Sasse, Klaus published the artcile1-Substituted 1,6-dihydro-4-mercapto-6-pyrimidinones and 1,2,3,6-tetrahydro-4-(methylthio)-2,6-pyrimidinediones, Product Details of C5H8N2O, the publication is Justus Liebigs Annalen der Chemie (1976), 768-80, database is CAplus.
RNHCOCH2CSNH2 [R = alkyl, allyl, MeO(CH2)3, Ph, cyclohexyl, PhCHMe, furfuryl] reacted with MeO2CH and Na in EtOH to give 23.1-93.0% pyrimidinones I or EtNHCOCH2CSNH2 reacted with MeO2CH and KOCMe3 in Et2O to give 56% pyridinedicarboxamide II. I were methylated to give 42.2-79.5% III which gave 44.6-73.1% 5-halo derivatives with SOCl2 or Br. Treating RNHCOCH2C(SMe):NH·HI with EtO2Cl (55.-91.4% yields) and cyclizing the RNHCOCH:C(SMe)NHCO2Et in alk. solution gave 23.9-73.3% pyrimidinediones IV. These were halogenated in the 5 position (48.4-77.5% yields) and methylated (MeI) on the N3 position (70.4-81.4% yields).
Justus Liebigs Annalen der Chemie published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Product Details of C5H8N2O.
Referemce:
https://en.wikipedia.org/wiki/Amide,
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