Controlled synthesis of N,N-dimethylarylsulfonamide derivatives as nematicidal agents was written by Chen, Gen-Qiang;Xia, Yan-Fei;Yang, Jin-Ming;Che, Zhi-Ping;Sun, Di;Li, Shen;Tian, Yue-E.;Liu, Sheng-Ming;Jiang, Jia;Lin, Xiao-Min. And the article was included in Journal of Asian Natural Products Research in 2020.HPLC of Formula: 383-31-3 This article mentions the following:
Gramine could be intelligently and efficiently supplied with N,N-dimethylamino group and then reacted with the corresponding sulfonyl chlorides to synthesize N,N-dimethylarylsulfonamides I [R = Ph, 4-FC6H4, 2-thienyl, etc.]. Herein designed and controlled synthesis of N,N-dimethylarylsulfonamide derivatives and first reported the results of the nematicidal activity of N,N-dimethylarylsulfonamide compounds against Meloidogyne incongnita in vitro, resp. Among all of the N,N-dimethylarylsulfonamide derivatives, compounds I [R = Ph, 4-MeOC6H4, 4-O2NC6H4, 8-quinolyl] exhibited potent nematicidal activity with median lethal concentration (LC50) values ranging from 0.22 to 0.26 mg/L. Most noteworthy, compounds I [R = 4-MeOC6H4, 8-quinolyl] showed the best promising and pronounced nematicidal activity, with LC50 values of 0.2381 and 0.2259 mg/L, resp. In the experiment, the researchers used many compounds, for example, 4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3HPLC of Formula: 383-31-3).
4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.HPLC of Formula: 383-31-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics