Antidiabetic activity of Swarna makshika bhasma, Shuddha shilajatu and their combination in Streptozotocin-induced diabetic Wistar rats was written by Sanjeev, Singh;Khemchand, Sharma. And the article was included in International Journal of Research in Ayurveda & Pharmacy in 2022.Product Details of 10238-21-8 This article mentions the following:
Swarna makshika bhasma and Shilajatu are mentioned by Acharya Sushruta in Madhumeha Chikitsa. These two Rasayanas play a role in glucose and insulin metabolism The present study was undertaken to assess the anti-diabetic activity in Wistar strain albino rats, thirty-six in number divided into six groups. Streptozotocin was given to induce diabetes. Glibenclamide was used as a standard control drug. Doses of all drugs in each group were according to an accepted standard Mild diabetic rats (blood sugar > 200 mg/dL) were given medication after their body weight and blood glucose levels were determined The treatment was maintained on days 7, 14, 21, and 28, and biochem. parameters were calculated From the fourth day of Streptozotocin induction of diabetes, Makshika bhasma, Shuddha shilajatu and their combination, Glibenclamide, were given once daily. After administration, the effects of Swarna makshika bhasma, Shuddha shilajatu, and Combination of Makshika bhasma and Shuddha shilajatu on bodyweight were statistically non-significant. However, there was a distinction between the before and after-effects. The most remarkable changes in blood glucose levels were reported for Makshika bhasma, Shuddha shilajatu, and Makshika bhasma with Shuddha shilajatu. To conclude, the Combination of Shilajatu and Makshika bhasma is the most efficient and remarkably therapy alternative in Madhumeha. Their multifaceted impact makes them a viable method in the long-term control of diabetes. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Product Details of 10238-21-8).
5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Product Details of 10238-21-8
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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics