The ortho effect in pyridines. Part XI. Substituent effects on basicity of 2- and 4-substituted 3-aminopyridines was written by Rasala, D.. And the article was included in Bulletin de la Societe Chimique de France in 1992.Safety of 3-Aminopicolinamide This article mentions the following:
The substituent effects on the pKa values corresponding to the first protonation site of thirty 2- and 4-substituted 3-aminopyridines have been studied. The relative localized and delocalized effects are apparently sensitive to the variation of substituent position in the pyridine ring. An interaction of the 2-substituent with the protonation center has mainly inductive character, whereas, the pKa values of 4-substituted 3-aminopyridines are highly affected by through-resonance. The steric effect was insignificant. In the experiment, the researchers used many compounds, for example, 3-Aminopicolinamide (cas: 50608-99-6Safety of 3-Aminopicolinamide).
3-Aminopicolinamide (cas: 50608-99-6) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Safety of 3-Aminopicolinamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics