Ogawa, Nobuo et al. published their research in Chemical & Pharmaceutical Bulletin in 1988 | CAS: 119023-25-5

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Safety of 2-Amino-4-fluorobenzamide

Synthesis and histamine H2-antagonist activity of 4-quinazolinone derivatives was written by Ogawa, Nobuo;Yoshida, Toshihiko;Aratani, Takayuki;Koshinaka, Eiichi;Kato, Hideo;Ito, Yasuo. And the article was included in Chemical & Pharmaceutical Bulletin in 1988.Safety of 2-Amino-4-fluorobenzamide This article mentions the following:

With the aim of developing new antiulcer agents, a series of 4-quinazolinone derivatives e.g., I (R = piperidino, pyrrolidino, morpholino, R1 = H, OMe, R2 = H, Me; n = 2, 3, 4) was synthesized and tested for histamine H2-antagonist activity and gastric antisecretory activity. Thus, 2-alkylamino-, 2-alkylthio-, and 2-alkyl-4-quinazolinones were prepared by the condensation of alkylamines with 2-chloro- or 2-methylthio-4-quinazolinones, the condensation of alkyl bromides with 2-mercapto-4-quinazolinones, and the condensation of alkylcarboxylic acids with anthranilamides, resp. Several of the 4-quinazolinone derivatives showed potent H2-antagonist activity, and one of them, I (R = piperidino, R1 = R2 = H, n = 3), showed the most potent antisecretory activity. The structure-activity relationships are discussed. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Safety of 2-Amino-4-fluorobenzamide).

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Safety of 2-Amino-4-fluorobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics