Cashman, John R. published the artcileRelative hepatotoxicity of ortho and meta monosubstituted thiobenzamides in the rat, Application In Synthesis of 64559-06-4, the publication is Chemico-Biological Interactions (1983), 45(3), 341-7, database is CAplus and MEDLINE.
The hepatotoxicity of ortho and meta monosubstituted thiobenzamides was studied in rats injected i.p. with 2.0 mmol/kg of various monosubstituted compounds Among the meta-substituted compounds, hepatotoxicity varied in strict accordance with the electronic character of the substituent, whereas the ortho-substituted compounds showed no toxicity at comparable doses regardless of the nature of the substituent. Explanations for these substituent effects are provided in terms of the chem. reactivity of the compounds and their corresponding S-oxide and S,S-dioxide metabolites.
Chemico-Biological Interactions published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Application In Synthesis of 64559-06-4.
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