Organophotocatalytic selective deuterodehalogenation of aryl or alkyl chlorides was written by Li, Yanjun;Ye, Ziqi;Lin, Yu-Mei;Liu, Yan;Zhang, Yumeng;Gong, Lei. And the article was included in Nature Communications in 2021.Quality Control of 6-Chloro-N,N-dimethylnicotinamide This article mentions the following:
A photocatalytic system consisting of an aryl-amine photocatalyst and a disulfide co-catalyst in the presence of sodium formate as an electron and hydrogen donor was developed. Accordingly, many aryl chlorides, alkyl chlorides, and other halides were converted to deuterated products at room temperature in air (>90 examples, up to 99% D-incorporation). The mechanistic studies revealed that the aryl amine served as reducing photoredox catalyst to initiate cleavage of the C-Cl bond, at the same time as energy transfer catalyst to induce homolysis of the disulfide for consequent deuterium transfer process. This economic and environmentally-friendly method could be used for site-selective D-labeling of a number of bioactive mols. and direct H/D exchange of some drug mols. In the experiment, the researchers used many compounds, for example, 6-Chloro-N,N-dimethylnicotinamide (cas: 54864-83-4Quality Control of 6-Chloro-N,N-dimethylnicotinamide).
6-Chloro-N,N-dimethylnicotinamide (cas: 54864-83-4) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Quality Control of 6-Chloro-N,N-dimethylnicotinamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics