Month: December 2022

Mijin, Dusan published the artcileSynthesis of N-substituted 4,6-dimethyl-3-cyano-2-pyridones under microwave irradiation, Name: 2-Cyano-N-ethylacetamide, the publication is Synthetic Communications (2006), 36(2), 193-198, database is CAplus.

N-substituted 4,6-dimethyl-3-cyano-2-pyridones were prepared from acetylacetone, N-substituted cyanoacetamide, and piperidine as catalyst under microwave irradiation without solvent. The rapid and simple method produced pure products in high yields.

Synthetic Communications published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Name: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ilic, Natasa published the artcileEI/MS/MS spectra of N-monosubstituted cyanoacetamides, SDS of cas: 15029-36-4, the publication is Chemical Industry & Chemical Engineering Quarterly (2010), 16(4), 387-397, database is CAplus.

The electron-ionization induced mass spectra of twenty six N-monosubstituted cyanoacetamides were recorded and their fragmentation patterns were studied. The effect of N-alkyl and N-aryl substituents to the fragmentation of the investigated compounds was discussed. Mechanistic generalization lead to a conclusion that fission of the carbon-carbon bonds next to carbonyl function or nitrogen were processes common for N-alkyl and N-(4-substituted phenyl) cyanoacetamides. In some amides, the elimination of the acyl group by a ketene fragment gave rise to the more stable ion. Cycloalkyl amides could not fragment by single carbon-carbon bond fission, but subsequent rearrangement resulted in formation of stable even electron ion. N-(4-substituted phenyl) cyanoacetamides were more stable showing also characteristic fragmentation depending on substituent present at Ph ring.

Chemical Industry & Chemical Engineering Quarterly published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, SDS of cas: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Goncalves, Aurelie published the artcileIntestinal Scavenger Receptors Are Involved in Vitamin K1 Absorption, Formula: C12H23N3S, the publication is Journal of Biological Chemistry (2014), 289(44), 30743-30752, database is CAplus and MEDLINE.

Vitamin K1 (phylloquinone) intestinal absorption is thought to be mediated by a carrier protein that still remains to be identified. Apical transport of vitamin K1 was examined using Caco-2 TC-7 cell monolayers as a model of human intestinal epithelium and in transfected HEK cells. Phylloquinone uptake was then measured ex vivo using mouse intestinal explants. Finally, vitamin K1 absorption was compared between wild-type mice and mice overexpressing scavenger receptor class B type I (SR-BI) in the intestine and mice deficient in cluster determinant 36 (CD36). Phylloquinone uptake by Caco-2 cells was saturable and was significantly impaired by co-incubation with α-tocopherol (and vice versa). Anti-human SR-BI antibodies and BLT1 (a chem. inhibitor of lipid transport via SR-BI) blocked up to 85% of vitamin K1 uptake. BLT1 also decreased phylloquinone apical efflux by ∼80%. Transfection of HEK cells with SR-BI and CD36 significantly enhanced vitamin K1 uptake, which was subsequently decreased by the addition of BLT1 or sulfo-N-succinimidyl oleate (CD36 inhibitor), resp. Similar results were obtained in mouse intestinal explants. In vivo, the phylloquinone postprandial response was significantly higher, and the proximal intestine mucosa phylloquinone content 4 h after gavage was increased in mice overexpressing SR-BI compared with controls. Phylloquinone postprandial response was also significantly increased in CD36-deficient mice compared with wild-type mice, but their vitamin K1 intestinal content remained unchanged. Overall, the present data demonstrate for the first time that intestinal scavenger receptors participate in the absorption of dietary phylloquinone.

Journal of Biological Chemistry published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Formula: C12H23N3S.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Cohen, Yifat published the artcileMechanisms of absorption of vitamin D₃ delivered in protein nanoparticles in the absence and presence of fat, Category: amides-buliding-blocks, the publication is Food & Function (2021), 12(11), 4935-4946, database is CAplus and MEDLINE.

Novel protein-based nanovehicles offer alternatives to fat for delivery of lipophilic bioactives (nutraceuticals and drugs), yet they raise important questions regarding the bioavailability and absorption mechanism of the bioactive without fat. To provide answers, we chose vitamin D₃ (VD3) as a model lipophilic-nutraceutical, re-assembled casein-micelles (rCM) as model protein-based nanovehicles, and non-fat yoghurt as a model food. We prepared three yoghurt formulations: 3% fat with D₃ dissolved in milk-fat, non-fat and 3% fat, both latter enriched with VD3 within rCM. Following in vitro digestion, D₃ retention and bioaccessibility were high (∼90% and ∼70%, resp.) in all formulations. VD3 uptake by Caco-2 cells was three-fold higher (p < 0.005) in the non-fat yoghurt enriched with VD₃ in rCM compared with enriched fat-containing yoghurts. SR-BI, CD36 and NPC1L1 transporters were involved in VD₃ absorption irresp. of the composition Thus, our findings demonstrate that protein nanovehicles may improve D₃ bioavailability, without altering its absorption mechanism compared to that from fat.

Food & Function published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Gabryelski, Wlad. published the artcileAbsorption of ultra-violet light by some organic substances. XXVIII, Recommanded Product: N,N-Diethylisonicotinamide, the publication is Bulletin International de l’Academie Polonaise des Sciences et des Lettres, Classe des Sciences Mathematiques et Naturelles, Serie A: Sciences Mathematiques (1933), 87-94, database is CAplus.

cf. C. A. 24, 21. The following substances do not cause selective absorption of ultra-violet light between 4900 and 2100 A. U.: cellobiose (in H₂O), raffinose, acetylcellobiose, β-acetyllactobiose (in CHCl₃), acetylsucrose (in CHCl₃), acetylmaltose (in CHCl₃). The 2 absorption bands with maximum at 2680 and 3200 A. U., which appear when glucose is treated with NaOH in weak concentrations (C. A. 26, 5078) are probably due to the aldehyde form, for if the NaOH is neutralized with HCl after a short time, the original spectrum showing practically no selective absorption is obtained. Prolonged action of OH^– on glucose gives a product showing selective absorption which does not disappear on addition of acid.

Bulletin International de l’Academie Polonaise des Sciences et des Lettres, Classe des Sciences Mathematiques et Naturelles, Serie A: Sciences Mathematiques published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Recommanded Product: N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wang, Bin published the artcileNew and convergent synthesis of saflufenacil, Safety of N-Methyl-N-isopropylsulfamoyl amide, the publication is Journal of Heterocyclic Chemistry (2020), 57(1), 151-156, database is CAplus.

A new practical and hundred-gram scale synthesis of saflufenacil, a protoporphyrinogen oxidase (PPO) inhibitor herbicide was described. The key intermediate N-methyl-N-iso-Pr sulfamide was obtained from sulfuryl chloride isocyanate, t-butanol and N-methyl-N-isopropylamine in 74.8% yield over 3 steps. Saflufenacil was prepared in 48.6% yield over 8 steps and 98.7% purity (HPLC).

Journal of Heterocyclic Chemistry published new progress about 372136-76-0. 372136-76-0 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Amine,Aliphatic hydrocarbon chain, name is N-Methyl-N-isopropylsulfamoyl amide, and the molecular formula is C4H6O3, Safety of N-Methyl-N-isopropylsulfamoyl amide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zali-Boeini, Hassan published the artcileTribromo Phloroglucinol as a Novel and Highly Efficient Reagent for the Conversion of Benzothioamides to the Corresponding 1,2,4-Thiadiazoles, Quality Control of 2447-79-2, the publication is Synthetic Communications (2015), 45(14), 1681-1687, database is CAplus.

2,4,6-Tribromo-1,3,5-trihydroxybenzene (TBTHB) as a reagent was efficiently reacted with 6 molar equivalents of benzothioamides in DMSO (DMSO), and the corresponding 3,5-diaryl-1,2,4-thiadiazoles were obtained in almost quant. yields (91-98%) and in short times (15-20 min) with the formation of hexahydroxybenzene as a rather valuable byproduct.

Synthetic Communications published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C12H13NO3, Quality Control of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mancuso, Elettra published the artcileHDL (High-Density Lipoprotein) and ApoA-1 (Apolipoprotein A-1) Potentially Modulate Pancreatic α-Cell Glucagon Secretion, Related Products of amides-buliding-blocks, the publication is Arteriosclerosis, Thrombosis, and Vascular Biology (2020), 40(12), 2941-2952, database is CAplus and MEDLINE.

Subjects with low levels of HDL (high-d. lipoprotein) and ApoA-1 (apolipoprotein A-1) have increased risk to develop type 2 diabetes. HDL levels are an independent predictor of β-cell function and pos. modulate it. Type 2 diabetes is characterized by defects in both β and α-cell function, but the effect of HDL and ApoA1 on β-cell function is unknown. We observed a significant neg. correlation (r = -0.422, P<0.0001) between HDL levels and fasting glucagon in a cohort of 132 Italian subjects. In a multivariable regression anal. including potential confounders such as age, sex, BMI, triglycerides, total cholesterol, fasting and 2-h postload glucose, and fasting insulin, the association between HDL and fasting glucagon remained statistically significant (β = -0.318, P = 0.006). CD1 mice treated with HDL or ApoA-1 for 3 consecutive days showed a 32% (P<0.001) and 23% (P<0.05) reduction, resp., in glucagon levels following insulin-induced hypoglycemia, compared with controls. Treatment of pancreatic αTC1 clone 6 cells with HDL or ApoA-1 for 24 h resulted in a significant reduction of glucagon expression (P<0.04) and secretion (P<0.01) after an hypoglycemic stimulus and increased Akt (RAC-alpha serine/threonine-protein kinase) and FoxO1 (forkhead/winged helix box gene, group O-1) phosphorylation. Pretreatment with Akt inhibitor VIII, PI3K (phosphatidylinositol 3-kinase) inhibitor LY294002, and HDL receptor SCARB-1 (scavenger receptor class B type 1) inhibitor BLT-1 (block lipid transport-1) restored αTC1 cell response to low glucose levels. These results support the notion that HDL and ApoA-1 modulate glucagon expression and secretion by binding their cognate receptor SCARB-1, and activating the PI3K/Akt/FoxO1 signaling cascade in an in vitro α-cell model. Overall, these results raise the hypothesis that HDL and ApoA-1 may have a role in modulating glucagon secretion.

Arteriosclerosis, Thrombosis, and Vascular Biology published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Srinivasan, S. published the artcileFormamide as an ammonia synthon in amination of acid chlorides, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Synthetic Communications (2010), 40(23), 3538-3543, database is CAplus.

The use of formamide as a convenient source of ammonia was explored for the direct transformation of acid chlorides to primary amides. Various aliphatic, alicyclic aromatic, and heterocyclic acid chlorides are converted to the corresponding carboxamides in good yields (75-94%).

Synthetic Communications published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C10H10O2, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

De Cola, Chiara published the artcileCarboxyalkyl peptoid PNAs: synthesis and hybridization properties, Name: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, the publication is Tetrahedron (2012), 68(2), 499-506, database is CAplus.

N ^γ-Carboxyalkyl modified peptide nucleic acids (PNAs), containing the four canonical nucleobases, were prepared via solid-phase oligomerization. The inserted peptoid monomers (I) (n = 1 and 5; Fmoc = 9-fluorenylmethoxycarbonyl) were constructed through simple synthetic procedures, utilizing appropriate glycidol and iodoalkyl electrophiles. Thermal denaturation studies, performed with complementary antiparallel DNA strands, demonstrated that the length of the N ^γ-side chain strongly influences the modified PNAs hybridization properties. Moreover, multiple neg. charges on the oligoamide backbone, when present on γ-nitrogen C₆ side chains proved to be beneficial for the oligomers’ water solubility and DNA hybridization specificity.

Tetrahedron published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Name: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics