Walczynski, K. published the artcileHistamine H1 receptor ligands. Part I. Novel thiazol-4-ylethanamine derivatives: synthesis and in vitro pharmacology, Recommanded Product: 3-Methoxybenzothioamide, the publication is Farmaco (1999), 54(8), 533-541, database is CAplus and MEDLINE.
A series of 2-substituted thiazol-4-ylethanamines have been synthesized and tested for their histaminergic H1-receptor activities. The compounds with 2-Ph substitution, regardless of the different physicochem. properties of the meta-substituents at the Ph ring, showed weak H1-agonistic activity with pD2 values ranging from 4.35 to 5.36. When the Ph group was replaced by a benzyl group, the resulting compounds all exhibited weak H1-antagonistic activity (pA2: 4.14-4.82).
Farmaco published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C10H9NO4S, Recommanded Product: 3-Methoxybenzothioamide.
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