Amberlyst A26 OH as a recyclable catalyst for hydration of nitriles and water-based synthesis of 4(1H)-quinazolinones from 2-aminobenzonitrile and carbonyl compounds was written by Tamaddon, Fatemeh;Pouramini, Farzaneh. And the article was included in Synlett in 2014.Quality Control of 2-(2-Chlorophenyl)acetamide This article mentions the following:
Selective hydration of nitriles to primary amides as well as the base-catalyzed synthesis of 2-substituted 4(1H)-quinazolinones, e.g., I, via reaction of 2-aminobenzonitrile with carbonyl compounds using macroporous Amberlyst A26 OH in H2O-EtOH is described. The latter reaction proceeds via tandem hydration of 2-aminobenzonitrile, condensation of the in situ generated 2-aminobenzamide with carbonyl compounds, and cyclization of the imine intermediate to give the quinazolinone derivatives In the experiment, the researchers used many compounds, for example, 2-(2-Chlorophenyl)acetamide (cas: 10268-06-1Quality Control of 2-(2-Chlorophenyl)acetamide).
2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Quality Control of 2-(2-Chlorophenyl)acetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics