Month: December 2022

Ovchinnikova, N. S. published the artcileMass-spectroscopic study of fluoroalkylated and fluoroacylated alkylamines, ethylenediamines and propylenediamines, Product Details of C6H10F3NO, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1986), 827-32, database is CAplus.

The mass spectra of RCONEt₂ (R = CF₃, C₆F₁₃), R¹CONHCH₂CH₂NHCOR (R¹ = CF₃, C₈F₁₇), C₈F₁₇CONHCH₂CH₂NH₂, CF₃CONHCH₂CH(CF₃)NHCOCF₃, R²XNHCH₂CHMeNH₂ (R² = CF₃, C₃F₇, C₆F₁₃, C₈F₁₇; X = CO, CH₂), and R²XNH(CH₂)₃NMe₂ (same R², X) were analyzed. The structure of the amine affected the spectra more strongly than the size of the fluorinated radical.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Product Details of C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Svoboda, Vaclav published the artcileCo-crystal Phase Diagram Determination by the Solution Addition Method, Product Details of C6H6N2O, the publication is Crystal Growth & Design (2022), 22(5), 3376-3384, database is CAplus.

Multicomponent crystals such as co-crystals, salts, and solid solutions can be used to modify phys. properties of active pharmaceutical ingredients. Phase diagrams of such multicomponent crystals are essential for crystallization process development, especially in the case where multiple solid phases may coexist. However, addnl. components and solid phases make phase diagrams more complex and their determination more time consuming. We propose to accelerate this process by identifying the eutectic points and constructing the rest of the phase diagram using thermodn. models, informed by further measurements, if necessary. In this work, a novel solution addition method is proposed for determining the eutectic points in a co-crystal system. This method implements gradual compositional changes to traverse various regions of the phase diagram. Phase boundaries are determined by monitoring changes in the liquid phase (UV-vis) and solid phase (Raman), and eutectic points are obtained from intersection of phase boundaries. The results from solution addition are compared to those of an equilibration method, which combines gravimetry, XRPD, and NMR to identify the eutectic solution composition starting from a composition in the three-phase region of a co-crystal phase diagram. Both methods were able to locate all eutectic points, allowing construction of the ternary phase diagrams of benzoic acid and isonicotinamide in ethanol.

Crystal Growth & Design published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C19H17N3O, Product Details of C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bossi, R. published the artcileAnalysis of polar pesticides in rainwater in Denmark by liquid chromatography-tandem mass spectrometry, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Journal of Chromatography A (2002), 957(1), 27-36, database is CAplus and MEDLINE.

A new LC-MS-MS method for anal. of rainwater was developed and validated for 53 pesticides, degradation products of pesticides and selected nitrophenols. The method was used to monitor the concentration of pesticides in rainwater at one location near Roskilde, Denmark from Feb. 2000 to August 2000. Sampling was done in periods of up to 4 wk using a cooled wet-only sampler. H₂O samples were extracted by solid-phase extraction on Oasis HLB columns. The anal. of the extracts was performed by LC-MS-MS with electrospray ionization. All samples were analyzed in neg. and in pos. ionization mode, resp. for acidic and neutral compounds All analyses were done in the selected reaction monitoring mode to obtain a better signal-to-noise ratio. The method was validated for the following parameters: recovery, detection limit, uncertainty and linearity. Atrazine, terbuthylazine, isoproturon, mechlorprop and (2-methyl-4-chlorophenoxy)acetic acid were measured at concentrations >0.100 μg/l, mainly during the period of agricultural use. Nitrophenols were measured at high concentrations all year with peaks in the cold season (Feb.-Mar.).

Journal of Chromatography A published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Pal, Manojit published the artcileSynthesis of fused sulfonamide (1,1-dioxoisothiazole)-substituted 1,5-diarylpyrazoles as cyclooxygenase inhibitors, Related Products of amides-buliding-blocks, the publication is Journal of the Indian Chemical Society (2003), 80(12), 1095-1101, database is CAplus.

First synthesis of novel 1,1-dioxo-2,3-dihydrobenzo[d]isothiazolyl substituted arylpyrazoles, e.g., I, has been accomplished via oxidative cyclization of 4-fluoro-2-Me benzenesulfonamide followed by the treatment with hydrazine and then with 1,3-dicarbonyl compounds A number of 1,5-diarylpyrazoles were synthesized in good yields and some of them were of potential biol. interest. In studies evaluating cyclooxygenase inhibiting activity, I was found to be more than 100 fold selective in COX-2 inhibition over COX-1.

Journal of the Indian Chemical Society published new progress about 489-17-8. 489-17-8 belongs to amides-buliding-blocks, auxiliary class Fluoride,Sulfamide,Amine,Benzene, name is 4-Fluoro-2-methylbenzenesulfonamide, and the molecular formula is C7H8FNO2S, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Pal, Manojit published the artcileSynthesis and cyclooxygenase-2 (COX-2) inhibiting properties of 1,5-diarylpyrazoles possessing N-substitution on the sulfonamide (-SO₂NH₂) moiety, HPLC of Formula: 489-17-8, the publication is Letters in Drug Design & Discovery (2005), 2(4), 329-340, database is CAplus.

A number of novel 1,5-diarylpyrazoles possessing N-substitution on the sulfonamide (SO₂NH₂) moiety were synthesized and tested for COX-1/COX-2 inhibition in vitro. Many of these 1,1-dioxo-2,3-dihydrobenzo[d]isothiazolyl substituted 1,5-diarylpyrazoles, where the SO₂NH₂ group was a part of the fused ring, showed COX inhibitory activity. Few of them were identified as selective COX-2 inhibitors. A structure-activity relationship study within the series are discussed. Compounds prepared for this study included derivatives of 5-[3-(difluoromethyl)-5-[2-fluoro-4-(methylthio)phenyl]-1H-pyrazol-1-yl]-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide and 5-[5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,3-dihydro-1,2-benzisothiazole dioxide (i.e., cyclic benzenesulfonamide analogs).

Letters in Drug Design & Discovery published new progress about 489-17-8. 489-17-8 belongs to amides-buliding-blocks, auxiliary class Fluoride,Sulfamide,Amine,Benzene, name is 4-Fluoro-2-methylbenzenesulfonamide, and the molecular formula is C7H8FNO2S, HPLC of Formula: 489-17-8.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Semichenko, E. S. published the artcileZeolites in the synthesis of 1-alkyl-2-oxonicotinonitriles, Product Details of C5H8N2O, the publication is Russian Journal of Organic Chemistry (2005), 41(2), 313-314, database is CAplus.

Cyclocondensation of acetylacetone with cyanoacetamide or N-alkylcyanoacetamides (alkyl = Me, Et) in the presence of NaA zeolite afforded 4,6-dimethyl-2-oxonicotinonitrile or 1-alkyl-4,6-dimethyl-2-oxonicotinonitriles, resp. The condensation of 3-hydroxyiminopenta-2,4-dione with cyanoacetamide in the same manner furnished 4,6-dimethyl-5-nitroso-2-oxonicotinonitrile.

Russian Journal of Organic Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C13H10O2, Product Details of C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tharp, Jeffery M. published the artcileGenetic Encoding of Three Distinct Noncanonical Amino Acids Using Reprogrammed Initiator and Nonsense Codons, Application In Synthesis of 2418-95-3, the publication is ACS Chemical Biology (2021), 16(4), 766-774, database is CAplus and MEDLINE.

We recently described an orthogonal initiator tRNA (itRNA^Ty2) that can initiate protein synthesis with noncanonical amino acids (ncAAs) in response to the UAG nonsense codon. Here, we report that a mutant of itRNA^Ty2 (itRNA^Ty2_AUA) can efficiently initiate translation in response to the UAU tyrosine codon, giving rise to proteins with an ncAA at their N-terminus. We show that, in cells expressing itRNA^Ty2_AUA, UAU can function as a dual-use codon that selectively encodes ncAAs at the initiating position and predominantly tyrosine at elongating positions. Using itRNA^Ty2_AUA, in conjunction with its cognate tyrosyl-tRNA synthetase and two mutually orthogonal pyrrolysyl-tRNA synthetases, we demonstrate that UAU can be reassigned along with UAG or UAA to encode two distinct ncAAs in the same protein. Furthermore, by engineering the substrate specificity of one of the pyrrolysyl-tRNA synthetases, we developed a triply orthogonal system that enables simultaneous reassignment of UAU, UAG, and UAA to produce proteins containing three distinct ncAAs at precisely defined sites. To showcase the utility of this system, we produced proteins containing two or three ncAAs, with unique bioorthogonal functional groups, and demonstrate that these proteins can be sep. modified with multiple fluorescent probes.

ACS Chemical Biology published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C4H8Cl2S2, Application In Synthesis of 2418-95-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Lange, Jos H. M. published the artcileNovel 3,4-diarylpyrazolines as potent cannabinoid CB₁ receptor antagonists with lower lipophilicity, Recommanded Product: N-Methyl-N-isopropylsulfamoyl amide, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(21), 4794-4798, database is CAplus and MEDLINE.

3,4-Diarylpyrazolines as potent CB₁ receptor antagonists with lipophilicity lower than that of SLV319 are described. The key change was the replacement of the arylsulfonyl group in the original series by a dialkylaminosulfonyl moiety. The absolute configuration (4S) of enantiomer I was established by X-ray diffraction anal. and I showed a close mol. fit with rimonabant in a CB₁ receptor-based model. II exhibited the highest CB₁ receptor affinity (K_i = 24 nM) in this series, as well as very potent CB₁ antagonistic activity (pA ₂ = 8.8) and a high CB₁/CB₂ subtype selectivity (∼147-fold).

Bioorganic & Medicinal Chemistry Letters published new progress about 372136-76-0. 372136-76-0 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Amine,Aliphatic hydrocarbon chain, name is N-Methyl-N-isopropylsulfamoyl amide, and the molecular formula is C4H12N2O2S, Recommanded Product: N-Methyl-N-isopropylsulfamoyl amide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Michaelis, Julia published the artcileDNA-Triggered Dye Transfer on a Quantum Dot, Safety of 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, the publication is Bioconjugate Chemistry (2014), 25(1), 18-23, database is CAplus and MEDLINE.

Nucleic acid-templated reactions are frequently explored tools in nucleic acid diagnosis. To enable a separation-free DNA detection, the reactive probe mols. require conjugation with reporter groups that provide measurable changes of an observable parameter upon reaction. A widely used, generic read-out method is based on fluorescence resonance energy transfer (FRET) between two appended dyes. Yet, spectral cross-talk usually limits the achievable enhancements of the FRET signal in DNA-directed chemistries. We describe a DNA-triggered transfer reaction which provides for strong increases of a fluorescent signal caused by FRET. The method may involve DNA- and PNA-based probes and is based upon a proximity-triggered transfer reaction which leads to the covalent fixation of a fluorescence dye on the surface of a quantum dot (QD). The transfer reaction brings the dye closer to the QD than hybridization alone. The resulting FRET signal is a specific monitor of the reaction and allows efficient discrimination of single base mismatched templates. Of note, the 35-fold increase of the FRET signal is measured at 310 nm apparent Stokes shift and turnover in template provides a means for signal amplification.

Bioconjugate Chemistry published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Safety of 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Batenko, N. G. published the artcileSynthesis of 2,5-bis(2-aminothiazol-5-yl)-3,6-dichloro-1,4-benzoquinones, Application In Synthesis of 14294-10-1, the publication is Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) (2000), 36(6), 733-737, database is CAplus.

A series of 2-(2-aminothiazol-5-yl)-3,6-dichloro-5-diethylaminoethenyl-1,4-benzoquinones was synthesized from 2-(2-aminothiazol-5-yl)-3,5,6-trichloro-1,4-benzoquinones using acetaldehyde and diethylamine in toluene solution Refluxing these compounds with substituted thioureas in acetonitrile in the presence of hydrochloric acid gives the corresponding 2,5-bis(2-aminothiazol-5-yl)-3,6-dichlorohydroquinones which can be oxidized to the target products with ferric chloride in aqueous DMF.

Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Application In Synthesis of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics