November 2022 - Page 69 of 223 - Amides-buliding-blocks

Soma, Mounica et al. published their research in Molecular Biology Reports in 2022 | CAS: 1094-61-7

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.COA of Formula: C11H15N2O8P

The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions was written by Soma, Mounica;Lalam, Satya Kumar. And the article was included in Molecular Biology Reports in 2022.COA of Formula: C11H15N2O8P The following contents are mentioned in the article:

A review. Biosynthesis and regulation of NAD (NAD+) has recently gained a lot of attention. A systemic decline in NAD+ across many tissues is associated with all the hallmarks of aging. NAD+ can affect a variety of cellular processes, including metabolic pathways, DNA repair, and immune cell activity, both directly and indirectly. These cellular processes play a vital role in maintaining homeostasis, but as people get older, their tissue and cellular NAD+ levels decrease, and this drop in NAD+ levels has been connected to a number of age-related disorders. By restoring NAD+ levels, several of these age-related disorders can be delayed or even reversed. Some of the new studies conducted in mice and humans have targeted the NAD+ metabolism with NAD+ intermediates. Of these, NMN (NMN) has been shown to offer great therapeutic potential with promising results in age-related chronic conditions such as diabetes, cardiovascular issues, cognitive impairment, and many others. Further, human interventions are required to study the long-term effects of supplementing NMN with varying doses. The paper focuses on reviewing the importance of NAD+ on human aging and survival, biosynthesis of NAD+ from its precursors, key clin. trial findings, and the role of NMN on various health conditions. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7COA of Formula: C11H15N2O8P).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ono, Atsushi et al. published their research in Food and Chemical Toxicology in 2012 | CAS: 18836-52-7

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Category: amides-buliding-blocks

Validation of the (Q)SAR combination approach for mutagenicity prediction of flavor chemicals was written by Ono, Atsushi;Takahashi, Mika;Hirose, Akihiko;Kamata, Eiichi;Kawamura, Tomoko;Yamazaki, Takeshi;Sato, Kyoko;Yamada, Masami;Fukumoto, Takayuki;Okamura, Hiroyuki;Mirokuji, Yoshiharu;Honma, Masamitsu. And the article was included in Food and Chemical Toxicology in 2012.Category: amides-buliding-blocks The following contents are mentioned in the article:

Most exposure levels of flavor in food are considered to be extremely low. If at all, genotoxic properties should be taken into account in safety evaluations. We have recently established a (quant.) structure-activity relationship, (Q)SAR, combination system, which is composed of three individual models of mutagenicity prediction for industrial chems. A decision on mutagenicity is defined as the combination of predictive results from the three models. To validate the utility of our (Q)SAR system for flavor evaluation, we assessed 367 flavor chems. that had been evaluated mainly by JECFA and for which Ames test results were available. When two or more models gave a pos. evaluation, the sensitivity was low (19.4%). In contrast, when one or more models gave a pos. evaluation, the sensitivity increased to 47.2%. The contribution of this increased sensitivity was mainly due to the result of the prediction by Derek for Windows, which is a knowledge-based model. Structural anal. of false negatives indicated some common sub-structures. The approach of improving sub-structural alerts could effectively contribute to increasing the predictability of the mutagenicity of flavors, because many flavors possess categorically similar functional sub-structures or are composed of a series of derivatives This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Category: amides-buliding-blocks).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Alluraiah, G. et al. published their research in Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences in 2019 | CAS: 18836-52-7

Insilico binding studies of anti-MRSA compounds on Pencillin Binding Protein 2a was written by Alluraiah, G.;Sreenu Babu, A.;Hari babu, D.. And the article was included in Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences in 2019.COA of Formula: C14H25NO The following contents are mentioned in the article:

The study evaluates a few selected plant derived products including Sesamin, Pellitorine, Guineesine, Brachystamide B and Pipataline from piper longum for their binding with and inhibitory capacity on Penicillin Binding Protein 2a of Methicillin Resistant Staphylococcus aureus (MRSA) using computational methods. The crystal structure of Penicillin Binding Protein 2a was taken from the Protein Data Bank (PDB_ID:1VQQ). Possible binding sites of Penicillin Binding Protein 2a were searched with CASTP server. Mol. docking was performed using the Gold (Genetic Optimization of Ligand Docking) software which is based on genetic algorithm (GA), to study the binding orientation of compounds into the Penicillin Binding Protein 2a structure. The efficiency and drug-likeness of various plant compounds were identified by using pre-ADMET software. In this study, all docked compounds were found to have some interaction between an oxygen atom of the Compounds and Penicillin Binding Protein 2a. In the binding pocket, common H-bonding interactions were formed between all docked compounds and ASP-65, CYS-66, CYS-88. The docking results agreed well with the observed in vitro data, which showed that the Penicillin Binding Protein 2a inhibitory activity of pepataline was higher than those of other compounds This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7COA of Formula: C14H25NO).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pang, Huanhuan et al. published their research in Nature Metabolism in 2021 | CAS: 1094-61-7

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Product Details of 1094-61-7

Aberrant NAD⁺ metabolism underlies Zika virus-induced microcephaly was written by Pang, Huanhuan;Jiang, Yisheng;Li, Jie;Wang, Yushen;Nie, Meng;Xiao, Nan;Wang, Shuo;Song, Zhihong;Ji, Fansen;Chang, Yafei;Zheng, Yu;Yao, Ke;Yao, LiAng;Li, Shao;Li, Peng;Song, Lei;Lan, Xun;Xu, Zhiheng;Hu, Zeping. And the article was included in Nature Metabolism in 2021.Product Details of 1094-61-7 The following contents are mentioned in the article:

Zika virus (ZIKV) infection during pregnancy can cause microcephaly in newborns, yet the underlying mechanisms remain largely unexplored. Here, we reveal extensive and large-scale metabolic reprogramming events in ZIKV-infected mouse brains by performing a multi-omics study comprising transcriptomics, proteomics, phosphoproteomics and metabolomics approaches. Our proteomics and metabolomics analyses uncover dramatic alteration of NAD (NAD+)-related metabolic pathways, including oxidative phosphorylation, TCA cycle and tryptophan metabolism Phosphoproteomics anal. indicates that MAPK and cyclic GMP-protein kinase G signaling may be associated with ZIKV-induced microcephaly. Notably, we demonstrate the utility of our rich multi-omics datasets with follow-up in vivo experiments, which confirm that boosting NAD+ by NAD+ or nicotinamide riboside supplementation alleviates cell death and increases cortex thickness in ZIKV-infected mouse brains. Nicotinamide riboside supplementation increases the brain and body weight as well as improves the survival in ZIKV-infected mice. Our study provides a comprehensive resource of biol. data to support future investigations of ZIKV-induced microcephaly and demonstrates that metabolic alterations can be potentially exploited for developing therapeutic strategies. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Product Details of 1094-61-7).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Luo, Chengting et al. published their research in Journal of Nutritional Biochemistry in 2022 | CAS: 1094-61-7

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Synthetic Route of C11H15N2O8P

Nicotinamide reprograms adipose cellular metabolism and increases mitochondrial biogenesis to ameliorate obesity was written by Luo, Chengting;Yang, Changmei;Wang, Xueying;Chen, Yuling;Liu, Xiaohui;Deng, Haiteng. And the article was included in Journal of Nutritional Biochemistry in 2022.Synthetic Route of C11H15N2O8P The following contents are mentioned in the article:

Obesity poses a global health challenge and is a major risk factor for diabetes mellitus, cardiovascular diseases, hypertension, stroke and certain kinds of cancers. Although the effects of nicotinamide (NAM) on liver metabolism and diseases were well documented, its effects on adipose tissue are yet to be characterized. Herein, we found that NAM supplementation significantly reduced fat mass and improved glucose tolerance in obese mice. Proteomic anal. revealed that NAM supplementation upregulates mitochondrial proteins while quant. polymerase chain reaction showed that PPARα and PGC1α were both upregulated in adipose tissues, proposing that NAM increased mitochondrial biogenesis in adipose tissue. Indeed, NAM treatment increased proteins related to mitochondrial functions including oxidative phosphorylation, fatty acid oxidation, and TCA cycle. Furthermore, isotope-tracing assisted metabolic profiling revealed that NAM activated NAMPT and increased cellular NAD+ level by 30%. Unexpectedly, we found that NAM also increased glucose derived amino acids to enhance glutathione synthesis for maintaining cellular redox homeostasis. Taken together, our results demonstrated that NAM reprogramed cellular metabolism, enhanced adipose mitochondrial functions to ameliorate symptoms associated with obesity. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Synthetic Route of C11H15N2O8P).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Luo, Chengting et al. published their research in Journal of Nutritional Biochemistry in 2022 | CAS: 1094-61-7

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Synthetic Route of C11H15N2O8P

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gaur, Pooja et al. published their research in ACS Agricultural Science & Technology in 2022 | CAS: 18836-52-7

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Reference of 18836-52-7

Utilization of Agro-Waste of Piper longum for a Potential Pancreatic Lipase Inhibitor was written by Gaur, Pooja;Tiwari, Neerja;Shanker, Karuna. And the article was included in ACS Agricultural Science & Technology in 2022.Reference of 18836-52-7 The following contents are mentioned in the article:

The present study demonstrates the alternative source for pseudoalkaloids as well as the utilization of the agricultural wastes of Piper longum (PiL) as possible antiobesity agents. HPLC-based bioactivity-guided micro-fractionation of PiL root has resulted in five known compounds, piplartine (1), piperlonguminine (2), piperine (3), piperanine (5), pellitorine (6), and a new compound, piperdardine (4). Isolated compounds (1-6) were evaluated for their pancreatic lipase (PL) inhibitory potential. Pellitorine (PTR) was the most active component with IC₅₀ = 3.35 μg/mL, which inhibited PL reversibly and in a mixed-type manner. The synergistic effect of PTR with orlistat (0.17 μM) was also observed at a concentration lower than 15.70 μM. The findings of Fourier transform IR spectral studies demonstrated the structural compactness of PL with PTR. The thermodn. studies have confirmed the binding interaction of PTR with PL as hydrophobic. Furthermore, mol. docking studies showed that PTR interacted in the catalytic active amino side residue (Ser153-Asp80-His264) of the protein (1ETH) by hydrogen bonds with affinity (ΔG = -7.0 kcal/mol). The findings of the study support PTR as a potential lead for further validation in animal studies to lead toward clin. translation as an anti-obesity supplement. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Reference of 18836-52-7).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Qiang et al. published their research in Aquaculture in 2022 | CAS: 1094-61-7

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 1094-61-7

Long-chain fatty acids regulate SIRT3 expression by affecting intracellular NAD⁺ levels in large yellow croaker (Larimichthys crocea) was written by Chen, Qiang;Liu, Qiangde;Hao, Tingting;Cui, Kun;Zhao, Zengqi;Mai, Kangsen;Ai, Qinghui. And the article was included in Aquaculture in 2022.SDS of cas: 1094-61-7 The following contents are mentioned in the article:

Sirtuin 3 (SIRT3) is a major deacetylase in the mitochondria and sensitive to diverse nutrient signals. However, how dietary fatty acids regulate SIRT3 expression remains poorly understood. Here, sirt3 gene from large yellow croaker was characterized and can be activated by the oxidized NAD (NAD⁺) precursor, NMN (NMN). Moreover, the expression of SIRT3 is regulated differently by dietary fatty acids. In vivo, soybean oil increased the mRNA expression of sirt3 in head kidney. In vitro, stearic acid (SA) decreased the expression of SIRT3 in macrophages, while DHA and EPA increased the mRNA expression of sirt3. Meanwhile, all long-chain polyunsaturated fatty acids (LC-PUFAs) enhanced the protein levels of SIRT3, which was consistent with the trend of fatty acids affecting NAD⁺ levels. Furthermore, inhibition of NAD⁺de novo synthesis blocked DHA-induced increases in SIRT3 expression, and NMN supplement reversed SA-induced decreases in SIRT3 expression. In conclusion, these findings suggest that dietary fatty acids may regulate SIRT3 expression by affecting intracellular NAD⁺ synthesis. Regarding the important role of SIRT3 in regulating mitochondrial function, appropriate activation of SIRT3 may be an important way to alleviate metabolic disorders in aquaculture. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7SDS of cas: 1094-61-7).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Qiang et al. published their research in Aquaculture in 2022 | CAS: 1094-61-7

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 1094-61-7

Long-chain fatty acids regulate SIRT3 expression by affecting intracellular NAD⁺ levels in large yellow croaker (Larimichthys crocea) was written by Chen, Qiang;Liu, Qiangde;Hao, Tingting;Cui, Kun;Zhao, Zengqi;Mai, Kangsen;Ai, Qinghui. And the article was included in Aquaculture in 2022.Recommanded Product: 1094-61-7 The following contents are mentioned in the article:

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 1094-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pollard, Charley-Lea et al. published their research in The Journal of reproduction and development in 2021 | CAS: 1094-61-7

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Application of 1094-61-7

Supplementing media with NAD⁺ precursors enhances the in vitro maturation of porcine oocytes. was written by Pollard, Charley-Lea;Gibb, Zamira;Hawdon, Azelle;Swegen, Aleona;Grupen, Christopher G. And the article was included in The Journal of reproduction and development in 2021.Application of 1094-61-7 The following contents are mentioned in the article:

In vitro maturation (IVM) is an important reproductive technology used to produce embryos in vitro. However, the developmental potential of oocytes sourced for IVM is markedly lower than those matured in vivo. Previously, NAD⁺-elevating treatments have improved oocyte quality and embryo development in cattle and mice, suggesting that NAD⁺ is important during oocyte maturation. The aim of this study was to examine the effects of nicotinic acid (NA), nicotinamide (NAM) and nicotinamide mononucleotide (NMN) on oocyte maturation and subsequent embryo development. Porcine oocytes from small antral follicles were matured for 44 h in a defined maturation medium supplemented with NA, NAM and resveratrol or NMN. Mature oocytes were artificially activated and presumptive zygotes cultured for 7 days. Additionally, oocytes were matured without treatment then cultured for 7 days with NMN. Supplementing the IVM medium with NA improved maturation and blastocyst formation while NAM supplementation improved cleavage rates compared with untreated controls. Supplementing the IVM or embryo culture media with NMN had no effect on maturation or embryo development. The results show that supplementing the maturation medium with NA and NAM improved maturation and developmental potential of porcine oocytes. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Application of 1094-61-7).

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics