Bronsted acid-assisted N-alkylation of sulfonamides using ethers as the alkylation reagents was written by Shi, Wei;Bai, Chun-Mei;Zhu, Kai;Cui, Dong-Mei;Zhang, Chen. And the article was included in Tetrahedron in 2014.Application of 5339-69-5 This article mentions the following:
N-Alkylation of sulfonamides using cyclic ethers as alkylation reagents and Bronsted acid as a catalyst produced pyrrolidine and piperidine derivatives in good yields. When using sym. and unsym. ethers as alkylation reagents, mono-N-alkylation of sulfonamides took place to afford the corresponding products. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Application of 5339-69-5).
N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Application of 5339-69-5
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics