Month: November 2022

Good, Norman E. et al. published their research in Plant Physiology in 1961 | CAS: 730-25-6

N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Safety of N-(3,4-Dichlorophenyl)octanamide

Inhibitors of the Hill reaction was written by Good, Norman E.. And the article was included in Plant Physiology in 1961.Safety of N-(3,4-Dichlorophenyl)octanamide The following contents are mentioned in the article:

Compounds (147) of the general formula RNHC(X)R’ were studied as inhibitors of the reduction of ferricyanide by illuminated chloroplasts. The following were prepared (R, X, R’, and m.p. given): octyl, O, Me2N, 27-8°; cyclohexyl, O, Me2N, 156-7°; benzyl, O, Me2N, 76-7°; and Ph, O. 2-methyl-1-propenyl, 127-9°. Similarly, 4-ClC6H4NHC(X)R'(X, R’, and m.p. given): O, Cl2CH 137-8°; O Cl3C, 127-8°; S, Et, 77-8°; O, 1-chloroethyl, 112°; O, 1,1-dichloroethyl, 94-5°; O, 2-methyl-1-propenyl, 121-2°; O, Me3C, 148-9°; and S, 4-chloroanilino, 178-9°. Similarly, 3-ClC6H4NHC(X)R’; O, H, 55-6°; O, ClCH2, 99-100°; O, Cl3C, 101-2°; O, Pr, 45-6°; O, iso-Pr, 112°; O, 2-methyl-1-propenyl, 112-13°; O, Me2N, 139-41°; and O, 4-chloro-3-butynoxy, 75-6°. Similarly, 2-ClC6H4NHC(X)R’: O, Cl3C, 62°; O, 1-chloroethyl, 59°; O, Pr, 80°; O, iso-Pr, 93-4°; O, 2-methyl-2-propenyl, 88-9°; and O, Me3C, 76. Similarly, 3,5-Cl2C6H3NHC(X)R”: O, H, 127°; O, Cl3C, 121-2°; O, Et, 118-20°; O, 2-chloroethyl, 97-8°; O, Pr, 85-6°; O, iso-Pr, 134-5°; O, 2-methyl-1-propenyl, 106-7°; and O, Me2N, 163-5°. Similarly, 3,4-Cl2C6H3NHC(X)R’: O, ClCH2, 106-7°; O, Cl3C, 124-6°; O, BrCH2, 99-101°; O, 1,1-dichloroethyl, 110-12°; S, Et, 71-2°; O, 2-chloroethyl, 112-13°; O, 2-propenyl, 120-2°; O, Me3C, 145-6°; O, sec-Bu, 112-13°; O, pentyl, 75-6°; O, heptyl, 42°; O, octyl, 69-70°; O, nonyl, 70-1°; O, Ph, 145-6°; O, 2-ClC6H4, 152-3°; O, 4-ClC6H4, 172-3°; O, 2,4-Cl2C6H3, 156-7°; O, 3,4-Cl2C6H3, 227-8°; O, cyclohexyl, 137-8°; O, benzyl, 132°; O, 3,4-dichlorobenzyl, 186-7°; O, PhOCH2 141-2°; O, 2,4-Cl2C6H3OCH2, 160-1°; O, 2-methyl-1-propenyl, 103°; O, 3-phenylpropyl, 74-5°; O, trans-2-naphthylmethyl, 157-8°; O, 1-naphthylmethyl, 170-2°; O, PrNH, 128-9°; O, BuNH, 121-2°; O, hexylamino, 104-5°; O, benzylamino, 171-2°; O, 2-hydroxylethylamino, 137-8°; O, Et2N, 111-2; O, Pr2 , 96-7°; O, iso-Pr2N, 130-1°; O, piperidino, 172-3°; S, Et2N, 95-6°; and S, EtNH, 114-15°. Similarly, iso-PrC(O)NHR: 2,3-Cl2C6H3, 108-9°; 2,5-Cl2C6H3, 137-9°; 2,4,5-Cl3C6H2 145-6°; 2,4,6-Cl3C6H2, 151-2°; 2-MeOC6H4, 44°; 4-MeOC6H4, 109-11°; 4-O2NC6H4, 167-9°; 3-O2NC6H4, 93°; 3-chloro-4-methylphenyl, 146-7°; 2-methyl-3-chlorophenyl, 142-3°; 2-methyl-4-chlorophenyl, 163-4°; 3-nitro-4-methylphenyl, 106-7°; 1-naphthyl, 147-9°; 5,6,7,8-tetrahydro-2-naphthyl, 102°; 4-Me2NC6H4, 157-8°; 2,6-dimethylphenyl, -; cyclohexyl, 116-17°; and benzyl, 91-2°. Generalizations: substitution on the 3-, 4-, or 5-positions of the benzene ring of the aniline derivatives by Cl, Br, MeO, or Me increased the inhibition. Other parts of the mol. being equal, the activity of the chloroanilides was in the decreasing order: 3,4; 3,5 and 3 and 4; unsubstituted and 2,4,5; 2,5 and 2,3; 2. p- and m-Nitro groups reduced activity slightly and p-dimethylamino reduced it greatly. The effects of modifying the acyl moiety of the anilides was too complex to classify. Polar groups reduced activity. N-Chloroacetyl-N-methylaniline, lacking an imino H, was barely inhibitory. The role of H bonding was uncertain. Substitutions on the aniline moiety which favor H bonding increased the effectiveness, but modification of the acyl moiety did not, since the imino H atoms of chloroacetyl and trichloroacetyl-3,4-dichloroaniline form bonds with carbonyl O to a very limited extent, although both were excellent inhibitors. The same was true of the triazines. This study involved multiple reactions and reactants, such as N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6Safety of N-(3,4-Dichlorophenyl)octanamide).

N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Safety of N-(3,4-Dichlorophenyl)octanamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ponci, R. et al. published their research in Farmaco, Edizione Scientifica in 1963 | CAS: 83909-69-7

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Safety of N-Benzyl-2-chloro-5-nitrobenzamide

Preparation of 5-nitroisothiazolone and derivatives was written by Ponci, R.;Baruffini, A.;Croci, M.;Gialdi, F.. And the article was included in Farmaco, Edizione Scientifica in 1963.Safety of N-Benzyl-2-chloro-5-nitrobenzamide The following contents are mentioned in the article:

Adding a solution of KOH in EtOH with stirring to 80 g. 2,5-Cl(O2N)C6H3CO2H (I) in 300 cc. EtOH and concentrating to dryness at 40° gave I K salt. Powd. and dried I K salt (24 g.) was suspended in 220 cc. absolute EtOH, the mixture heated to boiling, 0.05 mole freshly prepared Na2S2 in 96% EtOH added with stirring in 90 min., and the mixture heated 1 hr. to give 65-70% yellow [2,4-HO2C(O2N)C6H3]2S (II), m. 280° (decomposition) (AcOH). A suspension of 6 g. II in anhydrous PhMe and 7 g. PCl5 was refluxed 2.5 hrs. to give 6.5 g. yellow [2,4-ClOC(O2N)C6H3]2S (III), m. 229-30° (dioxane). III was converted with refluxing absolute EtOH to [2,4-EtO2C(O2N)C6H3]2S, m. 169° (benzene-petr. ether). Powd. 2,5-Cl(O2N)C6H3CO2H was covered with SOCl2 and the mixture refluxed 1.5 hrs. to give 90% 2,5-Cl(O2N)C6H3COCl (IV), m 60-1° (ligroine). IV was converted to the following 2,5-Cl(O2N)C6H3CONHR (V) with a dioxane solution of the appropriate amine (or by bubbling in NH3) (R and m.p. given): H, 178°; Ph, 158°; Bu, 136°; PhCH2, 195°; 3-pyridylmethyl, 201°. III and a dioxane solution of the appropriate amine (method A) or 0.02 mole V and 0.01 mole freshly prepared Na2S2 in EtOH refluxed 90 min. (method B) gave the following: [2,4-ROC(O2N)C6H3]2S (VI) (method, R, and m.p. given): A, NH2, 250° (decomposition); A, MeNH, 255° (decomposition); A or B, BuNH, 215-18°; B, PhCH2NH, 243-5°; A, piperidino, 183°; A or B, PhNH, 241-3°; A, p-ClC6H4NH, >230° (decomposition); A or B, 3-pyridylmethylamino, 194-5°. Treating V (R = PhCH2NH) (VII) with an equivalent amount of Na2S2.9H2O gave 2,5-EtO(O2N)C6H3CONHCH2Ph (VIII), m. 151° (EtOH), which was also obtained directly from VII and alc. NaOH. VII and methanolic NaOH gave 2,5-MeO(O2N)C6H3CONHCH2Ph, m. 108° (benzene-petr. ether). Heating 1 mole 2,5-EtO(O2N)C6H3COCl, m. 80° (prepared from the corresponding acid, m. 161-3°, and SOCl2) with 2 moles PhCH2NH2 in 10% dioxane 20 min. at 50° gave VIII. III (5 g.) in 150 cc. anhydrous (CHCl2)2 was treated with 4 cc. Br, the mixture refluxed 90 min., excess Br removed in vacuo, the solution concentrated to half volume, anhydrous CCl4 added in 2 80-cc. portions, and the solution concentrated to 70 cc., and filtered. Then, 12 cc. 20% aqueous NH3 was introduced slowly with vigorous stirring at <20°, and the mixture kept 2 hrs. at ambient temperatures to give about 3 g. yellow IX (R = H), m. >280° (AcOH) (method C). Refluxing 1 g. VI(R = NH2) in 50 cc.(CHCl2)2 with 1.5 cc. Br 6 hrs. gave 0.4 g. IX (R = H) (method D). The following IX were thus prepared (method, R, and m.p. given): C or D, Me, 229-30°; C or D, PhCH2, 142°; C or D, Ph, 228°; C, p-C6H4Cl, 215-17°; C, Bu, 79°. The last compound was also prepared by suspending 2.17 g. III in 40 cc. anhydrous (CHCl2)2, adding 6 drops of 20% oleum, and heating at 50-60° while introducing a fast stream of Cl. The excess Cl was removed in a stream of dry N and the filtered solution dropped into 20 cc. anhydrous CCl4 containing 4.4 g. BuNH2. After standing 1 hr. at ambient temperatures, the mixture was extracted with very cold dilute HCl and then washed with H2O. The identity of IX was confirmed by conversion to the corresponding 5-nitrosaccharins (X). To a suspension of 3 g. IX (R = H) in 30 cc. AcOH was added 10 cc. 30% H2O2 and the mixture heated 60 min. at 100° to give X (R = H), m. 213-16° (method E). An ethereal solution of 2 g. 2,4-Cl(O2N)C6H3SO2Cl was dropped with stirring into 5 cc. 20% NH3 with cooling. The mixture was kept 2 hrs. at ambient temperatures, concentrated, and dried in vacuo at low temperature A 1-g. portion of the residue was dissolved in 100 cc. H2O, passed through a 2-cm. diameter column containing 40 g. Amberlite C.G. 120 activity, and eluted with 150 cc. H2O to give X (R = H) (method F). X (R = Na) (1 g.) in 5 cc. HCONMe2 was heated slowly to reflux with 2 equivalents MeI and the mixture refluxed 15 min. to give 70% X (R = Me) (method G). The following X were also prepared (method, R, and m.p. given): E, Me, 170°; E or G, Bu, 74°; E or G, PhCH2, 139°; E or F, Ph, 203°; E, p-C6H4Cl, 181°. Dried and powd. 7 g. II was added in small portions with stirring to 50 cc. HNO3 (d. 1.52) kept at 0°, the mixture kept 30 min. with stirring at ambient temperatures, and 100 cc. 10% K2CO3 added dropwise with external cooling to give 8.5 g. 2,4-HO2C(O2N)C6H3SO3K (XI). A suspension of 6.1 g. 2,5-H2N(O2N)C6H3Me in 20 cc. concentrated HCl was cooled to -5° and diazotized with 2.8 g. NaNO2 in 10 cc. H2O. The mixture was poured slowly with stirring into AcOH saturated with SO2, and 2 g. CuCl2.2H2O dissolved in a min. amount of H2O was added. The mixture was allowed to warm to 20°, stirred until gas evolution had ceased, and diluted with 240 cc. H2O to precipitate 2,4-Me(O2N)C6H3SO2Cl (XII). XII was suspended in 60 cc. 5% KOH, heated to solution, treated with 120 cc. 10% KMnO4, and heated until the color of KMnO4 disappeared to give 3 g. XI. XI was converted to the acid chloride with PCl5 in the usual manner. Dissolving X (R = H) in 100 cc. EtOH, adding a stoichiometric amount of EtONa in EtOH, and allowing the mixture to stand in ice several hrs. gave X (R = Na). This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Safety of N-Benzyl-2-chloro-5-nitrobenzamide).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Safety of N-Benzyl-2-chloro-5-nitrobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sheng, Yuwen’s team published research in Journal of Medicinal Chemistry in 65 | CAS: 2418-95-3

Journal of Medicinal Chemistry published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C18H23N3O4S, Formula: C11H22N2O4.

Sheng, Yuwen published the artcileIdentification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming, Formula: C11H22N2O4, the publication is Journal of Medicinal Chemistry (2022), 65(1), 460-484, database is CAplus and MEDLINE.

Cancer cell proliferation in some organs often depends on conversion of pyruvate to oxaloacetate via pyruvate carboxylase (PC) for replenishing the tricarboxylic acid cycle to support biomass production In this study, PC was identified as the cellular target of erianin using the photoaffinity labeling-click chem.-based probe strategy. Erianin potently inhibited the enzymic activity of PC, which mediated the anticancer effect of erianin in human hepatocellular carcinoma (HCC). Erianin modulated cancer-related gene expression and induced changes in metabolic intermediates. Moreover, erianin promotes mitochondrial oxidative stress and inhibits glycolysis, leading to insufficient energy required for cell proliferation. Anal. of 14 natural analogs of erianin showed that some compounds exhibited potent inhibitory effects on PC. These results suggest that PC is a cellular target of erianin and reveal the unrecognized function of PC in HCC tumorigenesis; erianin along with its analogs warrants further development as a novel therapeutic strategy for the treatment of HCC.

Journal of Medicinal Chemistry published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C18H23N3O4S, Formula: C11H22N2O4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

He, Rui’s team published research in Pharmacological Research in 158 | CAS: 321673-30-7

Pharmacological Research published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Application In Synthesis of 321673-30-7.

He, Rui published the artcileThe role of the LTB4-BLT1 axis in health and disease, Application In Synthesis of 321673-30-7, the publication is Pharmacological Research (2020), 104857, database is CAplus and MEDLINE.

A review. Leukotriene B4 (LTB4) is a major type of lipid mediator that is rapidly generated from arachidonic acid through sequential action of 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTA4 hydrolase (LTA4H) in response to various stimuli. LTB4 is well known to be a chemoattractant for leukocytes, particularly neutrophils, via interaction with its high-affinity receptor BLT1. Extensive attention has been paid to the role of the LTB4-BLT1 axis in acute and chronic inflammatory diseases, such as infectious diseases, allergy, autoimmune diseases, and metabolic disease via mediating recruitment and/or activation of different types of inflammatory cells depending on different stages or the nature of inflammatory response. Recent studies also demonstrated that LTB4 acts on non-immune cells via BLT1 to initiate and/or amplify pathol. inflammation in various tissues. In addition, emerging evidence reveals a complex role of the LTB4-BLT1 axis in cancer, either tumor-inhibitory or tumor-promoting, depending on the different target cells. In this review, we summarize both established understanding and the most recent progress in our knowledge about the LTB4-BLT1 axis in host defense, inflammatory diseases and cancer.

Pharmacological Research published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Application In Synthesis of 321673-30-7.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Gao, Yong-chao’s team published research in Nongyao in 51 | CAS: 372136-76-0

Nongyao published new progress about 372136-76-0. 372136-76-0 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Amine,Aliphatic hydrocarbon chain, name is N-Methyl-N-isopropylsulfamoyl amide, and the molecular formula is C4H12N2O2S, Quality Control of 372136-76-0.

Gao, Yong-chao published the artcileSynthesis and herbicidal activity of saflufenacil, Quality Control of 372136-76-0, the publication is Nongyao (2012), 51(8), 565-568, database is CAplus.

Saflufenacil is a new kind of herbicide with excellent herbicidal activity. The aim is to study its synthesis, anal. method and evaluate herbicidal activity. Me 5-amino-2-chloro-4-fluorobenzoate (5) was produced from 2-chloro-4-fluorobenzoic acid by esterification, nitration and reduction, then reacted with triphosgene to give Me 2-chloro-4-fluoro-5-isocyanatobenzoate (6), 6 was cyclized with Et 3-amino-4,4,4-trifluorobut-2-enoate, then methylated, followed by hydrolysis to obtain 2-chloro-5-(2, 6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-l (6H)-yl)-4-fluorobenzoic acid (10), which was reacted with N-methyl-N-iso-Pr sulfamide to give target compound Overall yield was 6.26%. The chem. structures were confirmed by 1H NMR, IR and MS. Purity was 99.8% by HPLC anal. The herbicidal activities of the target compound and purchased saflufenacil were compared. And the same results were obtained.

Nongyao published new progress about 372136-76-0. 372136-76-0 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Amine,Aliphatic hydrocarbon chain, name is N-Methyl-N-isopropylsulfamoyl amide, and the molecular formula is C4H12N2O2S, Quality Control of 372136-76-0.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Qian, Yunkun’s team published research in Water Research in 194 | CAS: 79-07-2

Water Research published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Application In Synthesis of 79-07-2.

Qian, Yunkun published the artcileFormation and control of C- and N-DBPs during disinfection of filter backwash and sedimentation sludge water in drinking water treatment, Application In Synthesis of 79-07-2, the publication is Water Research (2021), 116964, database is CAplus and MEDLINE.

Drinking water treatment plants (DWTPs) produce filter backwash water (FBW) and sedimentation sludge water (SSW) that may be partially recycled to the head of DWTPs. The impacts of key disinfection conditions, water quality parameters (e.g., disinfection times, disinfectant types and doses, and pH values), and bromide concentration on controlling the formation of trihalomethanes (THMs), haloacetic acids (HAAs), haloacetonitriles (HANs), and haloacetamides (HAMs) during disinfection of FBW and SSW were investigated. Concentrations of most disinfection byproducts (DBPs) and associated calculated toxicity increased with extended chlorination for both FBW and SSW. During chlorination of both FBW and SSW, elevated chlorine doses significantly increased THM yields per unit dissolved organic carbon (DOC), but decreased HAN and HAM yields, with min. effect on HAA yields. Chloramine disinfection effectively inhibited C-DBP formation but promoted N-DBPs yields, which increased with chloramine dose. Calculated toxicities after chloramination increased with chloramine dose, which was opposite to the trend found after free chlorine addition An examination of pH effects demonstrated that C-DBPs were more readily generated at alk. pH (pH=8), while acidic conditions (pH=6) favored N-DBP formation. Total DBP concentrations increased at higher pH levels, but calculated DBP toxicity deceased due to lower HAN and HAM concentrations Addition of bromide markedly increased bromo-THM and bromo-HAN formation, which are more cytotoxic than chlorinated analogs, but had little impact on the formation of HAAs and HAMs. Bromide incorporation factors (BIFs) for THMs and HANs from both water samples all significantly increased as bromide concentrations increased. Overall, high bromide concentrations increased the calculated toxicity values in FBW and SSW after chlorination. Therefore, while currently challenging, technologies capable of removing bromide should be explored as part of a strategy towards controlling cumulative toxicity burden (i.e., hazard) while simultaneously lowering individual DBP concentrations (i.e., exposure) to manage DBP risks in drinking water.

Water Research published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Application In Synthesis of 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ma, Chao’s team published research in ACS Omega in 7 | CAS: 79-07-2

ACS Omega published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Computed Properties of 79-07-2.

Ma, Chao published the artcilePerformance Evaluation of Composite Antisalt Agents and the Antisalt Dynamics Simulation Mechanism, Computed Properties of 79-07-2, the publication is ACS Omega (2022), 7(15), 13075-13082, database is CAplus and MEDLINE.

The conventional ferrocyanide complex ([Fe(CN)6]4-) has been widely used as a scale inhibitor under mild conditions, but its oxidation at high temperature compromises the subsequent wastewater treatment processes. To conquer the inadequacies of [Fe(CN)6]4-, aminotriacetamide (NTA) was synthesized using chloroacetic acid as an initial material and its mol. structure was characterized using FT-IR spectroscopy, H-NMR, and TGA. NTA was exploited in combination with polyaspartic acid (PASP) and sodium dodecyl benzene sulfonate (SDBS) to prepare a high-performance antisalt composite, and the scaling inhibitor performance was evaluated. The results revealed that as the concentration of the antisalt composite increased from 0.5 to 1.2 weight %, the solubility and inhibition rate increased by 95.6 and 12.33%, resp., at 100°C. The results from mol. simulation evidenced that the order of binding energy between a unit mass of the salt inhibitor and sodium chloride crystal increased in the following order; SDBS > NTA > PASP. The deformation strength between the salt inhibitor and sodium chloride crystal increased as follows: NTA > PASP > SDBS. In addition, the antisalt composite mainly hampered salt precipitation through strong adsorptions arising from both the nitrogen atom of NTA and oxygen atom of SDBS with the sodium atom of sodium chloride crystals, and as a result, it not only altered the crystalline form of sodium chloride but also reduced the adsorption of sodium atoms and eventually improved the salt solubility

ACS Omega published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Computed Properties of 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yang, Jing’s team published research in Ecotoxicology and Environmental Safety in 224 | CAS: 79-07-2

Ecotoxicology and Environmental Safety published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C4H3Cl2N3, Quality Control of 79-07-2.

Yang, Jing published the artcileApplicability of Enchytraeus bulbosus as a model species in ecotoxicology and risk assessment, Quality Control of 79-07-2, the publication is Ecotoxicology and Environmental Safety (2021), 112660, database is CAplus and MEDLINE.

Enchytraeus bulbosus is listed in the ISO and OECD standard guidelines as a possible test species of enchytraeid. However, in contrast to other listed species, its applicability in ecotoxicol. studies as well as its sensitivity is widely unknown. Therefore, copper, pentachlorophenol(PCP), carbendazim, and chloroacetamide have been investigated by performing two-generation studies with multiple endpoints. Comparable toxicity trends to the existing studies were shown for copper and PCP in the two-generation studies of E. bulbosus. Dose-related abnormal swelling of clitella were found for the first time with PCP and chloroacetamide treatments. Sensitivity comparisons of E. bulbosus to other terrestrial test species were also conducted. E. bulbosus showed high sensitivity, it has comparable sensitivity as other sensitive species of genus Enchytraeus ( E. albidus or E. luxuriosus)to different chems., and was more sensitive than E. crypticus and earthworm species ( Eisenia fetida or Eisenia andrei). Combined with the phylogenetic and biol. characterization, the results lead to the conclusion that E.bulbosus is a suitable model species in ecotoxicol. and the chem. risk assessment (especially in multi-generation) because it has a short generation time, comparatively moderate fecundity, ideal and reasonable sensitivity.

Ecotoxicology and Environmental Safety published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C4H3Cl2N3, Quality Control of 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hu, Xiafei’s team published research in Organic Letters in 23 | CAS: 2418-95-3

Organic Letters published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, SDS of cas: 2418-95-3.

Hu, Xiafei published the artcileConstruction of peptide macrocycles via radical-mediated intramolecular C-H alkylations, SDS of cas: 2418-95-3, the publication is Organic Letters (2021), 23(3), 716-721, database is CAplus and MEDLINE.

Enzyme-catalyzed radical-mediated C-H functionalization reactions allow nature to create natural products of unusual three-dimensional structures from simple linear peptide precursors. In comparison, chemist’s ability to harness radical C-H functionalization reactions for synthesis of complex peptides remains limited. In this work, new methods have been developed to construct peptide macrocycles via radical-mediated intramol. C-H alkylation reactions under photoredox catalysis. Linear peptide precursors equipped with a C-terminal N-(acyloxy)phthalimide ester can cyclize with the α C-H bond of N-terminal glycine or aryl C-H bond of N-heteroarene capping units in high yield and selectivity under mild conditions. The strategy uses the C-H cyclization step to incorporate lysine, homolysine, and various heteroarene-derived amino acid linchpins into peptide macrocycles, enabling convergent and flexible synthesis of complex peptide macrocycles from simple building blocks.

Organic Letters published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, SDS of cas: 2418-95-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Meng, Xu’s team published research in Journal of Heterocyclic Chemistry in 51 | CAS: 2447-79-2

Journal of Heterocyclic Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Product Details of C7H5Cl2NO.

Meng, Xu published the artcileNBS-mediated aziridination between styrenes and amides under transition metal-free conditions, Product Details of C7H5Cl2NO, the publication is Journal of Heterocyclic Chemistry (2014), 51(4), 937-942, database is CAplus.

An efficient and simple protocol for N-bromosuccinimide (NBS)-mediated aziridination of styrenes using amides as the nitrenoid source was developed. This aziridination affords the desired products in moderate to good yields without using transition metal catalyst under very mild reaction condition.

Journal of Heterocyclic Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Product Details of C7H5Cl2NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics