Studies on the metabolism of procarbazine by mass spectrometry was written by Kuttab, Simon H.;Tanglertpaibul, S.;Vouros, Paul. And the article was included in Biomedical Mass Spectrometry in 1982.Safety of 4-Formyl-N-isopropylbenzamide This article mentions the following:
The mass spectrometric properties of procarbazine (I, R = NHNHMe) [671-16-9] and some of its breakdown products were determined by isotopic labeling and high resolution mass spectrometry, and used for the identification of in vivo metabolites in plasma from rats given the drug (23.2 mg, i.p.). N-isopropyl-α–(2-methylazo)-p-toluamide (I, R = N=NMe) [2235-59-8] was the principal circulating metabolite. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Safety of 4-Formyl-N-isopropylbenzamide).
4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Safety of 4-Formyl-N-isopropylbenzamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics