Month: November 2022

Search for glioma direct binding site of alkaloid using protein-ligand ant system was written by Rifai, Yusnita. And the article was included in Asian Journal of Pharmaceutical and Clinical Research in 2018.Reference of 18836-52-7 The following contents are mentioned in the article:

This research aims to know the best affinity and the best chem. conformation of anticancer compounds from alkaloid groups that have closed direction to Glioma-associated oncogene using protein-ligand ant system (PLANTS). The interaction energy and hydrogen bond are included as evaluated targets. In this research, 27 ligands with root mean square deviation score at 1.614 Å and cyclopamine as native ligand are used. Meanwhile, staurosporinone acts as gliomas directed-binding-site-internal-control. Each ligand is docked in GLI with Protein Data Bank code 2GLI using two methods, GLI contains water and without water. PLANTS score for native ligand in the first and the second method is -73.9002 and -73.2700, resp. Pancracristine, homoharringtonine, and sanguinarine showed PLANTS score closed to the cyclopamine score result, but their hydrogen bond interaction differed from native ligan interaction. Evodiamine ligand has a good score and hydrogen bond to the same amino acid of protein GLI, which are GLU 175 and THR 173. This result indicated that evodiamine has the same identical mechanism as staurosporinone. The evodiamine is determined to have the same working mechanism as a GLI inhibitor. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Reference of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Reference of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Exploratory study on the occurrence and dynamics of yeast-mediated nicotinamide riboside production in craft beers was written by Garofalo, Cristiana;Sabbatini, Riccardo;Zamporlini, Federica;Minazzato, Gabriele;Ferrocino, Ilario;Aquilanti, Lucia;Raffaelli, Nadia;Osimani, Andrea. And the article was included in LWT–Food Science and Technology in 2021.Formula: C11H15N2O8P The following contents are mentioned in the article:

In this study, nicotinamide riboside (NR), a form of vitamin B3, and its precursors NMN (NMN) and NAD+ were quantitated by a fluorometric assay in ten com. craft beers and throughout the fermentation process of a laboratory-scale beer. All tested beers from different com. Saccharomyces cerevisiae strains contained NAD+ (ranging from 1.10μM to 17.80μM). NR concentrations ranged from 0.48 to 3.25μM, while the content of NMN was approx. 0.9μM. NR and NMN were only present in beers produced with S. cerevisiae strain US-05. Data from laboratory-scale beer productions using S. cerevisiae strain US-05 showed that the addition of hops [amarillo (alpha acid: 9.0%) (4 g/L) and centennial (alpha acid: 8.5%) (4 g/L) varieties] at the 9th day of fermentation significantly increased NR production up to 6.11μM at the end of a typical fermentation of 21 days, and up to 11.42μM at 45 days of fermentation The rapid increase in NR formation only occurred if both hops and yeast were present, and the burst was also confirmed in fermentations trials performed with S. cerevisiae strain CBS1171T and by replacing wort with YPD medium. This study can serve as baseline for further research on yeast-hop interaction. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Formula: C11H15N2O8P).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Formula: C11H15N2O8P

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Preclinical and clinical evidence of NAD⁺ precursors in health, disease, and ageing was written by Reiten, Ole Kristian;Wilvang, Martin Andreas;Mitchell, Sarah J.;Hu, Zeping;Fang, Evandro F.. And the article was included in Mechanisms of Ageing and Development in 2021.Computed Properties of C11H15N2O8P The following contents are mentioned in the article:

A review. NAD⁺ is a fundamental mol. in human life and health as it participates in energy metabolism, cell signalling, mitochondrial homeostasis, and in dictating cell survival or death. Emerging evidence from preclin. and human studies indicates an age-dependent reduction of cellular NAD⁺, possibly due to reduced synthesis and increased consumption. In preclin. models, NAD⁺ repletion extends healthspan and / or lifespan and mitigates several conditions, such as premature ageing diseases and neurodegenerative diseases. These findings suggest that NAD⁺ replenishment through NAD⁺ precursors has great potential as a therapeutic target for ageing and age-predisposed diseases, such as Alzheimers disease. Here, we provide an updated review on the biol. activity, safety, and possible side effects of NAD⁺ precursors in preclin. and clin. studies. Major NAD⁺ precursors focused on by this review are nicotinamide riboside (NR), NMN (NMN), and the new discovered dihydronicotinamide riboside (NRH). In summary, NAD⁺ precursors have an exciting therapeutic potential for ageing, metabolic and neurodegenerative diseases. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Computed Properties of C11H15N2O8P).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Computed Properties of C11H15N2O8P

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Preclinical and clinical evidence of NAD⁺ precursors in health, disease, and ageing was written by Reiten, Ole Kristian;Wilvang, Martin Andreas;Mitchell, Sarah J.;Hu, Zeping;Fang, Evandro F.. And the article was included in Mechanisms of Ageing and Development in 2021.Electric Literature of C11H15N2O8P The following contents are mentioned in the article:

A review. NAD⁺ is a fundamental mol. in human life and health as it participates in energy metabolism, cell signalling, mitochondrial homeostasis, and in dictating cell survival or death. Emerging evidence from preclin. and human studies indicates an age-dependent reduction of cellular NAD⁺, possibly due to reduced synthesis and increased consumption. In preclin. models, NAD⁺ repletion extends healthspan and / or lifespan and mitigates several conditions, such as premature ageing diseases and neurodegenerative diseases. These findings suggest that NAD⁺ replenishment through NAD⁺ precursors has great potential as a therapeutic target for ageing and age-predisposed diseases, such as Alzheimers disease. Here, we provide an updated review on the biol. activity, safety, and possible side effects of NAD⁺ precursors in preclin. and clin. studies. Major NAD⁺ precursors focused on by this review are nicotinamide riboside (NR), NMN (NMN), and the new discovered dihydronicotinamide riboside (NRH). In summary, NAD⁺ precursors have an exciting therapeutic potential for ageing, metabolic and neurodegenerative diseases. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Electric Literature of C11H15N2O8P).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Electric Literature of C11H15N2O8P

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nicotinamide mononucleotide attenuates doxorubicin-induced cardiotoxicity by reducing oxidative stress, inflammation and apoptosis in rats was written by Wan, Yixuan;He, Bo;Zhu, Dongyong;Wang, Lei;Huang, Ruijue;Zhu, Jing;Wang, Chunhua;Gao, Fabao. And the article was included in Archives of Biochemistry and Biophysics in 2021.Product Details of 1094-61-7 The following contents are mentioned in the article:

Doxorubicin (DOX) is an effective and widely used antineoplastic drug. However, its clin. application is limited due to its dose-dependent cardiotoxicity. Great efforts have been made to explore the pathol. mechanism of DOX-induced cardiotoxicity (DIC), but new drugs and strategies to alleviate cardiac damage are still needed. Here, we aimed to investigate the effect of NMN (NMN) on DIC in rats. The results of the present study showed that DOX treatment significantly induced cardiac dysfunction and cardiac injury, whereas NMN alleviated these changes. In addition, NMN inhibited Dox-induced activation of nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome-mediated inflammation, as evidenced by decreased caspase 1 and IL-1β activity. Moreover, NMN treatment increased glutathione (GSH) levels and superoxide dismutase (SOD) activity and decreased the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in DOX-treated rats. Furthermore, NMN treatment mitigated DOX-induced cardiomyocyte apoptosis and cardiac fibrosis. In conclusion, the results indicated that NMN protects against DIC in rats by inhibiting NLRP3 inflammasome activation, oxidative stress, and apoptosis. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Product Details of 1094-61-7).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Product Details of 1094-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nicotinamide mononucleotide attenuates doxorubicin-induced cardiotoxicity by reducing oxidative stress, inflammation and apoptosis in rats was written by Wan, Yixuan;He, Bo;Zhu, Dongyong;Wang, Lei;Huang, Ruijue;Zhu, Jing;Wang, Chunhua;Gao, Fabao. And the article was included in Archives of Biochemistry and Biophysics in 2021.Recommanded Product: ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate The following contents are mentioned in the article:

Doxorubicin (DOX) is an effective and widely used antineoplastic drug. However, its clin. application is limited due to its dose-dependent cardiotoxicity. Great efforts have been made to explore the pathol. mechanism of DOX-induced cardiotoxicity (DIC), but new drugs and strategies to alleviate cardiac damage are still needed. Here, we aimed to investigate the effect of NMN (NMN) on DIC in rats. The results of the present study showed that DOX treatment significantly induced cardiac dysfunction and cardiac injury, whereas NMN alleviated these changes. In addition, NMN inhibited Dox-induced activation of nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome-mediated inflammation, as evidenced by decreased caspase 1 and IL-1β activity. Moreover, NMN treatment increased glutathione (GSH) levels and superoxide dismutase (SOD) activity and decreased the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in DOX-treated rats. Furthermore, NMN treatment mitigated DOX-induced cardiomyocyte apoptosis and cardiac fibrosis. In conclusion, the results indicated that NMN protects against DIC in rats by inhibiting NLRP3 inflammasome activation, oxidative stress, and apoptosis. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Recommanded Product: ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Increasing the selectivity of biologically active tetranuclear arene ruthenium assemblies was written by Gupta, Gajendra;Nowak-Sliwinska, Patrycja;Herrero, Noelia;Dyson, Paul J.;Therrien, Bruno. And the article was included in Journal of Organometallic Chemistry in 2015.Name: N1,N2-Di(pyridin-4-yl)oxalamide The following contents are mentioned in the article:

A series of arene ruthenium metalla-rectangles of general formula [(η⁶-p-cymene)₄Ru₄(μ₄-embelin)₂(μ₂-N-N)₂](CF₃SO₃)₄ was prepared from the embelin-derived metalla-clip (η⁶-p-cymene)₂Ru₂(μ₄-embelin)Cl₂ (1), silver triflate and several linear ditopic N-ligands (N-N); pyrazine (prz), 4,4′-bipyridine (bpy), 1,2-bis(4-pyridyl)ethylene (bpe), 4,4′-azopyridine (azp) and di(pyridin-4-yl)oxalamide (bpo). The antiproliferative activity of these multinuclear arene ruthenium metalla-rectangles was evaluated in vitro on the human ovarian cancer cells A2780 and A2780cisR and on the noncancerous cell line HEK-293. Among these complexes, two rectangles, [(η⁶-p-cymene)₄Ru₄(μ₄-embelin)₂(μ₂-bpy)₂](CF₃SO₃)₄ and [(η⁶-p-cymene)₄Ru₄(μ₄-embelin)₂(μ₂-bpo)₂](CF₃SO₃)₄, display excellent activity and selectivity for cancer cells. This study involved multiple reactions and reactants, such as N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7Name: N1,N2-Di(pyridin-4-yl)oxalamide).

N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Name: N1,N2-Di(pyridin-4-yl)oxalamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

NAD+ Precursors Repair Mitochondrial Function in Diabetes and Prevent Experimental Diabetic Neuropathy was written by Chandrasekaran, Krish;Najimi, Neda;Sagi, Avinash R.;Yarlagadda, Sushuma;Salimian, Mohammad;Arvas, Muhammed Ikbal;Hedayat, Ahmad F.;Kevas, Yanni;Kadakia, Anand;Russell, James W.. And the article was included in International Journal of Molecular Sciences in 2022.Recommanded Product: ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate The following contents are mentioned in the article:

Axon degeneration in diabetic peripheral neuropathy (DPN) is associated with impaired NAD+ metabolism We tested whether the administration of NAD+ precursors, NMN (NMN) or nicotinamide riboside (NR), prevents DPN in models of Type 1 and Type 2 diabetes. NMN was administered to streptozotocin (STZ)-induced diabetic rats and STZ-induced diabetic mice by i.p. injection at 50 or 100 mg/kg on alternate days for 2 mo. mice The were fed with a high fat diet (HFD) for 2 mo with or without added NR at 150 or 300 mg/kg for 2 mo. The administration of NMN to STZ-induced diabetic rats or mice or dietary addition of NR to HFD-fed mice improved sensory function, normalized sciatic and tail nerve conduction velocities, and prevented loss of intraepidermal nerve fibers in skin samples from the hind-paw. In adult dorsal root ganglion (DRG) neurons isolated from HFD-fed mice, there was a decrease in NAD+ levels and mitochondrial maximum reserve capacity. These impairments were normalized in isolated DRG neurons from NR-treated mice. The results indicate that the correction of NAD+ depletion in DRG may be sufficient to prevent DPN but does not significantly affect glucose tolerance, insulin levels, or insulin resistance. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Recommanded Product: ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Recommanded Product: ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics