Month: December 2022

Trecourt, Francois published the artcileSynthesis of 7H-pyrido[2,3-c]carbazoles from 5-bromo-8-methoxyquinolines via coupling and azide cyclization reactions, Quality Control of 146140-95-6, the publication is Journal of Heterocyclic Chemistry (1995), 32(4), 1261-7, database is CAplus.

A new strategy for the synthesis of substituted 7H-pyrido[2,3-c]carbazoles has been developed from substituted 5-bromoquinolines by using cross-coupling reaction with (2-aminophenyl)boric acids, followed by a regioselective azide cyclization.

Journal of Heterocyclic Chemistry published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C8H15ClN2, Quality Control of 146140-95-6.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rebstock, Anne-Sophie published the artcileSynthesis and deprotonation of 2-(pyridyl)phenols and 2-(pyridyl)anilines, SDS of cas: 146140-95-6, the publication is Organic & Biomolecular Chemistry (2003), 1(17), 3064-3068, database is CAplus and MEDLINE.

2-(2- And 3-Pyridyl)anilines, 2,2-dimethyl-N-[2-(2- and 3-pyridyl)phenyl]propanamides, and 2-, 3- and 4-(2-methoxyphenyl)pyridines are readily synthesized using cross-coupling reactions. Whereas 2-(3-pyridinyl)benzenamine and 2-(2-pyridinyl)benzenamine undergo side reactions, the corresponding 2,2-dimethyl-N-[2-(2-pyridinyl)phenyl]propanamide and 2,2-dimethyl-N-[2-(3-pyridinyl)phenyl]propanamide (amides) are deprotonated with lithium 2,2,6,6-tetramethylpiperidide. When 2-(2-methoxyphenyl)pyridine (ether) is subjected to the same reagent, lithiation occurs at C6′.

Organic & Biomolecular Chemistry published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, SDS of cas: 146140-95-6.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Saravanan, Janardhanan published the artcileSynthesis of some 3-substituted amino-4,5-tetramethylene thieno[2,3-d][ 1,2,3]-triazin-4(3H)-ones as potential antimicrobial agents, Formula: C5H8N2O, the publication is European Journal of Medicinal Chemistry (2010), 45(9), 4365-4369, database is CAplus and MEDLINE.

3-Substituted 4,5-tetramethylene thieno[2,3-d][1,2,3]-triazin-4(3H)-ones I have been synthesized from cyclohexanone and N-substituted 2-cyanoacetamides via the Gewald reaction followed by diazotization. Compounds I were evaluated for their antimicrobial activity by the agar diffusion method against four bacteria and three fungi, with Ampicillin and Miconazole nitrate as standards I (R = 4-FC₆H₄ and 2-, 3-, and 4-ClC₆H₄) showed an antimicrobial efficacy considerably greater than the compounds with hydrogen, Ph, and electron donating (activating) R groups like Me, Et, and tolyl. This suggests that lipophillic groups like chloro and fluoro substituted on the Ph ring play an important role in enhancing the antimicrobial properties of this class of compounds From the screening results it is shown that the compounds having lipophillic R groups like chlorophenyl and fluorophenyl exhibit appreciable antimicrobial activities.

European Journal of Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Basha, Shaik Jeelan published the artcileNew Flavone-Cyanoacetamide Hybrids with a Combination of Cholinergic, Antioxidant, Modulation of β-Amyloid Aggregation, and Neuroprotection Properties as Innovative Multifunctional Therapeutic Candidates for Alzheimer’s Disease and Unraveling Their Mechanism of Action with Acetylcholinesterase, Synthetic Route of 15029-36-4, the publication is Molecular Pharmaceutics (2018), 15(6), 2206-2223, database is CAplus and MEDLINE.

In line with the modern multi target-directed ligand paradigm of Alzheimer’s disease (AD), a series of nineteen compounds composed of flavone and cyanoacetamide groups have been synthesized and evaluated as multifunctional agents against AD. Biol. evaluation demonstrated that compounds 7j, 7n, 7o, 7r and 7s exhibited excellent inhibitory potency (AChE, IC50 0.271 ± 0.012 to ± 0.075 M) and good selectivity toward acetylcholinesterase, significant antioxidant activity, good modulation effects on self-induced Aβ aggregation, low cytotoxicity and neuroprotection in human neuroblastoma SK-N-SH cells. Further, an inclusive study on the interaction of 7j, 7n, 7o, 7r and 7s with AChE at physiol. pH 7.2 using fluorescence, CD and mol. docking methods suggesting that these derivatives bind strongly to peripheral anionic site of AChE mostly through hydrophobic interactions. Overall, the multifunctional profiles and strong AChE binding affinity highlight these compounds as promising prototypes for further pursuit of innovative multifunctional drugs for AD.

Molecular Pharmaceutics published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Synthetic Route of 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Avitabile, Concetta published the artcileDevelopment of an efficient and low-cost protocol for the manual PNA synthesis by Fmoc chemistry, COA of Formula: C40H35N7O8, the publication is Tetrahedron Letters (2010), 51(29), 3716-3718, database is CAplus.

An efficient and low-cost protocol for the manual synthesis of peptide nucleic acids is reported here. The protocol relies on coupling reactions carried out with 2.5 equiv of PNA monomers activated with HOBT/HBTU, in the presence of pyridine/NMM. The protocol has been tested on four PNA oligomers with a length ranging from 9 to 12 bases and a purine content up to 67%.

Tetrahedron Letters published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, COA of Formula: C40H35N7O8.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Giurg, M. published the artcileHydrogen peroxide oxidation of N,N-dimethylhydrazones promoted by selenium compounds, titanosilicalites or acetonitrile, Application of 2,4-Dichlorobenzamide, the publication is Polish Journal of Chemistry (2002), 76(12), 1713-1720, database is CAplus.

Hydrogen peroxide oxidation of aldehyde dimethylhydrazones promoted by the title reagents has been investigated. Depending on the substrate, nitriles or amides were obatined as the major products accompanied by carboxylic acids and aldehydes. Formation of nitriles using H₂O₂ in acetonitrile without base is limited to electron-rich substrates. Reaction of electron-deficient dimethylhydrazones with hydrogen peroxide and aqueous sodium carbonate in acetonitrile/water gives amides as the major products. Aliphatic, unsaturated and aromatic nitriles are prepared by the oxidation of the corresponding aldehyde dimethylhydrazones with hydrogen peroxide in the presence of poly(bis-9,10-anthracenyl) diselenide (PADS) as a catalyst. A mechanism for the oxidation of N,N-dimethylhydrazones is proposed; peroxyiminoacetic acid is suggested as the active oxidant in situ.

Polish Journal of Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Application of 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Miyabe, Yoshishige published the artcileLTB₄ and BLT1 in inflammatory arthritis, Application of [(2-Hexylcyclopentylidene)amino]thiourea, the publication is Seminars in Immunology (2017), 52-57, database is CAplus and MEDLINE.

Inflammatory arthritis, including rheumatoid arthritis (RA), is characterized by infiltration of inflammatory cells into the joints. Biol. agents targeting TNF-α and IL-6 dramatically improve RA. However, some RA patients do not respond to current treatments and these broadly active upstream biol. agents increase the risk of severe infection. Therefore, there remains a need for other effective and safe treatments for RA. Many studies have implicated that blockade of leukotriene B4 (LTB₄) and its high affinity receptor BLT1 dramatically suppress arthritis in animal models. In addition, levels of LTB₄ in serum, synovial fluid and synovial tissue are increased in RA patients compared to healthy donors or osteoarthritis patients. These data suggest that LTB₄ and BLT1 likely contribute to the pathogenesis of human RA. However, several clin. trials inhibiting BLT1 in RA were not successful. Our recent data revealed that LTB₄ is a key mediator in a complement, lipid, cytokine and chemokine cascade that first initiates and then sustains neutrophilic inflammation in inflammatory arthritis. These new mechanistic studies suggest novel ways to target the LTB₄-BLT1 pathway for the treatment of RA and other inflammatory diseases.

Seminars in Immunology published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Application of [(2-Hexylcyclopentylidene)amino]thiourea.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Schmidt, Joachim published the artcileBasic hydrolysis of N-alkyltrifluoroacetamides in 50% ethanol. Are these reactions suitable for determining steric substituent constants?, Category: amides-buliding-blocks, the publication is Wissenschaftliche Zeitschrift der Paedagogischen Hochschule Karl Liebknecht Potsdam (1987), 31(1), 23-31, database is CAplus.

The velocity constants for the second-order basic hydrolysis of CF₃CONRR¹ [R = Me, Et, Pr, Me₂CH, Bu, Me₂CHCH₂, Me(CH₂)_n (n = 4, 5, 6, 7), Me₂CHCH₂CH₂, Me₃C, R¹ = H (I); R = R¹ = H, Me, Et, Pr] in 50% aqueous EtOH, determined at ≤75% reaction, had good LFER with Charton υ(OR) or υ(NHR) steric constants The extensive deprotonation of I was kinetically characterized.

Wissenschaftliche Zeitschrift der Paedagogischen Hochschule Karl Liebknecht Potsdam published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Joris, L. published the artcileEffects of polar aprotic solvents on linear free-energy relations in hydrogen-bonded complex formation, Application of N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Journal of the American Chemical Society (1972), 94(10), 3438-42, database is CAplus.

The effects of polar aprotic solvents on linear free-energy relations in H-bonded complex formation were studied. The behavior of strong pKa bases has suggested the utility of the concept of solvent-induced (partial) ionization in H-bonded complexes as distinct from partial H-bonded ion-pair formation or ionic dissociation

Journal of the American Chemical Society published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Application of N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Titskii, G. D. published the artcileIsoparametric correlations in reactions of 4-R-N-arylpyridinium salts with arylamines, Recommanded Product: N,N-Diethylisonicotinamide, the publication is Theoretical and Experimental Chemistry (Translation of Teoreticheskaya i Eksperimental’naya Khimiya) (2000), 35(4), 215-220, database is CAplus.

Isoparametric dependencies of the structure of the reagents (including noncatalytic rate constants, substitution constants (σ⁰), basicity constants, and charges at the reaction centers) were obtained for the reactions between 4-R-N-(2,4-dinitrophenyl)pyridinium salts with arylamines. The electron-acceptor 4-R-substituents studied reduced the pos. charge on the reaction center (the α-atom) and the N atom of the N-arylpyridinium cation.

Theoretical and Experimental Chemistry (Translation of Teoreticheskaya i Eksperimental’naya Khimiya) published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C9H9F5Si, Recommanded Product: N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics