Liu, Bin published the artcileMechanistic Investigation on Oxidative Degradation of ROS-Responsive Thioacetal/Thioketal Moieties and Their Implications, Product Details of C4H6F3NOS, the publication is Cell Reports Physical Science (2020), 1(12), 100271, database is CAplus.
In this work, through a series of structure-property relationship studies such as Hammett correlation, a mechanism of the oxidative cleavage of thioacetals and thioketals, where the thiolate components were converted to the corresponding disulfide product along with the formation of the resp. aldehydes and ketones, is proposed. The mechanism involves thioether oxidation that leads to the formation of a thionium intermediate, hydrolysis of which leads to the aldehyde/ketone product. In addition, a preliminary demonstration of the utility of such an understanding, as it offers the sequential release of two distinct small mols. caged in a substrate using two contradictory stimuli, viz. oxidative and reductive conditions, is presented.
Cell Reports Physical Science published new progress about 1869-45-0. 1869-45-0 belongs to amides-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide, and the molecular formula is C4H6F3NOS, Product Details of C4H6F3NOS.
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