Wang, Nan published the artcileTransition metal-free NaOH-catalyzed hydration of nitriles to primary amides in NH3·H2O-DMSO mixture, Computed Properties of 1453-82-3, the publication is Molecular Diversity (2021), 25(2), 1131-1136, database is CAplus and MEDLINE.
An efficient protocol for hydration of aryl(hetero)/alkyl nitriles RCN (R = Bu, cyclohexyl, thiophen-2-yl, 4-chlorophenyl, etc.) toward primary amides RC(O)NH2 with 0.1 equivalent was reported. NaOH in NH3·H2O-DMSO under mild conditions is used. Various substituted nitriles are smoothly converted to the corresponding amides with good to excellent isolated yields. Gram-scale reactions were also performed to produce the desired products in high yields. In addition, the excessive hydrolysis of the benzonitrile to form benzoic acid was also achieved with increasing the amount of NaOH and prolonging the reaction time.
Molecular Diversity published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C16H20N2, Computed Properties of 1453-82-3.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics