Month: November 2022

Abulkhair, Hamada S. published the artcileIn vivo- and in silico-driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors, Recommanded Product: 2-Chloroacetamide, the publication is Archiv der Pharmazie (Weinheim, Germany) (2021), 354(5), 2000449, database is CAplus and MEDLINE.

The lack of effective therapies for epileptic patients and the potentially harmful consequences of untreated seizure incidents have made epileptic disorders in humans a major health concern. Therefore, new and more potent anticonvulsant drugs are continually sought after, to combat epilepsy. On the basis of the pharmacophoric structural specifications of effective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists with an efficient anticonvulsant activity, the present work reports the design and synthesis of two novel sets of quinoxaline derivatives The anticonvulsant activity of the synthesized compounds was evaluated in vivo according to the pentylenetetrazol-induced seizure protocol, and the results were compared with those of perampanel as a reference drug. Among the synthesized compounds, four showed promising activities with ED₅₀ values of 37.50, 23.02, 29.16, and 23.86 mg/kg. Docking studies of these compounds suggested that AMPA binding could be the mechanism of action of these derivatives Overall, the pharmacophore-based structural optimization, in vivo and in silico docking, and druglikeness studies indicated that the designed compounds could serve as promising candidates for the development of effective anticonvulsant agents with good pharmacokinetic profiles.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Recommanded Product: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wang, Meng published the artcileDifferential contribution of BLT1 and BLT2 to leukotriene B4-induced human NK cell cytotoxicity and migration, Related Products of amides-buliding-blocks, the publication is Mediators of Inflammation (2015), 389849/1-389849/14, database is CAplus and MEDLINE.

Accumulating evidence indicates that leukotriene B4 (LTB4) via its receptors BLT1 and/or BLT2 (BLTRs) could have an important role in regulating infection, tumor progression, inflammation, and autoimmune diseases. In the present study, we showed that LTB4 not only augments cytotoxicity by NK cells but also induces their migration. We found that approx. 30% of fresh NK cells express BLT1, 36% express BLT2, and 15% coexpress both receptors.The use of selective BLTR antagonists indicated that BLT1 was involved in both LTB4-induced migration and cytotoxicity, whereas BLT2 was involved exclusively in NK cell migration, but only in response to higher concentrations of LTB4. BLT1 and BLT2 expression increased after activation of NK cells with IL-2 and IL-15.These changes of BLTR expression by cytokines were reflected in enhanced NK cell responses to LTB4. Our findings suggest that BLT1 and BLT2 play differential roles in LTB4-induced modulation of NK cell activity.

Mediators of Inflammation published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C5H5F3O2, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Darwish, Sara A. published the artcileNew tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies, Product Details of C17H14F3N3O2S, the publication is Bioorganic Chemistry (2022), 105644, database is CAplus and MEDLINE.

New tilomisole-based benzimidazothiazole derivatives were designed and synthesized in this work. Their anti-inflammatory activity was assessed through the in vivo carrageenan rat paw edema model, and the in vitro COX inhibition assay. Compounds 13, 20, 30, 40, 43, and 46 demonstrated values of inhibition of induced edema in the in vivo assay comparable to celecoxib. All the synthesized compounds expressed their activity on COX-2 enzyme more than COX-1, proving their advantageous selectivity. In addition, compounds 13, 16, 20, 25, and 46 displayed lower IC₅₀ values than celecoxib as a reference drug against COX-2 enzyme; having values of 0.09, 13.87, 32.28, 33.01, and 5.18 nM resp. vs 40.00 nM for celecoxib. Particularly, the most active compound (13) with its extreme potency (400 folds more potent than celecoxib) exhibited a notable high selectivity index (SI = 159.5). In silico studies, including ADMET prediction, compliance to Lipinski′s rule of five, and mol. docking into the active site of both COX isoenzymes were conducted for the synthesized compounds The results suggested that these compounds are good candidates for orally active drugs, and docking revealed higher number of interactions with COX-2 for 13 as the most active compound compared with COX-1 reflecting its advantageous selectivity and explaining its extreme potency.

Bioorganic Chemistry published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, Product Details of C17H14F3N3O2S.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

El Hefny, Eman A. published the artcileSynthesis, characterization, antitumor evaluation and molecular docking of some triazolotriazine derivatives, Name: 2-Cyano-N-ethylacetamide, the publication is Journal of Pharma Research (2014), 3(5), 79-87, database is CAplus.

The synthesis of 4-amino-[1,2,4]triazolo[5,1-c][1,2,4]triazine derivatives I (R = CN, COOC₂H₅, CONH₂) using readily available starting materials is described. In this study, six selected derivatives, compounds I (R = CN), II, III, IV (Ar = 4-ClC₆H₄, 2-ClC₆H₄) and V were subjected to a screening system for investigation of their antitumor potency against liver (HEPG2) cell line in comparison to known anticancer drugs, 5-fluorouracil and Doxorubicin. The antitumor activity results indicated that the selected compounds I (R = CN), II, III, IV (Ar = 4-ClC₆H₄, 2-ClC₆H₄) and V derivatives showed growth inhibition activity against the tested cell line but with varying intensities in comparison to 5-fluorouracil and Doxorubicin. Compounds II and III were investigated for the binding affinity of c-Kit tyrosine kinases receptor.

Journal of Pharma Research published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Name: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Brun, Omar published the artcileOn-Resin Conjugation of Diene-Polyamides and Maleimides via Diels-Alder Cycloaddition, Product Details of C40H35N7O8, the publication is Journal of Organic Chemistry (2015), 80(12), 6093-6101, database is CAplus and MEDLINE.

The reaction between maleimides and resin-bound diene-polyamides (polyamides are represented by peptides and peptide nucleic acids or PNAs) allows the latter to be used in the preparation of conjugates. Conjugation takes place by reacting the insoluble, hydrophobic diene component either with water-soluble dienophiles or with dienophiles requiring mixtures of water and organic solvents. Exptl. conditions can be adjusted to furnish the target conjugate in good yield with no need of adding large excesses of soluble reagent. In case protected maleimides are used, maleimide deprotection and Diels-Alder cycloaddition can be simultaneously carried out to render conjugates with different linking positions. On-resin conjugation is followed by an acidic treatment that removes the polyamide protecting groups with no harm to the cycloadduct, in contrast with the unreacted diene that is indeed degraded under these conditions. Cycloadducts incorporating suitable functional groups can undergo subsequent addnl. conjugation reactions in solution to furnish double conjugates.

Journal of Organic Chemistry published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Product Details of C40H35N7O8.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Al-Etaibi, Alya published the artcileThe effect of dispersing agent on the dyeing of polyester fabrics with disperse dyes derived from 1,4-diethyl-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile, Name: 2-Cyano-N-ethylacetamide, the publication is European Journal of Chemistry (2013), 4(3), 240-244, database is CAplus.

1,4-Diethyl-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile (8), is synthesized by reacting Et cyanoacetate with Et amine to produce the amide 4, which when reacted with Et propionylacetate, afforded compound 8. Compound 8 is then coupled with aromatic diazonium salts to give the corresponding arylhydrazono-1,4-diethyl-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile disperse dyes, 11a-d, whose structures were elucidated by using X-ray crystal structure determinations A high temperature dyeing method was employed to apply these dyes for polyester fabrics. The relationship between dyeing properties and the concentration of dispersing agent present in a dye bath is evaluated.

European Journal of Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Name: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Saha, Sayantani published the artcileMild catalytic deoxygenation of amides promoted by thorium metallocene, Application of N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Dalton Transactions (2020), 49(36), 12835-12841, database is CAplus and MEDLINE.

The organoactinide-catalyzed (Cp*₂ThMe₂) hydroborated reduction of a wide range of tertiary, secondary, and primary amides to the corresponding amines/amine-borane adducts via deoxygenation of the amides is reported herein. The catalytic reactions proceed under mild conditions with low catalyst loading and pinacolborane (HBpin) concentration in a selective fashion. Cp*₂ThMe₂ is capable of efficiently catalyzing the gram-scale reaction without a drop in efficiency. The amine-borane adducts are successfully converted into free amine products in high conversions, which increases the usefulness of this catalytic system. A plausible mechanism is proposed based on detailed kinetics, stoichiometric, and deuterium labeling studies.

Dalton Transactions published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Application of N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Perova, N. M. published the artcileTransformation of 2-cycloalkylimino-6H-1,3,4-thiadiazines under action of UV-irradiation, Name: Morpholine-4-carbothioamide, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1993), 565-6, database is CAplus.

UV irradiation of thiadiazines I (R¹ = H, R² = morpholino, piperidino, 1-pyrrolidinyl, 1H-azepin-1-yl) gave pyrazoles II and in the case of I (R¹ = H, R² = morpholino) 1-(4-phenyl-2-thiazolyl)morpholine was obtained.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Name: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kawada, Hatsuo published the artcileLead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation, Recommanded Product: N-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(3), 673-678, database is CAplus and MEDLINE.

Lead compound I, for a phosphoinositide 3-kinase (PI3K) inhibitor, was metabolically unstable because of rapid glucuronidation of the phenol moiety. Based on structure-activity relationship (SAR) information and a FlexSIS docking simulation score, aminopyrimidine was identified as a bioisostere of phenol. An X-ray structure study revealed a hydrogen bonding pattern of aminopyrimidine derivatives Finally, aminopyrimidine derivative II showed strong tumor growth inhibition against a KPL-4 breast cancer xenograft model in vivo.

Bioorganic & Medicinal Chemistry Letters published new progress about 1197171-76-8. 1197171-76-8 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronate Esters,Boronic Acids,Boronic acid and ester,, name is N-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide, and the molecular formula is C14H20BNO3, Recommanded Product: N-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Dyachenko, Ivan V. published the artcileNovel multicomponent synthesis of 6,7-dihydro-5H-cyclopenta[b]pyridine derivatives, Formula: C2H4ClNO, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2020), 56(12), 1592-1598, database is CAplus.

The multicomponent condensation of malononitrile, hydrogen sulfide, aldehydes RCHO (R = Et, cyclohex-3-en-1-yl, Ph, 4-hydroxyphenyl, etc.), 1-(cyclopent-1-en-1-yl)pyrrolidine, and alkylating agents XCH₂Z (X = Br, Cl, I; Z = H, ethoxycarbonyl, CN, Ph, etc.) leads to the formation of 6,7-dihydro-5H-cyclopenta[b]pyridine derivatives, e.g., I.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Formula: C2H4ClNO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics