Month: December 2022

Wu, Y.-Q. published the artcileCyanogen halides, cyanates and their sulfur, selenium, and tellurium analogues, sulfinyl and sulfonyl cyanides, cyanamides, and phosphaalkynes, Related Products of amides-buliding-blocks, the publication is Science of Synthesis (2005), 17-63, database is CAplus.

A review of the preparation of cyanogen halides and cyanates as well as their application to organic synthesis. Sulfur, selenium, and tellurium analogs, sulfinyl and sulfonyl cyanides, cyanamides, and phosphaalkynes are included.

Science of Synthesis published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C9H9F5Si, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tisler, M. published the artcileSyntheses of some N-substituted thiocarbamylpiperidines and thiocarbamylmerpholines, Recommanded Product: Morpholine-4-carbothioamide, the publication is Croatica Chemica Acta (1957), 409-11, database is CAplus.

RCNS (0.02 mole) in 10 ml. Et₂O added to an ice-cold solution of 0.02 mole piperidine or morpholine in 10 ml. Et₂O, kept 15 min., the solution filtered and the precipitate crystallized (EtOH or aqueous EtOH) gave 82-90% XCSNHR [R, m.p., and EtOH-H₂O ratio for crystallization given]: (Χ = piperidino) 2,3-Me₂C₆H₃, 138°, 3:1; 2,4-Me₂C₆H₃, 119°, 1:1; 2,5-Me₂C₆H₃, 118°, 2:1; 2-MeOC₆H₄, 61°, 2:1; 4-MeOC₆H₄, 146°, 3:1; 3-ClC₆H₄, 135°, 1:0; 4-Me₂NC₆H₄ (I), 129°, 1:1; C₆H₁₂, 133°, 3:1; Ph, 99°, -; 2-MeC₆H₄, 98°, -; 3-MeC₆H₄, 102°, -; 4-MeC₆H₄, 134°, -; 4-ClC₆H₄, 153°, -; 4-BrC₆H₄, 166°, -; PhCH₂, 88°, -; 1-C₁₀H₇, 125°, -; Me, 131°, -; (Χ = morpholino) Ph, 134°, 1:0; 2-MeC₆H₄, 144°, 1:0; 2-MeOC₆H₄, 91°, 1:1; 2,3-Me₂C₆H₃, 147°, 1:0; 2,4-Me₂C₆H₃, 148°, 1:0; 2,5-Me₂C₆H₃, 156°, 1:0; 3-ClC₆H₄, 162°, 1:0; 4-Me₂NC₆H₄, 170°, 1:0; PhCH₂, 100°, 3:1; C₆H₁₂, 136°, 2:1. Tested against M. tuberculosis H37Rv strain on liquid Sula medium only I showed complete inhibition at 5 γ/ml.

Croatica Chemica Acta published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C7H7N3, Recommanded Product: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Threlfall, T. published the artcileThe infrared spectra of amides. Part 1. The stretching vibrations of primary carboxamides, SDS of cas: 79-07-2, the publication is Vibrational Spectroscopy (2022), 103386, database is CAplus.

The IR spectra of more than 150 primarycarboxamides in the NH stretching and the carbonyl region have been measured. Comparison is made with Bellamys anal. of the stretching modes of amines. The offset to higher frequencies of amides compared with amines is attributed to the widening of the bond angle. The sym. and antisym. stretching of the NH₂ bonds is analyzed via a rearrangement of the Linnett equations. It is shown thereby that changes of bond strength vary the sym. and antisym. frequencies approx. proportionately while deviations from that relationship are due either to changes of the bond angle, steric hindrance or to hydrogen bonding. The spectral changes of m- and p-substituted amides are correlated with Hammett sigma functions, both in the carbonyl and the NH2 stretching region. Intensities and the influence of steric effects are also discussed.

Vibrational Spectroscopy published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C18H20N2O12, SDS of cas: 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Threlfall, T. published the artcileThe infrared spectra of amides. Part 1. The stretching vibrations of primary carboxamides, Category: amides-buliding-blocks, the publication is Vibrational Spectroscopy (2022), 103386, database is CAplus.

The IR spectra of more than 150 primarycarboxamides in the NH stretching and the carbonyl region have been measured. Comparison is made with Bellamys anal. of the stretching modes of amines. The offset to higher frequencies of amides compared with amines is attributed to the widening of the bond angle. The sym. and antisym. stretching of the NH₂ bonds is analyzed via a rearrangement of the Linnett equations. It is shown thereby that changes of bond strength vary the sym. and antisym. frequencies approx. proportionately while deviations from that relationship are due either to changes of the bond angle, steric hindrance or to hydrogen bonding. The spectral changes of m- and p-substituted amides are correlated with Hammett sigma functions, both in the carbonyl and the NH2 stretching region. Intensities and the influence of steric effects are also discussed.

Vibrational Spectroscopy published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C48H47FeP, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sproviero, Jorge F. published the artcileAmmonolysis of acylated 2-amino-2-deoxy-D-glucoses, Name: (3R,4R,5S,6R)-6-(Acetoxymethyl)-3-benzamidotetrahydro-2H-pyran-2,4,5-triyl triacetate, the publication is Anales de la Asociacion Quimica Argentina (1965), 53(3-4), 261-7, database is CAplus.

MeOH-NH3 or MeONa treatment of tetra-O-acetyl-N-acetyl-D-glucosamine nitrile gave no pentose derivatives N-Acetyl-and N-benzoyl-D-glucosamines were stable to MeOH-NH3, but acetylated and benzoylated derivatives gave low recoveries and appreciable quantities of chromogens [including 2-(1,2-dihydroxyethyl)-4-acetamidofuran] and reducing substances, identified on paper chromatog.

Anales de la Asociacion Quimica Argentina published new progress about 14086-92-1. 14086-92-1 belongs to amides-buliding-blocks, auxiliary class Sugar Units,Glu, name is (3R,4R,5S,6R)-6-(Acetoxymethyl)-3-benzamidotetrahydro-2H-pyran-2,4,5-triyl triacetate, and the molecular formula is C4H10O2, Name: (3R,4R,5S,6R)-6-(Acetoxymethyl)-3-benzamidotetrahydro-2H-pyran-2,4,5-triyl triacetate.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Soni, Navneet Omprakash published the artcileTargeting LTB4 -BLT1 – in diabetic nephropathy?, Category: amides-buliding-blocks, the publication is World Journal of Pharmacy and Pharmaceutical Sciences (2017), 6(9), 312-315, database is CAplus.

A review. Lipid mediators play important role in renal injury many of lipid mediators are expressed and up regulated in response to toxins, drugs and in metabolic disorder. Lipid mediators also play role in vascular complication. So new intervention target can be thought by targeting the mediators Diabetic complication can be reduced unfortunately very few study are available to test the hypothesis and come to conclusion. But from all available study reports one can say targeting lipid mediators have future scope as well as limitation.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C14H14, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Shiau, Lie-Ding published the artcileComparison of the Nucleation Kinetics Obtained from the Cumulative Distributions of the Metastable Zone Width and Induction Time Data, Product Details of C6H6N2O, the publication is Molecules (2022), 27(9), 3007, database is CAplus and MEDLINE.

A linearized integral model based on classical nucleation theory is applied in this work to determine the interfacial energy and pre-exponential factor using a linear plot from the cumulative distributions of the metastable zone width (MSZW) data for some systems reported in the literature, including isonicotinamide, Bu paraben, dicyandiamide, and salicylic acid. Based on the same criterion for the nucleation point, the interfacial energy and pre-exponential factor are determined using the conventional linear regression method from the cumulative distributions of the induction time data for the same systems. The results indicate that the interfacial energy and pre-exponential factor calculated from the MSZW data are consistent with those calculated from the induction time for the studied systems.

Molecules published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C16H23BO4, Product Details of C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Scott, Francis L. published the artcileNitrogen systems. VI. Some nucleophilic displacements on 1-carbamoylpyrazoles, SDS of cas: 14294-10-1, the publication is Chemistry & Industry (London, United Kingdom) (1956), 547-8, database is CAplus.

cf. C.A. 49, 15i. ZCSNH₂ (throughout this abstract Z = 3,5-dimethyl-1-pyrazolyl) (I) refluxed in EtOH with RNH₂ [R = Bu] (II), cyclohexyl (III), Ph₂NCONH, H₂O.NH₂, or PhNHNH₂ (IV)], morpholine (V), or piperidine (VI) gave the corresponding monosubstituted thiourea. I with aniline (VII) or benzylamine the sym. disubstituted thiourea. ZC(:NH)NHR [R = Bz (VIII), SO₂C₆H₄Me-p (IX), and CSNHPh (X)] were unaffected by II, III, IV, V, or VI in EtOH, but, in the absence of EtOH, VIII on refluxing with II, III, VI, or VII gave the corresponding Bz derivatives of the mono substituted guanidines and with V gave both 4-(benzoylguanyl)morpholine and BzN:CR₂(R = morpholino). Similarly IX refluxed with II, III, IV, V or VI in the absence of EtOH gave the p-tolylsulfonyl derivatives of the corresponding monosubstituted guanidines. ZC(:NH)NHC(SMe):NR.HI or its 4-Cl or 4-Br derivative (R = Ph) on refluxing in EtOH with amines gives very little reaction, but refluxing with II, III, or V in the absence of EtOH gives RC(:NH)NHC(SMe):NPh (R = the corresponding amino group), α-C₁₀H₇NHCONHC(:NH)Z in EtOH refluxed with II, III, IV, V, or VI gives the corresponding α-naphthyl ureas and ZH. Use of an azide ion gives with ZC(:NH)NHR(R = H or NO₂) 5-amino- and 5-nitraminotetrazoles, resp. Cf. C.A. 47, 6886a, 8670g, 9923c.

Chemistry & Industry (London, United Kingdom) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C14H21BO2, SDS of cas: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Schindler, Norbert published the artcileReactions with dialkylcyanamides. Reaction of dialkylcyanamides with sulfur or phosphorus halides. Synthesis of substituted chloroformamidines, Application of N,N-Dibenzylcyanamide, the publication is Chemische Berichte (1973), 106(1), 56-61, database is CAplus.

Reaction of R2NCN (R = Et, PhCH2, cyclohexyl; R2N = piperidino) with SCl2 (or SOCl2), SO2Cl2, and P(X)Cl3 (X = O or S) yielded ≤90% (R2NCCl:N)2S+Cl Cl-, ≤100% R2NCCl:NSO2Cl, and ≤87% R2NCCl:NP(X)Cl2, resp. The compounds obtained were characterized by the ir spectra.

Chemische Berichte published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Application of N,N-Dibenzylcyanamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sasse, Klaus published the artcile1-Substituted 1,6-dihydro-4-mercapto-6-pyrimidinones and 1,2,3,6-tetrahydro-4-(methylthio)-2,6-pyrimidinediones, Product Details of C5H8N2O, the publication is Justus Liebigs Annalen der Chemie (1976), 768-80, database is CAplus.

RNHCOCH2CSNH2 [R = alkyl, allyl, MeO(CH2)3, Ph, cyclohexyl, PhCHMe, furfuryl] reacted with MeO2CH and Na in EtOH to give 23.1-93.0% pyrimidinones I or EtNHCOCH2CSNH2 reacted with MeO2CH and KOCMe3 in Et2O to give 56% pyridinedicarboxamide II. I were methylated to give 42.2-79.5% III which gave 44.6-73.1% 5-halo derivatives with SOCl2 or Br. Treating RNHCOCH2C(SMe):NH·HI with EtO2Cl (55.-91.4% yields) and cyclizing the RNHCOCH:C(SMe)NHCO2Et in alk. solution gave 23.9-73.3% pyrimidinediones IV. These were halogenated in the 5 position (48.4-77.5% yields) and methylated (MeI) on the N3 position (70.4-81.4% yields).

Justus Liebigs Annalen der Chemie published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Product Details of C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics