioned in the article:

A series of fatty acid amides and anilides was prepared; a number of compounds in the series were highly active against gram pos. bacteria but ineffective against gram neg. organisms. The N,N-dimethyl- and N,N-diethylamides of C₁₂-C₁₄ fatty acids had minimal inhibitory concentration (MIC) values of 100 ppm or less. Substituted anilides of C₆-C₁₁ fatty acids were active when the following groups were attached to the aromatic ring: 3,4-dichloro, 3-nitro, 4-nitro, 5-nitro-2-hydroxy, 4-chloro-3-nitro, and 2-hydroxy-5-nitro. Some of these compounds had a MIC value of 0.1 ppm. Significantly, the presence of soap did not reduce the activity of these bacteriostats, whereas polysorbate 80 at high concentrations deactivated the compounds This study involved multiple reactions and reactants, such as N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6HPLC of Formula: 730-25-6).

N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.HPLC of Formula: 730-25-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Anticholinesterases and antioxidant alkamides from Piper nigrum fruits was written by Tu, Yanbei;Zhong, Yujiao;Du, Hongjian;Luo, Wei;Wen, Yaya;Li, Qin;Zhu, Chao;Li, Yanfang. And the article was included in Natural Product Research in 2016.HPLC of Formula: 18836-52-7 The following contents are mentioned in the article:

The anticholinesterase and antioxidant effects of five different extracts of Piper nigrum were evaluated. Twenty-one known alkamides were isolated from active Et acetate extract and investigated for their cholinesterase inhibitory and antioxidant effects. Among them, piperine, piperettine and piperettyline exhibited dual inhibition against AChE and BChE, and feruperine was the most potent selective inhibitor of BChE. Mol. docking simulation was performed to get insight into the binding interactions of the ligands and enzymes. In addition, N-trans-feruloyltyramine contributed to the strongest DPPH radical-scavenging activity. The self-induced Aβ aggregation inhibition of, and was further evaluated. Results indicated that some alkamides could be multifunctional lead candidates for Alzheimer’s disease therapy. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7HPLC of Formula: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.HPLC of Formula: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging was written by Wei, Zisong;Chai, Hua;Chen, Yan;Cheng, Yue;Liu, Xiaojing. And the article was included in Current Opinion in Pharmacology in 2021.HPLC of Formula: 1094-61-7 The following contents are mentioned in the article:

A review. NAD (NAD) is essential for cellular physiol. processes, directly or indirectly affecting metabolism and gene expression. The decline of NAD⁺ levels in the heart is accompanied by aging, causing cardiac pathol. remodeling and dysfunction. Niacinamide mononucleotide (NMN) has emerged as a precursor to alleviate age-related cardiac pathophysiol. changes by improving cardiac NAD⁺ homeostasis. Preclin. trials on the efficacy and safety of intaking NMN have shown encouraging results, revealing a cardioprotective effect without significant side effects. Strategies for improving the effectiveness of NMN are also evolving. The present review aimed to summarize the potentials of NMN as a nutraceutical against cardiac aging and highlight the relationship between NMN supplementation and cardiac protection. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7HPLC of Formula: 1094-61-7).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.HPLC of Formula: 1094-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging was written by Wei, Zisong;Chai, Hua;Chen, Yan;Cheng, Yue;Liu, Xiaojing. And the article was included in Current Opinion in Pharmacology in 2021.COA of Formula: C11H15N2O8P The following contents are mentioned in the article:

A review. NAD (NAD) is essential for cellular physiol. processes, directly or indirectly affecting metabolism and gene expression. The decline of NAD⁺ levels in the heart is accompanied by aging, causing cardiac pathol. remodeling and dysfunction. Niacinamide mononucleotide (NMN) has emerged as a precursor to alleviate age-related cardiac pathophysiol. changes by improving cardiac NAD⁺ homeostasis. Preclin. trials on the efficacy and safety of intaking NMN have shown encouraging results, revealing a cardioprotective effect without significant side effects. Strategies for improving the effectiveness of NMN are also evolving. The present review aimed to summarize the potentials of NMN as a nutraceutical against cardiac aging and highlight the relationship between NMN supplementation and cardiac protection. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7COA of Formula: C11H15N2O8P).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.COA of Formula: C11H15N2O8P

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Alkaloids and lignans from stems of Piper betel was written by Huang, Xiangzhong;Yin, Yan;Huang, Wenquan;Sun, Kuizong;Cheng, Chunmei;Bai, Lian;Dai, Yun. And the article was included in Zhongguo Zhongyao Zazhi in 2010.HPLC of Formula: 18836-52-7 The following contents are mentioned in the article:

Alkaloids and lignans from the stems of Piper betel were studied. Compounds were isolated and purified by repeated silica gel, reverse phase silica gel, Sephadex LH-20 column chromatog., and preparative thin layer chromatog. The structures were elucidated on the basis of spectral anal. From the Et acetate soluble fractions of the 70% acetone extract, 10 compounds were isolated and identified as piperine; pellitorine; N-isobutyl-2E,4E-dodecadienamide; dehydropipernonaline; piperdardine; piperolein-B; guineensine; (2E,4E)-N-isobutyl-7-(3′,4′-methylene dioxyphenyl)-2,4-heptadienamide; syringaresinol-O-β-D-glucopyranoside; and pinoresinol (10). All compounds were isolated from the plant for the first time, and syringaresinol-O-β-D-glucopyranoside and pinoresinol were isolated from the genus for the first time. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7HPLC of Formula: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.HPLC of Formula: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Search for β-Secretase Inhibitors from Natural Spices was written by Matsumura, Shinichi;Murata, Kazuya;Yoshioka, Yuri;Matsuda, Hideaki. And the article was included in Natural Product Communications in 2016.Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

The growing number of Alzheimer’s disease (AD) patients prompted us to seek effective natural resources for the prevention of AD. We focused on the inhibition of β-secretase, which is known to catalyze the production of senile plaque. Sixteen spices used in Asian countries were selected for the screening. Among the extracts tested, hexane extracts obtained from turmeric, cardamom, long pepper, cinnamon, Sichuan pepper, betel, white turmeric and aromatic ginger showed potent inhibitory activities. Their active principles were identified as sesquiterpenoids, monoterpenoids, fatty acid derivatives and phenylpropanoids using GC-MS analyses. The chem. structures and IC₅₀ values of the compounds are disclosed. The results suggest that long-term consumption of aromatic compounds from spices could be effective in the prevention of AD. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Preparation of bioactive amide compounds from black pepper by countercurrent chromatography and preparative HPLC was written by Jin, Yongyang;Qian, Dengyong;Du, Qizhen. And the article was included in Industrial Crops and Products in 2013.SDS of cas: 18836-52-7 The following contents are mentioned in the article:

Amide compounds are the major bioactive substances in black pepper. Black pepper extracts were fractionated by high-speed countercurrent chromatog. resulting in three compounds: dehydropipernonaline, piperine and (2E,4E,12Z)-N-isobutyl-octadecatrienamide, and four fractions which were separated by preparative HPLC to yield ten purified compounds: retrofractamide-A, (2E,4E)-N-isobutyl-decadienamide, retrofractamide-C, piperoleine A, dehydropiperoleine A, retrofractamide-B, piperoleine B, pipernonaline, pipercyclobutanamides A and (2E,4E,14Z)-N-isobutyleicosa-2,4,14-trienamide as identified by ESI-MS and NMR anal. The results of the present study indicated that HSCCC is an effective technique for the preparation of bioactive amide compounds from black pepper. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7SDS of cas: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.SDS of cas: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics